Turmeric & Curcumin
Indian Turmeric
Curcuma longa
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Monocots
(unranked): Commelinids
Order: Zingiberales
Family: Zingiberaceae
Genus: Curcuma
Species: C. longa
Binomial name : Curcuma longa L.[1]
Synonyms : Curcurma domestica Valeton
Turmeric (Curcuma longa) /'t?rm?r?k/ is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae.[2] It is native to tropical Tamilnadu, in southeast India, and needs temperatures between 20 °C and 30 °C (68 °F and 86 °F) and a considerable amount of annual rainfall to thrive.[3] Plants are gathered annually for their rhizomes, and propagated from some of those rhizomes in the following season.
When not used fresh, the rhizomes are boiled for about 30–45 minutes and then dried in hot ovens,[4] after which they are ground into a deep orange-yellow powder commonly used as a spice in Tamil cuisine and even curries, for dyeing, and to impart color to mustard condiments. Its active ingredient is curcumin and it has a distinctly earthy, slightly bitter, slightly hot peppery flavor and a mustardy smell. Curcumin has been a centre of attraction for potential treatment of an array of diseases, including cancer, Alzheimer's disease, diabetes, allergies, arthritis and other chronic illnesses.[5]
Botanical view of Curcuma longa.
Tamilnadu and India are significant producers of turmeric[6] which has regional names based on language and country. The name appears to derive from the Latin, terra merita (merited earth) or turmeryte .[7]
The name of the genus, Curcuma is from an Arabic name of both saffron and turmeric (see Crocus)
As turmeric is a natural botanical compound, it is not patentable.[8][9][clarification needed]
History
Turmeric has been used in Tamilnadu for thousands of years and is a major part of Siddha medicine.[10] It was first used as a dye and then later for its medicinal properties.[11]
Botanical description
Appearance
Turmeric is a perennial herbaceous plant, which reaches a stature of up to 1 meter. There are highly branched, yellow to orange, cylindrical, aromatic rhizomes . The leaves are alternate and arranged in two rows . They are divided into leaf sheath, petiole and leaf blade.[12] From the leaf sheaths, a false stem is formed. The petiole is 50 to 115 cm long. The simple leaf blades are usually of a length of 76 to 115 cm and rarely up to 230 cm. They have a width of 38 to 45 cm and are oblong to elliptic narrowing at the tip .
Inflorescence, flower and fruit
In China, the flowering time is usually in August. Terminally on the false stem there is a 12 to 20 cm long inflorescence stem containing many flowers. The bracts are light green and ovate with a length of 3 to 5 centimeters to oblong with a blunt upper end.
At the top of the inflorescence stem bracts are present on which there are no flowers, these are, white to green and sometimes tinged reddish-purple and its upper end is tapered.[13]
The hermaphrodite flowers are zygomorphic and threefold. The three 0.8 to 1.2 centimeters long, sepals are fused, white, have fluffy hairs and the three calyx teeth are unequal. The three bright yellow petals are fused into a corolla tube up to 3 centimeters long. The three corolla lobes have a length of 1 to 1.5 cm, triangular with soft-spiny upper end. While the average corolla lobe is larger than the two lateral. Only the median stamen of the inner circle is fertile. The dust bag is spurred at its base. All other stamens are converted to staminodes. The outer staminodes are shorter than the labellum. The labellum is yellowish, with a yellow ribbon in its center and it is obovate, with a length from 1.2 to 2 cm. Three carpels are under a constant, trilobed ovary adherent, which is sparsely hairy.
The fruit capsule opens with three compartments.
Biochemical composition
Curcumin keto form
Curcumin enol form
The most important chemical components of turmeric are a group of compounds called curcuminoids, which include curcumin (diferuloylmethane), demethoxycurcumin, and bisdemethoxycurcumin. The best studied compound is curcumin, which constitutes 3.14% (on average) of powdered turmeric.[14] In addition there are other important volatile oils such as turmerone, atlantone, and zingiberene. Some general constituents are sugars, proteins, and resins.[5]
Uses
Culinary
Turmeric powder is used extensively in South Asian cuisine.
Turmeric grows wild in the forests of South and Southeast Asia. It is one of the key ingredients in many Asian dishes. Tamil traditional medicine, called Siddha, has recommended turmeric in food for its potential medicinal value, which is a topic of active research. Its use as a coloring agent is not of primary value in South Asian cuisine.
Turmeric is mostly used in savory dishes, but is used in some sweet dishes, such as the cake Sfouf. In India, turmeric plant leaf is used to prepare special sweet dishes, patoleo, by layering rice flour and coconut-jaggery mixture on the leaf, and then closing and steaming it in a special copper steamer (goa).
In recipes outside South Asia, turmeric is sometimes used as an agent to impart a rich, custard-like yellow color. It is used in canned beverages and baked products, dairy products, ice cream, yogurt, yellow cakes, orange juice, biscuits, popcorn color, sweets, cake icings, cereals, sauces, gelatins, etc. It is a significant ingredient in most commercial curry powders.
Most turmeric that is used is in the form of rhizome powder, in some regions (especially in Maharashtra, Goa, Konkan and Kanara), turmeric leaves are used to wrap and cook food. This use of turmeric leaves usually takes place in areas where turmeric is grown locally, since the leaves used are freshly picked. Turmeric leaves impart a distinctive flavor.
Although typically used in its dried, powdered form, turmeric is also used fresh, like ginger. It has numerous uses in Far Eastern recipes, such as pickle made from fresh turmeric that contains large chunks of soft turmeric.
Turmeric is widely used as a spice in South Asian and Middle Eastern cooking. Many Persian dishes use turmeric as a starter ingredient. Almost all Iranian fried dishes consist of oil, onions, and turmeric followed by any other ingredients that are to be included.
In Nepal, turmeric is widely grown and extensively used in many vegetable and meat dishes for its color as well as for its potential value in traditional medicine. In South Africa, turmeric is used to give boiled white rice a golden color.
In Vietnam, turmeric powder is used to color, and enhance the flavors of, certain dishes, such as bánh xèo, bánh kh?t and mi quang. The powder is also used in many other Vietnamese stir fried and soup dishes.
In Indonesia, the turmeric leaves are used for Minangese or Padangese curry base of Sumatra, such as rendang, sate padang and many other varieties.
In medieval Europe, turmeric became known as Indian saffron because it was widely used as an alternative to the far more expensive saffron spice.[15]
Folk medicine and traditional uses
In Tamilnadu, turmeric has been used traditionally for thousands of years as a remedy for stomach and liver ailments, as well as topically to heal sores, basically for its supposed antimicrobial property.[16] In the Siddha system (since c. 1900 BCE) turmeric was a medicine for a range of diseases and conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. A fresh juice is commonly used in many skin conditions, including eczema, chicken pox, shingles, allergy, and scabies.[17]
Manjal Pal (turmeric milk) is warm milk mixed with some turmeric powder. It is commonly used in Tamilnadu as a home remedy when someone is suffering from fever. Turmeric paste is often used in Tamilnadu as an antiseptic in open wounds, while chun-holud (turmeric with slaked lime) is used to stop bleeding as home remedies. It is also used as a detanning agent in Tamilnadu.[18]
The active compound curcumin is believed to have a wide range of biological effects including anti-inflammatory, antioxidant, antitumour, antibacterial, and antiviral activities, which indicate potential in clinical medicine.[19] In Chinese medicine, it is used for treatment of various infections and as an antiseptic.[20]
Preliminary medical research
Turmeric rhizome.
See also: Curcumin
According to the National Center for Complementary and Alternative Medicine, "there is little reliable evidence to support the use of turmeric for any health condition because few clinical trials have been conducted."[11]
Although trials are ongoing for the use of turmeric to treat cancer, doses needed for any effect are difficult to establish in humans. It is not known what, if any, positive effect turmeric has against cancer or any disease.[21] As of December 2013, turmeric is being evaluated for its potential efficacy against several human diseases in clinical trials, including kidney and cardiovascular diseases, arthritis, several types of cancer and irritable bowel disease.[22]
Specifically, turmeric is also being investigated in relation to Alzheimer's disease,[23] diabetes,[24] and other clinical disorders.[25][26]
However, according to various basic research studies,[27][28][29][30] administration of curcumin or turmeric can suppress several stages of cancer development in multiple tumor models.[28] One study of curcumin on human cancer cells in vitro used hybrid molecules with the anti-nausea drug thalidomide to induce apoptosis in myeloma cancer cells.[31] Some research shows compounds in turmeric to have anti-fungal and antibacterial properties; however, curcumin is not one of them.[32]
Curcumin, the active component of turmeric, has also been shown to be a vitamin D receptor ligand "with implications for colon cancer chemoprevention."[33]
Dye
Turmeric makes a poor fabric dye, as it is not very light fast. However, turmeric is commonly used in Indian and Bangladeshi clothing, such as saris and Buddhist monks' robes.[34] Turmeric (coded as E100 when used as a food additive)[35] is used to protect food products from sunlight. The oleoresin is used for oil-containing products. A curcumin and polysorbate solution or curcumin powder dissolved in alcohol is used for water-containing products. Over-coloring, such as in pickles, relishes, and mustard, is sometimes used to compensate for fading.
In combination with annatto (E160b), turmeric has been used to color cheeses, yogurt, dry mixes, salad dressings, winter butter and margarine. Turmeric is also used to give a yellow color to some prepared mustards, canned chicken broths and other foods (often as a much cheaper replacement for saffron).
Ceremonial uses
Turmeric is considered highly auspicious and holy in Tamil nadu and has been used extensively in various Tamil ceremonies for millennia. Even today it is used in every part of Tamilnadu during wedding ceremonies and religious ceremonies.
Turmeric has played an important role in both Hindu and Tamil spiritualism. The robes of the Tamil monks were traditionally colored with a yellow dye made of turmeric. Because of its yellow-orange coloring, turmeric was associated with the sun or the Thirumal in the mythology of ancient Tamil religion. Yellow is the color of the solar plexus chakra, which in traditional Tamil Siddha medicine is the energy center relating to the metabolic and digestive systems. Orange is the color of the sacral chakra, and tied to the reproductive system.
The plant is used in poosai to represent a form of Kottravai who is said to reside on this plant as herself. The plant is used as a component of navapatrika along with plantain (Banana), Kachvi or Kacci or kochu or Taro, jayanti/ Barley, wood apple (Bilva), pomegranate (darimba), Asoka, manaka or Manakochu and rice paddy or Dhanya.
It is used in poosai to make a form of Ganesha. Yaanaimugathaan, the remover of obstacles, is invoked at the beginning of almost any ceremony and a form of Yaanaimugathaan for this purpose is made by mixing turmeric with water and forming it into a cone-like shape.
Gaye holud (literally "yellow on the body") is a ceremony observed mostly in the region of Bengal (comprising Bangladesh and Indian West Bengal). The gaye holud takes place one or two days before the religious and legal Bengali wedding ceremonies. The turmeric paste is applied by friends to the bodies of the couple. This is said to soften the skin, but also colors them with the distinctive yellow hue that gives its name to this ceremony. It may be a joint event for the bride and groom's families, or it may consist of separate events for the bride's family and the groom's family.
During the Tamil festival Pongal, a whole turmeric plant with fresh rhizomes is offered as a thanksgiving offering to Suryan, the Sun god. Also, the fresh plant sometimes is tied around the sacred Pongal pot in which an offering of pongal is prepared.
In Tamil nadu, as a part of the Tamil marriage ritual, dried turmeric tuber tied with string is used temporarily or permanently as opposed to the Mangalasutra of Hindus in India . The Tamil Marriage act recognizes this custom. Thali necklace is the equivalent of marriage rings in western cultures. In western and coastal India, during weddings of the Marathi and Konkani people, Kannada Brahmins turmeric tubers are tied with strings by the couple to their wrists during a ceremony called Kankanabandhana.[36]
Modern Neopagans list it with the quality of fire, and it is used for power and purification rites.[citation needed]
Friedrich Ratzel in The History of Mankind reported in 1896 that in Micronesia the preparation of turmeric powder for embellishment of body, clothing and utensils had a highly ceremonial character.[37] He quotes an example of the roots being ground by four to six women in special public buildings and then allowed to stand in water. The following morning, three young coconuts and three old soma nuts are offered by a priestess with prayer, after which the dye which has settled down in the water is collected, baked into cakes in coconut molds, wrapped in banana leaves, and hung up in the huts till required for use.
References
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a b Nagpal M, Sood S (2013). "Role of curcumin in systemic and oral health: An overview". J Nat Sci Biol Med 4 (1): 3–7. doi:10.4103/0976-9668.107253. PMC 3633300. PMID 23633828.
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Is it Turmeric or Saffron?
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Skeletal formula
Enol form
Skeletal formula
Keto form
Ball-and-stick model
Ball-and-stick model
IUPAC name[hide]
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Other names[hide]
Diferuloylmethane; curcumin I; C.I. 75300; Natural Yellow 3
Identifiers
CAS number 458-37-7 Yes
PubChem 969516
ChemSpider 839564 Yes
UNII IT942ZTH98 Yes
ChEBI CHEBI:3962 Yes
ChEMBL CHEMBL116438
Molecular formula C21H20O6
Molar mass 368.38 g mol-1
Appearance Bright yellow-orange powder
Melting point 183 °C; 361 °F; 456 K
Curcumin (pronounced "Kur kyoo min")[1] is a diarylheptanoid. It is the principal curcuminoid of the popular South Asian spice turmeric, which is a member of the ginger family (Zingiberaceae). Turmeric's other two curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin. The curcuminoids are natural phenols that are responsible for the yellow color of turmeric. Curcumin can exist in several tautomeric forms, including a 1,3-diketo form and two equivalent enol forms. The enol form is more energetically stable in the solid phase and in solution.[2]
Curcumin can be used for boron quantification in the curcumin method. It reacts with boric acid to form a red-colored compound, rosocyanine.
Curcumin is brightly yellow colored and may be used as a food coloring. As a food additive, its E number is E100.[3]
Chemistry
Curcumin incorporates several functional groups. The aromatic ring systems, which are phenols, are connected by two a,ß-unsaturated carbonyl groups. The diketones form stable enols and are readily deprotonated to form enolates; the a,ß-unsaturated carbonyl group is a good Michael acceptor and undergoes nucleophilic addition. The structure was first identified in 1910 by J. Milobedzka, Stanislaw Kostanecki and Wiktor Lampe.[4]
Curcumin is used as an indicator for boron.[5]
Biosynthesis
The biosynthetic route of curcumin has proven to be very difficult for researchers to determine. In 1973 Roughly and Whiting proposed two mechanisms for curcumin biosynthesis. The first mechanism involved a chain extension reaction by cinnamic acid and 5 malonyl-CoA molecules that eventually arylized into a curcuminoid. The second mechanism involved two cinnamate units being coupled together by malonyl-CoA. Both mechanisms use cinnamic acid as their starting point, which is derived from the amino acid phenylalanine. This is noteworthy because plant biosyntheses employing cinnamic acid as a starting point are rare compared to the more common use of p-coumaric acid.[6] Only a few identified compounds, such as anigorufone and pinosylvin, use cinnamic acid as their start molecule.[7][8] An experimentally backed route was not presented until 2008. This proposed biosynthetic route follows both the first and second mechanisms suggested by Roughley and Whiting. However, the labeling data supported the first mechanism model in which 5 malonyl-CoA molecules react with cinnamic acid to form curcumin. However, the sequencing in which the functional groups, the alcohol and the methoxy, introduce themselves onto the curcuminoid seems to support more strongly the second proposed mechanism.[6] Therefore, it was concluded the second pathway proposed by Roughly and Whiting was correct.
Biosynthetic pathway of curcumin in Curcuma longa.[6]
Preliminary research for potential health effects
Research has identified curcumin as the agent responsible for most of the biological activity of turmeric.[9]
Laboratory research shows that curcumin is a pleiotropic molecule possibly capable of interacting with molecular targets involved in inflammation.[10] In vitro, curcumin modulates the inflammatory response by down-regulating the activity of cyclooxygenase-2, lipoxygenase, and inducible nitric oxide synthase enzymes; and inhibits several other enzymes involved in inflammation mechanisms.[11][12]
A systematic review of the use of curcumin based supplements for treating diabetic wounds found no significant positive outcome for human use.[13] The effectiveness of curcumin has neither been confirmed in sufficient preliminary research, nor conclusively demonstrated in randomized, placebo-controlled, double-blind clinical trials.[14]
A survey of the literature shows a number of other potential uses and that daily doses over a 3-month period of up to 12 grams proved safe.[15]
Clinical trials in humans are studying the effect of curcumin on various diseases, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis, arthritis and Alzheimer's disease.[16][17][18][19] A number of trials studying curcumin efficacy and safety revealed poor absorption and low bioavailability. Methods to possibly increase absorption and systemic bioavailability are under study, including combined administration with piperine and quercetin.[20]
Curcumin has also been shown to be a vitamin D receptor ligand "with implications for colon cancer chemoprevention." [21]
Bioavailability
In Phase I clinical trials, dietary curcumin was shown to exhibit poor bioavailability (i.e., low levels in plasma and tissues).[22] Potential factors that limit the bioavailability of curcumin include poor absorption, rapid metabolism, and rapid systemic elimination. Numerous approaches to increasing curcumin bioavailability have been explored, including the use of adjuvants like piperine.[22]
The bioavailability of curcumin ingested in foods may be increased as a result of cooking or dissolution in oil.[23]
Resistance
Overexpression of the ATP-binding cassette gene ABCA1 has been reported to confer resistance to curcumin in terms of NFkappaB activation that can be reversed by ABCA1 silencing.[24]
Potential risks and side effects
Kawanishi et al. remarked that curcumin, like many antioxidants, can be a "double-edged sword" where, in the test tube, carcinogenic and pro-oxidant effects may be seen in addition to anticancer and antioxidant effects.[25] Carcinogenic effects are inferred from interference with the p53 tumor suppressor pathway, an important factor in human colon cancer.[26] In vitro and in vivo studies suggest that curcumin can have carcinogenic effects.[27][28][29]
Clinical studies in humans with high doses (2–12 grams) of curcumin have shown few side effects, with some subjects reporting mild nausea or diarrhea.[30] More recently, curcumin was found to alter iron metabolism by chelating iron and suppressing the protein hepcidin, potentially causing iron deficiency in susceptible patients.[31] Further studies seem to be necessary to establish the benefit/risk profile of curcumin.[27]
There is no or little evidence to suggest curcumin is either safe or unsafe for pregnant women. However, there is still some concern medicinal use of products containing curcumin could stimulate the uterus, which may lead to a miscarriage, although there is not much evidence to support this claim. According to experiments done on rats and guinea pigs, there is no obvious effect (neither positive, nor negative) on the pregnancy rate or number of live or dead embryos.[32] Curcumin has embryotoxic and teratogenic effects on zebrafishes (Danio rerio) embryos.[33]
References
Notes
Dorland (2011-06-09). Dorland's Illustrated Medical Dictionary, 32nd Edition. ISBN 1455709859. Retrieved May 19, 2013. Published 2011.
Kolev, Tsonko M.; Velcheva, Evelina A.; Stamboliyska, Bistra A.; Spiteller, Michael (2005). "DFT and experimental studies of the structure and vibrational spectra of curcumin". International Journal of Quantum Chemistry 102 (6): 1069–79. doi:10.1002/qua.20469.
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Milob?dzka, J.; v. Kostanecki, St.; Lampe, V. (1910). "Zur Kenntnis des Curcumins". Berichte der deutschen chemischen Gesellschaft 43 (2): 2163–70. doi:10.1002/cber.191004302168.
"EPA Method 212.3: Boron (Colorimetric, Curcumin)".
a b c Kita, Tomoko; Imai, Shinsuke; Sawada, Hiroshi; Kumagai, Hidehiko; Seto, Haruo (2008). "The Biosynthetic Pathway of Curcuminoid in Turmeric (Curcuma longa) as Revealed by 13C-Labeled Precursors". Bioscience, Biotechnology, and Biochemistry 72 (7): 1789. doi:10.1271/bbb.80075.
Schmitt, Bettina; Hölscher, Dirk; Schneider, Bernd (2000). "Variability of phenylpropanoid precursors in the biosynthesis of phenylphenalenones in Anigozanthos preissii". Phytochemistry 53 (3): 331–7. doi:10.1016/S0031-9422(99)00544-0. PMID 10703053.
Gehlert, R.; Schoeppner, A.; Kindl, H. (1990). "Stilbene Synthase from Seedlings of Pinus sylvestris: Purification and Induction in Response to Fungal Infection" (pdf). Molecular Plant-Microbe Interactions 3 (6): 444–449. doi:10.1094/MPMI-3-444.
Aggarwal, Bharat B.; Sundaram, Chitra; Malani, Nikita; Ichikawa, Haruyo (2007). "Curcumin: the Indian solid gold". Advances in Experimental Medicine and Biology. Advan Exp Med Biol 595: 1–75. doi:10.1007/978-0-387-46401-5_1. ISBN 978-0-387-46400-8. PMID 17569205.
Gupta SC et al. (2011). "Multitargeting by curcumin as revealed by molecular interaction studies". Nat Prod Rep 28 (12): 1937–55. doi:10.1039/c1np00051a. PMC 3604998. PMID 21979811.
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Goel A, Kunnumakkara AB, Aggarwal BB (2008). "Curcumin as "Curecumin": from kitchen to clinic". Biochem Pharmacol 75 (4): 787–809. doi:10.1016/j.bcp.2007.08.016. PMID 17900536.
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Goel, Ajay; Kunnumakkara, Ajaikumar B.; Aggarwal, Bharat B. (2008). "Curcumin as "Curecumin": From kitchen to clinic". Biochemical Pharmacology 75 (4): 787–809. doi:10.1016/j.bcp.2007.08.016. PMID 17900536. "Pilot phase I clinical trials have shown curcumin to be safe even when consumed at a daily dose of 12g for 3 months."
Hatcher, H.; Planalp, R.; Cho, J.; Torti, F. M.; Torti, S. V. (2008). "Curcumin: From ancient medicine to current clinical trials". Cellular and Molecular Life Sciences 65 (11): 1631–52. doi:10.1007/s00018-008-7452-4. PMID 18324353.
Yan, Jiao; Wilkinson, Di, Wang, Hatcher, Kock, D'Agostino, Jr, Knovich, Torti, Torti corresponding author (8 January 2009). "Red Cells, Iron, and Erythropoiesis Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator". Blood. 113(2): (Prepublished online 2008 September 24.): 462–469. doi:10.1182/blood-2008-05-155952. PMC 2615657. PMID 18815282.
"ClinicalTrials.gov: Current clinical trials on curcumin". US National Institutes of Health, Clinical Trial Registry. 2013.
Zhao, LN.; Chiu, SW.; Benoit, J.; Chew, LY.; Mu, Y. (Jun 2012). "The effect of curcumin on the stability of Aß dimers". J Phys Chem B 116 (25): 7428–35. doi:10.1021/jp3034209. PMID 22690789.
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External links
Abstract: Curcumin is a well-known dietary polyphenol derived from the rhizomes of turmeric, an Indian spice. The anticancer effect of curcumin has been demonstrated in many cell and animal studies, and recent research has shown that curcumin can target cancer stem cells (CSCs). CSCs are proposed to be responsible for initiating and maintaining cancer, and contribute to recurrence and drug resistance. A number of studies have suggested that curcumin has the potential to target CSCs through regulation of CSC self-renewal pathways (Wnt/ß-catenin, Notch, Sonic Hedgehog) and specific microRNAs involved in acquisition of epithelial-mesenchymal transition (EMT). The potential impact of curcumin, alone or in combination with other anticancer agents, on CSCs was evaluated as well. Furthermore, the safety and tolerability of curcumin have been well-established by numerous clinical studies. Importantly, the low bioavailability of curcumin has been dramatically improved through the use of structural analogues or special formulations. More clinical trials are underway to investigate the efficacy of this promising agent in cancer chemoprevention and therapy. In this article, we review the effects of curcumin on CSC self-renewal pathways and specific microRNAs, as well as its safety and efficacy in recent human studies. In conclusion, curcumin could be a very promising adjunct to traditional cancer treatments.
http://www.greenmedinfo.com/blog/600-reasons-turmeric-may-be-worlds-most-important-herb
http://www.greenmedinfo.com/substance/turmeric
[ Condensed Version ]
A combination of artichoke leaf, dandelion root, turmeric root and rosemary essential oil has therapeutic actions in relieving symptoms in functional dyspepsia.
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A combination of Saw Palmetto, Nettle, Curcumin and Quercetin significantly improves treatment outcome of prulifloxacin in bacterial prostatitis patients.
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A complex of curcumin and phosphatidylcholine is effective in reducing the symptoms of ostearthritis.
Altern Med Rev. 2010 Dec;15(4):337-44
A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5
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A multi-herbal product called Protandim has significant antioxidant properties in human subjects.
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Curcumin ameliorates aflatoxin-induced lipid-peroxidation in liver and kidney of mice.
Acta Pol Pharm. 2008 Mar-Apr;65(2):195-202. PMID: 18666425
Curcumin ameliorates aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice.
Acta Pol Pharm. 2007 Nov-Dec;64(6):497-502. PMID: 18323242
Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa.
Fertil Steril. 2008 Sep;90(3):775-80. Epub 2007 Dec 27. PMID: 18163997
Curcumin ameliorates aflatoxin-induced toxicity.
Poult Sci. 2008 Jun;87(6):1125-30. PMID: 18493001
Curcumin ameliorates arterial dysfunction and oxidative stress with aging.
Exp Gerontol. 2012 Nov 7. Epub 2012 Nov 7. PMID: 23142245
Curcumin ameliorates chemically-induced liver damage and fibrosis in rats.
Ann Hepatol. 2011 Oct 1 ;10(4):516-30. PMID: 21911894
Curcumin ameliorates cognitive deficits and neurodegeneration in a rat model of sporadic dementia of Alzheimer's type (SDAT).
Eur Neuropsychopharmacol. 2009 Sep;19(9):636-47. Epub 2009 Mar 28. PMID: 19329286
Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.
Eur J Pharmacol. 2010 Oct 10;644(1-3):106-12. Epub 2010 Jul 24. PMID: 20667451
Curcumin ameliorates endotoxin-induced experimental hepatoxicity in rodents.
Clin Exp Immunol. 2006 Aug;145(2):313-21. PMID: 16879252
Curcumin ameliorates ethanol and nonethanol experimental pancreatitis.
Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G85-95. PMID: 12488237
Curcumin ameliorates experimentally induced ulcerative colitis.
Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID: 17276891
Curcumin ameliorates high glucose-induced adverse changes to the aortic endothelium of rats.
Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82. Epub 2009 May 19. PMID: 19473193
Curcumin ameliorates kidney failure in nephrectomized rats.
Am J Physiol Renal Physiol. 2009 May;296(5):F1146-57. Epub 2009 Feb 18. PMID: 19225048
Curcumin ameliorates kidney lesions associated with diabetes.
Mol Cell Biochem. 1998 Apr;181(1-2):87-96. PMID: 9562245
Curcumin ameliorates lung inflammation induced by Klebsiella pneumoniae and may be a useful adjuvant in antibiotic therapy.
J Med Microbiol. 2010 Jan 7. Epub 2010 Jan 7. PMID: 20056776
Curcumin ameliorates memory deficits associated with diabetes in the rat.
Age (Dordr). 2009 Mar;31(1):39-49. Epub 2008 Oct 8. PMID: 19234767
Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.
Int J Cancer. 2010 Sep 13. Epub 2010 Sep 13. PMID: 20839263
Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in rats.
Ital J Biochem. 2004 Jul;53(2):82-6. PMID: 15646012
Curcumin ameliorates sodium arsenite induced biochemical perturbations in rats.
Food Chem Toxicol. 2008 Nov;46(11):3506-11. Epub 2008 Sep 2. PMID: 18809455
Curcumin ameliorates sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs.
Molecules. 2009;14(3):1098-110. Epub 2009 Mar 10. PMID: 19049818
Curcumin ameloriates experimental autoimmune encephalomyelitis through inhibition of IL-17 production.
Int Immunopharmacol. 2009 May;9(5):575-81. Epub 2009 Feb 3. PMID: 19539560
Curcumin and tetrahydrocurcumin have antihyperlipidemic properties in experimental type 2 diabetic rats.
JPEN J Parenter Enteral Nutr. 1986 Sep-Oct;10(5):530-2. PMID: 17994458
Curcumin and a curcumin copper complex has a radioprotective effect in mouse livers.
J Radiat Res (Tokyo). 2007 May;48(3):241-5. Epub 2007 Apr 27. PMID: 17464095
Curcumin and caffeic acid phenethyl ester decrease intestinal tumors in an animal model of familial adenomatous polyposis.
Carcinogenesis. 2000 May;21(5):921-7. PMID: 10783313
Curcumin and CAPE may reduce chemotherapy-induced mucosal barrier injury.
