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Patents : Herbs vs Depression







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COMPOSITIONS OF CALIFORNIA POPPY AND METHOD FOR THE TREATMENT OF SLEEP AND DREAM-RELATED DISORDERS
WO2018145216

An herbal pharmaceutical compositions of California poppy and methods for the treatment of sleep disorders and dream-related disorders is disclosed. The formulation may be in the form of capsules, tablets, caplets or other oral dosage forms and comprises preferably 600 to 2400 mg of a ratio of 4-10 parts (wt) dried plant material to 1 part (wt) aqueous alcohol (50-90 vol% ethanol) extract that is equivalent to 3-12 grams of the dried herb top of California poppy and contain at least 0.8 wt% isoquinoline alkaloids. The composition may further comprise isoquinoline alkaloids whose composition contains Californidine, Escholtzine and Protopine. California poppy can also be used as a therapy for managing people that have sleep and dream disorders such as Post Traumatic Stress syndrome and similar conditions that induce nightmares as well as people using tranquilizer, antidepressant, antipsychotic, sedative, hypnotic and analgesic drugs.



Extraction method for cistanche based phenylethanoid glycoside substance and anti-depression application thereof
CN107397798

The invention relates to application of a cistanche based extract, i.e. application of the cistanche extract to preparation of anti-depression drugs. The cistanche extract is an effective part obtained by subjecting cistanche herbal powder to liquid reflux extraction to obtain a concentrated solution, and finally conducting macroporous adsorption resin column chromatography separation. The effective component prepared by subjecting cistanche deserticola and cistanche tubulosa to certain extraction and separation has good anti-depression effect, and can be applied to preparation and development of antidepressant preparations.



Antidepressant health-care product containing rice husk flavone
CN107184834

The invention discloses an antidepressant health-care product containing rice husk flavone. The antidepressant health-care product is prepared from the following raw materials in percentage by weight: 50 to 70 percent of the rice husk flavone, 5 to 10 percent of a rhizoma cyperi extract, 5 to 10 percent of a rhizoma atractylodis macrocephalae extract, 5 to 10 percent of a poria extract, 5 to 10 percent of a radix notoginseng extract and 5 to 10 percent of a medicated leaven extract. A groundbreaking technology disclosed by the invention is that the rice husk flavone is used as an antidepressant core functional material; a provided traditional Chinese medicinal composition for treating depression is reasonable in matching; a flavone and Chinese herbal medicine mixed health-care product with an antidepressant effect is formed. According to the antidepressant health-care product disclosed by the invention, found by experimental research on an in vitro depression cell model, the composition containing the rice husk flavone has a better protecting effect on cells and obvious effects on prevention and treatment of the depression; toxic and/or side effects caused by excessive chemical synthetic drugs can be avoided; in addition, the antidepressant health-care product is low in price and wide in sources, so the rice husk flavone composition attracts a wide spread attention.



HERBAL TEA COMPOSITION
PH22016000601

The present utility model discloses herbal tea composition comprising juices of: ginger, turmeric, lemon grass, malunggay (moringa) leaves and sugar. It also relates to a process for producing the tea composition comprising the steps of: cleaning, juice extraction, measuring, combining, cooking, cooling, straining and packing. The present herbal tea composition have enhance health benefits that helps relief various ailments and health conditions such as nausea, morning sickness, inflammatory skin conditions, dysmenorrhea, stomach pain, diarrhea, intestinal gas, headaches, colds, and mouth sores. It furthermore acts as antidepressant, cleansing agent, anti-inflammatory, anti-oxidants and anti-ageing. Having the ginger, malunggay (moringa), turmeric, lemongrass and brown sugar present in the herbal tea composition provide good source of vitamins such as A, B, C, E and K, folate, folic acid, magnesium, zinc, copper, iron, potassium, sodium, phosphorus, calcium, manganese, Omega-3 fatty acids.


   
Pharmaceutical compositions and application thereof in treating or preventing depressive and neurodegenerative diseases
TW201321011

The present invention discloses a group of Chinese herbal medicine (CHM) for preventing or treating depression and neurodegeneration disease potential, which including Cortex Phellodendri, Scutellariae Radix, Rhizoma Chuanxiong, Astragali Radix, Eucommia ulmoides, Saposhnikovia divaricata, Corydalis yanhusuo as the active ingredient. These herbal medicines promote proliferation of hippocampal newborn cell in vitro and in vivo; in a depression-like animal model, these herbal medicines exhibit significant antidepressant effect, anti-apoptosis effect, and modulate HPA axis.



