Sunjie YE, et al.
Gold Nanotubes vs Cancer
February 17, 2015
Gold nanotubes image and destroy
cancer cells in three ways
Pulsed near infrared light (shown in red) is shone onto a tumor
(shown in white) that is encased in blood vessels. The tumor is
imaged by multispectral optoacoustic tomography via the ultrasound
emission (shown in blue) from the gold nanotubes.
(credit: Jing Claussen/iThera Medical, Germany)
Leeds scientists have shown that gold nanotubes can fight cancer
in three ways: as internal nanoprobes for high-resolution
photoacoustic imaging, as drug delivery vehicles, and as agents
for destroying cancer cells.
The study, published in the journal Advanced Functional Materials,
details the first successful demonstration of the biomedical use
of gold nanotubes in a mouse model of human cancer — an
alternative to existing chemotherapy and radiotherapy methods,
which have serious side effects.
“To the best of our knowledge, this is the first [combination] in
vitro [lab] and in vivo [live in animals] study of gold
nanotubes,” the researchers say.
According to study lead author Sunjie Ye, who is based in the
School of Physics and Astronomy and the Leeds Institute for
Biomedical and Clinical Sciences at the University of Leeds, “high
recurrence rates of tumors after surgical removal remain a
formidable challenge in cancer therapy. Gold nanotubes have the
potential to enhance the efficacy of these conventional treatments
by integrating diagnosis and therapy in one single system.”
Gold nanotube schematic showing hollow interior (left) and
transmission electron microscope image (right) (credit: Jeremy
Freear/Advanced Functional Materials)
The researchers injected the gold nanotubes intravenously. They
controlled the length of the nanotubes for the right dimensions to
absorb near-infrared light (which penetrates tissue well) from a
pulsed infrared laser beam.
By adjusting the brightness of the laser pulse, the researchers
were able to control whether the gold nanotubes were in imaging
mode or cancer-destruction mode.
For imaging, after absorbing energy from the laser pulse, the gold
nanotubes generated ultrasound for multispectral optoacoustic
tomography (MSOT), used to detect the gold nanotubes.
For cancer destruction, there were two options:
Use a stronger laser beam to rapidly raise the temperature in the
vicinity of the nanotubes so that the temperature was high enough
to destroy cancer cells.
Load the central hollow core of the nanotubes with a therapeutic
The gold nanotubes were coated with protective sodium
polystyrenesulfonate (PSS) and were excreted from the body, and
therefore are unlikely to cause problems in terms of toxicity, an
important consideration when developing nanoparticles for clinical
use, the researchers say.
Advanced Functional Materials, 2015
12 FEB 2015
Engineering Gold Nanotubes with
Controlled Length and Near-Infrared Absorption for
Sunjie Ye, Gemma Marston, James R. McLaughlan, Daniel O. Sigle,
Nicola Ingram, Steven Freear, Jeremy J. Baumberg, Richard J.
Bushby, Alexander F. Markham, Kevin Critchley, Patricia Louise
Coletta and Stephen D. Evans
Important aspects in engineering gold nanoparticles for
theranostic applications include the control of size, optical
properties, cytotoxicity, biodistribution, and clearance. In this
study, gold nanotubes with controlled length and tunable
absorption in the near-infrared (NIR) region have been exploited
for applications as photothermal conversion agents and in vivo
photoacoustic imaging contrast agents. A length-controlled
synthesis has been developed to fabricate gold nanotubes (NTs)
with well-defined shape (i.e., inner void and open ends), high
crystallinity, and tunable NIR surface plasmon resonance. A
coating of poly(sodium 4-styrenesulfonate) (PSS) endows the
nanotubes with colloidal stability and low cytotoxicity. The
PSS-coated Au NTs have the following characteristics: i) cellular
uptake by colorectal cancer cells and macrophage cells, ii)
photothermal ablation of cancer cells using single wavelength
pulse laser irradiation, iii) excellent in vivo photoacoustic
signal generation capability and accumulation at the tumor site,
iv) hepatobiliary clearance within 72 h postintravenous injection.
These results demonstrate that these PSS-coated Au NTs have the
ideal attributes to develop their potential as effective and safe
in vivo imaging nanoprobes, photothermal conversion agents, and
drug delivery vehicles. To the best of knowledge, this is the
first in vitro and in vivo study of gold nanotubes.
High-length-to-diameter-ratio solid-walled hollow
gold/gold-silver nanotube and manufacturing method thereof
The invention discloses a high-length-to-diameter-ratio
solid-walled hollow gold/gold-silver nanotube and a controllable
synthesis manufacturing method of the nanotube. According to the
method, a high-length-to-diameter-ratio silver nanowire serves as
a template; as Au (I) salt is adopted as a gold source in an
optimized mode for replacement reaction, the adjustability of the
replacement reaction rate and the precise controllability of
experiments can be improved; in this way, the wall thickness of
the nanotube and the flatness of the surface of the nanotube can
be controlled more accurately, and the situation that a porous
wall and a uneven surface are produced, or the nanotube collapses
or fractures is avoided. The high-length-to-diameter-ratio
solid-walled hollow gold/gold-silver nanotube has better
conductivity, oxidation resistance, strength, bending resistance,
light transmittance and abrasion resistance.
Noble metal nanotube and method for preparation thereof
Also published as: EP1550632 // JP3842177
A nanotube of which basic skeleton is made of a noble metal
element is provided. The skeleton of the nanotube is made of (1) a
single noble metal element of gold (Au), silver (Ag), platinum
(Pt), palladium (Pd), rhodium (Rh), or iridium (Ir) as noble metal
elements, of (2) a mixture in which (Ru) is added to the above (1)
in any proportion, or of (3) a mixture in which a base metal
element is added to the above (1) or (2) in any proportion, and
the noble metal nanotube has a tubular form of about 5-7 nm in
outer diameter, about 2-4 nm in inner diameter, about 1-2 nm in
thickness, and 10 nm or more in length.
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