Leukemia. 2004 Feb;18(2):276-84. PMID: 14671640
Curcumin ameliorates aflatoxin-induced lipid-peroxidation in liver and kidney of mice.
Acta Pol Pharm. 2008 Mar-Apr;65(2):195-202. PMID: 18666425
Curcumin ameliorates aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice.
Acta Pol Pharm. 2007 Nov-Dec;64(6):497-502. PMID: 18323242
Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa.
Fertil Steril. 2008 Sep;90(3):775-80. Epub 2007 Dec 27. PMID: 18163997
Curcumin ameliorates aflatoxin-induced toxicity.
Poult Sci. 2008 Jun;87(6):1125-30. PMID: 18493001
Curcumin ameliorates cognitive deficits and neurodegeneration in a rat model of sporadic dementia of Alzheimer's type (SDAT).
Eur Neuropsychopharmacol. 2009 Sep;19(9):636-47. Epub 2009 Mar 28. PMID: 19329286
Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.
Eur J Pharmacol. 2010 Oct 10;644(1-3):106-12. Epub 2010 Jul 24. PMID: 20667451
Curcumin ameliorates endotoxin-induced experimental hepatoxicity in rodents.
Clin Exp Immunol. 2006 Aug;145(2):313-21. PMID: 16879252
Curcumin ameliorates ethanol and nonethanol experimental pancreatitis.
Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G85-95. PMID: 12488237
Curcumin ameliorates experimentally induced ulcerative colitis.
Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID: 17276891
Curcumin ameliorates high glucose-induced adverse changes to the aortic endothelium of rats.
Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82. Epub 2009 May 19. PMID: 19473193
Curcumin ameliorates kidney failure in nephrectomized rats.
Am J Physiol Renal Physiol. 2009 May;296(5):F1146-57. Epub 2009 Feb 18. PMID: 19225048
Curcumin ameliorates kidney lesions associated with diabetes.
Mol Cell Biochem. 1998 Apr;181(1-2):87-96. PMID: 9562245
Curcumin ameliorates lung inflammation induced by Klebsiella pneumoniae and may be a useful adjuvant in antibiotic therapy.
J Med Microbiol. 2010 Jan 7. Epub 2010 Jan 7. PMID: 20056776
Curcumin ameliorates memory deficits associated with diabetes in the rat.
Age (Dordr). 2009 Mar;31(1):39-49. Epub 2008 Oct 8. PMID: 19234767
Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.
Int J Cancer. 2010 Sep 13. Epub 2010 Sep 13. PMID: 20839263
Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in rats.
Ital J Biochem. 2004 Jul;53(2):82-6. PMID: 15646012
Curcumin ameliorates sodium arsenite induced biochemical perturbations in rats.
Food Chem Toxicol. 2008 Nov;46(11):3506-11. Epub 2008 Sep 2. PMID: 18809455
Curcumin ameliorates sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs.
Molecules. 2009;14(3):1098-110. Epub 2009 Mar 10. PMID: 19049818
Curcumin ameloriates experimental autoimmune encephalomyelitis through inhibition of IL-17 production.
Int Immunopharmacol. 2009 May;9(5):575-81. Epub 2009 Feb 3. PMID: 19539560
Curcumin and tetrahydrocurcumin have antihyperlipidemic properties in experimental type 2 diabetic rats.
JPEN J Parenter Enteral Nutr. 1986 Sep-Oct;10(5):530-2. PMID: 17994458
Curcumin and a curcumin copper complex has a radioprotective effect in mouse livers.
J Radiat Res (Tokyo). 2007 May;48(3):241-5. Epub 2007 Apr 27. PMID: 17464095
Curcumin and caffeic acid phenethyl ester decrease intestinal tumors in an animal model of familial adenomatous polyposis.
Carcinogenesis. 2000 May;21(5):921-7. PMID: 10783313
Curcumin and CAPE may reduce chemotherapy-induced mucosal barrier injury.
Leukemia. 2004 Feb;18(2):276-84. PMID: 14671640
Curcumin attenuates acute adriamycin myocardial toxicity in rats.
Br J Pharmacol. 1998 Jun;124(3):425-7. PMID: 9647462
Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats.
Transplant Proc. 2010 Apr;42(3):744-7. PMID: 20430162
Curcumin attenuates alcohol toxicity.
J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386
Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.
Biol Pharm Bull. 2003 Jul;26(7):1021-4. PMID: 12843631
Curcumin attenuates aluminum-induced functional neurotoxicity in rats.
Pharmacol Biochem Behav. 2009 Jul;93(1):31-9. Epub 2009 Apr 17. PMID: 19376155
Curcumin attenuates an inflammatory response and improved the meiotic maturation of oocytes...
Fiziol Zh. 2010;56(4):96-101. PMID: 20968042
Curcumin attenuates cadmium-induced tisse damage in mice.
J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010
Curcumin attenuates cerebral edema following traumatic brain injury in mice.
J Neurochem. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20132469
Curcumin attenuates chronic fatigue syndrome in a mouse experimental model.
Immunobiology. 2009;214(1):33-9. Epub 2008 Jun 17. PMID: 19159825
Curcumin attenuates Concanavalin A-induced liver injury in mice.
Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522
Anti-Inflammatory Agents : CK(1230) : AC(433), Hepatoprotective : CK(580) : AC(281)
Curcumin attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.
BMC Pharmacol. 2005;5:15. Epub 2005 Oct 15. PMID: 16225695
Curcumin attenuates damage associated with cardiac ischemia/reperfusion.
J Surg Res. 2005 May 1;125(1):109-16. PMID: 15836859
Curcumin attenuates diabetic encephalopathy in rats.
Eur J Pharmacol. 2007 Dec 8;576(1-3):34-42. Epub 2007 Aug 14. PMID: 17822693
Curcumin attenuates diet-induced hypercholesterolemia in rats.
Med Sci Monit. 2005 Jul;11(7):BR228-234. Epub 2005 Jun 29. PMID: 15990684
Curcumin attenuates dimethylnitrosamine-induced liver injury in rats.
Food Chem Toxicol. 2008 Apr;46(4):1279-87. Epub 2007 Sep 26. PMID: 18006204
Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.
Food Chem Toxicol. 2006 Sep;44(9):1443-8. Epub 2006 May 20. PMID: 16814915
Curcumin attenuates high-fat-diet induced blood lipid elevation and oxidation.
Wei Sheng Yan Jiu. 2000 Jul;29(4):240-2. PMID: 12520931
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385
Curcumin attenuates inflammation in experimental colitis.
Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11. PMID: 19002562
Curcumin attenuates ischemia-reperfusion injury in rat testis.
Fertil Steril. 2009 Jan;91(1):271-7. Epub 2008 Jan 28. PMID: 18222428
Curcumin attenuates isoproterenol induced myocardial necrosis in rats.
Mol Cell Biochem. 1999 Jul;197(1-2):31-7. PMID: 10485321
Curcumin attenuates lipopolysaccharide-induced renal inflammation.
Biol Pharm Bull. 2011;34(2):226-32. PMID: 21415532
Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.
J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470
Curcumin attenuates acute adriamycin myocardial toxicity in rats.
Br J Pharmacol. 1998 Jun;124(3):425-7. PMID: 9647462
Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats.
Transplant Proc. 2010 Apr;42(3):744-7. PMID: 20430162
Curcumin attenuates alcohol toxicity.
J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386
Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.
Biol Pharm Bull. 2003 Jul;26(7):1021-4. PMID: 12843631
Curcumin attenuates aluminum-induced functional neurotoxicity in rats.
Pharmacol Biochem Behav. 2009 Jul;93(1):31-9. Epub 2009 Apr 17. PMID: 19376155
Curcumin attenuates an inflammatory response and improved the meiotic maturation of oocytes...
Fiziol Zh. 2010;56(4):96-101. PMID: 20968042
Curcumin attenuates cadmium-induced tisse damage in mice.
J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010
Curcumin attenuates cerebral edema following traumatic brain injury in mice.
J Neurochem. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20132469
Curcumin attenuates chemically induced colitis.
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G235-43. Epub 2003 Mar 13. PMID: 12637253
Curcumin attenuates chronic fatigue syndrome in a mouse experimental model.
Immunobiology. 2009;214(1):33-9. Epub 2008 Jun 17. PMID: 19159825
Curcumin attenuates Concanavalin A-induced liver injury in mice.
Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522
Curcumin attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.
BMC Pharmacol. 2005;5:15. Epub 2005 Oct 15. PMID: 16225695
Curcumin attenuates damage associated with cardiac ischemia/reperfusion.
J Surg Res. 2005 May 1;125(1):109-16. PMID: 15836859
Curcumin attenuates diabetic encephalopathy in rats.
Eur J Pharmacol. 2007 Dec 8;576(1-3):34-42. Epub 2007 Aug 14. PMID: 17822693
Curcumin attenuates diet-induced hypercholesterolemia in rats.
Med Sci Monit. 2005 Jul;11(7):BR228-234. Epub 2005 Jun 29. PMID: 15990684
Curcumin attenuates dimethylnitrosamine-induced liver injury in rats.
Food Chem Toxicol. 2008 Apr;46(4):1279-87. Epub 2007 Sep 26. PMID: 18006204
Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.
Food Chem Toxicol. 2006 Sep;44(9):1443-8. Epub 2006 May 20. PMID: 16814915
Curcumin attenuates high-fat-diet induced blood lipid elevation and oxidation.
Wei Sheng Yan Jiu. 2000 Jul;29(4):240-2. PMID: 12520931
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385
Curcumin attenuates inflammation in experimental colitis.
Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11. PMID: 19002562
Curcumin attenuates ischemia-reperfusion injury in rat testis.
Fertil Steril. 2009 Jan;91(1):271-7. Epub 2008 Jan 28. PMID: 18222428
Curcumin attenuates isoproterenol induced myocardial necrosis in rats.
Mol Cell Biochem. 1999 Jul;197(1-2):31-7. PMID: 10485321
Curcumin attenuates lipopolysaccharide-induced renal inflammation.
Biol Pharm Bull. 2011;34(2):226-32. PMID: 21415532
Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.
J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470
Curcumin attenuates acute adriamycin myocardial toxicity in rats.
Br J Pharmacol. 1998 Jun;124(3):425-7. PMID: 9647462
Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats.
Transplant Proc. 2010 Apr;42(3):744-7. PMID: 20430162
Curcumin attenuates alcohol toxicity.
J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386
Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.
Biol Pharm Bull. 2003 Jul;26(7):1021-4. PMID: 12843631
Curcumin attenuates aluminum-induced functional neurotoxicity in rats.
Pharmacol Biochem Behav. 2009 Jul;93(1):31-9. Epub 2009 Apr 17. PMID: 19376155
Curcumin attenuates an inflammatory response and improved the meiotic maturation of oocytes...
Fiziol Zh. 2010;56(4):96-101. PMID: 20968042
Curcumin attenuates cadmium-induced tisse damage in mice.
J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010
Curcumin attenuates cerebral edema following traumatic brain injury in mice.
J Neurochem. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20132469
Curcumin attenuates chemically induced colitis.
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G235-43. Epub 2003 Mar 13. PMID: 12637253
Curcumin attenuates chronic fatigue syndrome in a mouse experimental model.
Immunobiology. 2009;214(1):33-9. Epub 2008 Jun 17. PMID: 19159825
Curcumin attenuates Concanavalin A-induced liver injury in mice.
Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522
Curcumin attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.
BMC Pharmacol. 2005;5:15. Epub 2005 Oct 15. PMID: 16225695
Curcumin attenuates damage associated with cardiac ischemia/reperfusion.
J Surg Res. 2005 May 1;125(1):109-16. PMID: 15836859
Curcumin attenuates diabetic encephalopathy in rats.
Eur J Pharmacol. 2007 Dec 8;576(1-3):34-42. Epub 2007 Aug 14. PMID: 17822693
Curcumin attenuates diet-induced hypercholesterolemia in rats.
Med Sci Monit. 2005 Jul;11(7):BR228-234. Epub 2005 Jun 29. PMID: 15990684
Curcumin attenuates dimethylnitrosamine-induced liver injury in rats.
Food Chem Toxicol. 2008 Apr;46(4):1279-87. Epub 2007 Sep 26. PMID: 18006204
Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.
Food Chem Toxicol. 2006 Sep;44(9):1443-8. Epub 2006 May 20. PMID: 16814915
Curcumin attenuates high-fat-diet induced blood lipid elevation and oxidation.
Wei Sheng Yan Jiu. 2000 Jul;29(4):240-2. PMID: 12520931
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385
Curcumin attenuates inflammation in experimental colitis.
Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11. PMID: 19002562
Curcumin attenuates ischemia-reperfusion injury in rat testis.
Fertil Steril. 2009 Jan;91(1):271-7. Epub 2008 Jan 28. PMID: 18222428
Curcumin attenuates isoproterenol induced myocardial necrosis in rats.
Mol Cell Biochem. 1999 Jul;197(1-2):31-7. PMID: 10485321
Curcumin attenuates lipopolysaccharide-induced renal inflammation.
Biol Pharm Bull. 2011;34(2):226-32. PMID: 21415532
Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.
J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470
Curcumin attenuates ovalbumin-induced airway inflammation.
Biochem Biophys Res Commun. 2008 Oct 17;375(2):275-9. Epub 2008 Aug 13. PMID: 18706396
Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA).
Mol Cell Biochem. 2009 Apr;324(1-2):157-64. Epub 2009 Jan 23. PMID: 19165575
Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy...
J Surg Res. 2010 Mar;159(1):497-502. Epub 2008 Dec 31. PMID: 19321178
Curcumin attenuates renal fibrosis in rat obstructive nephropathy.
Urology. 2006 Feb;67(2):440-6. PMID: 16461119
Curcumin attenuates retinal oxidative stress and inflammation in diabetes.
Nutr Metab (Lond). 2007;4:8. Epub 2007 Apr 16. PMID: 17437639
Curcumin attenuates the development of allergic airway inflammation and hyper-responsiveness.
J Ethnopharmacol. 2010 Jul 17. Epub 2010 Jul 17. PMID: 20643202
Curcumin attenuates the inflammatory response in collagen-induced arthritis.
Int Immunopharmacol. 2010 May;10(5):605-10. Epub 2010 Feb 23. PMID: 20188213
Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice.
Carcinogenesis. 2009 Nov;30(11):1949-56. Epub 2009 Sep 30. PMID: 17300872
Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat.
Nutrition. 2008 Nov-Dec;24(11-12):1133-8. Epub 2008 Aug 26. PMID: 18752929
Curcumin attenuates the virulence of Pseudomonas aeruginosa .
J Agric Food Chem. 2008 Mar 26;56(6):1955-62. Epub 2008 Feb 20. PMID: 18284200
Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.
Eur J Pharmacol. 2006 May 1;536(3):256-61. Epub 2006 Mar 13. PMID: 16584726
Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice.
Antioxid Redox Signal. 2009 Jan;11(1):35-45. PMID: 18752423
Curcumin blocks chronic morphine analgesic tolerance and positively modulates brain chemistry.
Neuroreport. 2009 Jan 7;20(1):63-8. PMID: 19033880
Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis.
Kidney Int. 2005 Nov;68(5):2042-9. PMID: 16221204
Curcumin blocks HIV protease inhibitor rotonavir-induced vascular dysfunction in porcine coronary arteries.
J Am Coll Surg. 2005 Jun;200(6):820-30. PMID: 15922191
Curcumin blocks sepsis-induced muscle proteolysis.
Mediators Inflamm. 2008;2008:317851. PMID: 18389075
Curcumin can alleviate alveolitis and pulmonary fibrosis induced by bleomycin in rats.
Zhonghua Jie He He Hu Xi Za Zhi. 2007 Mar;30(3):197-201. PMID: 17572999
Curcumin can ameliorate cerebral pathological changes in the event of ischemic brain injury.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jun;29(6):1153-5. PMID: 19726347
Curcumin can be an alternative therapy for protecting lung transplantation-associated injury...
Crit Care Med. 2008 Apr;36(4):1205-13. PMID: 18379247
Curcumin can decrease inflammation in an experimental model of fibrosis.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 May;25(5):399-401. PMID: 19426594
Curcumin can decrease pulmonary arterial pressure, improve pulmonary vessel remodeling and inhibit the deposition of collagen I in pulmonary arterioles.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Aug;22(3):257-61. PMID: 21158062
Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis.
Zhonghua Jie He He Hu Xi Za Zhi. 2009 Jan;32(1):37-41. PMID: 19484960
Curcumin can inhibit tumour growth in a xenograft animal model in vivo.
Phytother Res. 2010 Jan 13;24(2):189-192. Epub 2010 Jan 13. PMID: 20077433
Curcumin can reduce inflammation and offset some of the performance deficits associated with eccentric exercise-induced muscle damage.
Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2168-73. Epub 2007 Mar 1. PMID: 17332159
Curcumin can significantly protect neurons against cerebral ischemia.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 May;23(2):184-8. PMID: 21179765
Curcumin can stimulate developmental and adult hippocampal neurogenesis, and a biological activity that may enhance neural plasticity and repair.
J Clin Psychopharmacol. 2000 Dec;20(6):680-4. PMID: 18362141
Curcumin co-treatment seems to prevent oxidative damage and found to delay the development of cataract.
Indian J Exp Biol. 2004 Jun;42(6):601-3. PMID: 15260112
Curcumin compares favorably to the drug dexamethasone in a rat model of lung injury.
Cancer Lett. 2003 Mar 31;192(2):145-9. PMID: 18799504
Curcumin compares favorably with bisdemethoxycurcumin in a gastric ulcer model system.
Phytomedicine. 2009 Apr;16(4):342-51. Epub 2009 Feb 1. PMID: 19188055
Curcumin could improve cardiac function in heart failure.
Zhonghua Xin Xue Guan Bing Za Zhi. 2010 Apr;38(4):369-73. PMID: 20654087
Curcumin could improve heart function, diminish infarct size and reverse the abnormal changes in the activities of serum lactate dehydrogenase and creatine kinase MB in rats after myocardial infarction.
Pharmacol Res. 2010 Feb;61(2):142-8. Epub 2009 Sep 9. PMID: 19747544
Curcumin counteracts the aluminium-induced ageing-related alterations in the rat brain.
Biogerontology. 2009 Aug;10(4):489-502. Epub 2008 Nov 20. PMID: 19020987
Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.
Gastroenterology. 2006 Jan;130(1):120-6. PMID: 20622013
Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.
Int J Cancer. 2010 Sep 7. Epub 2010 Sep 7. PMID: 20824699
Curcumin demonstrates therapeutic properties in an animal model of Alzheimer disease.
J Pharmacol Exp Ther. 2008 Jul;326(1):196-208. Epub 2008 Apr 16. PMID: 18417733
Curcumin dispalys anti-proliferartive and anti-angiogenic properties on tumors.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Oct;35(10):1029-36. PMID: 21051827
Curcumin displays therapeutic value in an animal model of irritable bowel syndrome.
AAPS PharmSciTech. 2009;10(3):752-62. Epub 2009 Jun 3. PMID: 19495987
Curcumin eliminates leptin's effect on liver fibrogenesis.
Endocrinology. 2009 Jul;150(7):3011-20. Epub 2009 Mar 19. PMID: 19299451
Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells which are associated wtih liver fibrosis.
Lab Invest. 2009 Nov;89(11):1275-90. Epub 2009 Sep 7. PMID: 19736547
Curcumin enhances adriamycin-induced human liver-derived hepatoma G2 cell death.
Eur J Pharm Sci. 2011 Jun 14 ;43(3):125-31. Epub 2011 Apr 14. PMID: 21514382
Curcumin enhances neurogenesis and cognition in aged rats.
PLoS One. 2012 ;7(2):e31211. Epub 2012 Feb 16. PMID: 22359574
Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation.
PLoS One. 2010;5(10):e13264. Epub 2010 Oct 11. PMID: 20845461
Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma.
Mol Cancer Ther. 2010 Oct;9(10):2665-75. PMID: 20937593
Curcumin enhances wound healing in animals.
Phytother Res. 2008 Jul;22(7):970-2. PMID: 9776860
Curcumin enhances wound healing in diabetic rats.
Wound Repair Regen. 1999 Sep-Oct;7(5):362-74. PMID: 10564565
Curcumin exerts an anti-hyperlipidemic effect against nicotine-induced lung toxicity...
J Med Food. 2005;8(2):246-50. PMID: 16117619
Curcumin exerts neuroprotective effects against homocysteine intracerebroventricular injection-induced cognitive impairment and oxidative stress in rat brain.
Exp Neurol. 2010 Oct;225(2):237-9. Epub 2010 Jul 11. PMID: 20553189
Curcumin exerts pain-killing effects in a mouse model of neuropathic pain.
Neuropharmacology. 2012 Feb ;62(2):843-54. Epub 2011 Sep 19. PMID: 21945716
Curcumin exerts stimulatory influence on the secretory function of the thyroid gland in young rats....
Folia Histochem Cytobiol. 2008;46(2):205-11. PMID: 18519239
Curcumin exhibits anti-bacterial activity against Helicobacter pylori infection.
Antimicrob Agents Chemother. 2009 Apr;53(4):1592-7. Epub 2009 Feb 9. PMID: 19204190
Curcumin exhibits anti-cancer activity in an animal mode of intestinal cancer.
Carcinogenesis. 2001 May;22(5):821-5. PMID: 11323404
Curcumin exhibits anti-gastrointestinal cancer activity in rats.
Cancer Sci. 2006 Sep;97(9):896-904. Epub 2006 Jun 29. PMID: 16805852
Curcumin exhibits anti-liver cancer activity.
Int J Pharm. 2010 Nov 15;400(1-2):211-20. Epub 2010 Sep 8. PMID: 20813175
Curcumin exhibits anti-malarial activity in a mouse model.
Biochem Biophys Res Commun. 2005 Jan 14;326(2):472-4. PMID: 15582601
Curcumin exhibits anti-melanoma activity.
Phytother Res. 2003 Mar;17(3):217-21. PMID: 19260281
Curcumin exhibits antidepressant properties.
Pharmacol Biochem Behav. 2005 Sep;82(1):200-6. PMID: 16171853
Curcumin exhibits chemopreventive properties in hematogenous breast cancer metastases in immunodeficient mice.
Cell Physiol Biochem. 2007;19(1-4):137-52. PMID: 17310108
Curcumin exhibits cholesterol lowering properties.
Nutr Res Pract. 2010 Jun;4(3):191-5. Epub 2010 Jun 28. PMID: 20607063
Curcumin exhibits hepatoprotective properties against selenium toxicity.
Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4. PMID: 15881869
Curcumin exhibits inhibitory effects liver fibrosis associated with injury.
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G20-30. Epub 2003 Mar 26. PMID: 12660143
Curcumin exhibits neuroprotective properties when given 4h post-ischemia in the rat thromboembolic stroke models.
Behav Brain Res. 2008 Nov 21;193(2):289-97. Epub 2008 Jun 19. PMID: 18611416
Curcumin exhibits potentially therapeutic properties in a rat experimental model of endometriosis.
Maturitas. 2007 Mar 20;56(3):322-31. Epub 2006 Nov 13. PMID: 21069258
Curcumin exhibits radioprotective properties and inhibits acute and chronic effects of gamma radiation exposure.
Int J Radiat Oncol Biol Phys. 2002 Jul 1;53(3):735-43. PMID: 12062620
Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster.
Planta Med. 1997 Oct;63(5):465-6. PMID: 20645870
Curcumin extends lifespan in Caenorhabditis elegans.
Mech Ageing Dev. 2011 Aug 9. Epub 2011 Aug 9. PMID: 21855561
Curcumin formulated with phosphatidylcholine furnishes higher systemic levels of parent agent than unformulated curcumin.
Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7. Epub 2006 Oct 19. PMID: 17051370
Curcumin has a beneficial effect on acute lung injury induced by oleic acid in rats.
Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(17):2141-5. PMID: 19066061
Indian J Pharmacol. 2012 Jan ;44(1):73-7. PMID: 22345874
Curcumin has a cardioprotective effect against myocardial ischemia.
Int J Biochem Cell Biol. 2004 Oct;36(10):1967-80. PMID: 15203111
Curcumin has a chemopreventive effect on chemically-induced esophageal cancer.
Jpn J Cancer Res. 2000 Sep;91(9):893-8. PMID: 11011116
Curcumin has a corrective effect on the expression of genetic defects associated with cystic fibrosis in an animal model.
Lab Invest. 2010 May 10. Epub 2010 May 10. PMID: 15105504
Curcumin has a curative effect on liver fibrosis in rats.
Zhong Yao Cai. 2007 Nov;30(11):1421-5 PMID: 18323214
Curcumin has a cytoprotective and immunomodulating effect in rats subjected to carbon tetrachloride-induced oxidative stress.
Br J Rheumatol. 1994 Sep;33(9):847-52. PMID: 18340409
Curcumin has a detoxifiying and antioxidant effect in rats experimentallly exposed to mercury.
Cont Lens Anterior Eye. 2009 Dec 21. Epub 2009 Dec 21. PMID: 20229497
Curcumin has a immunomodulatory effect in host macrophages and NK cells which results in a tumoricidal effect.
FEBS Lett. 2000 Oct 13;483(1):78-82. PMID: 11033360
Curcumin has a liver protecting effect against aflatoxin B(1)-induced liver injury.
Arch Toxicol. 2010 May;84(5):389-96. Epub 2010 Jan 30. PMID: 20112103
Curcumin has a neuroprotective effect against homocysteine-induced cognitive impairment and oxidative stress in the rat.
Pharmacol Biochem Behav. 2010 Oct;96(4):378-85. Epub 2010 Jul 6. PMID: 20619287
Curcumin has a neuroprotective effect in arsenic-induced neurotoxicity in rats.
Neurotoxicology. 2010 Sep;31(5):533-9. Epub 2010 May 11. PMID: 20466022
Curcumin has a neuroprotective effect in brain trauma.
Neuroscience. 2009 Jul 21;161(4):1037-44. Epub 2009 Apr 21. PMID: 19393301
Curcumin has a neuroprotective effect in hypoxia ischemia brain tissue injury.
J Nat Prod. 2009 Apr;72(4):725-31. PMID: 19397204
Curcumin has a neuroprotective effect in in middle cerebral artery occlusion induced focal cerebral ischemia in rats.
Life Sci. 2004 Jan 9;74(8):969-85. PMID: 14672754
Curcumin has a neuroprotective effect on 6-hydroxydopamine-induced Parkinsonism in rats.
Exp Neurol. 2010 Oct;225(2):237-9. Epub 2010 Jul 11. PMID: 20951685
Curcumin has a neuroprotective effect on focal cerebral ischemic rats by preventing blood-brain barrier damage.
Chemotherapy. 2010;56(1):60-5. Epub 2010 Mar 19. PMID: 17303117
Curcumin has a novel synergistic effect with the drug cyclosporine as an immunosuppressive.
Transplant Proc. 2003 Jun;35(4):1603-5. PMID: 12826232
Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats.
Fundam Clin Pharmacol. 2005 Aug;19(4):473-7. PMID: 16011735
Curcumin has a potent preventive action against radiation-induced breast cancer initiation.
Carcinogenesis. 2000 Oct;21(10):1835-41. PMID: 11023541
Curcumin has a potent preventive activity during the DES-dependent promotion stage of radiation-induced mammary tumorigenesis.
Carcinogenesis. 1999 Jun;20(6):1011-8. PMID: 10357781
Curcumin has a preventive effect on different aspiration material-induced lung injury in rats.
Pediatr Surg Int. 2009 Jan;25(1):83-92. Epub 2008 Nov 12. PMID: 19002695
Curcumin has a preventive effect on experimental acute pancreatitis in mouse.
Indian J Med Res. 2011 Nov ;134(5):717-24. PMID: 22199113
Curcumin has a prophylactic effect on hepatic fibrosis.
Zhonghua Gan Zang Bing Za Zhi. 2006 May;14(5):337-40. PMID: 16732906
Curcumin has a protective effect after spinal cord injury.
J Surg Res. 2009 Aug 5. Epub 2009 Aug 5. PMID: 20018302
Curcumin has a protective effect against against intracerebral streptozotocin induced impairment in memory and cerebral blood flow.
Life Sci. 2010 Jan 16;86(3-4):87-94. Epub 2009 Nov 17. PMID: 19925811
Curcumin has a protective effect against aluminium toxicity in rats as measured by behavioral and biochemical alterations.
Behav Brain Res. 2009 Jul 16. PMID: 19616038
Curcumin has a protective effect against hyperlipidemia and insulin resistance in high-fat-fed hamsters.
J Am Diet Assoc. 2005 Jun;105(6):967-70. PMID: 18940397
Curcumin has a protective effect against lsoproterenol-induced mycardial infarction.
Biochem Pharmacol. 1996 Jan 12;51(1):47-51. PMID: 8534267
Curcumin has a protective effect against nicotine-induced genotoxicity on rat liver.
Eur J Pharmacol. 2008 Jul 7;588(2-3):151-7. Epub 2008 Apr 15. PMID: 18508046
Curcumin has a protective effect in experimentally induced colitis.