Herbal extracts from the evening primrose (Oenothera biennis) for the treatment of central nervous system disorders
EP2703002

Oenothera extract or its derivative and/or ingredient, is claimed. An independent claim is included for an agent comprising Oenothera extract or its derivative and/or ingredient. ACTIVITY : Antidepressant; CNS-Gen.; Nootropic; Antiparkinsonian; Anabolic.



FORMULATION BASED ON SULPIRIDE AND A SYNERGISTIC HOMEOPATHIC COMPOSITION FOR TREATMENT OF DEPRESSIVE SYNDROME
WO2011148203

The discloses involve a therapeutic formulation comprising (i) sulpiride (1); (ii) a homeopathic composition consisting of the Krebs cycle involving compounds and herbal extracts; and (iii) one or more excipients which yield in desired final dosage form: injection, tablets, capsules, oral solution, and syrup. The formulation exhibits a profound antidepressant activity due to synergistic action of homeopathic composition of Krebs cycle- involving components and herbal extracts on basic pharmacological effects of sulpiride, providing: potent antidepressant action at dosages of sulpiride up to seven times (7x) lower than is usual according to conventional clinical procedures; absence of side- effects of sulpiride due to significatly reduced dosages; as well as substantial anxiolytic and hypnotic activities.



Herbal composition for side-effect free treatment of depression, comprising herbs or herbal extracts for promoting blood flow and reducing coagulated blood levels, calming, sedation and flow of Qi
DE202004018534

A herbal composition (I) comprises herbs (or their extracts) for: (a) promoting blood flow and reducing coagulated blood levels; (b) calming; (c) sedation; and (d) flow of 'Qi'; where (a) is one of 15 specific herbs (e.g. Salvia multiorhiza), (b) is one of 9 specific herbs (e.g. Lilium brownii), (c) is one of 4 specific herbs (e.g. Rehmannia glutinosa) and (d) is one of 20 specific herbs (e.g. Citrus cinensis). A herbal composition (I) comprises herbs (or their extracts) for: (a) promoting blood flow and reducing coagulated blood levels; (b) calming; (c) sedation; and (d) flow of 'Qi'. Herb (a) is Salvia multiorhiza, Lablab pruprueus, Dendranthema x grandiflorum, Cyperus rotundus, Prunus persica, Prunus davidiana, Paeonia sufruticosa, Senna tora, Tribulus terrestris, Paeonia lactiflora, Crocus sativus, Andrographus paniculata, Ligusticum chuanxiong, Gardenia jasminoidesor Cryptotaenia japonica. Herb (b) is Lilium brownii, Ziziphus jujuba, Polygala tenuifolia, Atractylodes macrocephala, Triticum aestivum, Acorus calamus, Anemarrhena asphodeloides, Phyllostachys nigraor Ocimum basilicum. Herb (c) is Rehmannia glutinosa, Gentiara triflora, Gentiann scabraor Schisandra chinensis. Herb (d) is Citrus cinensis, Citrus aurantium, Citrus reticulata, Perillas frutescens, Centella asiatica, Lingusticum sinsense, Angelica sinensis, Curcuma longa, Glycyrrhizia uralensis, Lindera strychnifolia, Gastrodia elata, Saussurea costus, Sparganium stoliniferum, Foeniculum vulgare, Angelica pubescens, Arisaemia amurense, Acorus gramineus, Anemone altaica, Gentiana macrophyllaor Gentiana dahuria. ACTIVITY : Antidepressant; Tranquilizer. In a force swimming test for antidepressant activity in mice, the immobility time for mice treated orally with 6000 mg/kg of a 1:1:1:1 mixture of dried aqueous extracts of Salvia multiorhiza, Lilium brownii, Rehmannia glutinosaand Citrus cinensis was 114 seconds, compared with 104 seconds for mice treated orally with 10 mg/kg of imipramine and 180 seconds for vehicle-only controls.






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