Martina
ABRIGO, et al
Antibacterial Nanofibers
http://www.swinburne.edu.au/media-centre/news/2015/08/smart-dressings-speed-healing-of-chronic-wounds-.html
21 Aug 2015
21 Aug 2015
Smart dressings speed healing of chronic wounds
Researchers at Swinburne University of Technology are developing innovative nanofibre meshes that might draw bacteria out of wounds and speed up the healing process.
The research is the focus of Swinburne PhD candidate Martina Abrigo, who received the university’s Chancellor's Research Scholarship to undertake this work.
Using a technique called electrospinning – in which polymer filaments 100 times thinner than a human hair are squeezed out of an electrified nozzle – Ms Abrigo and her colleagues have made nanofibre meshes that can draw bacteria from a wound.
In the first phase of research polymer nanofibres were placed over the top of films of Staphylococcus aureus, a bacterium involved in chronic wound infection. The researchers found the bacteria quickly attached to the fibres.
When the fibres were smaller than the individual bacteria, fewer cells attached and those that did attach died as they attempted to wrap around the fibre.
In the second phase, the tiny nanofibres were coated with different compounds and tested on the bacteria Escherichia coli, also commonly found in chronic wounds.
The researchers found these bacteria rapidly transferred onto fibres coated with allylamine, independent of the fibre size, but did not attach to fibres coated with acrylic acid.
In the third phase of research, the nanofibre meshes have been tested on tissue-engineered skin models in a partnership with researchers at the University of Sheffield in the UK. The results of this research are yet to be published, but indicate that similar effects could be seen in living tissue.
“For most people, wounds heal quickly. But for some people, the repair process gets stuck and so wounds take much longer to heal. This makes them vulnerable to infection,” Mas Abrigo said.
“We hope this work will lead to smart wound dressings that could prevent infections. Doctors could put a nanomesh dressing on a wound and simply peel it off to get rid of the germs.”
[Now add silver ... ]
http://pubs.acs.org/doi/abs/10.1021/acsami.5b00453
http://scitation.aip.org/content/avs/journal/bip/10/4/10.1116/1.4927218?TRACK=RSS
Bacterial
response to different surface chemistries fabricated by
plasma polymerization on electrospun nanofibers
Martina Abrigo1, Peter Kingshott1 and Sally L. McArthur
Martina Abrigo1, Peter Kingshott1 and Sally L. McArthur
Control over bacterial attachment and proliferation onto nanofibrous materials constitutes a major challenge for a variety of applications, including filtration membranes, protective clothing, wound dressings, and tissue engineering scaffolds. To develop effective devices, the interactions that occur between bacteria and nanofibers with different morphological and physicochemical properties need to be investigated. This paper explores the influence of fiber surface chemistry on bacterial behavior. Different chemical functionalities were generated on the surface of electrospun polystyrene nanofibers through plasma polymerization of four monomers (acrylic acid, allylamine, 1,7-octadiene, and 1,8-cineole). The interactions of Escherichia coli with the surface modified fibers were investigated through a combination of scanning electron microscopy and confocal laser scanning microscopy. Fiber wettability, surface charge, and chemistry were found to affect the ability of bacterial cells to attach and proliferate throughout the nanofiber meshes. The highest proportion of viable cells attachment occurred on the hydrophilic amine rich coating, followed by the hydrophobic octadiene. The acrylic acid coating rich in carboxyl groups showed a significantly lower attraction of bacterial cells. The 1,8-cineole retained the antibacterial activity of the monomer, resulting with a high proportion of dead isolated cells attached onto the fibers. Results showed that the surface chemistry properties of nanofibrous membranes can be strategically tuned to control bacterial behavior.
KR101336251
METHOD FOR FABRICATION OF ELECTROSPUN POLYSTYRENE NANOFIBER AND METHOD FOR FABRICATION OF ELECTROSPUN POLYSTYRENE-QUANTUM DOT HYBRID NANOFIBER USING STYRENE MONOMER
METHOD FOR FABRICATION OF ELECTROSPUN POLYSTYRENE NANOFIBER AND METHOD FOR FABRICATION OF ELECTROSPUN POLYSTYRENE-QUANTUM DOT HYBRID NANOFIBER USING STYRENE MONOMER
Inventor: LEE TAE WOO, et al.
Applicant: POSTECH ACAD IND FOUND
The present invention relates to a method for manufacturing electrospun polystyrene nanofibers and a method for manufacturing electrospun polystyrene-quantum dot hybrid nanofibers using a styrene monomer, without using a solvent, wherein the method for manufacturing electrospun polystyrene-quantum dot hybrid nanofibers comprises the steps of: manufactuirng a polystyrene-quantum dot composite by heating the mixture of liquid styrene monomer and a quantum dot; and a electrospinning the polystyrene-quantum dot composite.