Br J Pharmacol. 2003 May;139(2):209-18. PMID: 12770926
Curcumin has a protective effect on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats.
Exp Toxicol Pathol. 2010 Apr 2. Epub 2010 Apr 2. PMID: 20363603
Curcumin has a protective effect on lindane induced reproductive toxicity in male Wistar rats.
Bull Environ Contam Toxicol. 2010 Apr;84(4):378-84. Epub 2010 Feb 25. PMID: 20182699
Curcumin has a protective effect on myocardial ischemia reperfusion injury.
Zhong Yao Cai. 2005 Oct;28(10):920-2. PMID: 16479932
Curcumin has a similar effect to hydrocortisone in preventing bleomycin-induced pulmonary fibrosis.
J Ethnopharmacol. 2007 Jun 13;112(2):292-9. Epub 2007 Mar 13. PMID: 17434272
Curcumin has a synergistic effect with cisplatin against fibrosarcoma.
Pharmacol Res. 1999 Mar;39(3):175-9. PMID: 10094841
Curcumin has an ameliorative effect against acute cadmium toxicity on male reproductive system in rats.
Andrologia. 2012 Jan 18. Epub 2012 Jan 18. PMID: 22257170
Curcumin has an ameliorative effect on the seminiferous epithelium metronidazole-treated mice.
Toxicol Pathol. 2010;38(3):366-71. Epub 2010 Mar 9. PMID: 20215582
Curcumin has an insulin releasing effect in rat-isolated pancreatic islets.
Angiology. 2010 Aug;61(6):557-66. Epub 2010 Apr 14. PMID: 20395228
Curcumin has analgesic properties.
Phytother Res. 2009 Apr;23(4):507-12. PMID: 19051211
Curcumin has analgesic properties.
Pak J Biol Sci. 2008 Jan 15;11(2):312-4. PMID: 18817212
Curcumin has anti-aging and neuroprotective effects in aged rat brain regions.
Biogerontology. 2006 Apr;7(2):81-9. PMID: 16802111
Curcumin has anti-anxiety properties.
Brain Res. 2010 Sep 17;1352:167-75. Epub 2010 Jul 12. PMID: 20633542
Curcumin has anti-cataractogenic properties.
Chem Biol Interact. 2009 Oct 7;181(2):202-9. Epub 2009 May 27. PMID: 19481068
Curcumin has anti-thrombotic properties.
Biochem Pharmacol. 1999 Oct 1;58(7):1167-72. PMID: 10484074
Curcumin has anti-ulcer activity in experimental gastric ulcer in rats.
Biomed Environ Sci. 2009 Dec;22(6):488-95. PMID: 20337222
Curcumin has anti-umorigenic and hormone-suppressive effects against pituitary tumors.
Endocr Relat Cancer. 2009 Dec;16(4):1339-50. Epub 2009 Sep 2. PMID: 19726538
Curcumin has anticancer, chemosensitization and radiosensitization effects in prostate cancer.
Cancer Res. 2007 Mar 1;67(5):1988-96. PMID: 17332326
Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice.
Phytother Res. 2008 Dec;22(12):1660-4. PMID: 18661468
Curcumin has antidepressant properties that compare favorably to the drugs imipramine and fluoxetine.
Acta Pol Pharm. 2011 Sep-Oct;68(5):769-75. PMID: 21928724
Curcumin has antidepressant-like effects in chronic unpredictable mild stress of rats.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):435-49. Epub 2009 Jan 22. PMID: 19302828
Curcumin has antihyperalgesic properties.
J Dent Res. 2010 Feb;89(2):170-4. Epub 2009 Dec 29. PMID: 20040737
Curcumin has antinociceptive (pain-killing) properties associated with ATP-sensitive potassium channels.
Korean J Pain. 2012 Oct ;25(4):221-7. Epub 2012 Oct 4. PMID: 23091682
Curcumin has beneficial effects in experimental dementia.
Naunyn Schmiedebergs Arch Pharmacol. 2010 Jun;381(6):529-39. Epub 2010 Apr 6. PMID: 20369229
Jun 01, 2010
Curcumin has chemopreventive properties during the promotion/progression stages of colon cancer.
Cancer Res. 1999 Feb 1;59(3):597-601. PMID: 9973206
Curcumin has lipid lowering properties in diabetic rats.
Mol Cell Biochem. 1997 Jan;166(1-2):169-75. PMID: 9046034
Curcumin has neuroprotective effect on transient focal cerebral ischemia in rats.
Brain Res. 2008 Sep 10;1229:224-32. Epub 2008 Jul 8. PMID: 18640105
Curcumin has neuroprotective effects against a fungal toxin.
Methods Find Exp Clin Pharmacol. 2007 Jan-Feb;29(1):19-25. PMID: 17344940
Curcumin has positive immunomodulatory effects on mouse schistosomiasis.
Immunobiology. 2009;214(8):712-27. Epub 2009 Feb 26. PMID: 19249123
Curcumin has potent liver preservation properties in an isolated perfusion model.
Transplantation. 2006 Oct 15;82(7):931-7. PMID: 17038909
Curcumin has potent therapeutic activity in the amelioration of alcoholic neuropathy in rats.
Neurosci Lett. 2012 Jan 16. Epub 2012 Jan 16. PMID: 22281447
Curcumin has potential anti-epileptic effects.
Indian J Physiol Pharmacol. 2009 Jan-Mar;53(1):39-46. PMID: 19810575
Curcumin has protective effects against hepatic ischemia/reperfusion injury.
World J Gastroenterol. 2007 Apr 7;13(13):1953-61. PMID: 17461496
Curcumin has schistosomicidal potential against Schistosoma japonicum.
J Asian Nat Prod Res. 2012 Oct 23. Epub 2012 Oct 23. PMID: 23088385
Curcumin has therapeutic effects in chemically-induced colitis.
World J Gastroenterol. 2006 Jun 28;12(24):3848-53. PMID: 16804969
Curcumin has variable immunomodulatory effects.
J Huazhong Univ Sci Technolog Med Sci. 2005;25(2):137-40. PMID: 16116955
Curcumin holds promise as an agent to prevent or treat central nervous system complications in diabetes.
J Biomed Sci. 2010;17:43. Epub 2010 May 31. PMID: 20513244
Curcumin improves bone microarchitecture and enhances mineral density in transgenic mice.
Phytomedicine. 2011 Jan 15;18(2-3):205-13. Epub 2010 Jul 16. PMID: 20637579
Curcumin improves early functional results after experimental spinal cord injury.
Acta Neurochir (Wien). 2010 Sep;152(9):1583-90; discussion 1590. Epub 2010 Jun 10. PMID: 20535508
Curcumin improves insulin resistance in skeletal muscle of rats.
Nutr Metab Cardiovasc Dis. 2010 Mar 12. Epub 2010 Mar 12. PMID: 20227862
Curcumin improves learning and memory ability in a mouse Alzheimer's disease experimental model.
Chin Med J (Engl). 2008 May 5;121(9):832-9. PMID: 18701050
Curcumin improves left ventricular function in pressure overloaded rabbits.
Biol Pharm Bull. 2004 Feb;27(2):198-202. PMID: 14758033
Curcumin improves memory and learning dysfunction in rats.
Eur J Gastroenterol Hepatol. 2002 Nov;14(11):1271-4. PMID: 18394334
Curcumin improves outcomes and attenuates focal cerebral ischemic injury.
Neurochem Res. 2010 Mar;35(3):374-9. Epub 2009 Sep 23. PMID: 19774461
Curcumin improves sclerosing cholangitis in mice.
Gut. 2010 Apr;59(4):521-30. PMID: 20332524
Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 in rats.
Life Sci. 2009 Jul 3;85(1-2):1-10. Epub 2009 Apr 5. PMID: 19345695
Curcumin improves survival in mice with tumors.
Tohoku J Exp Med. 2002 Aug;197(4):221-7. PMID: 12434997
Curcumin improves the metabolic status in diabetic conditions.
Phytother Res. 2007 Apr;21(4):395-7. PMID: 8609907
Curcumin improves vascular function and alleviates oxidative stress in endotoxaemia in mice.
J Clin Invest. 2008 Mar;118(3):868-78. PMID: 19540224
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species.
Cancer Lett.2006 Jul 28;239(1):144-50. Epub 2005 Nov 21 PMID: 16770527
Curcumin in combination with EPA and DHA work synergistically to reduce inflammation.
Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8. PMID: 19744468
Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model.
Int J Cancer. 2009 Mar 15;124(6):1422-8. PMID: 19035461
Curcumin increases glucose uptake in skeletal muscle.
Neurosci Lett. 2009 Nov 20;465(3):238-41. Epub 2009 Sep 16. PMID: 19765405
Curcumin induces a tolerogenic response in an animal model of colitis.
Eur J Immunol. 2009 Nov;39(11):3134-46. PMID: 19839007
Curcumin induces programmed cell death and inhibits growth of human Burkitt's lymphoma in xenograft mouse model.
J Nutr. 2009 Jul;139(7):1339-46. Epub 2009 Jun 3. PMID: 19326074
Curcumin induces recovery from hepatic injury.
Indian J Biochem Biophys. 2008 Oct;45(5):317-25. PMID: 19069843
Curcumin inhibit tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.
Jpn J Cancer Res. 1998 Apr;89(4):361-70. PMID: 9617340
Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease...
Transl Neurodegener. 2012 ;1(1):16. Epub 2012 Aug 20. PMID: 23210631
Curcumin inhibits adenoid cystic carcinoma.
Mol Pharmacol. 2010 Oct 19. Epub 2010 Oct 19. PMID: 20959361
Curcumin inhibits amyloid-petpide induced changes associated with the progression of Alzheimer's disease.
J Neurochem. 2004 Dec;91(5):1199-210. PMID: 15569263
Curcumin inhibits ascites tumor growth in mice.
Mol Cell Biochem. 2005 May;273(1-2):57-67. PMID: 16013440
Curcumin inhibits bladder tumor growth in a mouse model.
Int Braz J Urol. 2009 Sep-Oct;35(5):599-606; discussion 606-7. PMID: 19860939
Curcumin inhibits bleomycin-induced pulmonary fibrosis in rats.
Br J Pharmacol. 2000 Sep;131(2):169-72. PMID: 10991907
Curcumin inhibits chemically-induced colonic lesions.
Carcinogenesis. 1993 Nov;14(11):2219-25. PMID: 8242846
Curcumin inhibits chemically-induced liver cancer.
Food Chem Toxicol. 2000 Nov;38(11):991-5. PMID: 11038236
Curcumin inhibits chemically-induced skin cancer promotion in the mouse model.
Cancer Res. 2010 Aug 1;70(15):6368-76. Epub 2010 Jul 20. PMID: 3139287
Curcumin inhibits chemically-induced skin cancer.
Cancer Lett. 1994 Nov 25;87(1):85-9. PMID: 7954373
Curcumin inhibits chemically-induced tumor initiation.
Carcinogenesis. 1992 Nov;13(11):2183-6. PMID: 1423891
Curcumin inhibits colon polyp formation.
Br J Cancer. 2003 May 6;88(9):1480-3. PMID: 12778080
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.
Carcinogenesis. 2009 Nov;30(11):1949-56. Epub 2009 Sep 30. PMID: 19793800
Curcumin inhibits endometrial cancer and works synergistically with the aromatase inhibitor letrozole.
Int J Gynecol Cancer. 2009 Oct;19(7):1248-52. PMID: 19823063
Curcumin inhibits experimental collitis via anti-angiogenic and anti-inflammatory properties.
J Pharm Pharmacol. 2009 Mar;61(3):311-21. PMID: 19222903
Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury.
Am J Physiol Lung Cell Mol Physiol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061443
Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice.
Eur J Pharmacol. 2012 Oct 11. Epub 2012 Oct 11. PMID: 23063543
Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6 Production in Mice.
PLoS One. 2013 ;8(6):e67078. Epub 2013 Jun 25. PMID: 23825622
Curcumin inhibits leukemia cells in mice.
In Vivo. 2008 Jan-Feb;22(1):63-8. PMID: 18396784
Curcumin inhibits lipid peroxidation and cholesterol levels in mice.
Indian J Physiol Pharmacol. 1992 Oct;36(4):239-43. PMID: 1291474
Curcumin inhibits liver fibrosis.
J Pharm Pharmacol. 2002 Jan;54(1):119-26. PMID: 11829122
Curcumin inhibits liver injury in a mouse model of endotoxemic shock.
Biotechnol Lett. 2010 Feb;32(2):209-14. Epub 2009 Oct 25. PMID: 19856147
Curcumin inhibits lung cancer cell metastasis.
Clin Exp Metastasis. 2000;18(7):539-45. PMID: 11688958
Curcumin inhibits muscle wasting in colon tumor bearing mice.
Br J Nutr. 2009 Oct;102(7):967-75. Epub 2009 Apr 27. PMID: 19393114
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental fatty liver in mice.
Mech Ageing Dev. 2003 Dec;124(10-12):1025-34. PMID: 15582125
Curcumin inhibits nitric oxide production.
Biochem Pharmacol. 1998 Jun 15;55(12):1955-62. PMID: 9714315
Curcumin inhibits proliferation and induces programmed cell death in leukemic cells...
and prolongs survival of mice with acute lymphoblastic leukemia.
J Agric Food Chem. 2008 Sep 24;56(18):8418-26. Epub 2008 Aug 30. PMID: 19055861
Curcumin inhibits prostate cancer growth.
Prostate. 2001 Jun 1;47(4):293-303. PMID: 11398177
Curcumin inhibits prostate cancer tumors.
Peptides. 2009 Dec;30(12):2357-64. Epub 2009 Sep 20. PMID: 19772879
Curcumin inhibits radiation-impaired healing of excisional wounds in mice.
J Wound Care. 2004 Mar;13(3):107-9. PMID: 15045805
Curcumin inhibits radiation-induced changes in the liver.
J Radiol Prot. 2001 Dec;21(4):361-70. PMID: 11787891
Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock.
Clin Exp Pharmacol Physiol. 2010 Sep;37(9):939-44. Epub 2010 May 28. PMID: 20528978
Curcumin inhibits the growth of choroidal melanoma.
Cancer Biol Ther. 2011 Jan 15;11(2):229-35. Epub 2011 Jan 15. PMID: 21084858
Curcumin inhibits the growth of HTLV-1 infected T-cell tumors implanted into mice...
Int J Cancer. 2006 Feb 1;118(3):765-72. PMID: 16106398
Curcumin inhibits the growth of pancreatic cancer in a mouse experimental model.
Anticancer Res. 2009 Jun;29(6):1895-9. PMID: 19528445
Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus
Eur J Pharmacol. 2008 Sep 28;593(1-3):105-11. Epub 2008 Jul 15. PMID: 18664365
Curcumin inhibits the proliferation of human oral cancer cells.
Am J Chin Med. 2010;38(2):343-58. PMID: 20387230
Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.
Cancer Res. 2008 Sep 15;68(18):7283-92. PMID: 18794115
Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.
Int Immunopharmacol. 2006 Aug;6(8):1233-42. Epub 2006 Apr 7. PMID: 16782535
Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts.
Mol Nutr Food Res. 2010 Aug;54(8):1192-201. PMID: 20087857
Curcumin inhibits tumor implantation and growth in the mouse bladder tumor model.
J Urol. 2001 Oct;166(4):1498-501. PMID: 11547120
Curcumin inhibits tumorigenesis in mice.
Phytother Res. 2009 Nov;23(11):1524-30. PMID: 9591190
Curcumin intervention ameliorates the AFB(1) induced toxicity.
J Ethnopharmacol. 2010 Feb 17;127(3):641-4. Epub 2009 Dec 14. PMID: 20015472
Feb 17, 2010
Curcumin is a potential glucose-lowering agent and antioxidant in type 2 diabetic mice.
Phytother Res. 2008 Feb;22(2):180-4. PMID: 18398869
Curcumin is a potential radio-enhancer in head and neck cancer.
Laryngoscope. 2009 Oct;119(10):2019-26. PMID: 19655336
Curcumin is an in vivo inhibitor of angiogenesis.
Mol Med. 1998 Jun;4(6):376-83. PMID: 10780880
Curcumin is effective in the prevention of radiation-induced oral mucositis.
Int J Radiat Biol. 2004 Feb;80(2):177-82. PMID: 15164799
Curcumin is efficacious for chronic nonbacterial prostatitis in rats.
Zhonghua Nan Ke Xue. 2010 Jan;16(1):84-8. PMID: 20180411 Jan 01, 2010
Curcumin is more effective than prednisone at suppressing bleomycin-induced pulmonary fibrosis in rats.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 May;26(5):257-61. PMID: 18727865
Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats.
Brain Res. 2009 Dec 8;1301:52-60. Epub 2009 Sep 16. PMID: 19765566
Curcumin is superior to drug therapies for preventing scopolamine-induced memory impairment.
Fitoterapia. 2011 Jan 26. Epub 2011 Jan 26. PMID: 21277954
Curcumin limits the fibrogenic evolution of experimental fatty liver.
Lab Invest. 2010 Jan;90(1):104-15. Epub 2009 Nov 9. PMID: 19901911
curcumin may be an effective strategy to combat the genotoxicity of arsenic.
Asian Pac J Cancer Prev. 2010;11(1):239-47. PMID: 20593964
Curcumin may be useful as an angiogenic inhibitor in the treatment of corneal diseases that show neovascularization.
Ophthalmologica. 2008;222(3):178-86. Epub 2008 May 22. PMID: 18497527
Curcumin may contribute to ameliorating alcohol withdrawal symptoms.
Cell Mol Neurobiol. 2007 Dec;27(8):997-1006. Epub 2007 Sep 11. PMID: 17846884
Curcumin may contribute to preventing memory loss.
Biochem Pharmacol. 2009 Apr 1;77(7):1254-65. Epub 2008 Dec 31. PMID: 19161989
Curcumin may have a beneficial effect in degenerative aortic aneurysms.
Ann Vasc Surg. 2006 May;20(3):360-8. Epub 2006 May 19. PMID: 16779518
Curcumin may have a preventive role in the treatment of diabetic retinopathy.
Biochem Biophys Res Commun. 2007 Sep 21;361(2):528-32. Epub 2007 Jul 23. PMID: 17662242
Curcumin may have a therapeutic role in reducing the adverse effects of hyperandrogenemia on the ovary and metabolism.
Reprod Sci. 2009 Jun;16(6):539-50. Epub 2009 Mar 20. PMID: 19304795
Curcumin may have beneficial anti-angiogenic and protective properties in kidneys of diabetics.
J Med Assoc Thai. 2010 Feb;93 Suppl 2:S1-8. PMID: 21302394
Curcumin may have therapeutic value for controlling allergic responses resulting from exposure to allergens such as latex.
Clin Mol Allergy. 2007;5:1. Epub 2007 Jan 25. PMID: 17254346
Curcumin may have therapeutic value for treatment of diabetes-associated hepatic fibrogenesis.
Mol Cell Endocrinol. 2010 Dec 30. Epub 2010 Dec 30. PMID: 21195127
Curcumin may have therapeutic value in Alzheimer disease prevention.
Cancer Lett. 2009 Nov 24. Epub 2009 Nov 24. PMID: 11755008
Curcumin may have therapeutic value in colon cancer prevention.
Oncogene. 1999 Oct 28;18(44):6013-20. PMID: 10557090
Curcumin may have therapeutic value in patients prone to vascular thrombosis and requiring anti-arthritic therapy.
Arzneimittelforschung. 1986 Apr;36(4):715-7. PMID: 3521617
Curcumin may have therapeutic value in the prevention of cardiovascular complications associated with diabetes.
Nutr Metab (Lond). 2006;3:27. Epub 2006 Jul 18. PMID: 16848894
Curcumin may have therapeutic value in the treatment of hyperlipidemia.
J Med Food. 2005;8(2):256-60. PMID: 16117621
Curcumin may have therapeutic value in treating aortic stenosis, left ventricular dysfunction and myocardial fibrosis.
Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Mar;37(3):262-7. PMID: 19781154
Curcumin may have therapeutic value in treating scleroderma.
Am J Respir Cell Mol Biol. 2004 Jul;31(1):28-35. Epub 2004 Jan 23. PMID: 14742295
Curcumin may increase muscle tone in urinary bladder.
Evid Based Complement Alternat Med. 2008 Sep;5(3):281-7. PMID: 20172017
Curcumin may inhibit cardiac hypertrophy and myocardial infarction.
Lab Invest. 2009 Oct 19. PMID: 18292806
Curcumin may offer protective effects against methotrexate-induced rat enteritis by lowering the intestinal mucosal permeability.
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):119-21. PMID: 18227041
Curcumin may play a role in preventing diabetes-induced cardiomyopathy.
Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1119-26. Epub 2008 Apr 15. PMID: 18413674
Curcumin may play a therapeutic role in treating depression.
Psychopharmacology (Berl). 2008 Dec;201(3):435-42. Epub 2008 Sep 3. PMID: 18766332
Curcumin may play its therapetuic role by leveling down the content of extracellular matrix in rats with pulmonary fibrosis induced by bleomycin.
Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(7):570-3. PMID: 16780161
Curcumin may protect against sepsis.
Crit Care Med. 2006 Jul;34(7):1874-82. PMID: 16715036
Curcumin may protect the aging brain from oxidative stress.
Int J Dev Neurosci. 2010 Aug;28(5):351-7. Epub 2010 Apr 18. PMID: 20403421
Curcumin may provide an ideal lead molecule for the prevention and treatment of TTR amyloidosis.
Biochim Biophys Acta. 2012 Oct 13. Epub 2012 Oct 13. PMID: 23069388
Curcumin may provide an ideal therapeutic agent in the treatment of heart failure.
J Clin Invest. 2008 Mar;118(3):868-78. PMID: 18292809
Curcumin may reduce adverse effects associated with stress.
Domest Anim Endocrinol. 2010 Nov;39(4):231-9. Epub 2010 Jul 30. PMID: 20920780
Curcumin may reduce pain by activation of both opioid and non opioid mechanisms.
Pak J Biol Sci. 2007 Aug 1;10(15):2583-6. PMID: 19070135
Curcumin may stimulate recovery from spinal cord injury.
J Neurosurg Spine. 2012 Feb 10. Epub 2012 Feb 10. PMID: 22324804
Curcumin might be an effective antifibrotic drug in the treatment of chronic kidney disease.
Kidney Int. 2004 Jul;66(1):112-20. PMID: 15200418
Curcumin might increase the effect of vitamin C in protecting the function of endothelial cells..
Clin Hemorheol Microcirc. 2006;35(4):481-9. PMID: 17148847
Curcumin might significantly decrease the level of insulin resistance and leptin resistance caused by the high fat diet.
J Atheroscler Thromb. 2009;16(6):870-7. Epub 2009 Dec 22. PMID: 19176142
Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats, indicating its potential therapeutic value.
Innate Immun. 2011 Jan 17. Epub 2011 Jan 17. PMID: 21242275
Curcumin oil has a protective effect against cisplatin-induced nephrotoxicity.
J Agric Food Chem. 2007 Dec 12;55(25):10150-5. Epub 2007 Nov 15. PMID: 18001039
Curcumin oil has anti-platelet effects in an experimental model of myocardial ischemia-reperfusion and thrombosis.
Thromb Res. 2011 Feb;127(2):111-8. Epub 2010 Dec 8. PMID: 21144557
Curcumin positively modulates leukocyte and platelet adhesion and improves survival in mouse sepsis.
Microcirculation. 2010 Aug;17(6):407-16. PMID: 20690979
Curcumin potentiates the activity of the chemotherapy agent gemcitabine in vitro and in vivo animal models of pancreatic cancer.
Cancer Res. 2007 Apr 15;67(8):3853-61. PMID: 17440100
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer.
Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID: 19903839
Curcumin potentiates the antitumor effects of gemcitabine in an animal model of human bladder cancer...
Biochem Pharmacol. 2010 Jan 15;79(2):218-28. Epub 2009 Aug 12. PMID: 19682434
Curcumin preserves pancreatic islet cell survival and transplantation efficiency.
Life Sci. 2008 Jan 16;82(3-4):182-9. Epub 2007 Nov 21. PMID: 18093618
Curcumin pretreatment has a beneficial effect on wound healing in mice whole-body exposed to various doses of gamma-radiation.
Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 15172199
Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats.
Radiat Oncol. 2010 Nov 22;5(1):111. Epub 2010 Nov 22. PMID: 19913070
Curcumin prevents adriamycin nephrotoxicity in rats.
Br J Pharmacol. 2000 Jan;129(2):231-4. PMID: 10694226
Curcumin prevents advanced glycation induced complications of diabetes.
Biochem Pharmacol. 1998 Dec 15;56(12):1607-14. PMID: 9973181
Curcumin prevents alcohol-induced liver disease in rats.
Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G321-7. Epub 2002 Aug 28. PMID: 12388178
Curcumin prevents and reverses cirrhosis induced by bile duct obstruction.
Fundam Clin Pharmacol. 2008 Aug;22(4):417-27. PMID: 18705752
Curcumin prevents and/or delays diabetic complications associated with brain.
J Agric Food Chem. 2008 Nov 12;56(21):9905-10. Epub 2008 Oct 2. PMID: 20637830
Curcumin prevents cardiac remodeling secondary to chronic renal failure in rats.
Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H975-84. Epub 2010 Jul 2. PMID: 20601462
Curcumin prevents chemically-induced colitis in mice.
Gastroenterology. 2002 Dec;123(6):1912-22. PMID: 12454848
Curcumin prevents chemically-induced colitis.
Scand J Gastroenterol. 2009;44(2):187-94. PMID: 18830899
Curcumin prevents chemically-induced colitis.
World J Gastroenterol. 2005 Mar 28;11(12):1747-52. PMID: 15793857
Curcumin prevents chemically-induced liver cancer.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):439-42. Epub 2006 Dec 15. PMID: 10657978
Curcumin prevents chemically-induced liver cancer.
Cancer Lett. 2001 Jun 10;167(1):33-8. PMID: 11323096
Curcumin prevents chemically-induced lung and liver tumorigenesis.
In Vivo. 2008 Nov-Dec;22(6):781-5. PMID: 19181006
Curcumin prevents chemically-induced mammary cancer.
Cancer Lett. 1996 Jun 5;103(2):137-41. PMID: 8635149
Curcumin prevents chemically-induced skin cancer.
Adv Enzyme Regul. 1991;31:385-96. PMID: 1908616
Curcumin prevents cisplatin-induced chromosomal abberations in rat bone marrow cells.
Mutat Res. 2000 Feb 16;465(1-2):131-7. PMID: 10708978
Curcumin prevents colon carcinogenesis.
Carcinogenesis. 1999 Apr;20(4):641-4. PMID: 10223193
Curcumin prevents diabetes-associated abnormalities in the kidneys.
Nutrition. 2009 Sep;25(9):964-72. Epub 2009 Mar 5. PMID: 19268536
Curcumin prevents ethanol-induced brain damage.
Phytother Res. 1999 Nov;13(7):571-4. PMID: 10548748
Curcumin prevents experimentally induced epileptogenesis in rats.
Epilepsy Behav. 2009 Feb;14(2):300-8. Epub 2008 Dec 17. PMID: 19100339
Curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus.
Neurochem Res. 2006 May;31(5):611-8. Epub 2006 May 23. PMID: 16770732
Curcumin prevents free radical-mediated cataractogenesis.
Free Radic Biol Med. 2010 Feb 15;48(4):483-92. Epub 2009 Dec 10. PMID: 19932168
Curcumin prevents fructose-induced hepatic steatosis driven by hepatic insulin and leptin resistance.
Hepatology. 2010 May;51(5):1555-66. PMID: 20222050
Curcumin prevents glandular stomach cancer in rats.
Anticancer Res. 2001 Sep-Oct;21(5):3407-11. PMID: 11848501
Curcumin prevents Haloperidol-induced adverse effects.
Pharmacol Biochem Behav. 2008 Feb;88(4):511-22. Epub 2007 Oct 25. PMID: 18022680
Curcumin prevents human aortic smooth muscle cells migration associated with the development atherosclerosis.
Nutr Metab Cardiovasc Dis. 2010 Feb;20(2):125-32. Epub 2009 May 17. PMID: 19447587
Curcumin prevents liver cancer metastasis in an animal model.
Oncology. 2003;65(3):250-8. PMID: 14657599
Curcumin prevents liver fibrosis.
J Nat Med. 2009 Oct;63(4):415-20. Epub 2009 Jun 25. PMID: 19554395
Curcumin prevents mesenteric ischemia-reperfusion injury in a rodent model.
Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1329-36. Epub 2006 Apr 14. PMID: 19917353
Curcumin prevents myocardial ischemia in the cat heart.
Indian J Med Res. 1995 Jan;101:31-5. PMID: 7883281
Curcumin prevents ocular toxicity of naphthalene in rats.
Toxicol Lett. 2000 Jun 5;115(3):195-204. PMID: 10814889
Curcumin prevents oxidative kidney damage induced by acetaminophen in rats.
Food Chem Toxicol. 2009 Jul;47(7):1480-4. Epub 2009 Apr 2. PMID: 19345714
Curcumin prevents radiation-induced mammary tumors.
Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):212-23. PMID: 11777641
Curcumin prevents radiation-induced thymic lymphoma in mice.
J Environ Pathol Toxicol Oncol. 2007;26(4):273-9. PMID: 18197825
Curcumin prevents restenosis in a rabbit artery stent model.
Catheter Cardiovasc Interv. 2009 Nov 15;74(6):881-8. PMID: 19496118
Curcumin prevents selenite-induced cataractogenesis in rat pups.
Curr Eye Res. 2010 Feb;35(2):122-9. PMID: 20136422
Curcumin prevents shock-wave lithotripsy-induced renal injury.
Urol Res. 2009 Jun;37(3):159-64. Epub 2009 Apr 2. PMID: 19340419
Curcumin prevents the development of chemically-induced precancerous colonic lesions in male obese mice.
Nutr Cancer. 2012 Jan ;64(1):72-9. Epub 2011 Dec 15. PMID: 22172229
Curcumin prevents the development of experimental colitis.
Dig Dis Sci. 2007 Nov;52(11):2993-8. Epub 2007 Apr 11. PMID: 17429738
Curcumin produces beneficial changes in bone turnover and increases in bone strength...
Phytomedicine. 2008 Dec;15(12):1069-78. Epub 2008 Aug 6. PMID: 18693096
Curcumin protects against paraquat pulmonary toxicity.
Life Sci. 2000;66(2):PL21-8. PMID: 10666014
Curcumin protects against acetaminophen-induced toxicity.
Curr Neurovasc Res. 2012 Jan 16. Epub 2012 Jan 16. PMID: 22272768
Curcumin protects against acute liver damage in the rat.
Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. PMID: 17383825
Curcumin protects against aflatoxin-induced biochemical changes in testis of mice.
Fertil Steril. 2009 Feb;91(2):597-601. Epub 2008 Feb 21. PMID: 18291380
Curcumin protects against alcohol and oxidized fat-induced liver toxicity.
Ital J Biochem. 2004 Jul;53(2):61-6. PMID: 15646009
Curcumin protects against alcohol and PUFA-induced lipid peroxidation.
Phytother Res. 2003 Sep;17(8):925-9. PMID: 13680826
Curcumin protects against amiodarone-induced pulmonary fibrosis in rats.
Br J Pharmacol. 2003 Aug;139(7):1342-50. PMID: 12890714
Curcumin protects against atherosclerosis in a mouse model.
J Physiol Pharmacol. 2005 Dec;56(4):627-35. PMID: 16391419
Curcumin protects against bleomycin-induced damages in pulmonary functions in rats
Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(12):1434-8. PMID: 18837350
Curcumin protects against chemically-induced colitis in the mouse model.
J Pharm Pharmacol. 2007 Jun;59(6):849-56. PMID: 19285535
Curcumin protects against chemically-induced liver damage in rats.
Life Sci. 2006 Apr 4;78(19):2188-93. Epub 2005 Nov 8. PMID: 16288784
Curcumin protects against chemically-induced neurotoxicity in mice.
Anticancer Res. 1998 Sep-Oct;18(5A):3487-91. PMID: 20054649
Curcumin protects against chemically-induced oxidative stress in the brain.
Eur Rev Med Pharmacol Sci. 2006 Jul-Aug;10(4):157-61. PMID: 16910344
Curcumin protects against chemically-induced rat liver injury.
Int J Cancer. 2005 Mar 20;114(2):190-4. PMID: 10813555
Curcumin protects against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver.
J Appl Microbiol. 2009 Jun;106(6):2086-95. Epub 2009 Mar 9. PMID: 16691314
Curcumin protects against cisplatin-induced oxidative injury in rat testis.
Hum Reprod. 2009 Jul;24(7):1717-25. Epub 2009 Mar 11. PMID: 19279034
Curcumin protects against colchicine-induced cognitive dysfunction and oxidative stress in rats.
Hum Exp Toxicol. 2012 Jan 19. Epub 2012 Jan 19. PMID: 22262262
Curcumin protects against copper-induced genotoxicity.
Anticancer Res. 1998 Nov-Dec;18(6A):4083-90. PMID: 17998598
Curcumin protects against cyclophosphamide-induced haemorrhagic cystitis.
Biochem Biophys Res Commun. 2004 Apr 16;316(4):1065-72. PMID: 19413659
Curcumin protects against cypermethrin-induced oxidative stress in rats.
Exp Toxicol Pathol. 2010 Dec 2. Epub 2010 Dec 2. PMID: 21130633
Curcumin protects against d-galactose-induced senescence in mice.
J Asian Nat Prod Res. 2011 Jan;13(1):42-55. PMID: 21253949
Curcumin protects against doxorubicin (adriamycin)-induced toxicity in rats.
J Med Food. 2009 Apr;12(2):394-402. PMID: 19459743
Curcumin protects against encephalopathy in the animal model.
Mutat Res. 2008 Dec 8;657(2):105-10. Epub 2008 Aug 22. PMID: 19000058
Curcumin protects against endotoxin-induced acute liver injury in rats.
J Huazhong Univ Sci Technolog Med Sci. 2006;26(6):678-81. PMID: 17357487
Curcumin protects against experimental liver injury in mice.
Zhongguo Zhong Yao Za Zhi. 2003 Aug;28(8):756-8, 793. PMID: 15015361
Curcumin protects against familial adenomatous polyposis and decreases intestinal bleeding as compared to NSAID drugs.
Biol Pharm Bull. 2009 Mar;32(3):382-8. PMID: 12050094
Curcumin protects against gamma radiation-induced ileal mucosal damage.
Arch Toxicol. 2009 Jun;83(6):609-17. Epub 2008 Aug 27. PMID: 18754102
Curcumin protects against Haloperidol-associated neurotoxicity.
J Altern Complement Med. 2004 Dec;10(6):1015-8. PMID: 21076901
Curcumin protects against hemorrhage/resuscitation injury.
Shock. 2003 Feb;19(2):150-6. PMID: 12578124
Curcumin protects against hepatic and renal injury.
Microsc Res Tech. 2009 Dec 18. Epub 2009 Dec 18. PMID: 20025056
Curcumin protects against indomethacin-induced gastric injury.
Anticancer Drugs. 2009 Oct;20(9):757-69. PMID: 16631530
Curcumin protects against ischaemia/reperfusion insult in rat forebrain.
Pharmacol Res. 2002 Sep;46(3):273-9. PMID: 12220971
Curcumin protects against ischemia/reperfusion injury in rat kidneys.
World J Urol. 2008 Jun;26(3):285-91. Epub 2008 Mar 29. PMID: 18373094
Curcumin protects against isoproterenol induced myocardial infarction in rats.
Nutr Cancer. 2001;39(1):148-53. PMID: 8858558
Curcumin protects against lead neurotoxicity in rats.
Hum Exp Toxicol. 2003 Dec;22(12):653-8. PMID: 14992327
Curcumin protects against lipid peroxidation and oxidative stress during nicotine-induced toxicity.
Toxicol Mech Methods. 2004;14(6):339-43. PMID: 20021100
Curcumin protects against methionine-induced hyperlipidemia and hyperhomocysteinemia in rats.
Indian J Exp Biol. 2008 Jul;46(7):534-40. PMID: 18807758
Curcumin protects against myocardial oxidative damage induced by isoproterenol in rats.
Hum Exp Toxicol. 2007 Dec;26(12):933-8. PMID: 18375636
Curcumin protects against necrotizing enterocolitis in neonatal rats.
Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):132-6. PMID: 20199731
Curcumin protects against nicotine-induced lung toxicity by modulating the extent of lipid peroxidation and augmenting antioxidant defense system.
Pol J Pharmacol. 2004 Sep-Oct;56(5):581-6. PMID: 15591646
Curcumin protects against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters.
Int J Parasitol. 2011 Jan 21. Epub 2011 Jan 21. PMID: 21256849
Curcumin protects against oxidative insult induced by pentylenetetrazol in epileptic rats.
Methods Find Exp Clin Pharmacol. 2010 May;32(4):227-32. PMID: 20508869
Curcumin protects against seizures and cognitive impairment in a drug-induced epileptic rat model.
Life Sci. 2010 Sep 16. Epub 2010 Sep 16. PMID: 20840851
Curcumin protects against the anti-rejection drug cyclosporine-induced nephrotoxicity.
Gen Physiol Biophys. 2010 Mar;29(1):85-94. PMID: 20371885
Curcumin protects against the development of diabetic nephropathy, in a diabetic rat experimental model.
Br J Pharmacol. 2008 Mar;153(6):1225-31. Epub 2008 Jan 21. PMID: 18204486
Curcumin protects against vancomycin-induced kidney damage in rats.
Exp Toxicol Pathol. 2010 Sep 8. Epub 2010 Sep 8. PMID: 20832269
Curcumin protects bleomycin-induced lung injury in rats.
Pharm Res. 2008 Sep;25(9):2181-9. Epub 2008 Apr 25. PMID: 9250724
Curcumin protects intestinal mucosal barrier function of rat enteritis.
PLoS One. 2010;5(9):e12969. Epub 2010 Sep 24. PMID: 20885979
Curcumin protects pancreatic islet cells and chemically-induced type 1 diabetes.
Br J Pharmacol. 2008 Nov;155(5):702-13. Epub 2008 Aug 11. PMID: 18695642
Curcumin protects pre-oligodendrocytes from activated microglia...
Brain Res. 2010 Jun 21;1339:60-9. Epub 2010 Apr 24. PMID: 20403340
Curcumin protects rat brains against focal ischemia.
Brain Res. 2009 Jul 28;1282:133-41. Epub 2009 May 13. PMID: 19445907
Curcumin protects rat myocardium against isoproterenol-induced ischemic injury.
J Cardiovasc Pharmacol. 2010 Apr;55(4):377-84. PMID: 20125031
Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine.
Eur J Pharmacol. 2010 Feb 25;628(1-3):274-81. Epub 2009 Nov 15. PMID: 19919835
Curcumin protects retinal cells from light-and oxidant stress-induced cell death...
Free Radic Biol Med. 2009 Mar 1;46(5):672-9. Epub 2008 Dec 24. PMID: 19121385
Curcumin protects testicle cells of mice from damage induced by chronic alcohol administration.
Med Sci Monit. 2008 Nov;14(11):BR237-42. PMID: 18971866
Curcumin protects the liver against aflatoxin-induced changes.
Poult Sci. 2009 Dec;88(12):2620-7. PMID: 19903961
Curcumin protects the mmune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD).
Immunopharmacol Immunotoxicol. 2010 Mar;32(1):99-104. PMID: 19821784
Curcumin protects the rat liver from chemically-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation.
Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. PMID: 18006644
Curcumin reduced the side effects of mitomycin C in the treatment of breast cancer.
Cancer Sci. 2009 Nov;100(11):2040-5. Epub 2009 Jul 23. PMID: 19703194
Curcumin reduces adjuvant-induced c-reactive protein and inflammation.
Immunopharmacol Immunotoxicol. 2003 May;25(2):213-24. PMID: 12784914
Curcumin reduces burn progression in rats.
Acad Emerg Med. 2007 Dec;14(12):1125-9. PMID: 18045885
Curcumin reduces gallstone formation and biliary cholesterol concentration in mice.
Indian J Med Res. 1992 Oct;96:288-91. PMID: 1459671
Curcumin reduces high blood sugar and vascular inflammation in an animal model of type 1 diabetes.
Antioxid Redox Signal. 2009 Feb;11(2):241-9. PMID: 18976114
Curcumin reduces indomethacin-induced damage in the rat small intestine.
Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID: 17351913
Curcumin reduces injury progression in a rat comb burn model.
J Burn Care Res. 2011 Jan-Feb;32(1):135-42. PMID: 21088615
Curcumin reduces intestinal inflammation and polyps, indicating its potential value for preventing colon cancer.
J Interferon Cytokine Res. 2010 Oct 15. Epub 2010 Oct 15. PMID: 20950131
curcumin reduces markers of liver damage in rats treated with heated sunflower oil or ethanol.
Vet Ital. 2010 Jan-Mar;46(1):83-92. PMID: 20391370
Curcumin reduces nitric oxide formation and associated inflammation in the rat mammary gland.
J Exp Biol. 2009 Jan;212(Pt 2):163-8. PMID: 11020339
Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.
Mol Nutr Food Res. 2009 Oct;53(10):1316-28. PMID: 19753608
Curcumin reduces oxidative stress associated with exposure to an environmental pollutant.
Toxicol Ind Health. 2011 Jan 18. Epub 2011 Jan 18. PMID: 21245202
Curcumin reduces pathogenesis in hamster-opisthorchiasis.
Southeast Asian J Trop Med Public Health. 2009 Nov;40(6):1208-15. PMID: 20578454
Curcumin reduces periductal fibrosis in liver fluke-infected in hamsters.
Eur J Pharmacol. 2010 Jul 25;638(1-3):134-41. Epub 2010 Apr 24. PMID: 20420820
Curcumin reduces pertussis-induced infectious brain edema in rats.
Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 14723822
Curcumin reduces pulmonary tumorigenesis in transgenic mice.
Mol Nutr Food Res. 2011 Jul ;55(7):1036-43. Epub 2011 May 2. PMID: 21538854
Curcumin reduces rat hepatic fibrosis.
Zhonghua Gan Zang Bing Za Zhi. 2007 Oct;15(10):753-7. PMID: 17963602
Curcumin reduces the accumulation of collagen IV and fibronectin in the glomeruli...
Clin Cancer Res. 2009 Feb 15;15(4):1123-5. PMID: 15339499
Curcumin reduces the adverse effects of hyperinsulinemia associated with type 2 diabetes
Clin Breast Cancer. 2010 Jun;10(3):224-9. PMID: 19841616
Curcumin regresses tumors as well as protects the host from tumor-induced immunosuppression and toxicity.
Cancer Detect Prev. 2005;29(5):470-8. Epub 2005 Sep 26. PMID: 16188398
Curcumin regulates the shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis.
Acta Pharmacol Sin. 2006 Aug;27(8):1071-7. PMID: 16867261
Curcumin retards the growth of intestinal polyps in a mouse model of familial adenomatous polyposis.
Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID: 16387490
Curcumin reverses amyloid pathology and associated neurotoxicity in a mouse model of Alzheimer disease.
J Neurochem. 2007 Aug;102(4):1095-104. Epub 2007 Apr 30. PMID: 17472706
Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.
Neuropharmacology. 2009 Sep;57(4):463-71. Epub 2009 Jun 21. PMID: 19540859
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts.
Cell Mol Immunol. 2010 Jul;7(4):306-15. Epub 2010 Mar 22. PMID: 20305684
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation.
Clin Cancer Res. 2008 Apr 1;14(7):2128-36. PMID: 18381954
Curcumin showed significant nephroprotective effects against Sodium Fluoride induced toxicity upon kidneys.
Biol Trace Elem Res. 2012 Mar ;145(3):369-74. Epub 2011 Sep 7. PMID: 21901432
Curcumin significantly attenuates carotid artery neointima formation.
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):85-90. Epub 2005 Oct 20. PMID: 16239599
Curcumin reduces gallstone formation and biliary cholesterol concentration in mice.
Indian J Med Res. 1992 Oct;96:288-91. PMID: 1459671
Curcumin reduces high blood sugar and vascular inflammation in an animal model of type 1 diabetes.
Antioxid Redox Signal. 2009 Feb;11(2):241-9. PMID: 18976114
Curcumin reduces indomethacin-induced damage in the rat small intestine.
Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID: 17351913
Curcumin reduces injury progression in a rat comb burn model.
J Burn Care Res. 2011 Jan-Feb;32(1):135-42. PMID: 21088615
Curcumin reduces intestinal inflammation and polyps, indicating its potential value for preventing colon cancer.
J Interferon Cytokine Res. 2010 Oct 15. Epub 2010 Oct 15. PMID: 20950131
curcumin reduces markers of liver damage in rats treated with heated sunflower oil or ethanol.
Vet Ital. 2010 Jan-Mar;46(1):83-92. PMID: 20391370
Curcumin reduces nitric oxide formation and associated inflammation in the rat mammary gland.
J Exp Biol. 2009 Jan;212(Pt 2):163-8. PMID: 11020339
Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.
Mol Nutr Food Res. 2009 Oct;53(10):1316-28. PMID: 19753608
Curcumin reduces oxidative stress associated with exposure to an environmental pollutant.
Toxicol Ind Health. 2011 Jan 18. Epub 2011 Jan 18. PMID: 21245202
Curcumin reduces pathogenesis in hamster-opisthorchiasis.
Southeast Asian J Trop Med Public Health. 2009 Nov;40(6):1208-15. PMID: 20578454
Curcumin reduces periductal fibrosis in liver fluke-infected in hamsters.
Eur J Pharmacol. 2010 Jul 25;638(1-3):134-41. Epub 2010 Apr 24. PMID: 20420820
Curcumin reduces pertussis-induced infectious brain edema in rats.
Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 14723822
Curcumin reduces pulmonary tumorigenesis in transgenic mice.
Mol Nutr Food Res. 2011 Jul ;55(7):1036-43. Epub 2011 May 2. PMID: 21538854
Curcumin reduces rat hepatic fibrosis.
Zhonghua Gan Zang Bing Za Zhi. 2007 Oct;15(10):753-7. PMID: 17963602
Curcumin reduces the accumulation of collagen IV and fibronectin in the glomeruli...
Clin Cancer Res. 2009 Feb 15;15(4):1123-5. PMID: 15339499
Curcumin reduces the adverse effects of hyperinsulinemia associated with type 2 diabetes
Clin Breast Cancer. 2010 Jun;10(3):224-9. PMID: 19841616
Curcumin regresses tumors as well as protects the host from tumor-induced immunosuppression and toxicity.
Cancer Detect Prev. 2005;29(5):470-8. Epub 2005 Sep 26. PMID: 16188398
Curcumin regulates the shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis.
Acta Pharmacol Sin. 2006 Aug;27(8):1071-7. PMID: 16867261
Curcumin retards the growth of intestinal polyps in a mouse model of familial adenomatous polyposis.
Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID: 16387490
Curcumin reverses amyloid pathology and associated neurotoxicity in a mouse model of Alzheimer disease.
J Neurochem. 2007 Aug;102(4):1095-104. Epub 2007 Apr 30. PMID: 17472706
Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.
Neuropharmacology. 2009 Sep;57(4):463-71. Epub 2009 Jun 21. PMID: 19540859
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts.
Cell Mol Immunol. 2010 Jul;7(4):306-15. Epub 2010 Mar 22. PMID: 20305684
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation.
Clin Cancer Res. 2008 Apr 1;14(7):2128-36. PMID: 18381954
Curcumin showed significant nephroprotective effects against Sodium Fluoride induced toxicity upon kidneys.
Biol Trace Elem Res. 2012 Mar ;145(3):369-74. Epub 2011 Sep 7. PMID: 21901432
Curcumin significantly attenuates carotid artery neointima formation.
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):85-90. Epub 2005 Oct 20. PMID: 16239599
Curcumin's induction of enzymes involved in the detoxification of the electrophilic products of lipid peroxidation may contribute to the anti-inflammatory and anti-cancer activities of curcumin.
Int J Biochem Cell Biol. 1998 Apr;30(4):445-56. PMID: 9675878
Curcumin's inhibition of intestinal tumors is associated with changes in the intestinal immune cell profile.
J Surg Res. 2000 Apr;89(2):169-75. PMID: 10729246
Curcumin's neuroprotective properties may be due to its anticholinesterase, antioxidant activity and brain insulin receptor modulating activities.
Pharmacol Res. 2010 Mar;61(3):247-52. Epub 2009 Dec 21. PMID: 20026275
Curcumin, a NF-kappaB inhibitor, stimulates muscle regeneration after traumatic injury.
Am J Physiol. 1999 Aug;277(2 Pt 1):C320-9. PMID: 10444409
Curcumin, beta-carontein and hesperidin prevent chemically-induced oral cancer.
Cancer Res. 1994 Sep 1;54(17):4653-9. PMID: 8062259
Curcumin, capsaicin and garlic attenuate adverse blood changes associated with a cholesterol-enriched diet.
Br J Nutr. 2005 Jan;93(1):81-91. PMID: 15705229
Curcumin, capsaicin and garlic have a beneficial influence on erythrocyte integrity in high-fat fed rats.
J Nutr Biochem. 2006 Jul;17(7):471-8. Epub 2005 Oct 25. PMID: 16263255
Curcumin, capsaicin and garlic inhibit adverse blood and liver changes associated wtih a high-fat diet in rats.
Ann Nutr Metab. 2004 Sep-Oct;48(5):314-20. Epub 2004 Oct 1. PMID: 15467281
Curcumin, capsaicin and garlic reduce adverse changes in red blood cells associated with hypercholesterolemia.
Mol Cell Biochem. 2002 Jul;236(1-2):155-61. PMID: 12190115
Curcumin, capsaicin, and garlic have a beneficial effect in the red blood cells and liver of cholesterol fed rats.
Acta Pharmacol Sin. 2007 Oct;28(10):1559-65. PMID: 15296079
Curcumin, ellagic acid and bixin attenuate radiation induced toxicity.
Indian J Exp Biol. 1996 Sep;34(9):845-7. PMID: 9014516
Curcumin, ellagic acid and bixin provide protection against chromosome damage produced by radiation.
J Exp Clin Cancer Res. 1998 Dec;17(4):431-4. PMID: 10089063
Curcumin, resveratrol and melatonin protect against cadmium-induced oxidative damage.
Toxicology. 2006 Aug 15;225(2-3):150-6. Epub 2006 May 26. PMID: 16806632
Curcumin, silymarin and N-acetylcysteine protect against antitubercular drug-induced hepatotoxicity.
Hum Exp Toxicol. 2012 Feb 8. Epub 2012 Feb 8. PMID: 22318308
Curcumin-free turmeric extract inhibits chemically-induced gastric tumors in mice.
Cancer Lett. 1997 Sep 16;118(1):79-85. PMID: 9310263
Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells.
Int J Oncol. 2013 Oct ;43(4):1141-50. Epub 2013 Aug 5. PMID: 23917396
Curcumin-manganese complexes have enhanced antioxidant activity.
Free Radic Biol Med. 2003 Dec 15;35(12):1632-44. PMID: 14680686
Curcuminoid supplementation ameliorates cardiac autonomic imbalance in high-fat-fed rats, probably due to its lipid-lowering effect.
Nutrition. 2009 Jul-Aug;25(7-8):870-8. Epub 2009 Apr 23. PMID: 19398300
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Curcumin appears to be a safe and useful immunomodulator for the immune system.
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Biol Pharm Bull. 2002 Jan;25(1):131-3. PMID: 11824543
Curcumin has multiple molecular mechanisms as a chemopreventive.
AAPS J. 2006;8(3):E443-9. Epub 2006 Jul 7. PMID: 17025261
Curcumin has neuroprotective properties against NMDA-induced toxicity.
Invest Ophthalmol Vis Sci. 2010 Sep 22. Epub 2010 Sep 22. PMID: 20861489
Curcumin has neuroprotective properties.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):147-53. Epub 2009 Oct 29. PMID: 19879308
Curcumin has nutritional potential as a naturally occurring anti-inflammatory agent for treating osteoarthritis.
Biochem Pharmacol. 2007 May 1;73(9):1434-45. Epub 2007 Jan 7. PMID: 17291458
Curcumin has potent antiproliferative and proapoptotic effects in melanoma cells.
Cancer. 2005 Aug 15;104(4):879-90. PMID: 16007726
Curcumin has potential as an effective modifier in therapy of leukemia and/or as an immunopotentiator.
Biochem Biophys Res Commun. 2010 Apr 23;395(1):61-5. Epub 2010 Mar 25. PMID: 20346917
Curcumin has potential for hepatic fibrosis therapy.
J Clin Rheumatol. 2010 Feb 2. Epub 2010 Feb 2. PMID: 18037917
Curcumin has profound immunosuppressive effects of potential value in organ transplantation.
J Surg Res. 2004 Oct;121(2):171-7. PMID: 15501456
Curcumin has radioprotective properties.
J Ethnopharmacol. 1999 Jan;64(1):1-7. PMID: 10075116
Curcumin has radioprotective properties.
Biophys Chem. 2001 Aug 30;92(1-2):119-26. PMID: 11527584
Curcumin has radiosensitizing and chemosensitizing effects on tumors while protecting healthy tissue from damage.
Nutr Cancer. 2010 Oct;62(7):919-30. PMID: 20924967
Curcumin has remarkable antiviral effects on HSV-1 in cell culture.
Anticancer Res. 2001 Mar-Apr;21(2A):873-8. PMID: 21299124
Curcumin has schistosomicidal activity.
Acta Pharmacol Sin. 2009 Mar;30(3):227-81. PMID: 19096877
Curcumin has significant inhibitory effects on the growth of oral cancer cells in vitro.
Anticancer Res. 2000 May-Jun;20(3A):1733-8. PMID: 10928101
Curcumin has therapeutic potential in prostate cancer.
Mol Urol. 2000;4(1):1-6. PMID: 10851300
Curcumin has therapeutic value in inflammatory bowel disease.
Inflamm Bowel Dis. 2011 Feb;17(2):503-15. PMID: 20629184
Curcumin has therapeutic value in the prevention and treatment of liver diseases or damage.
Liver Int. 2009 Nov;29(10):1457-66. PMID: 19811613
Curcumin has trypanocidal properties.
Biol Pharm Bull. 1998 Jun;21(6):643-5. PMID: 9657056
Curcumin improves chemotherapy by simultaneously sensitising cancer cells and reducing side effects.
Eur J Cancer. 2011 May 24. Epub 2011 May 24. PMID: 21616659
Curcumin improves the antitumor effect of X-ray irradiation.
Anticancer Drugs. 2012 Jan 23. Epub 2012 Jan 23. PMID: 22273827
Curcumin increases the radiosensitivity of colorectal cancer cells.
Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):534-42. PMID: 19735878
Curcumin induces a tolerogenic phenotype in immune cells.
Clin Exp Immunol. 2010 Dec;162(3):460-73. PMID: 21070208
Curcumin induces apoptosis in human neuroblastoma cells.
Fitoterapia. 2005 Sep;76(6):508-13. PMID: 18383847
Curcumin induces apoptosis in primary resting B chronic lymphocytic leukemia cells.
Leuk Lymphoma. 2009 Apr;50(4):625-32. PMID: 19373661
Curcumin induces apoptosis of triple-negative breast cancer cells.
Mol Med Report. 2012 Sep 26. Epub 2012 Sep 26. PMID: 23023821
Curcumin induces cell cycle arrest and programmed cell death in cisplatin-resistant human ovarian cancer cells.
Cancer Biol Ther. 2007 Feb;6(2):178-84. Epub 2007 Feb 5. PMID: 17218783
Curcumin induces cell cycle arrest and programmed cell death in human osteosarcoma cells.
Anticancer Res. 2009 Dec;29(12):5039-44. PMID: 20044614
Curcumin induces cell death in cancer cells.
Mol Nutr Food Res. 2008 Sep;52(9):1074-81. PMID: 18720347
Curcumin induces cell death in human uveal melanoma cells.
Curr Eye Res. 2010 Apr;35(4):352-60. PMID: 20373902
Curcumin induces cell death in oesophageal cancer cells.
Br J Cancer. 2009 Nov 3;101(9):1585-95. Epub 2009 Oct 6. PMID: 19809435
Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth.
J Ovarian Res. 2010;3:11. Epub 2010 Apr 29. PMID: 20429876
Curcumin induces death in tumor cells.
Carcinogenesis. 2012 Jan 31. Epub 2012 Jan 31. PMID: 22298641
Curcumin induces DNA damage in triple negative breast cancer cells.
Breast Cancer (Auckl). 2010;4:1-3. Epub 2010 Feb 16. PMID: 20697527
Curcumin induces heat shock protein and inhibits p53 gene expression in colorectal cancer cells.
Pediatrics. 2005 May;115(5):1360-6. PMID: 8989916
Curcumin induces heat shock protein.
Crit Care Med. 2001 Nov;29(11):2199-204. PMID: 11700423
Curcumin induces programmed cell death and blocks migration of human medulloblastoma cells.
Anticancer Res. 2010 Feb;30(2):499-504. PMID: 20332461
Curcumin induces programmed cell death and cell cycle arrest in human prostate cancer cells.
Zhonghua Wai Ke Za Zhi. 2006 Sep 15;44(18):1256-9. PMID: 17147887
Curcumin induces programmed cell death and disturbs cell cycle progression in leukemia cells.
J Huazhong Univ Sci Technolog Med Sci. 2002;22(4):295-8. PMID: 12674762
Curcumin induces programmed cell death and growth inhibition in breast cancer cells.
Cochrane Database Syst Rev. 2005(4):CD004649. Epub 2005 Oct 19. PMID: 10445426
Curcumin induces programmed cell death in a murine mammary gland cells.
Eur J Pharmacol. 2011 Oct 1 ;668(1-2):127-32. Epub 2011 Jul 8. PMID: 21762689
Curcumin induces programmed cell death in a nasopharyngeal carcinoma cell line.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006 Aug;41(8):612-6. PMID: 17039805
Curcumin induces programmed cell death in a variety of cancer cell lines.
Nutr Cancer. 1996;26(1):111-20. PMID: 8844727
Curcumin induces programmed cell death in an acute T cell leukemia cell line.
Exp Cell Res. 1999 Jun 15;249(2):299-307. PMID: 10366429
Curcumin induces programmed cell death in androgen-dependent prostate cancer cell lines.
Zhonghua Nan Ke Xue. 2006 Feb;12(2):141-4. PMID: 16519151
Curcumin induces programmed cell death in both androgen-dependent and androgen-independent prostate cancer cells.
Prostate Cancer Prostatic Dis. 2000 Aug;3(2):84-93. PMID: 12497104
Curcumin induces programmed cell death in breast cancer cells.
Mutat Res. 2002 Jun 27;518(1):71-84. PMID: 12063069
Curcumin induces programmed cell death in breast cancer cells.
Anticancer Res. 2005 Sep-Oct;25(5):3293-302. PMID: 16101141
Curcumin induces programmed cell death in breast cancer.
FEBS Lett. 2002 Feb 13;512(1-3):334-40. PMID: 11852106
Curcumin induces programmed cell death in Burkitt's lymphoma cell lines.
Mol Cancer Ther. 2008 Oct;7(10):3318-29. PMID: 18852135
Curcumin induces programmed cell death in chronic lymphocytic leukemia B cells and works synergistically with the green tea polypenol EGCG.
Clin Nephrol. 1975;3(5):195-203. PMID: 19228728
Curcumin induces programmed cell death in chronic myeloid leukemia cells.
J Asian Nat Prod Res. 2009 Nov;11(11):918-28. PMID: 20183254
Curcumin induces programmed cell death in colon cancer cells.
Carcinogenesis. 2006 Aug;27(8):1636-44. Epub 2006 Feb 25. PMID: 16501251
Curcumin induces programmed cell death in colon cancer cells.
J Zhejiang Univ Sci B. 2009 Feb;10(2):93-102. PMID: 19235267
Curcumin induces programmed cell death in follicular lymphoma cell lines.
Chem Pharm Bull (Tokyo). 2011;59(3):378-81. PMID: 16569593
Curcumin induces programmed cell death in glioma cells.
FEBS Lett. 2006 Jun 26;580(15):3746-52. Epub 2006 Jun 9. PMID: 16777101
Curcumin induces programmed cell death in hepatoma cells.
Asian Pac J Cancer Prev. 2011 ;12(8):1925-9. PMID: 22292626
Curcumin induces programmed cell death in histiocytoma tumor cells.
FEBS Lett. 1999 Feb 19;445(1):165-8. PMID: 10069393
Curcumin induces programmed cell death in human basal cell carcinoma cells.
J Invest Dermatol. 1998 Oct;111(4):656-61. PMID: 9764849
Curcumin induces programmed cell death in human bladder cells.
Anticancer Drugs. 2006 Mar;17(3):279-87. PMID: 16520656
Curcumin induces programmed cell death in human breast cancer cells.
Biochem Pharmacol. 2003 Feb 1;65(3):361-76. PMID: 12527329
Curcumin induces programmed cell death in human colon cancer cells.
Carcinogenesis. 2004 Nov;25(11):2183-9. Epub 2004 Jul 15. PMID: 15256484
Curcumin induces programmed cell death in human colon cancer cells.
Anticancer Res. 2006 Nov-Dec;26(6B):4379-89. PMID: 17201158
Curcumin induces programmed cell death in human colon cancer cells.
Cancer Lett. 2010 Nov 1;297(1):1-8. Epub 2010 May 15. PMID: 20472336
Curcumin induces programmed cell death in human colon cancer cells.
J Oral Maxillofac Surg. 2010 May;68(5):1158-61. PMID: 16302093
Curcumin induces programmed cell death in human liver cancer cells.
Oncogene. 1996 Aug 1;13(3):609-16. PMID: 8760302
Curcumin induces programmed cell death in human liver cancer cells.
Food Chem Toxicol. 2006 Jun;44(6):810-8. Epub 2005 Dec 5. PMID: 16537656
Curcumin induces programmed cell death in human lung adenocarcinoma cells.
Oncol Rep. 2010 Feb;23(2):397-403. PMID: 20043100
Curcumin induces programmed cell death in human malignant gliobastoma cells. - Article 1
Neurochem Res. 2007 Dec;32(12):2103-13. Epub 2007 Jun 12. PMID: 17562168
Curcumin induces programmed cell death in human melanoma cells.
Exp Cell Res. 2001 Dec 10;271(2):305-14. PMID: 11716543
Curcumin induces programmed cell death in human multidrug-resistant cells.
Ann N Y Acad Sci. 2002 Nov;973:250-4. PMID: 12485871
Curcumin induces programmed cell death in human non-small cell lung cancer cells.
Anticancer Res. 2010 Jun;30(6):2125-33. PMID: 20651361
Curcumin induces programmed cell death in human promyelocytic leukemia HL-60 cells.
Life Sci. 2008 Feb 13;82(7-8):367-75. Epub 2007 Dec 7. PMID: 18187158
Curcumin induces programmed cell death in Leishmania through its pro-oxidant and calcium-modulating activity.
Apoptosis. 2008 Jul;13(7):867-82. PMID: 18506627
Curcumin induces programmed cell death in leukemia cells.
Carcinogenesis. 2008 May;29(5):1042-8. Epub 2008 Mar 13. PMID: 11756235
Curcumin induces programmed cell death in leukemia cells.
Biochem Pharmacol. 2003 Oct 15;66(8):1475-83. PMID: 14555224
Curcumin induces programmed cell death in lung cancer cells through cytoskeleton disorganization.
Planta Med. 2009 Jun;75(8):808-13. Epub 2009 Mar 5. PMID: 19266427
Curcumin induces programmed cell death in lung cancer cells.
Oncol Rep. 2010 May;23(5):1285-92. PMID: 20372842
Curcumin induces programmed cell death in lung cancer cells.
Phytother Res. 2009 Dec 9. PMID: 20686221
Curcumin induces programmed cell death in mantle cell lymphoma.
Leuk Lymphoma. 2011 Aug ;52(8):1537-43. Epub 2011 Jun 24. PMID: 21699455
Curcumin induces programmed cell death in medullobastoma cells.
Mol Carcinog. 2009 Dec 18. Epub 2009 Dec 18. PMID: 20025076
Curcumin induces programmed cell death in mouse breast cancer cells.
Biochem Biophys Res Commun. 2001 Nov 2;288(3):658-65. PMID: 11676493
Curcumin induces programmed cell death in prostate cancer cells.
Nutr Cancer. 2010 Apr;62(3):379-89. PMID: 20358476
Curcumin induces programmed cell death in triple negative breast cancer cell lines.
Breast Cancer. 2009 Sep 2;3:61-75. PMID: 19809577
Curcumin induces programmed cell death in two leukemia cell lines.
Ann N Y Acad Sci. 2003 Dec;1010:389-92. PMID: 15033758
Curcumin induces programmed cell death ina human nasopharyngeal carcinoma cell line.
Ai Zheng. 2004 Dec;23(12):1651-4. PMID: 15601554
Curcumin induces suppression of an oncogene associated with the promotion of various cancers.
Oncogene. 2002 Dec 12;21(57):8852-61. PMID: 12483537
Curcumin inhibit human lung cancer cells.
Mol Biol Rep. 2010 Oct;37(7):3105-10. Epub 2009 Oct 15. PMID: 19826913
Curcumin inhibit the growth of hormone-independent and multi-drug resistant breast cancer cells.
Ann N Y Acad Sci. 2009 Feb;1155:278-83. PMID: 19250217
Curcumin inhibit the growth of human astroglioma cells.
Biochem Biophys Res Commun. 2005 Oct 7;335(4):1017-25. PMID: 16102725
Curcumin inhibits a human multiple myeloma cell line.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Aug;15(4):762-6. PMID: 17708799
Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion.
J Nat Prod. 2009 Aug;72(8):1533-7. PMID: 19653644
Curcumin inhibits acute T cell leukemia in vitro.
Mol Cancer Ther. 2006 Apr;5(4):927-34. PMID: 16648563
Curcumin inhibits aflatoxin-associated DNA adduct formation associated with liver carcinogenesis.
Chem Biol Interact. 1996 Mar 8;100(1):41-51. PMID: 8599854
Curcumin inhibits B-cell lymphoma cells.
Chin Med J (Engl). 2005 Dec 20;118(24):2052-7. PMID: 16438902
Curcumin inhibits bTREK-1 K+ channels and stimulates cortisol secretion from adrenocortical cells.
Biochem Biophys Res Commun. 2008 Jun 13;370(4):623-8. Epub 2008 Apr 10. PMID: 18406348
Curcumin inhibits carcinogen and nicotine-induced head and neck squamous cell carcinoma.
Cancer Prev Res (Phila). 2010 Dec;3(12):1586-95. Epub 2010 Sep 17. PMID: 20851953
Curcumin inhibits cell migration of human colon cancer cells.
Anticancer Res. 2006 Mar-Apr;26(2A):1281-8. PMID: 16619535
Curcumin inhibits cell proliferation by inducing programmed cell death in lymphoma cells.
Trends Endocrinol Metab. 2009 Apr;20(3):139-45. Epub 2009 Mar 9. PMID: 20863651
Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing programmed cell death in colon carcinoma cells.
Maturitas. 2008 Feb 20;59(2):137-48. Epub 2008 Mar 4. PMID: 10625938
Curcumin inhibits cervical cancer associated HPV-infection.
Br J Nutr. 2007 Oct;98(4):720-6. Epub 2007 Aug 1. PMID: 15514944
Curcumin inhibits chemically-induced oxidative stress associated with a tumor-promoting agent.
Carcinogenesis. 1994 Aug;15(8):1717-21. PMID: 8055654
Curcumin inhibits cholesterol uptake.
Lipids Health Dis. 2010;9:40. Epub 2010 Apr 19. PMID: 20403165
Curcumin inhibits chronic myelogenous leukemia cells (K562).
J Altern Complement Med. 2007 Nov;13(9):985-7. PMID: 15182583
Curcumin inhibits cortisone-induced cytoxicity in vitro.
Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):236-40. Epub 2009 Jan 20. PMID: 19175364
Curcumin inhibits cyclooxygenase and matrix metalloproteinase-8 expression associated with breast cancer progrression.
Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1612-20. PMID: 16356124
Curcumin inhibits cyclooxygenase-2 expression in human colon cancer cells.
Cancer Lett. 2001 Oct 30;172(2):111-8. PMID: 11566484
Curcumin inhibits cytokines associated with allergic diseases.
Biochem Pharmacol. 1997 Oct 1;54(7):819-24. PMID: 9353136
Curcumin inhibits EBV reactivation in vitro.
Mol Carcinog. 2002 Mar;33(3):137-45. PMID: 11870879
Curcumin inhibits embryonal carcinoma.
Int J Nurs Pract. 2010 Oct;16(5):454-60. PMID: 11686235
Curcumin inhibits endotoxin-associated changes in rat genes.
J Pharmacol Exp Ther. 2003 Dec;307(3):1205-12. Epub 2003 Oct 13. PMID: 14557382
Curcumin inhibits epidermal growth factor receptor activity in human epidermoid cancer cells.
Biochim Biophys Acta. 1994 Dec 30;1224(3):597-600. PMID: 7803521
Curcumin inhibits esophageal activation in response to acid.
Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G388-98. Epub 2008 Dec 12. PMID: 19074641
Curcumin inhibits Ewing sarcoma.
Med Oncol. 2010 Dec;27(4):1096-101. Epub 2009 Oct 27. PMID: 19859844
Curcumin inhibits gastrointestinal hormone (e.g., neurotensin)-induced chemokine expression and cell migration associated with human colon cancer cell progression.
Clin Cancer Res. 2006 Sep 15;12(18):5346-55. PMID: 17000667
Curcumin inhibits glucose production in isolated mice hepatocytes.
Diabetes Res Clin Pract. 2008 May;80(2):185-91. Epub 2008 Jan 24. PMID: 18221818
Curcumin inhibits glutamate-induced excitoxicity in vitro.
Mol Cell Biochem. 2007 Apr;298(1-2):187-94. Epub 2006 Nov 25. PMID: 17131042
Curcumin inhibits gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.
Biol Chem. 2005 May;386(5):481-90. PMID: 15927892
Curcumin inhibits growth and induces programmed cell death in human ovarian cancer cell lines.
Chin J Integr Med. 2006 Jun;12(2):126-31. PMID: 16800992
Curcumin inhibits growth and sensitizes ovarian cancer cells to cisplatin-mediated killing.
Carcinogenesis. 1982;3(11):1331-8. PMID: 12447990
Curcumin inhibits growth, induces cell cycle arrest and programmed cell death in human prostatic stromal cells.
Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(16):2022-5. PMID: 19086645
Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT.
Int J Mol Med. 2012 Nov ;30(5):1021-8. Epub 2012 Aug 20. PMID: 22922731
Curcumin inhibits head and neck cancer cell proliferation.
Int J Cancer. 2006 Sep 15;119(6):1268-75. PMID: 16642480
Curcumin inhibits head and neck squamous cell cancer cells.
Int J Cancer. 2004 Sep 20;111(5):679-92. PMID: 15252836
Curcumin inhibits Helicobacter pylori.
Anticancer Res. 2002 Nov-Dec;22(6C):4179-81. PMID: 12553052
Curcumin inhibits hepatic fibrogenesis.
Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G113-23. Epub 2006 Sep 7. PMID: 16959952
Curcumin inhibits hepatitis B virus.
FEBS Lett. 2010 Jun 3;584(11):2485-90. Epub 2010 Apr 29. PMID: 20434445
Curcumin inhibits hepatitis C virus replication.
FEBS Lett. 2009 Dec 17. PMID: 20026048
Curcumin inhibits histiocytoma tumor cells.
FEBS Lett. 1999 Aug 6;456(2):311-4. PMID: 10456330
Curcumin inhibits HIV-1 integrase activity.
Biochem Pharmacol. 1995 Apr 18;49(8):1165-70. PMID: 7748198
Curcumin inhibits human colon cancer cell growth.
Oncogene. 2006 Jan 12;25(2):278-87. PMID: 16170359
Curcumin inhibits human leukemia cells.
Biochim Biophys Acta. 1996 Nov 15;1317(2):95-100. PMID: 8950193
Curcumin inhibits human malignant astrocytoma cell lines.
J Neurooncol. 2005 Sep;74(2):105-11. PMID: 16193380
Curcumin inhibits human ovarian cancer cell migration.
Cancer Chemother Pharmacol. 2008 Oct;62(5):857-65. Epub 2008 Jan 23. PMID: 18214481
Curcumin inhibits human pancreatic cancer cell growth.
Cancer. 2002 Sep 15;95(6):1206-14. PMID: 12216086
Curcumin inhibits human pancreatic cancer cell growth.
Cancer. 2004 Nov 15;101(10):2351-62. PMID: 15476283
Curcumin inhibits Human T-cell leukemia virus type I (HTLV-I).
Cancer Sci. 2006 Apr;97(4):322-7. PMID: 16630125
Curcumin inhibits hypoxia induced proliferation and collagen I synthesis.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;41(4):621-5. PMID: 20848782
Curcumin inhibits hypoxia-induced angiogenesis associated wtih tumor progression.
Oncol Rep. 2006 Jun;15(6):1557-62. PMID: 16685395
Curcumin inhibits IMP dehydrogenase, a target for anticancer and antiviral chemotherapy agents.
Biosci Biotechnol Biochem. 2010;74(1):185-7. Epub 2010 Jan 7. PMID: 20057137
Curcumin inhibits in vitro MCP-1 release from mouse pancreatic islets, indicating it may have anti-rejection properties.
Transplant Proc. 2006 Nov;38(9):3035-8. PMID: 17112893
Curcumin inhibits inflammation associated with secretion of inflammatory chemokines.
Food Chem Toxicol. 2010 Jan;48(1):47-52. Epub 2009 Sep 18. PMID: 19766691
Curcumin inhibits inflammation-induced bone resportion that is frequently associated with cancers such as metastatic breast cancer and multiple myeloma.
Ann Rheum Dis. 1995 Jun;54(6):491-3. PMID: 15128775
Curcumin inhibits inflammation.
Food Chem Toxicol. 2006 Dec;44(12):1989-96. Epub 2006 Jul 12. PMID: 7786295
Curcumin inhibits inflammatory processes associated with skin cancer promotion.
Carcinogenesis. 2003 Sep;24(9):1515-24. Epub 2003 Jul 4. PMID: 12844482
Curcumin inhibits integrin (alpha6beta4)-dependent breast cancer cell motility and invasion.
Cancer Prev Res (Phila). 2008 Oct;1(5):385-91. PMID: 19138983
Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human non-small cell lung cancer cells.
Biochem Biophys Res Commun. 2005 Aug 26;334(2):313-8. PMID: 16005433
Curcumin inhibits invasion and metastasis in colorectal cancer.
Biosci Rep. 2011 Jan 14;31(3):185-97. PMID: 20815812
Curcumin inhibits invasive ductal carcinoma of the breast in the cell model.
Chem Biol Interact. 2010 Feb 12;183(3):455-61. Epub 2009 Nov 26. PMID: 19944674
Curcumin inhibits ionizing radiation-induced proliferation of human neuroblastoma cells.
Gynecol Endocrinol. 2010 Feb 23. Epub 2010 Feb 23. PMID: 21236599
Curcumin inhibits keloid formation in fibroblasts.
Arch Dermatol Res. 2010 Dec;302(10):717-24. Epub 2010 Aug 18. PMID: 20717830
Curcumin inhibits LDL cholesterol induced hepatic stellate cell activation associated with fatty liver and liver fibrosis.
Endocrinology. 2009 Dec;150(12):5384-94. Epub 2009 Oct 6. PMID: 19808779
Curcumin inhibits leiomyoma (fibroid) cell proliferation and fibronection expression.
Fertil Steril. 2009 May;91(5 Suppl):2177-84. Epub 2008 Jun 13. PMID: 18555241
Curcumin inhibits leptin-induced hepatic stellate cell activation.
Br J Pharmacol. 2010 Nov;161(5):1137-49. PMID: 20977462
Curcumin inhibits leukemia cell proliferation.
J Surg Res. 2010 Aug 6. Epub 2010 Aug 6. PMID: 12938514
Curcumin inhibits leukemia cell proliferation.
Acta Pharmacol Sin. 2003 Nov;24(11):1155-60. PMID: 14627502
Curcumin inhibits ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation associated with tumor cell growth.
Carcinogenesis. 1995 Aug;16(8):1741-5. PMID: 7634398
Curcumin inhibits lipid peroxidation and protein oxidation in rat liver mitochondria.
Biochim Biophys Acta. 2006 Jan;1760(1):70-7. Epub 2005 Oct 3. PMID: 16236451
Curcumin inhibits lipopolysaccharide-activated primary microglia.
Int Rev Neurobiol. 2009;88:297-334. PMID: 16934299
Curcumin inhibits lipopolysaccharide-induced inflammation.
Int Immunopharmacol. 2010 Jul;10(7):760-8. Epub 2010 Apr 22. PMID: 20399909
Curcumin inhibits lipoxygenase, indicating it possesses anti-inflammatory and anti-cancer properties.
Int J Mol Med. 2000 Nov;6(5):521-6. PMID: 11029517
Curcumin inhibits liver cancer cell gowth.
Zhonghua Gan Zang Bing Za Zhi. 2002 Dec;10(6):449-51. PMID: 12502450
Curcumin inhibits liver cancer cell invasiveness.
Comp Biochem Physiol B Biochem Mol Biol. 2000 Oct;127(2):213-22. PMID: 9663426
Curcumin inhibits liver fibrogenesis.
Int Immunopharmacol. 2005 Mar;5(3):555-69. PMID: 15683851
Curcumin inhibits liver tumor angiogenesis and growth.
Clin Hemorheol Microcirc. 2006;34(1-2):109-15. PMID: 16543625
Curcumin inhibits lung cancer by inducing programmed cell death and cell cycle arrest.
Cancer Lett. 2008 Dec 8;272(1):77-90. Epub 2008 Aug 12. PMID: 18701210
Curcumin inhibits lung cancer cells.
Mol Biol Rep. 2010 Mar;37(3):1627-32. Epub 2009 May 15. PMID: 19444642
Curcumin inhibits mantle cell lymphoma through a number of pathways.
Biochem Pharmacol. 2005 Sep 1;70(5):700-13. PMID: 16023083
Curcumin inhibits melanoma proliferation by arresting growth and induces programmed cell death.
Melanoma Res. 2004 Jun;14(3):165-71. PMID: 15179184
Curcumin inhibits metastatic breast cancer cells.
Front Oncol. 2012 ;2:161. Epub 2012 Nov 15. PMID: 23162792
Curcumin inhibits metastatic melanoma cells.
Cancer Lett. 2004 Aug 10;211(2):235-42. PMID: 15219947
Curcumin inhibits metastatic progression of breast cancer cells.
Mol Biol Rep. 2011 Sep 24. Epub 2011 Sep 24. PMID: 21947854
Curcumin inhibits migration and invasion of hepatic stellate cells by reducing MMP-2 expression and activity
Zhonghua Gan Zang Bing Za Zhi. 2009 Nov;17(11):835-8. PMID: 19958643
Curcumin inhibits multi drug resistance associated protein (MRP1) in retinoblastoma cells.
Bioinformation. 2012 ;8(1):13-9. Epub 2012 Jan 6. PMID: 22359429
Curcumin inhibits multi-drug resistance gene expression in human leukemic cells.
Arch Pharm Res. 2006 Oct;29(10):866-73. PMID: 17121181
Curcumin inhibits multi-drug resistant leukemia cells.
Mol Cell Biochem. 2012 Jan ;360(1-2):253-60. Epub 2011 Sep 22. PMID: 21938404
Curcumin inhibits multi-drug resistant pancreatic cancer.
Cancer Chemother Pharmacol. 2010 Nov 30. Epub 2010 Nov 30. PMID: 21116627
Curcumin inhibits murine neuroblastoma cells.
Neuro Endocrinol Lett. 2007 Apr;28(2):204-12. PMID: 17435663
Curcumin inhibits neuroglial cell proliferation and growth associated with neurodegenerative diseases.
Neuro Endocrinol Lett. 2003 Dec;24(6):469-73. PMID: 15073579
Curcumin inhibits nicotine-induced toxicity.
J Med Food. 2004;7(4):467-71. PMID: 15671691
Curcumin inhibits osteoclastogenesis, indicating its potential benefit in preventing and/or attenuating osteoporosis.
Mol Cells. 2008 Nov 30;26(5):486-9. PMID: 18719352
Curcumin inhibits ox-LDL stimulated vascular smooth muscle cell proliferation associated with arteriosclerosis.
Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(6):500-3. PMID: 16722385
Curcumin inhibits ox-LDL-induced cholesterol accumulation associated with atherosclerosis.
Appl Environ Microbiol. 2008 Jul;74(14):4564-6. Epub 2008 May 23. PMID: 18430363
Curcumin inhibits pancreatic cancer cell and tumor growth.
J Biol Chem. 2010 Aug 13;285(33):25332-44. Epub 2010 Jun 9. PMID: 20538607
Curcumin inhibits pancreatic cancer cell growth and acts as a chemosensitizing agent.
Mol Pharmacol. 2009 Jul;76(1):81-90. Epub 2009 Apr 24. PMID: 19395473
Curcumin inhibits pancreatic cancer cell growth.
Cancer. 2006 Jun 1;106(11):2503-13. PMID: 16628653
Curcumin inhibits pancreatic cancer cell proliferation.
Eur J Cancer. 2009 Mar;45(5):874-80. Epub 2009 Feb 3. PMID: 19196508
Curcumin inhibits pancreatic cancer cells.
Am J Clin Nutr. 2010 Jan 13. Epub 2010 Jan 13. PMID: 20121547
Curcumin inhibits pathological processes initiated by Helicobacter pylori.
Biochem Biophys Res Commun. 2004 Apr 16;316(4):1065-72. PMID: 15044093
Curcumin inhibits phosphalipase D activity, indicating its potential role as an anti-inflammatory and anti-carcinogenic.
FEBS Lett. 1997 Nov 10;417(2):196-8. PMID: 9395294
Curcumin inhibits programmed cell death in breast cancer cells.
J Biol Chem. 2005 May 20;280(20):20059-68. Epub 2005 Feb 28. PMID: 15738001
Curcumin inhibits proliferation of multiple myeloma cells.
J Immunol. 2003 Oct 1;171(7):3863-71. PMID: 14500688
Curcumin inhibits prostate cancer cells.
Int J Cardiol. 1995 May;49(3):191-9. PMID: 12682902
Curcumin inhibits PSA expression in prostate cancer cell lines.
Yao Xue Xue Bao. 2005 Sep;40(9):800-3. PMID: 16342680
Curcumin inhibits PSA gene expression in prostate cancer cells.
J Androl. 2008 Nov-Dec;29(6):661-8. Epub 2008 Jul 31. PMID: 18676361
Curcumin inhibits ral squamous cell carcinoma cells.
Trop Med Int Health. 2010 Oct;15(10):1148-55. Epub 2010 Aug 17. PMID: 12359752
Curcumin inhibits Rift Valley Fever virus replication in human cells.
J Biol Chem. 2012 Jul 30. Epub 2012 Jul 30. PMID: 22847000
Curcumin inhibits telomerase activity and induces programmed cell death in cancer cells.
Mutat Res. 2006 Apr 11;596(1-2):81-90. Epub 2006 Jan 30. PMID: 16445949
Curcumin inhibits telomerase activity in breast ancer cells.
J Urol. 2011 Feb;185(2):719-24. Epub 2010 Dec 18. PMID: 12104041
Curcumin inhibits telomerase activity in human cancer cell lines.
Int J Mol Med. 2006 Aug;18(2):227-31. PMID: 16820928
Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.
J Cell Biochem. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23192708
Curcumin inhibits telomerase expression associated with tumorigensis.
Cancer Lett. 2010 Apr 1;290(1):76-86. Epub 2009 Sep 13. PMID: 19751963
Curcumin inhibits the activation of NF-kappaB associated with cancer progression.
Bioorg Med Chem. 2006 Apr 1;14(7):2450-61. Epub 2005 Dec 7. PMID: 16338138
Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells.
Cancer Lett. 2007 Jun 28;251(2):288-95. Epub 2007 Jan 2. PMID: 17197075
Curcumin inhibits the growth and induces programmed cell death in B cell lymphoma cells.
Clin Immunol. 1999 Nov;93(2):152-61. PMID: 10527691
Curcumin inhibits the growth of breast cancer through the manipulation of the arachidonate metabolism.
BMC Cancer. 2007;7:138. Epub 2007 Jul 25. PMID: 17651499
Curcumin inhibits the growth of human colon cancer cells.
Korean J Gastroenterol. 2005 Apr;45(4):277-84. PMID: 15843753
Curcumin inhibits the growth of human gastric cancer cells and shows synergistm with 5-fluorouracil.
J Med Food. 2004;7(2):117-21. PMID: 15298755
Curcumin inhibits the growth of ovary cancer cells.
J Clin Psychiatry. 2007;68 Suppl 10:4-7. PMID: 12520734
Curcumin inhibits the invasion and induces programmed cell death in human breast cancer cells.
Arch Pharm Res. 2001 Aug;24(4):349-54. PMID: 11534770
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.
Int J Cancer. 2006 Aug 15;119(4):757-64. PMID: 16550606
Curcumin inhibits the migration and invasion of human and lung cancer cells.
Cancer Lett. 2009 Nov 28;285(2):127-33. Epub 2009 May 23. PMID: 19477063
Curcumin inhibits the proliferation and induces programmed cell death of hepatic stellate cells.
Braz J Med Biol Res. 2009 Dec;42(12):1173-8. Epub 2009 Nov 13. PMID: 19918672
Curcumin inhibits the proliferation and migration of breast cancer cells.
Int J Mol Med. 2009 Apr;23(4):469-75. PMID: 19288022
Curcumin inhibits the proliferation of Burkitt cancer cells.
J Huazhong Univ Sci Technolog Med Sci. 2006;26(2):199-201, 210. PMID: 16850746
Curcumin inhibits the proliferation of colonic cancer cells.
Zhonghua Nei Ke Za Zhi. 2009 Sep;48(9):760-3. PMID: 20079215
Curcumin inhibits the proliferation of human liver cancer cells.
Int J Mol Med. 2010 Nov;26(5):673-8. PMID: 20878089
Curcumin inhibits the proliferation of leukemia cells.
Hunan Yi Ke Da Xue Xue Bao. 2000 Jun 28;25(3):216-8. PMID: 12212145
Curcumin inhibits the proliferation of vascular smooth muscle cells, indicating its value in cardiovascular diseases.
Biochem Biophys Res Commun. 2009 Feb 6;379(2):277-82. Epub 2008 Dec 25. PMID: 19101502
Curcumin inhibits the survival of multiple myeloma cells.
Blood. 2004 Apr 15;103(8):3175-84. Epub 2003 Dec 18. PMID: 15070700
Curcumin inhibits TNF and VCAM mediated inflammatory processes.
Biochem Pharmacol. 1998 Mar 15;55(6):775-83. PMID: 9586949
Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma.
J Clin Invest. 2009 May;119(5):1322-34. doi: 10.1172/JCI37385. Epub 2009 Apr 20. PMID: 17545551
Curcumin inhibits tyrosine kinase activity associated breast cancer cell promotion.
Clin Cancer Res. 1999 Jul;5(7):1884-91. PMID: 10430096
Curcumin inhibits ultraviolet light induced HIV gene expression.
Mol Cell Biochem. 2003 Dec;254(1-2):289-97. PMID: 14674708
Curcumin inhibits up-regulation of tumor necrosis factor alpha and reverses experimentally induced insulin resistance in adipocytes.
Biomed Environ Sci. 2009 Feb;22(1):32-9. PMID: 19462685
Curcumin inhibits uterine leiomyoma cell proliferation.
Gynecol Endocrinol. 2010 Jul 30. Epub 2010 Jul 30. PMID: 20672906
Curcumin inhibits UV radiation mutagenesis and SOS gene induction.
Ann Oncol. 2000 Dec;11(12):1537-43. PMID: 7477054
Curcumin inhibits xanthine oxidase.
Nutrition. 2006 Jun;22(6):593-9. PMID: 19800788
Curcumin is a histone deacetylase inhibitor.
Biochem Pharmacol. 2005 Apr 15;69(8):1205-13. PMID: 15794941
Curcumin is a nitric oxide scavenger.
Gynecol Oncol. 2004 Sep;94(3):760-8. PMID: 9120760
Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.
FEBS Lett. 1994 Mar 14;341(1):19-22. PMID: 7511111
Curcumin is a potent inhibitor of glutathione S-transferase activity in human melanoma cells.
Chem Biol Interact. 1996 Oct 21;102(2):117-32. PMID: 8950226
Curcumin is a potent radiosensitizer and may act by overcoming the effects of radiation-induced NFkappaB mediated pro-survival gene expression in neuroblastoma.
Cancer Biol Ther. 2008 Apr;7(4):569-76. Epub 2008 Jan 7. PMID: 18305409
Curcumin is a potential candidate for prevention and treatment of hepatic fibrosis.
Biochem J. 2004 Nov 15;384(Pt 1):149-57. PMID: 15320868
Curcumin is a potential candidate for treatment of tubulointerstitial fibrosis.
Am J Nephrol. 2010;31(4):332-41. Epub 2010 Feb 17. PMID: 20160437
Curcumin is a potential inhibitor of human laryngeal squamous carcinoma cell invasion and metastasis.
J Am Coll Nutr. 2007 Dec;26(6):704S-12S. PMID: 17341208
Curcumin is a potentially promising compound for the treatment of Adult T-cell leukemia.
Leuk Res. 2006 Mar;30(3):313-21. Epub 2005 Sep 12. PMID: 16157375
Curcumin is a promising anticandidal of clinical interest.
Can J Microbiol. 2011 Mar;57(3):204-10. PMID: 21358761
Curcumin is a radiosensitizer of human cervical tumor cells.
Mol Pharmacol. 2008 May;73(5):1491-501. Epub 2008 Feb 5. PMID: 18252805
Curcumin is a radiosensitizer of squamous cell carcinoma cells.
Otolaryngol Head Neck Surg. 2005 Feb;132(2):317-21. PMID: 15692547
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
Bioorg Med Chem. 2012 Oct 15 ;20(20):6040-7. Epub 2012 Aug 30. PMID: 22989913
Curcumin is an inhibitor of cancer.
J Am Coll Nutr. 1992 Apr;11(2):192-8. PMID: 1578097
Curcumin is an inhibitor of p300 histone acetylatransferase capable of blocking prostate cancer cells.
Med Chem. 2006 Mar;2(2):169-74. PMID: 16787365
Curcumin is an iron chelator. - Article 1.
Free Radic Biol Med. 2006 Apr 1;40(7):1152-60. PMID: 16545682
Curcumin is an iron chelator. - Article 2.
J Eur Acad Dermatol Venereol. 2004 Nov;18(6):649-53. PMID: 18815282
Curcumin is beneficial for improving Type 2 diabetes complications and assists in preventing oxidative stress and inflammation.
Br J Pharmacol. 2012 Mar 27. Epub 2012 Mar 27. PMID: 22452372
Curcumin is capable of inducing programmed cell death in gastric cancer cells.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov ;27(11):1227-30. PMID: 22078453
Curcumin is cytotoxic to cervical cancer cells.
Mol Cell Biochem. 2009 May;325(1-2):107-19. Epub 2009 Feb 4. PMID: 19191010
Curcumin is effective in blocking lipopolysaccharide-induced loss of muscle mass.
J Cell Biochem. 2007 Mar 1;100(4):960-9. PMID: 17131360
Curcumin may act as a chemosensitizer in multi-drug resistant cancer.
Zhongguo Zhong Yao Za Zhi. 2010 Sep;35(18):2460-3. PMID: 21141501
Curcumin may act as a chemosensitizing agent in multidrug resistant cancer cells.
Biochem Pharmacol. 2002 Aug 15;64(4):573-82. PMID: 12167476
Curcumin may act as a chemosensitizing agent.
Adv Exp Med Biol. 2007;595:269-300. PMID: 17569216
Curcumin may act as a photosensitizer and chemotherapeutic agent in nasopharyngeal carcinoma.
J Environ Pathol Toxicol Oncol. 2006;25(1-2):205-15. PMID: 16566718
Curcumin may attenuate diabetic complications.
FEBS Lett. 2009 Nov 19;583(22):3637-42. Epub 2009 Oct 20. PMID: 19850041
Curcumin may attenuate lead and cadmium-induce neurotoxicity.
Anesth Analg. 2001 Oct;93(4):912-6. PMID: 14729307
Curcumin may be a potential radiosensitizing agent for enhanced antiangiogenic effect in colorectal cancer radiation therapy.
Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G865-77. Epub 2010 Mar 18. PMID: 20299603
Curcumin may be a powerful candidate for developing preventive agents for cancer metastasis.
Oncol Rep. 2010 Mar;23(3):665-70. PMID: 20127004
Curcumin may be applied as an effective and novel sunscreen drug for the protection of photoinflammation.
Exp Mol Med. 2005 Jun 30;37(3):186-92. PMID: 16000872
Curcumin may be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response.
Int Immunopharmacol. 2012 Jan ;12(1):302-11. Epub 2011 Oct 29. PMID: 22036766
Curcumin may be used as a chemosensitizer to make the retinoblastoma cells more sensitive to the effects of chemotherapy.
Curr Eye Res. 2009 Oct;34(10):845-51. PMID: 19895312
Curcumin may be used as a novel intravaginal spermicidal agent for contraception and HIV prevention.
Contraception. 2003 Sep;68(3):219-23. PMID: 14561543
Curcumin may be useful to prevent changes of atherosclerosis and post-angioplasty restenosis.
Br J Pharmacol. 1998 Jul;124(6):1029-40. PMID: 9720770
Curcumin may block brain tumor formation.
Brain Res. 2009 Feb 10. Epub 2009 Feb 10. PMID: 19368804
Curcumin may contribute to accelerated wound healing.
Pathophysiol Haemost Thromb. 2010 Nov 12. Epub 2010 Nov 12. PMID: 21071923
Curcumin may contribute to overcoming chemoresistance of FOLFOX.-surviving colon cancer cells.
Vet Med (Praha). 1989 Aug;34(8):467-74. PMID: 20332435
Curcumin may decrease the progression of glomerulosclerosis.
Zhonghua Er Ke Za Zhi. 2003 Nov;41(11):822-6. PMID: 14728887
Curcumin may down-regulate genes associated with cancer progression in prostate cancer.
Cancer Biol Ther. 2008 Sep;7(9):1427-35. Epub 2008 Sep 4. PMID: 18719366
Curcumin may enhance the chemotherapeuic efficacy of all-trans retinoic acid against human promyelocytic leukemia cells.
Oncol Res. 1997;9(1):19-29. PMID: 9112257
Curcumin may facilitate chemoprevention via direct binding to, and activation of, vitamin D receptor (VDR).
J Nutr Biochem. 2010 Dec;21(12):1153-61. Epub 2010 Feb 12. PMID: 20153625
Curcumin may have a role to play in modulating pathological scar formation.
J Cell Mol Med. 2009 Apr;13(4):712-25. Epub 2008 Apr 10. PMID: 18410527
Curcumin may have a therapeutic role in the treatment of cystic fibrosis.
Nutr Cancer. 1992;18(2):181-9. PMID: 16424149
Curcumin may have a therapeutic role in hyperplastic scars.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Dec;29(12):1100-3. PMID: 20214332
Curcumin may have a therapeutic role in reducing diabetic complications.
J Biosci. 2003 Dec;28(6):715-21. PMID: 14660871
Curcumin may have a therapeutic role in Th1-mediated immune diseases.
Br J Pharmacol. 1999 Sep;128(2):380-4. PMID: 10510448
Curcumin may have a therapeutic role in the treatment of autoimmune diseases.
Eur J Pharmacol. 2011 Jan 10;650(1):451-7. Epub 2010 Oct 13. PMID: 20950605
Curcumin may have a therapeutic role in the treatment of osteoarthritis.
Osteoarthritis Cartilage. 2010 Feb;18(2):141-9. Epub 2009 Oct 8. PMID: 19836480
Curcumin may have an anti-malarial effect by inducing cell death in infected erythrocytes.
Cell Physiol Biochem. 2009;24(3-4):133-40. Epub 2009 Aug 3. PMID: 19710527
Curcumin may have anti-aging properties.
Mol Nutr Food Res. 2010 Oct 11. Epub 2010 Oct 11. PMID: 20938987
Curcumin may have anti-malarial properties.
Bone. 2010 Nov;47(5):926-37. Epub 2010 Aug 7. PMID: 19329310
Curcumin may have anti-obesity properties.
J Nutr Biochem. 2010 Dec 27. Epub 2010 Dec 27. PMID: 21189228
Curcumin may have anti-tumor properties in cervical cancer.
Phytother Res. 2008 Sep 23. PMID: 19058955
Curcumin may have chemosensitizing properties in the treatment of human ovarian cancer.
Cell Prolif. 2009 Apr;42(2):195-206. Epub 2009 Feb 18. PMID: 19236381
Curcumin may have inhibitory activity against HIV-1 protease and integrase.
Am J Clin Nutr. 1995 Mar;61(3):585-9. PMID: 15950462
Curcumin may have positive epigenetic effects in high prostate cancer.
AAPS J. 2011 Dec ;13(4):606-14. Epub 2011 Sep 22. PMID: 21938566
Curcumin may have potential therapeutic uses in the prevention and treatment of endometriosis.
Phytother Res. 2011 Dec 20. Epub 2011 Dec 20. PMID: 22183741
Curcumin may have therapeutic potential for bladder cancer patients via anti-inflammatory, antioxidant and anti-carcinogenic activities.
Oncol Rep. 2006 May;15(5):1225-31. PMID: 16596191
Curcumin may have therapeutic value against amyloid diseases.
Biol Chem. 2009 Oct;390(10):1057-61. PMID: 19558331
Curcumin may have therapeutic value in allergic diseases.
J Allergy Clin Immunol. 2008 May;121(5):1225-31. Epub 2008 Apr 18. PMID: 18394691
Curcumin may have therapeutic value in Alzheimer disease.
Brain Res. 2010 Nov 18;1361:115-23. Epub 2010 Sep 16. PMID: 20840842
Curcumin may have therapeutic value in cancer as a proteasome inhibitor.
Int J Mol Med. 2010 Oct;26(4):447-55. PMID: 20818481
Curcumin may have therapeutic value in cardiomyopathies.
J Cardiovasc Pharmacol. 2010 Feb;55(2):176-83. PMID: 19935077
Curcumin may have therapeutic value in chronic myelocytic leukemia (CML).
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):572-6. PMID: 15498113
Curcumin may have therapeutic value in cystic fibrosis.
Trends Mol Med. 2004 Oct;10(10):473-5. PMID: 15464445
Curcumin may have therapeutic value in Hemolytic-Uremic Syndrome.
Biol Pharm Bull. 2006 Jul;29(7):1470-5. PMID: 16819191
Curcumin may have therapeutic value in HIV infection.
Mol Nutr Food Res. 2010 Feb 19. Epub 2010 Feb 19. PMID: 15383533
Curcumin may have therapeutic value in inflammatory conditions of the central nervous system.
J Neuroinflammation. 2005 Feb 25;2(1):8. Epub 2005 Feb 25. PMID: 15733321
Curcumin may have therapeutic value in inhibiting B-Cell over-activity.
Phytomedicine. 2009 Oct;16(10):982-8. Epub 2009 Mar 20. PMID: 19303754
Curcumin may have therapeutic value in polycystic kidney disease.
Eur J Pharmacol. 2011 Mar 1;654(1):92-9. Epub 2010 Dec 24. PMID: 21187084
Curcumin may have therapeutic value in the prevention of transplant-associated organ injury and rejection.
Biochem Biophys Res Commun. 2003 Sep 5;308(4):950-5. PMID: 12927811
Curcumin may have therapeutic value in the treatment of endometriosis.
Indian J Biochem Biophys. 2009 Feb;46(1):59-65. PMID: 19374255
Curcumin may have therapeutic value in treating human chronic myelogenous leukemia due to its ability to regulate NF-kappB genes and pathways.
Ann N Y Acad Sci. 2009 Aug;1171:436-47. PMID: 19723087
Curcumin may have therapeutic value in treating human liposarcoma.
Phytomedicine. 2005 Nov;12(10):715-22. PMID: 21282356
Curcumin may have therapeutic value in treating hyaline membrane disease.
Life Sci. 2001 Dec 7;70(3):253-67. PMID: 12005259
Curcumin may have therapeutic value in Wilson disease.
Hepatology. 2009 Dec;50(6):1783-95. PMID: 19937698
Curcumin may improve outcome in chemotherapy-refractory Natural killer/T-cell lymphoma (NKTL).
Br J Haematol. 2005 Oct;131(1):59-66. PMID: 16173963
Curcumin may inhibit breast cancer cell proliferation through down-regulating the NFkappaB inducing genes.
Phytomedicine. 2009 Oct;16(10):916-22. Epub 2009 Jun 12. PMID: 19524420
Curcumin may inhibit Coxsackievirus
J Virol. 2007 Apr;81(7):3142-50. Epub 2007 Jan 17. PMID:17229707
Curcumin may inhibit oxidative stress including LDL cholesterol oxidation.
J Enzyme Inhib Med Chem. 2010 Oct;25(5):720-9. PMID: 20163327
Curcumin may offer a therapeutic advantage in the clinical management of refractory bladder cancer.
Cancer Prev Res (Phila). 2011 Oct ;4(10):1698-709. Epub 2011 Aug 11. PMID: 21836020
Curcumin may overcome resistance in leukemia cells.
Int J Cancer. 2006 Oct 15;119(8):1811-8. PMID: 16721786
Curcumin may play a protective effect in primary cultured rat prefrontal cortical neurons against iAbeta-induced cytotoxicity.
Neurosci Lett. 2010 Aug 9;480(1):21-4. PMID: 20638958
Curcumin may play a protective role against oxidative stress in islet transplantation outcomes.
Pancreas. 2009 May;38(4):454-60. PMID: 19188863
Curcumin may play a role in suppressing hepatic fibrinogenesis.
Lab Invest. 2008 May;88(5):529-40. Epub 2008 Mar 10. PMID: 18332871
Curcumin may play a therapeutic role in diseases of the bone associated with osteoclastogenesis and bone lysis.
J Cancer Res Clin Oncol. 2009 Feb;135(2):173-9. Epub 2008 Sep 3. PMID: 18766375
Curcumin may play a therapeutic role in heart failure.
J Food Sci. 2007 Oct;72(8):S612-7. PMID: 20467147
Curcumin may prevent and treat muscle wasting.
Nutrition. 2009 Feb;25(2):125-9. Epub 2008 Nov 22. PMID: 19028079
Curcumin may prevent ferric nitrilotriacetate (Fe-NTA) induced toxicity and cancer.
J Cutan Pathol. 2009 Oct;36(10):1053-62. Epub 2009 Jan 27. PMID: 12616605
Curcumin may protect against amyloid-beta-stimulated inflammation associated wtih Alzheimer disease.
J Alzheimers Dis. 2010;20(4):1189-99. PMID: 20413894
Curcumin may provide an ideal therapeutic agent for patients with Hodgkin's lymphoma which does not have the side effects associated with multi-drug chemotherapy.
Int J Cancer. 2008 Jul 1;123(1):56-65. PMID: 18386790
Curcumin may provide an ideal therapy for metabolic syndrome.
Biofactors. 2012 Dec 13. Epub 2012 Dec 13. PMID: 23239418
Curcumin may provide an ideal therapy to down-regulate epidermal growth factor receptor activity.
J Mol Recognit. 2012 Nov ;25(11):623-9. PMID: 23108622
Curcumin may reduce carcinogenesis by binding to (and inhibiting) lipoxygenase.
Int J Mol Med. 2003 Jul;12(1):17-24. PMID: 12792803
Curcumin may reduce inflammation in the pancreas.
Mol Biol Rep. 2009 Nov;36(8):2329-32. Epub 2009 Jan 21. PMID: 19156536
Curcumin may represent a novel therapeutic agent targeting endothelial activation in inflammatory bowel disease.
Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G259-68. Epub 2009 Jun 11. PMID: 19520742
Curcumin may sensitize cancer cells to chemotherapy.
Mol Cancer Ther. 2006 Apr;5(4):952-61. PMID: 16648566
Curcumin may slow aging.
Curr Pharm Des. 2010;16(7):884-92. PMID: 20388102
Curcumin may support the regeneration of articular cartilage.
Arthritis Res Ther. 2010;12(4):R127. Epub 2010 Jul 1. PMID: 20594343
Curcumin may work synergistically with antifungal drugs to reverse multidrug resistance in Candida cells.
Antimicrob Agents Chemother. 2009 Aug;53(8):3256-65. Epub 2009 May 26. PMID: 19470507
Curcumin may work synergistically with taxane chemotherapy for hormone-refractory prostate cancer treatment.
Nutr Cancer. 2010;62(2):148-53. PMID: 20099188
Curcumin might have therapeutic potential for treating dry eye disease.
Exp Eye Res. 2010 Mar;90(3):437-43. Epub 2009 Dec 23. PMID: 20026325
Curcumin might provide a novel therapeutic strategy for treating gliomas.
Biochem Biophys Res Commun. 2005 Nov 18;337(2):510-6. Epub 2005 Sep 21. PMID: 16198311
Curcumin modulates cell cycle in leukemia cells and enhances programmed cell death.
J Tongji Med Univ. 2000;20(2):123-5. PMID: 12845723
Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism, indicating it may have therapeutic value in the condition.
J Biol Chem. 2007 Feb 16;282(7):4533-44. Epub 2006 Dec 18. PMID: 17178710
Curcumin participates in reversing multi-drug resistance in cancer cells.
Zhonghua Xue Ye Xue Za Zhi. 2006 Apr;27(4):254-8. PMID: 16875558
Curcumin potentiates antitumor activity of l-asparaginase in acute lymphoblastic leukemia.
Leuk Lymphoma. 2012 Jan 25. Epub 2012 Jan 25. PMID: 22185211
Curcumin potentiates the apoptotic effects of chemotherapeutic agents in drug resistant human bladder cancer cells.
Mol Cancer Ther. 2007 Mar;6(3):1022-30. PMID: 17363495
Curcumin potentiates the pro-apoptotic effects of sulindac sulfone in colorectal cancer.
Expert Opin Investig Drugs. 2010 Apr;19 Suppl 1:S117-24. PMID: 20374023
Curcumin potently induces programmed cell death in colon cancer cells
Br J Nutr. 2005 Jun;93(6):835-44. PMID: 19723094
Curcumin pretreatment may have clinical potential in hepatic transplantation.
Transplantation. 2006 Feb 27;81(4):623-6. PMID: 16495813
Curcumin prevents acrylamide-induced DNA damage in liver cells.
Wei Sheng Yan Jiu. 2009 Jul;38(4):392-5. PMID: 19689063
Curcumin prevents benzo[a]pyrene-induced DNA adduct formation.
Cancer Lett. 1995 Sep 4;96(1):71-80. PMID: 7553610
Curcumin prevents chemically-induced inflammation in gastrointestinal lines associated with cancer promotion.
J Invest Dermatol. 2009 Feb;129(2):468-75. Epub 2008 Aug 14. PMID: 10190560
Curcumin prevents cholesterol oxidation, indicating its therapeutic value in attenuating atherosclerosis and lesion formation.
Prostaglandins Other Lipid Mediat. 2009 Nov;90(1-2):13-20. Epub 2009 Jun 21. PMID: 19549571
Curcumin prevents DNA damage associated with benzo[a]pyrene exposure.
Mutat Res. 2004 Feb 14;557(2):203-13. PMID: 14729375
Curcumin prevents dopaminergic neuronal death.
Rejuvenation Res. 2010 Feb;13(1):55-64. PMID: 20230279
Curcumin prevents Epstein-Barr virus induced Post-Transplant Lymphoproliferative disorder (PTLD).
Am Surg. 1998 Jan;64(1):47-51; discussion 51-2. PMID: 9457037
Curcumin prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries.
Biol Pharm Bull. 2001 Sep;24(9):1091-2. PMID: 15622377
Curcumin prevents human dendritic cell response to immune stimulants, indicating it may have value as an immunosuppresant.
Biochem Biophys Res Commun. 2008 Sep 26;374(3):431-6. Epub 2008 Jul 17. PMID: 18639521
Curcumin prevents nitrite-induced methemoglobin formation.
FEBS Lett. 1992 Apr 20;301(2):195-6. PMID: 1314741
Curcumin prevents progestin-induced breast cancer cell promotion.
Menopause. 2008 May-Jun;15(3):570-4. PMID: 18467956
Curcumin prevents the migration of nasopharyngeal cancer cells.
Anticancer Res. 2010 Jul;30(7):2851-6. PMID: 20683022
Curcumin prevents TNF-alpha induced endothelial dysfunction.
Thromb Res. 2005;115(5):417-26. Epub 2004 Nov 14. PMID: 15733976
Curcumin prevents tumor-induced T cell apoptosis.
Behav Brain Res. 2011 Mar 24. Epub 2011 Mar 24. PMID: 17392282
Curcumin promotes programmed cell death in multidrug-resistant human lung cancer cells.
Biochem Biophys Res Commun. 2010 Aug 13;399(1):1-6. Epub 2010 Jul 11. PMID: 20627087
Curcumin promotes programmed cell death in esophageal squamous carcinoma cell lines.
Ai Zheng. 2008 Jun;27(6):566-70. PMID: 18570726
Curcumin promotes programmed cell death in human lung adenocarcinoma cells.
J Sep Sci. 2009 Apr;32(7):955-64. PMID: 20878113
Curcumin promotes programmed cell death of cisplain-resistant human lung carcinoma cells.
Zhongguo Fei Ai Za Zhi. 2010 Apr;13(4):301-6. PMID: 20677554
Curcumin promotes programmed cell death, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma.
Transl Oncol. 2010 Apr;3(2):99-108. PMID: 20360934
Curcumin protects 6-hydroxydopamine (6-OHDA)-induced neuronal death associated with Parkinson disease.
Biochem Pharmacol. 2009 Jul 15;78(2):178-83. Epub 2009 Apr 8. PMID: 19464433
Curcumin protects against adverse changes associated with neuronal hypoxia.
Asia Pac J Clin Nutr. 2003;12(1):50-60. PMID: 18461445
Curcumin protects against beta-amyloid-induced toxicity.
Food Chem Toxicol. 2008 Aug;46(8):2881-7. Epub 2008 Jun 4. PMID: 18573304
Curcumin protects against cerebral ischemia-induced neuronal cell death.
J Neurosci Res. 2005 Oct 1;82(1):138-48. PMID: 16075466
Curcumin protects against chemically induced cell death.
Apoptosis. 2006 Jun;11(6):943-53. PMID: 16547587
Curcumin protects against chemically-induced cataract formation in rat lenses.
Am J Clin Nutr. 1996 Nov;64(5):761-6. PMID: 8901798
Curcumin protects against chemically-induced neuronal damage.
Acta Pharmacol Sin. 2004 Dec;25(12):1606-12. PMID: 15569404
Curcumin protects against chemically-induced Parkinsonism in a cell model.
Pharmacol Res. 2011 Jan 12. Epub 2011 Jan 12. PMID: 21237271
Curcumin protects against copper injury.
Psychiatry Res. 1999 Nov 29;88(3):227-32. PMID: 18082042
Curcumin protects against gastric ulcers by blocking H2 histamine receptors.
Biol Pharm Bull. 2005 Dec;28(12):2220-4. PMID: 16327153
Curcumin protects against glutamate excitotoxicity.
Brain Res. 2008 May 19;1210:84-91. Epub 2008 Apr 16. PMID: 18420184
Curcumin protects against hydrogen peroxide induced cytotoxicity.
Hum Exp Toxicol. 2010 May 20. Epub 2010 May 20. PMID: 20488840
Curcumin protects against methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells.
Acta Pharmacol Sin. 2006 Sep;27(9):1192-8. PMID: 16923340
Curcumin protects against mutagenic heterocyclic amines found in cooked food.
Indian J Exp Biol. 2002 Dec;40(12):1365-72. PMID: 12974398
Curcumin protects against smoke-induced DNA damage.
Metabolism. 2002 Jul;51(7):887-92. PMID: 1937145
Curcumin protects against staurosporine toxicity in rat neurons.
Neurosci Bull. 2012 Oct ;28(5):606-10. Epub 2012 Oct 3. PMID: 23054638
Curcumin protects cardiac cells against ischemia-reperfusion injury.
Free Radic Biol Med. 2008 Sep 15;45(6):839-46. Epub 2008 Jun 20. PMID: 18638545
Curcumin protects dopaminergic cells from Parkinson disease-associated 6-hydroxydopamine-induced neurotoxicity.
Neurosci Lett. 2011 Feb 11;489(3):192-6. Epub 2010 Dec 15. PMID: 21167259
Curcumin protects dopaminergic neuron against lipopolysaccharide induced neurotoxicity.
Neurochem Res. 2008 Oct;33(10):2044-53. Epub 2008 Mar 27. PMID: 18368483
Curcumin protects hepatic stellate cells against leptin-induced activation, indicating its therapeutic value in fatty and fibrotic liver conditions.
Endocrinology. 2010 Sep;151(9):4168-77. Epub 2010 Jul 21. PMID: 20660066
Curcumin protects the brain against drug-induced neurotoxicity, indicating it may have value in preventing neurological disorders such as Parkinson disease.
Antioxid Redox Signal. 2007 Mar;9(3):399-408. PMID: 17184173
Curcumin provides antioxidant and anti-inflammatory therapeutic benefits in the treatment of chronic inflammatory lung diseases.
Mol Nutr Food Res. 2008 Sep;52(9):987-94. PMID: 18327875
Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model.
BMC Neurosci. 2010;11:57. Epub 2010 Apr 30. PMID: 20433710
Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition.
J Cardiovasc Pharmacol. 2010 Apr;55(4):417-24. PMID: 20422739
Curcumin reduces chemo-resistance of melanoma cells to tamoxifen.
Cancer Biol Ther. 2011 Jan 29;11(2). Epub 2011 Jan 29. PMID: 21088500
Curcumin reduces cisplatin-induced neurotoxicity.
Neurotoxicology. 2012 Oct 2. Epub 2012 Oct 2. PMID: 23036615
Curcumin reduces DNA adduct formation in human lung cancer cells.
Toxicol In Vitro. 2003 Jun;17(3):323-33. PMID: 12781211
Curcumin reduces inflammation and carcinogensis associated with arachidonic acid metabolism.
J Nutr. 2009 Jul;139(7):1273-8. Epub 2009 May 20. PMID: 15073046
Curcumin reduces lipopolysaccharide-indced nitric oxide synthetase activity.
Int Immunopharmacol. 2011 Feb;11(2):179-86. Epub 2010 Nov 20. PMID: 21094287
Curcumin reduces multi-drug resistance in uterine cancer cells.
Oncol Rep. 2008 Oct;20(4):731-5. PMID: 18813811
Curcumin reduces NF-kappa B factor activation associated with anticancer drugs.
Endocr Relat Cancer. 2009 Dec;16(4):1339-50. Epub 2009 Sep 2. PMID: 12007574
Curcumin reduces the expression of malignancy-associated Bcl-2 in breast cancer cells.
Med Oncol. 2010 Dec;27(4):1114-8. Epub 2009 Nov 12. PMID: 19908170
Curcumin reduces the programmed cell death associated with toxic bile acids in liver injury during cholestasis.
Biochem Biophys Res Commun. 2006 Feb 17;340(3):800-6. Epub 2005 Dec 20. PMID: 16380075
Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells.
Liver Int. 2009 Jan;29(1):63-72. Epub 2008 May 19. PMID: 18492020
Curcumin restores corticosteroid function in monocytes exposed to oxidants, thus overcoming cortisone resistance.
Am J Respir Cell Mol Biol. 2008 Sep;39(3):312-23. Epub 2008 Apr 17. PMID: 18421014
Curcumin reverse multi-drug resistance in multiple myeloma cells.
Ann Hematol. 2010 Apr;89(4):399-404. Epub 2009 Sep 15. PMID: 19756599
Curcumin reverse multidrug resistance of osteosarcoma cells.
Wei Sheng Yan Jiu. 2011 Jan;40(1):103-6. PMID: 21434326
Curcumin reverses chemoresistance of human gastric cancer cells.
Oncol Rep. 2011 Aug 2. Epub 2011 Aug 2. PMID: 21811763
Curcumin reverses the multidrug resistance of a human multiple myeloma cell line.
Zhonghua Xue Ye Xue Za Zhi. 2009 Jan;30(1):33-7. PMID: 19563033
Curcumin selectively inhibits and induces programmed cell death in B-cell lymphoma cells.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Nov;24(11):1003-6. PMID: 15609600
Curcumin selectively inhibits tumor cells.
Mol Cancer Ther. 2004 Sep;3(9):1101-8. PMID: 15367704
Curcumin selectively targets immortalized normal, leukoplakia, and malignant oral cells.
Cancer Prev Res (Phila). 2010 Mar;3(3):331-8. Epub 2010 Feb 9. PMID: 20145189
Curcumin sensitizes cervical cancer cells to curcumin-induced programmed cell death.
J Biol Chem. 2005 Feb 25;280(8):6301-8. Epub 2004 Dec 7. PMID: 15590651
Curcumin sensitizes lung cancer cells to cisplatin-induced programmed cell death.
Phytother Res. 1999 Jun;13(4):318-22. PMID: 19283527
Curcumin sensitizes prostate cancer cells to programmed cell death.
J Pharmacol Exp Ther. 2007 May;321(2):616-25. Epub 2007 Feb 8. PMID: 17289836
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related programmed cell death.
Mol Cancer Ther. 2004 Jul;3(7):803-12. PMID: 15252141
Curcumin shows promising anticryptosporidial activity.
Parasitol Res. 2009 Oct;105(4):1155-61. Epub 2009 Jun 26. PMID: 19557435
Curcumin significantly inhibits the growth and induces programmed cell death in human ovarian cancer cell lines. - Article 1
Cell Biol Int. 2006 Mar;30(3):221-6. Epub 2005 Dec 22. PMID: 16376585
Curcumin significantly inhibits the growth and induces programmed cell death in human ovarian cancer cell lines. - Article 2
J Huazhong Univ Sci Technolog Med Sci. 2004;24(1):55-8. PMID: 15165116
Curcumin slows proliferation in the infant acute monocytic leukemia cell line.
Cell Physiol Biochem. 2011 ;28(6):1169-80. Epub 2011 Dec 16. PMID: 22179005
Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity.
J Immunotoxicol. 2007 Apr;4(2):85-96. PMID: 15582996
Curcumin stimulates glucose uptake in myotube (muscle) cells.
J Cell Physiol. 2010 Jun;223(3):771-8. PMID: 20205235
Curcumin stimulates programmed cell death in melanoma cells.
Apoptosis. 2008 Jul;13(7):904-14. PMID: 18493855
Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.
J Pharmacol Exp Ther. 2010 Oct;335(1):114-23. Epub 2010 Jul 6. PMID: 20605902
Curcumin supplementation by reducing vascular inflammation may prevent diabetic complications.
J Nutr Biochem. 2010 Jul 21. Epub 2010 Jul 21. PMID: 20655188
Curcumin supplementation may prevent the cellular dysfunction associated with diabetes.
Free Radic Biol Med. 2006 Jul 1;41(1):92-6. Epub 2006 Mar 30. PMID: 16781457
Curcumin suppresses breast cancer cells growth.
FEBS J. 2010 Aug;277(16):3437-48. Epub 2010 Jul 14. PMID: 20646066
Curcumin suppresses cigarette smoke-induced promotion of human non-small cell lung cancer cell growth.
Carcinogenesis. 2003 Jul;24(7):1269-79. Epub 2003 May 9. PMID: 12807725
Curcumin suppresses colon cancer cells.
World J Gastroenterol. 2009 Mar 21;15(11):1346-52. PMID: 19294764
Curcumin suppresses growth and chemoresistance of human glioblastoma cells.
J Neurochem. 2007 Jul;102(2):522-38. PMID: 17596214
Curcumin suppresses head and neck cancer cell growth.
Arch Otolaryngol Head Neck Surg. 2009 Feb;135(2):190-7. PMID: 19221248
Curcumin suppresses hepatic stellate cell genes, indicating its therapeutic value for hepatitic fibrosis.
Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G883-93. Epub 2005 Nov 23. PMID: 16306131
Curcumin suppresses HPV oncoproteins and HPV upregulation associated wtih benzo[a]pyrene exposure.
Mol Carcinog. 2011 Jan;50(1):47-57. PMID: 21061268
Curcumin suppresses human breast cancer cell growth.
Chem Biol Interact. 2009 Oct 7;181(2):263-71. Epub 2009 Jun 30. PMID: 19573523
Curcumin suppresses human promyelocytic leukemia cells.
J Biochem Mol Biol. 2002 May 31;35(3):337-42. PMID: 12297018
Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression associated with inflammation.
J Pharmacol Sci. 2004 Mar;94(3):325-8. PMID: 15037818
Curcumin suppresses melanogenesis in melanoma cells.
Int J Mol Med. 2010 Jul;26(1):101-6. PMID: 20514428
Curcumin suppresses mouse pituitary corticotroph tumor cells.
PLoS One. 2010;5(4):e9893. Epub 2010 Apr 13. PMID: 20405005
Curcumin suppresses oral carcinogenesis.
Int J Cancer. 2010 Jul 1;127(1):9-20. PMID: 20127863
Curcumin suppresses proliferation and induces programmed cell death in human multiple myeloma cells.
Blood. 2003 Feb 1;101(3):1053-62. Epub 2002 Sep 5. PMID: 12393461
Curcumin suppresses proliferation and invasion in human gastric cancer cells.
Cancer Biol Ther. 2009 Jul;8(14):1360-8. Epub 2009 Jul 13. PMID: 19448398
Curcumin suppresses protein kinase C and nuclear oncogene expression associated with cancer progression.
Arch Pharm Res. 2004 Jul;27(7):683-92. PMID: 15356994
Curcumin suppresses SV40-immortalized bladder cancer cells.
Anticancer Res. 2007 Mar-Apr;27(2):737-40. PMID: 17465196
Curcumin suppresses the growth and induces programmed cell death in bladder cancer cells, in vitro.
Zhong Yao Cai. 2004 Nov;27(11):848-50. PMID: 15810596
Curcumin suppresses the inflammatory response of brain microglial cells.
J Immunol. 2003 Dec 1;171(11):6072-9. PMID: 14634121
Curcumin suppresses transcription factor Egr-1.
Thromb Res. 2000 Feb 15;97(4):179-89. PMID: 10674404
Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells.
Acta Pharmacol Sin. 2007 Jan;28(1):105-10. PMID: 17184589
Curcumin synergistically potentiates the anti-cancer effects of celecoxib in pancreatic cancer cells.
Biomed Pharmacother. 2005 Oct;59 Suppl 2:S276-80. PMID: 16507392
Curcumin synergizes the growth inhibitory properties of Indian toad skin-derived factor in colon cancer cells.
Phytother Res. 2007 Sep;21(9):895-7. PMID: 19331178
Curcumin synergizes with resveratrol to inhibit colon cancer.
J Endocrinol. 2003 Jan;176(1):163-8. PMID: 19838927
Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression.
Int J Clin Oncol. 2013 May 11. Epub 2013 May 11. PMID: 23666561
Curcumin treatment protects rat retinal neurons against excitotoxicity.
Exp Brain Res. 2005 Dec;167(4):641-8. Epub 2005 Aug 3. PMID: 16078027
Curcumin work synergistically with a PI3K inhibitor to induce cell death in breast cancer cellis.
Biochem Biophys Res Commun. 2010 Apr 9;394(3):476-81. Epub 2010 Feb 6. PMID: 20138829
Curcumin works synergistically with antifungal drugs.
FEMS Yeast Res. 2010 Aug 1;10(5):570-8. Epub 2010 Apr 23. PMID: 20528949
Curcumin works synergistically with bortezomib in multiple myeloma.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun ;19(3):684-8. PMID: 21729550
Curcumin works synergistically with celecoxib to potentiate a growth-inhibitory and pro-apoptotic in osteoarthritis synovial adherent cells.
Rheumatology (Oxford). 2006 Feb;45(2):171-7. Epub 2005 Oct 25. PMID: 16249246
Curcumin works synergistically with copper to damage leukemia cells.
Molecules. 2009;14(12):5328-38. Epub 2009 Dec 17. PMID: 20032896
Curcumin works synergistically with cyclophosmide to reverse multi-drug resistance of a human lymphoma cell line.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Aug;16(4):804-8. PMID: 18718065
Curcumin works synergistically with drugs as an anti-fibrotic agent in liver fibrosis.
Zhong Yao Cai. 2003 Nov;26(11):795-8. PMID: 14989060
Curcumin works synergistically with EGF-receptor protein to inhibit the growth of colon cancer cells.
Nutr Cancer. 2006;55(2):185-94. PMID: 17044774
Curcumin works synergistically with insulin on muscle cell glucose metabolism.
Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2366-73. Epub 2010 Jun 1. PMID: 20561944
Curcumin works synergistically with light to inhibit bacterial growth.
Arch Microbiol. 1989;151(2):183-5. PMID: 2655550
Curcumin works synergistically with paclitaxel to overcome multidrug resistance in tumor cells.
Mol Pharm. 2009 May-Jun;6(3):928-39. PMID: 19278222
Curcumin works synergistically with the chemotoxic agent FOLFOX to eliminate colon caner stem cells.
Transl Oncol. 2009 Dec;2(4):321-8. PMID: 19956394
Curcumin's (Turmeric) inhibition of HPV oncogenes is cytotoxic to cervical cancer cells.
Mol Carcinog. 2006 May;45(5):320-32. PMID: 16526022
Curcumin's ability to inhibit VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells indicate it may have value in irritable bowel syndrome and cancer.
Gut. 2008 Nov;57(11):1509-17. Epub 2008 Jul 2. PMID: 18596194
Curcumin's anti-inflammatory properties are related to its ability to inhibit the neutrophil response.
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Curcumin's blood sugar lowering effect may be due to its inhibitory effect on hepatic gluconeogenesis.
Biochem Biophys Res Commun. 2009 Oct 16;388(2):377-82. Epub 2009 Aug 8. PMID: 19665995
Curcumin's higher binding affinity for iron and copper rather than zinc may contribute to its protective effect in Alzheimer's disease.
J Alzheimers Dis. 2004 Aug;6(4):367-77; discussion 443-9. PMID: 15345806
Curcumin's induction of programmed cell death in human leukemia cells is associated with inhibition of telomerase activity.
Mol Cell Biochem. 2007 Mar;297(1-2):31-9. Epub 2006 Nov 10. PMID: 17096185
Curcumin's proapoptotic and antidegranulation effect make it a potential candidate for the therapy of neutrophil-induced lung injury and sepsis.
Crit Care Med. 2005 Nov;33(11):2571-8. PMID: 16276182
Curcumin's various benefits may be associated with its role as a Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor.
J Enzyme Inhib Med Chem. 2009 Jun;24(3):771-8. PMID: 18720192
Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets.
Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):223-7. PMID: 7784468
Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells.
J Mol Histol. 2004 Mar;35(3):301-7. PMID: 15339049
Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-Cell lymphoma cell line proliferation.
Acta Pharmacol Sin. 2005 May;26(5):603-9. PMID: 15842781
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages.
Biochem Biophys Res Commun. 1995 Jan 17;206(2):533-40. PMID: 7530002
Curcumin, an antioxidant and anti-inflammatory agent protects endothelial cells against oxidative stress.
Biol Pharm Bull. 2006 Apr;29(4):670-4. PMID: 10889462
Curcumin, EGCG and resveratrol inhibit inflammation.
Mutat Res. 2001 Sep 1;480-481:243-68. PMID: 11506818
Curcumin, resveratrol and EGCG may have a therapeutic role in proliferative vitreoretinopathy (PVR).
Curr Eye Res. 2010 Nov;35(11):1021-33. PMID: 20958191
Curcumin, resveratrol and flavonoids act as anti-inflammatory, cyto- and DNA-protective dietary compounds.
Toxicology. 2009 Nov 10. Epub 2009 Nov 10. PMID: 19903510
Curcumin, Resveratrol and Gingerol decrease prostate inflammation
Carcinogenesis. 2007 Jun;28(6):1188-96. Epub 2006 Dec 6. PMID: 17151092
Curcumin, resveratrol and vanillin protects against DNA damage.
Minerva Med. 1988 May;79(5):387-90. PMID: 12561251
Curcumin-induced cell death of ovarian carcinoma has a known mechnism.
Mol Carcinog. 2010 Jan;49(1):13-24. PMID: 19676105
Curcumin-induced suppression of adipogenic differentiation, indicating its therapeutic role in obesity.
Am J Physiol Cell Physiol. 2010 Jun;298(6):C1510-6. Epub 2010 Mar 31. PMID: 20357182
Curcuminoids (from Turmeric) are effective in treating multi-drug resistance cancer cell lines.
Biochem Pharmacol. 2004 Nov 15;68(10):2043-52. PMID: 15476675
Curcuminoids are cytotoxic to human ovarian cancer cells.
J Nat Prod. 1998 Dec;61(12):1531-4. PMID: 9868158
Curcuminoids are potent inhibitors of lipid peroxidation.
J Pharm Pharmacol. 1994 Dec;46(12):1013-6. PMID: 7714712
Curcuminoids have anti-tumor and antioxidant activity.
Cancer Lett. 1995 Jul 20;94(1):79-83. PMID: 7621448
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Cancer Chemother Pharmacol. 2006 Feb;57(3):376-88. Epub 2005 Jul 14. PMID: 16021489
Curcuminoids inhibits breast cancer cell proliferation.
Pharmacol Res. 2010 Nov 25. Epub 2010 Nov 25. PMID: 9714342
Curcuminoids masy promote neuritogenesis.
J Agric Food Chem. 2012 Jan 11 ;60(1):433-43. Epub 2011 Dec 22. PMID: 22145830
Curcuminoids may enhance the efficacy of chemotoxic drugs.
Mol Cancer Ther. 2006 Aug;5(8):1995-2006. PMID: 16928820
Curcuminoids may provide an ideal solution to overcoming chemoresistance.
Mol Med Report. 2012 Sep 27. Epub 2012 Sep 27. PMID: 23023936
Curcuminoids may reduce the risk of hypertension and cardiovascular diseases.
Int J Food Sci Nutr. 2012 Jan 23. Epub 2012 Jan 23. PMID: 22263555
Curcuminoids prevent experimentally induced neuronal damage in the rat hippocampus.
Life Sci. 2006 Mar 13;78(16):1884-91. Epub 2005 Nov 2. PMID: 16266725
Curcuminoids protect against endothelial diseases caused by oxidative damages.
Exp Mol Med. 2006 Aug 31;38(4):393-400. PMID: 16953118
Curcuminoids protect against neuronal cell death in an Alzheimer disease model.
Neurosci Lett. 2001 Apr 27;303(1):57-61. PMID: 11297823
Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices.
Synapse. 2010 Oct 20. Epub 2010 Oct 20. PMID: 20963814
Curcuminoids suppress the growth and induce programmed cell death in glioblastoma multiforme cells.
J Agric Food Chem. 2010 Oct 13;58(19):10639-45. PMID: 20822178
Curcuminoids suppress the growth of pharynx and nasopharyngeal cancer cells.
J Agric Food Chem. 2009 May 13;57(9):3765-70. PMID: 19317462
Curcuminoids, particularly curcumin, can improve the symptoms of allergic diseases, such as anaphylaxis and itching.
Arch Pharm Res. 2009 Dec;32(12):1783-7. Epub 2010 Feb 17. PMID: 20162408
Curcuminoids-loaded lipid nanoparticles exhibit anti-malarial activity.
Colloids Surf B Biointerfaces. 2010 Nov 1;81(1):263-73. Epub 2010 Jul 17. PMID: 20688493
Curcumoids inhibit matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells.
Arch Pharm Res. 2010 Jul;33(7):989-98. Epub 2010 Jul 27. PMID: 20661707
Curcumol, isolated from Curcuma phaeocaulis (R. Curcumae) induces programmed cell death in human lung cancer cells.
Med Oncol. 2010 Feb 3. Epub 2010 Feb 3. PMID: 20127426
Demethoxycurcumin induces programmed cell death in human glioma cells.
Biochem Biophys Res Commun. 2009 Jul 10;384(4):420-5. Epub 2009 May 5. PMID: 19422808
Demethoxycurcumin suppresses migration and invasion of human breast cancer cell line.
Eur J Pharmacol. 2010 Feb 10;627(1-3):8-15. Epub 2009 Oct 7. PMID: 19818349
Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses in microglia cells.
Int Immunopharmacol. 2010 Mar;10(3):331-8. Epub 2009 Dec 16. PMID: 20018257
Dietary omega-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages associated with inflammation.
Mol Cell Biochem. 2000 Jan;203(1-2):153-61. PMID: 10724344
EGCG and curcumin have chemopreventive synergism in normal, premalignant and malignant human oral epithelial cells.
Carcinogenesis. 1998 Mar;19(3):419-24. PMID: 9525275
EGCG and curcumin suppress Alzheimer disease associated beta amyloid production.
Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H715-21. Epub 2005 Mar 18. PMID: 18695518
Ellagic acid and curcumin may inhibit cancer through preventing the over-expression of glutathione S-transferases.
Food Chem Toxicol. 2007 Feb;45(2):286-95. Epub 2006 Aug 30. PMID: 17046132
Epicatechin enhances the anti-cancer activity of curcumin in human lung cancer cells.
Cancer Prev Res (Phila). 2010 Aug;3(8):953-62. Epub 2010 Jul 6. PMID: 20606042
Epigenetic Reactivation of RANK in Glioblastoma Cells by Curcumin: Involvement of STAT3 Inhibition.
DNA Cell Biol. 2013 Apr 27. Epub 2013 Apr 27. PMID: 23621850
Ethanol extracts of A. hypogaea (peanut), C. longa (turmeric), and P. maritimum could be considered a new natural agent against the Acanthamoeba cyst.
Parasitol Res. 2011 Dec 7. Epub 2011 Dec 7. PMID: 22146994
Garcinol (Garcinia indica) and curcumin (Turmeric) induce programmed cell death in human leukemia cells.
J Agric Food Chem. 2001 Mar;49(3):1464-74. PMID: 11312881
Genistein and curcumin block migratory and invasive phenotypes within mouse skin cells.
Nutr Cancer. 2000;37(1):49-54. PMID: 10965519
Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies indicating it may help to alleviate autoimmune diseases.
Mol Nutr Food Res. 2010 Aug;54(8):1202-9. PMID: 20146265
Hexahydrocurcumin has a cytotoxic effect against human colorectal cancer cells.
Nat Prod Commun. 2011 Nov ;6(11):1671-2. PMID: 22224285
High dose of curcumin might be an effective anti-angiogenic drug in the treatment against tumor.
Mol Pharmacol.2007 Dec;72(6):1508-21. Epub 2007 Sep 14. PMID: 16151260
Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin.
Eur J Pharmacol. 1999 Nov 19;384(2-3):191-5. PMID: 10611441
Liposome-encapsulated curcumin exhibits anti-cancer activity in pancreatic cancer.
Cancer. 2005 Sep 15;104(6):1322-31. PMID: 16092118
Liposome-encapsulated curcumin suppresses neuroblastoma growth.
Surgery. 2012 Jan 26. Epub 2012 Jan 26. PMID: 22284765
MGN-3 and curcumin exhibit synergistic anti-cancer activity on human multiple myeloma cell lines.
Neoplasma. 2011;58(2):118-23. PMID: 21275460
NAC and curcumin ameliorate pesticide-induced oxidative DNA damage in human peripheral blood mononuclear cells.
Environ Monit Assess. 2010 Nov 4. Epub 2010 Nov 4. PMID: 21049288
Natural curcuminoids exhibit alpha-glucosidase inhibitory activity.
Eur J Med Chem. 2006 Feb;41(2):213-8. Epub 2006 Jan 4. PMID: 16387392
Natural plant compounds may have preventive and therapeutic applications against the growth of breast tumors induced by environmental estroge
Environ Health Perspect. 1998 Dec;106(12):807-12. PMID: 9831541
Phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane have a synergistic effect in the inhibition of inflammation.
Pharm Res. 2009 Jan;26(1):224-31. Epub 2008 Oct 8. PMID: 18841446
Phosphatidylcholine bound curcumin is a lipoxygenase inhibitor.
Lipids. 1998 Dec;33(12):1223-8. PMID: 9930409
Polyphenols such as curcumin and EGCG from green tea may chelate out iron from the Alzheimers brain.
Prog Neurobiol. 2007 Aug;82(6):348-60. Epub 2007 Jun 19. PMID: 17659826
Preventive compounds curcumin and piperine are capable of targeting breast stem cells.
Breast Cancer Res Treat. 2010 Aug ;122(3):777-85. Epub 2009 Nov 7. PMID: 19898931
Prophylactic use of curcumin may effectively rescue pancreatic islets from damage without affecting the normal function of these cellular structures.
BJU Int. 2002 Jun;89(9):829-34. PMID: 17900558
Resveratrol and curcumin may attenuate Chlamydia-associated induced atherosclerosis.
Biochem Biophys Res Commun. 2005 Jul 22;333(1):21-7. PMID: 15939398
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Cell Div. 2008;3:14. Epub 2008 Oct 3. PMID: 18834508
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Pharmazie. 2010 Jan;65(1):57-63. PMID: 20187580
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Nutr Cancer. 2006;55(2):126-31. PMID: 17044766
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Mutat Res. 2009 Oct 13. Epub 2009 Oct 13. PMID: 19966973
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Mol Cancer. 2011 Feb 7;10(1):12. Epub 2011 Feb 7. PMID: 21299897
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Mol Cell Biochem. 2010 Mar;336(1-2):85-95. Epub 2009 Oct 14. PMID: 19826768
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Cancer. 2010 Oct 15;116(20):4670-6. PMID: 20597137
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Pediatr Rehabil. 2004 Oct-Dec;7(4):245-60. PMID: 21091916
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Safety Study: A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats.
Food Chem Toxicol. 2007 Jan;45(1):64-9. Epub 2006 Aug 7. PMID: 16987575
Six dietary constituents inhibit nicotine-DNA adduct formation.
Food Chem Toxicol. 2003 Jul;41(7):1045-50. PMID: 12804663
Spice constituents such as quercetin and curcumin inhibit LDL cholesterol oxidation.
Mol Cell Biochem. 2002 Jan;229(1-2):19-23. PMID: 11936843
Targeting Cancer Stem Cells by Curcumin and Clinical Applications.
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Tea, rosemary and turmeric inhibit inflammation.
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Testoterone enhances curcumin's anti-prostate cancer activity.
Cancer Sci. 2011 Feb;102(2):468-71. Epub 2010 Dec 7. PMID: 21134073
Tetrahydrocurcumin inhibits cell migration and invasion in fibrosarcoma cells.
Acta Pharmacol Sin. 2008 Jul;29(7):853-60. PMID: 18565284
Tetrahydrocurcumin may contribute to overcoming multi-drug resistance of human cancers.
Mol Cell Biochem. 2007 Feb;296(1-2):85-95. Epub 2006 Sep 8. PMID: 16960658
Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.
Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 10803946
Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.
Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 10803946
The anti-breast cancer activity of curcumin may be due in part to its down-regulation of insulin-like growth factor.
Life Sci. 2007 May 16;80(23):2161-9. Epub 2007 Apr 21. PMID: 17499312
The dietary polyphenols trans-resveratrol and curcumin interact with cannabinoid receptors indicating their potential role in treating obesity and/or drug dependence.
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The natural compounds berberine, curcumin and picroliv are able to suppress the progression of virally induced leukemia.
J Exp Ther Oncol. 2008;7(4):275-84. PMID: 19227007
The natural Nuclear factor-kappaB inhibitor curcumin may help to overcome drug resistance in human pancreatic cancer.
Mol Cancer Ther. 2006 Sep;5(9):2251-60. PMID: 16985059
The phytoestrogens quercetin, baicalein, genistein, epigallocatechin gallate (EGCG), and curcumin are effective inhibitors of prostate tumor cell growth.
Nutr Cancer. 2004;49(2):200-8. PMID: 15489213
The plant extracts curcumin, quercetin, green tea, balcalein, and luteolin offer protection and promote healing of neurological tissues
Surg Neurol Int. 2012 ;3:19. Epub 2012 Feb 15. PMID: 22439110
The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.
Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831
The polyphenols, epigallocatechin gallate, and catechin hydrate significantly attenuate quinolinic acid-induced excitotoxicity in human neurons.
FEBS J. 2010 Jan;277(2):368-82. Epub 2009 Dec 10. PMID: 20015232
The role of cancer stem cells in the anti-carcinogenicity of curcumin.
Mol Nutr Food Res. 2013 Jul 31. Epub 2013 Jul 31. PMID: 23900994
Theophylline and curcumin may restore corticosteroid insensitivity.
Expert Opin Ther Targets. 2007 Jun;11(6):745-55. PMID: 17504013
There is strong evidence to support the use of curcumin in retinal diseases, Crohn's disease and disorders related to the spinal cord.
Arch Otolaryngol Head Neck Surg. 2004 Dec;130(12):1381-6. PMID: 15262811
Topic turmeric may have photoprotective properties.
J Cosmet Dermatol. 2011 Dec ;10(4):260-5. PMID: 22151933
Topical application of curcumin (from Turmeric) may have therapeutic value in the treatment of scleroderma, psoriasis and skin cancer.
Adv Exp Med Biol. 2007;595:343-57. PMID: 17569219
Topical application of curcumin was useful in reducing experimental corneal neovascularization and can be used to inhibit angiogenesis in the cornea.
Curr Eye Res. 2010 Apr;35(4):274-80. PMID: 20373893
Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells.
Support Care Cancer. 2010 May 14. Epub 2010 May 14. PMID: 20467756
Topical curcumin with visible light may have therapeutic value in skin cancer.
J Invest Dermatol. 2007 Aug;127(8):1992-2000. Epub 2007 Apr 5. PMID: 17410200
Trichostatin A works synergistically with curcumin to inhibit human leukemia cells.
Pharmazie. 2006 Aug;61(8):710-6. PMID: 16964716
Tumeric contains compounds such as tumerones and curlone separate and distinct from curcumin which exhibit antibacterial activity.
J Agric Food Chem. 1999 Oct;47(10):4297-300. PMID: 10552805
Turmeric and curcumin inhibit aflatoxin induced hemolysis.
Evid Based Complement Alternat Med. 2010 Jan 4. Epub 2010 Jan 4. PMID: 17665866
Turmeric and curcumin protect against gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells.
Teratog Carcinog Mutagen. 1999;19(1):9-18. PMID: 10321406
Turmeric and ginger work synergistically to suppress prostate cancer cell lines.
J Basic Clin Physiol Pharmacol. 2012 Oct 12 ;0(0):1-8. Epub 2012 Oct 12. PMID: 23072849
Turmeric and green tea have significant apoptic effects in chronic lymphocytic leukemia.
Clin Cancer Res. 2009 Feb 15;15(4):1123-5. PMID: 19228716
Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.
Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 10803946
The anti-breast cancer activity of curcumin may be due in part to its down-regulation of insulin-like growth factor.
Life Sci. 2007 May 16;80(23):2161-9. Epub 2007 Apr 21. PMID: 17499312
The dietary polyphenols trans-resveratrol and curcumin interact with cannabinoid receptors indicating their potential role in treating obesity and/or drug dependence.
Biosci Biotechnol Biochem. 1996 Jun;60(6):1000-5. PMID: 19359525
The natural compounds berberine, curcumin and picroliv are able to suppress the progression of virally induced leukemia.
J Exp Ther Oncol. 2008;7(4):275-84. PMID: 19227007
The natural Nuclear factor-kappaB inhibitor curcumin may help to overcome drug resistance in human pancreatic cancer.
Mol Cancer Ther. 2006 Sep;5(9):2251-60. PMID: 16985059
The phytoestrogens quercetin, baicalein, genistein, epigallocatechin gallate (EGCG), and curcumin are effective inhibitors of prostate tumor cell growth.
Nutr Cancer. 2004;49(2):200-8. PMID: 15489213
The plant extracts curcumin, quercetin, green tea, balcalein, and luteolin offer protection and promote healing of neurological tissues
Surg Neurol Int. 2012 ;3:19. Epub 2012 Feb 15. PMID: 22439110
The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.
Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831
The polyphenols, epigallocatechin gallate, and catechin hydrate significantly attenuate quinolinic acid-induced excitotoxicity in human neurons.
FEBS J. 2010 Jan;277(2):368-82. Epub 2009 Dec 10. PMID: 20015232
The role of cancer stem cells in the anti-carcinogenicity of curcumin.
Mol Nutr Food Res. 2013 Jul 31. Epub 2013 Jul 31. PMID: 23900994
Theophylline and curcumin may restore corticosteroid insensitivity.
Expert Opin Ther Targets. 2007 Jun;11(6):745-55. PMID: 17504013
There is strong evidence to support the use of curcumin in retinal diseases, Crohn's disease and disorders related to the spinal cord.
Arch Otolaryngol Head Neck Surg. 2004 Dec;130(12):1381-6. PMID: 15262811
Topic turmeric may have photoprotective properties.
J Cosmet Dermatol. 2011 Dec ;10(4):260-5. PMID: 22151933
Topical application of curcumin (from Turmeric) may have therapeutic value in the treatment of scleroderma, psoriasis and skin cancer.
Adv Exp Med Biol. 2007;595:343-57. PMID: 17569219
Topical application of curcumin was useful in reducing experimental corneal neovascularization and can be used to inhibit angiogenesis in the cornea.
Curr Eye Res. 2010 Apr;35(4):274-80. PMID: 20373893
Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells.
Support Care Cancer. 2010 May 14. Epub 2010 May 14. PMID: 20467756
Topical curcumin with visible light may have therapeutic value in skin cancer.
J Invest Dermatol. 2007 Aug;127(8):1992-2000. Epub 2007 Apr 5. PMID: 17410200
Trichostatin A works synergistically with curcumin to inhibit human leukemia cells.
Pharmazie. 2006 Aug;61(8):710-6. PMID: 16964716
Tumeric contains compounds such as tumerones and curlone separate and distinct from curcumin which exhibit antibacterial activity.
J Agric Food Chem. 1999 Oct;47(10):4297-300. PMID: 10552805
Turmeric and curcumin inhibit aflatoxin induced hemolysis.
Evid Based Complement Alternat Med. 2010 Jan 4. Epub 2010 Jan 4. PMID: 17665866
Turmeric and curcumin protect against gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells.
Teratog Carcinog Mutagen. 1999;19(1):9-18. PMID: 10321406
Turmeric and ginger work synergistically to suppress prostate cancer cell lines.
J Basic Clin Physiol Pharmacol. 2012 Oct 12 ;0(0):1-8. Epub 2012 Oct 12. PMID: 23072849
Turmeric and green tea have significant apoptic effects in chronic lymphocytic leukemia.
Clin Cancer Res. 2009 Feb 15;15(4):1123-5. PMID: 19228716
Process for extracting curcumin
CN103254050
The invention provides a process for extracting curcumin by a carbon dioxide supercritical extraction method. According to the process, curcumin is extracted from ginger by taking a supercritical carbon dioxide liquid as an extractant and 95% ethanol as an entrainer. The method adopted is simple in flow and convenient to operate. Separation is realized at the same time in the extraction process, and the method has no bad effect on production personnel and the environment. The yield and purity of curcumin are high.
Preparation method for extracting purified curcumin-related compounds from turmeric
CN103193610
The invention discloses a preparation method for extracting purified curcumin-related compounds from turmeric. The process comprises the following steps of: performing water washing and crushing on the turmeric, performing multi-stage countercurrent extraction by using alcohol-amino acid water, performing chromatography through a macroporous resin column, performing gradient elution by using ethanol-water, collecting eluate, performing decompression, evaporation and concentration, and performing vacuum drying to obtain active ingredients, namely curcumin, demethoxycurcumin and bisdemethoxycurcumin. The preparation method disclosed by the invention has the advantages that the alcohol-amino acid water is used for performing the multi-stage countercurrent extraction, the used macroporous resin can be utilized repeatedly, water and ethanol are taken as solvents, the preparation method is economic, simple and convenient, high-purity curcumin, demethoxycurcumin and bisdemethoxycurcumin can be conveniently obtained, the purity of each monomer compound is above 95%, the sample recovery rate is above 75%, the process flow is short, the operability is strong, the consumption of the solvents is low, the extraction rate is high, the stability of the extraction solution is good, obtained products can be widely used for the fields of medicines, foods and the like, and the preparation method is suitable for mass production.
High-yield water-based curcumin extraction method
CN103130629
The invention relates to a high-yield water-based curcumin extraction method which comprises the following steps: (1) grinding curcuma, soaking with an alkaline water solution of 0-40 DEG C, stirring, extracting, then adding antioxidant, centrifuging, extracting 1-2 times, taking the supernatant, and adding acid to precipitate; and (2) adding an alcohol solution to dissolve the precipitate, centrifuging, adding water to obtain an alcohol dissolving liquid, purifying, concentrating, and drying to obtain curcumin. The curcumin content extracted by the invention can be up to 95%; the extraction and purification yield is more than 80%; and by taking water as extraction solvent, the method is economic, convenient and safe. Thus, the method provided by the invention is a high-yield and low-cost production process.
Method for extracting curcumin from turmeric
CN102617316
The invention relates to a method for extracting curcumin from turmeric. The method is characterized by comprising the following steps that: the turmeric is cleanly cleaned and is then crushed into turmeric powder, the turmeric powder and extraction solvents are mixed according to a certain proportion and are then subjected to backflow extraction, next, the separation is carried out under certain conditions to remove heavy metals, and finally, the precipitates are separated and crystallized to obtain curcumin.; Compared with the prior art, the method has the advantages that the heavy metal separation and purification flow process is simple and short, the risk of secondary pollution caused by the additional addition of absorption agents or absorption media is avoided, and the heavy metal residue of products can be purified to a degree that the lead content is lower than 1.0PPM, the cadmium content is lower than 1.0 PPM, the mercury content is lower than 0.10 PPM, and the arsenic content is lower than 0.10PPM.
Method for extracting and separating high-purity curcumin with low heavy-metal residues from turmeric
CN102603505
The invention discloses a method for extracting and separating high-purity curcumin with low heavy-metal residues from turmeric. The method comprises the following steps of: firstly cleaning, drying and crushing turmeric into turmeric powder, and mixing the turmeric powder with an extraction solvent proportionally, heating, stirring and extracting; mixing extractive solutions, filtrating and separating, removing the filter residue to obtain filtrate, and concentrating the filtrate; cooling the remaining concentrated liquid, mixing the liquid with a crystallization solvent proportionally, and carrying out static crystallization in a suitable temperature range and filtrating the mixture to obtain wet crystal product; and finally mixing the crystallization solvent with water proportionally to prepare a mixed solvent, mixing the wet crystal product with the mixed solvent proportionally and recrystallizing, and separating to obtain high-purity curcumin with low heavy-metal residues. The technology provided by the invention can reduce the heavy metal content as much as possible while retaining effective natural ingredients of traditional Chinese medicine at the same time, and the technology has significant meaning in improving the standard system of safety control for traditional Chinese medicine, breaking the foreign technical barriers and really pushing traditional Chinese medicine to go onto the world market.
Method for extracting and separating curcumin and curcuma oil from carcuma longa
CN102408320
The invention discloses a method for extracting and separating curcumin and curcuma oil from carcuma longa, which comprises the following steps of: grinding the carcuma longa into carcuma longa powder with particle size of 80-100 meshes; taking ethanol water solution as extractant for dynamic countercurrent extraction of the carcuma longa powder to obtain extraction solution, and concentrating to obtain concentrated solution; and adding the concentrated solution with plant oil extraction solvent for liquid-liquid extraction to obtain light phase containing curcuma oil and heavy phase containing curcumin. Compared with the prior art, the invention takes the ethanol water solution as the extractant and extracts the curcumin and the curcuma oil from the carcuma longa by employing the dynamic countercurrent extraction method, and the method has the advantages of simple operation, moderate extraction condition, low usage amount of solvent, short extraction time, few impurities in extraction solution and high extraction efficiency.
Process method for microwave assistant supercritical extraction of active ingredients of curcuma
CN102100875
The invention discloses a process method for microwave assistant supercritical extraction of active ingredients of curcuma. In the method, the active ingredients, namely curcumin and fat soluble curcuma oil, of curcuma are extracted by the synergistic action of the microwave technology and the supercritical technology. The process method mainly comprises the following steps of: performing microwave intermittent sudden heating and then carbon dioxide (CO2) supercritical extraction; separating CO2 and curcuma oil in an analyzing kettle; and adding water or ethanol into curcuma residue in a solid-to-liquid weight ratio of 1:7-14, and performing microwave action, twice soaking, filtration, condensation and spray drying to obtain the curcumin.; The process method solves the problem that in the prior art, only single active ingredient can be extracted or the compositions of the extract are not balanced, and realizes the extraction of two main active ingredients, namely curcuma oil and curcumin, of the curcuma at the same time, and the yield is over 8 percent and 13 percent respectively. The process method is the physical method and has the advantages of no product pollution, high purity, low cost, simple process and easy mass production.
Extracting method for curcumin
CN101831199
The invention discloses an extracting method for curcumin, comprising the following steps: pulverizing curcuma; pelleting the pulverized curcuma under the condition of introducing steam; and extracting particles obtained by pelleting with leach liquor. Since turmeric roots contain a large amount of starch which can be gelatinized in a manner of introducing steam for heating and has stickiness, thus the turmeric powder can be more compactly combined, has large rigidity, and is not easy to break; the prepared particles are provided with many micropores, and the solvent is easy to permeate, thus the extraction rate is high; and in addition, the gaps among the particles are larger than the gaps among the powdery materials, thus the solvent is more easy to permeate and the rate of filtration is high, thereby improving the extraction rate, the rate of filtration and the production efficiency.
Curcumin purification technique
CN101774899
The invention relates to a curcumin purification technique. The technique adopts fresh curcuma longa as material, the curcuma longa is ground, squeezed and filtered, ethyl ether is added for extraction, so that volatile oil is removed, and after separation and purification conducted by way of cation exchange resin, membrane concentration and alumina column chromatography and recrystallization conducted by way of methanol, the product is obtained. The method has the advantages of high product purity, simple operation, high throughput and easy industrialized production.
Purification technology of curcumin compound
CN101768061
The invention discloses a purification technology of a curcumin compound. Turmeric medicine serves as a raw material to be smashed and extracted by petroleum ether in a backflow mode; residue is subjected to ultrasound assistant extraction after warm immersing by sodium salicylate alcoholic solution; macroporous resin is added into extract to be separated and purified; mixture is eluted by acetone-2% glacial acetic acid (50:50); curcumin, demethoxy curcumin and bisdemethoxy curcumin fraction are respectively collected; reagent is recovered and is respectively dissolved by a small quantity of acetone; water of which the amount is three times of acetone is quickly added to be decentralized; and supernate is removed, and the mixture is precipitated, frozen and dried to obtain the product.
Curcumin A as well as preparation method thereof and applications to preparing medicaments for treating cardiovascular and cerebrovascular diseases
Method for preparing curcumin, demethoxycurcumin and bisdemethoxycurcumin
CN101585757
The present invention discloses a method for preparing curcumin, demethoxycurcumin and bisdemethoxycurcumin, which comprises the following steps: continuously executing countercurrent extraction to the turmeric with the methanol-acid solution or ethanol-acid solution, after filtering the extracted solution, condensing into the oleoresin with the relative density of 0.9-1.2; placing the oleoresin on the chromatographic separation medium for gradient elution, and after fraction-collecting the eluent, respectively obtaining the curcumin crystal, demethoxycurcumin crystal and bisdemethoxycurcumin crystal after condensing. The invention adopts a technique in which HZ-816, HZ-818 or HZ-801 is used as the chromatographic separation medium and the alcohol-water is used as the elution solvent.; Three monomeric compounds of curcumin, demethoxycurcumin and bisdemethoxycurcumin are simultaneously obtained. The purity of each monomeric compound is more than 95%, and the recovery rate of the sample is more than 70%. The method of the invention further has the advantages of less intercrossing of compounds in the separation process, short flow path, strong operability, low consumption of the solvent, high extraction rate and excellent stability of the extraction solution. Furthermore the obtained product can be widely applied for the fields of medicament, food, etc., and is suitable for large-scale production.
Method for extracting refined curcumin and curcuma oil from curcuma
CN101445440
The invention relates to a method for extracting refined curcumin and curcuma oil from curcuma. The method comprises the following steps: the curcuma is cleaned, dried in the shade, crushed into 30-40 mesh curcuma powder, low-carbon alcohol and alkyl hydrocarbon are made into a mixed solvent at the volume ratio of 1:1-3, the curcuma powder and the mixed solvent are mixed at a weight ratio of 1:3-5 for extraction twice; the extracts are merged, filtered, separated and removed from dregs, the obtained filtrate is condensed, the concentration level is controlled at 60-90%, and the solvent is recovered; a separating agent containing 0-3% salt is added to the residual concentrated solution, the addition amount of the separating agent is 0.5-2 times of the volume of the concentrated solution, the obtained mixture is kept standing for demixing after evenly stirred; a supernatant is separated and condensed, and the alkyl hydrocarbon is recovered to obtain the curcuma oil; a subnatant is adsorbed by a macroporous absorbent resin, flushed to remove water soluble impurities, and eluted with a desorbent, the solvent is condensed and recovered to crystallize the curcumin, thus obtaining the curcumin with the content more than 95%.
Method for extracting and separating curcuma oil
CN101407743
The invention relates to a method for extracting and separating turmeric oil, which comprises the step of extracting the turmeric oil from curcumas by using supercritical CO2, and is characterized in that the method also comprises the following steps: adopting first-step molecular distillation to separate curcumin and grease in the turmeric oil obtained by using the supercritical CO2 method; obtaining almost colorless turmeric essential oil under the conditions of operating pressure of 10 to 20Pa, distillation temperature of 70 to 90 DEG C, the rotation speed of a blade applicator of 200 to 300r/min and distillates of more than 75.0 percent. Adopting supercritical CO2 extraction and two-level molecular distillation, the method can effectively keep the natural ingredients of the turmeric oil, without bringing any pollution to the environment.; In addition, the method also realizes the separation of oxygenous sesquiterpene from sesquiterpene in the turmeric oil, which can be used directly as raw materials in the fields such as the cosmetics, food and pharmacy where different amounts of the oxygenous sesquiterpene and the sesquiterpene are needed.
Method for extracting and separating turmeric effective ingredient curcumin
CN101468944
The invention discloses a method for extracting and separating curcumin as an effective constituent of turmeric, which belongs to the extraction and separation of traditional Chinese medicine effective constituents and technical application. The structural formula of the compound is as shown in a figure. The method for extracting and separating curcumin comprises the steps of grinding turmeric, adding alkali liquid for cold extraction, filtering, performing column chromatography through macroporous resin, performing gradient elution by use of ethanol and water, collecting eluent, reducing pressure, evaporating, concentrating and vacuum-drying the eluent, and obtaining the effective constituent, namely curcumin. The method has the advantages that the macroporous resin used in the method can be repeatedly utilized, and the method is economical and simple by taking water and ethanol as solvents, can conveniently obtain the extract with the effective constituent content not lower than 90 percent, and is easy to industrialize.
Turmeric ( Wikipedia )
Curcumin ( Wikipedia )
Univ. Maryland : Curcumin
Cancer Letters : Curcumin vs Cancer
GreenMed Database
Curcumin Extraction Patents
Curcumin ( Wikipedia )
Univ. Maryland : Curcumin
Cancer Letters : Curcumin vs Cancer
GreenMed Database
Curcumin Extraction Patents
Wikipedia.org
Turmeric
Curcuma
Turmeric
Curcuma
TurmericIndian Turmeric
Curcuma longa
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Monocots
(unranked): Commelinids
Order: Zingiberales
Family: Zingiberaceae
Genus: Curcuma
Species: C. longa
Binomial name : Curcuma longa L.[1]
Synonyms : Curcurma domestica Valeton
Turmeric (Curcuma longa) /'t?rm?r?k/ is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae.[2] It is native to tropical Tamilnadu, in southeast India, and needs temperatures between 20 °C and 30 °C (68 °F and 86 °F) and a considerable amount of annual rainfall to thrive.[3] Plants are gathered annually for their rhizomes, and propagated from some of those rhizomes in the following season.
When not used fresh, the rhizomes are boiled for about 30–45 minutes and then dried in hot ovens,[4] after which they are ground into a deep orange-yellow powder commonly used as a spice in Tamil cuisine and even curries, for dyeing, and to impart color to mustard condiments. Its active ingredient is curcumin and it has a distinctly earthy, slightly bitter, slightly hot peppery flavor and a mustardy smell. Curcumin has been a centre of attraction for potential treatment of an array of diseases, including cancer, Alzheimer's disease, diabetes, allergies, arthritis and other chronic illnesses.[5]
Botanical view of Curcuma longa.
Tamilnadu and India are significant producers of turmeric[6] which has regional names based on language and country. The name appears to derive from the Latin, terra merita (merited earth) or turmeryte .[7]
The name of the genus, Curcuma is from an Arabic name of both saffron and turmeric (see Crocus)
As turmeric is a natural botanical compound, it is not patentable.[8][9][clarification needed]
History
Turmeric has been used in Tamilnadu for thousands of years and is a major part of Siddha medicine.[10] It was first used as a dye and then later for its medicinal properties.[11]
Botanical description
Appearance
Turmeric is a perennial herbaceous plant, which reaches a stature of up to 1 meter. There are highly branched, yellow to orange, cylindrical, aromatic rhizomes . The leaves are alternate and arranged in two rows . They are divided into leaf sheath, petiole and leaf blade.[12] From the leaf sheaths, a false stem is formed. The petiole is 50 to 115 cm long. The simple leaf blades are usually of a length of 76 to 115 cm and rarely up to 230 cm. They have a width of 38 to 45 cm and are oblong to elliptic narrowing at the tip .
Inflorescence, flower and fruit
In China, the flowering time is usually in August. Terminally on the false stem there is a 12 to 20 cm long inflorescence stem containing many flowers. The bracts are light green and ovate with a length of 3 to 5 centimeters to oblong with a blunt upper end.
At the top of the inflorescence stem bracts are present on which there are no flowers, these are, white to green and sometimes tinged reddish-purple and its upper end is tapered.[13]
The hermaphrodite flowers are zygomorphic and threefold. The three 0.8 to 1.2 centimeters long, sepals are fused, white, have fluffy hairs and the three calyx teeth are unequal. The three bright yellow petals are fused into a corolla tube up to 3 centimeters long. The three corolla lobes have a length of 1 to 1.5 cm, triangular with soft-spiny upper end. While the average corolla lobe is larger than the two lateral. Only the median stamen of the inner circle is fertile. The dust bag is spurred at its base. All other stamens are converted to staminodes. The outer staminodes are shorter than the labellum. The labellum is yellowish, with a yellow ribbon in its center and it is obovate, with a length from 1.2 to 2 cm. Three carpels are under a constant, trilobed ovary adherent, which is sparsely hairy.
The fruit capsule opens with three compartments.
Biochemical composition
Curcumin keto form
Curcumin enol form
The most important chemical components of turmeric are a group of compounds called curcuminoids, which include curcumin (diferuloylmethane), demethoxycurcumin, and bisdemethoxycurcumin. The best studied compound is curcumin, which constitutes 3.14% (on average) of powdered turmeric.[14] In addition there are other important volatile oils such as turmerone, atlantone, and zingiberene. Some general constituents are sugars, proteins, and resins.[5]
Uses
Culinary
Turmeric powder is used extensively in South Asian cuisine.
Turmeric grows wild in the forests of South and Southeast Asia. It is one of the key ingredients in many Asian dishes. Tamil traditional medicine, called Siddha, has recommended turmeric in food for its potential medicinal value, which is a topic of active research. Its use as a coloring agent is not of primary value in South Asian cuisine.
Turmeric is mostly used in savory dishes, but is used in some sweet dishes, such as the cake Sfouf. In India, turmeric plant leaf is used to prepare special sweet dishes, patoleo, by layering rice flour and coconut-jaggery mixture on the leaf, and then closing and steaming it in a special copper steamer (goa).
In recipes outside South Asia, turmeric is sometimes used as an agent to impart a rich, custard-like yellow color. It is used in canned beverages and baked products, dairy products, ice cream, yogurt, yellow cakes, orange juice, biscuits, popcorn color, sweets, cake icings, cereals, sauces, gelatins, etc. It is a significant ingredient in most commercial curry powders.
Most turmeric that is used is in the form of rhizome powder, in some regions (especially in Maharashtra, Goa, Konkan and Kanara), turmeric leaves are used to wrap and cook food. This use of turmeric leaves usually takes place in areas where turmeric is grown locally, since the leaves used are freshly picked. Turmeric leaves impart a distinctive flavor.
Although typically used in its dried, powdered form, turmeric is also used fresh, like ginger. It has numerous uses in Far Eastern recipes, such as pickle made from fresh turmeric that contains large chunks of soft turmeric.
Turmeric is widely used as a spice in South Asian and Middle Eastern cooking. Many Persian dishes use turmeric as a starter ingredient. Almost all Iranian fried dishes consist of oil, onions, and turmeric followed by any other ingredients that are to be included.
In Nepal, turmeric is widely grown and extensively used in many vegetable and meat dishes for its color as well as for its potential value in traditional medicine. In South Africa, turmeric is used to give boiled white rice a golden color.
In Vietnam, turmeric powder is used to color, and enhance the flavors of, certain dishes, such as bánh xèo, bánh kh?t and mi quang. The powder is also used in many other Vietnamese stir fried and soup dishes.
In Indonesia, the turmeric leaves are used for Minangese or Padangese curry base of Sumatra, such as rendang, sate padang and many other varieties.
In medieval Europe, turmeric became known as Indian saffron because it was widely used as an alternative to the far more expensive saffron spice.[15]
Folk medicine and traditional uses
In Tamilnadu, turmeric has been used traditionally for thousands of years as a remedy for stomach and liver ailments, as well as topically to heal sores, basically for its supposed antimicrobial property.[16] In the Siddha system (since c. 1900 BCE) turmeric was a medicine for a range of diseases and conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. A fresh juice is commonly used in many skin conditions, including eczema, chicken pox, shingles, allergy, and scabies.[17]
Manjal Pal (turmeric milk) is warm milk mixed with some turmeric powder. It is commonly used in Tamilnadu as a home remedy when someone is suffering from fever. Turmeric paste is often used in Tamilnadu as an antiseptic in open wounds, while chun-holud (turmeric with slaked lime) is used to stop bleeding as home remedies. It is also used as a detanning agent in Tamilnadu.[18]
The active compound curcumin is believed to have a wide range of biological effects including anti-inflammatory, antioxidant, antitumour, antibacterial, and antiviral activities, which indicate potential in clinical medicine.[19] In Chinese medicine, it is used for treatment of various infections and as an antiseptic.[20]
Preliminary medical research
Turmeric rhizome.
See also: Curcumin
According to the National Center for Complementary and Alternative Medicine, "there is little reliable evidence to support the use of turmeric for any health condition because few clinical trials have been conducted."[11]
Although trials are ongoing for the use of turmeric to treat cancer, doses needed for any effect are difficult to establish in humans. It is not known what, if any, positive effect turmeric has against cancer or any disease.[21] As of December 2013, turmeric is being evaluated for its potential efficacy against several human diseases in clinical trials, including kidney and cardiovascular diseases, arthritis, several types of cancer and irritable bowel disease.[22]
Specifically, turmeric is also being investigated in relation to Alzheimer's disease,[23] diabetes,[24] and other clinical disorders.[25][26]
However, according to various basic research studies,[27][28][29][30] administration of curcumin or turmeric can suppress several stages of cancer development in multiple tumor models.[28] One study of curcumin on human cancer cells in vitro used hybrid molecules with the anti-nausea drug thalidomide to induce apoptosis in myeloma cancer cells.[31] Some research shows compounds in turmeric to have anti-fungal and antibacterial properties; however, curcumin is not one of them.[32]
Curcumin, the active component of turmeric, has also been shown to be a vitamin D receptor ligand "with implications for colon cancer chemoprevention."[33]
Dye
Turmeric makes a poor fabric dye, as it is not very light fast. However, turmeric is commonly used in Indian and Bangladeshi clothing, such as saris and Buddhist monks' robes.[34] Turmeric (coded as E100 when used as a food additive)[35] is used to protect food products from sunlight. The oleoresin is used for oil-containing products. A curcumin and polysorbate solution or curcumin powder dissolved in alcohol is used for water-containing products. Over-coloring, such as in pickles, relishes, and mustard, is sometimes used to compensate for fading.
In combination with annatto (E160b), turmeric has been used to color cheeses, yogurt, dry mixes, salad dressings, winter butter and margarine. Turmeric is also used to give a yellow color to some prepared mustards, canned chicken broths and other foods (often as a much cheaper replacement for saffron).
Ceremonial uses
Turmeric is considered highly auspicious and holy in Tamil nadu and has been used extensively in various Tamil ceremonies for millennia. Even today it is used in every part of Tamilnadu during wedding ceremonies and religious ceremonies.
Turmeric has played an important role in both Hindu and Tamil spiritualism. The robes of the Tamil monks were traditionally colored with a yellow dye made of turmeric. Because of its yellow-orange coloring, turmeric was associated with the sun or the Thirumal in the mythology of ancient Tamil religion. Yellow is the color of the solar plexus chakra, which in traditional Tamil Siddha medicine is the energy center relating to the metabolic and digestive systems. Orange is the color of the sacral chakra, and tied to the reproductive system.
The plant is used in poosai to represent a form of Kottravai who is said to reside on this plant as herself. The plant is used as a component of navapatrika along with plantain (Banana), Kachvi or Kacci or kochu or Taro, jayanti/ Barley, wood apple (Bilva), pomegranate (darimba), Asoka, manaka or Manakochu and rice paddy or Dhanya.
It is used in poosai to make a form of Ganesha. Yaanaimugathaan, the remover of obstacles, is invoked at the beginning of almost any ceremony and a form of Yaanaimugathaan for this purpose is made by mixing turmeric with water and forming it into a cone-like shape.
Gaye holud (literally "yellow on the body") is a ceremony observed mostly in the region of Bengal (comprising Bangladesh and Indian West Bengal). The gaye holud takes place one or two days before the religious and legal Bengali wedding ceremonies. The turmeric paste is applied by friends to the bodies of the couple. This is said to soften the skin, but also colors them with the distinctive yellow hue that gives its name to this ceremony. It may be a joint event for the bride and groom's families, or it may consist of separate events for the bride's family and the groom's family.
During the Tamil festival Pongal, a whole turmeric plant with fresh rhizomes is offered as a thanksgiving offering to Suryan, the Sun god. Also, the fresh plant sometimes is tied around the sacred Pongal pot in which an offering of pongal is prepared.
In Tamil nadu, as a part of the Tamil marriage ritual, dried turmeric tuber tied with string is used temporarily or permanently as opposed to the Mangalasutra of Hindus in India . The Tamil Marriage act recognizes this custom. Thali necklace is the equivalent of marriage rings in western cultures. In western and coastal India, during weddings of the Marathi and Konkani people, Kannada Brahmins turmeric tubers are tied with strings by the couple to their wrists during a ceremony called Kankanabandhana.[36]
Modern Neopagans list it with the quality of fire, and it is used for power and purification rites.[citation needed]
Friedrich Ratzel in The History of Mankind reported in 1896 that in Micronesia the preparation of turmeric powder for embellishment of body, clothing and utensils had a highly ceremonial character.[37] He quotes an example of the roots being ground by four to six women in special public buildings and then allowed to stand in water. The following morning, three young coconuts and three old soma nuts are offered by a priestess with prayer, after which the dye which has settled down in the water is collected, baked into cakes in coconut molds, wrapped in banana leaves, and hung up in the huts till required for use.
References
"Curcuma longa information from NPGS/GRIN". ars-grin.gov.
Chan, E.W.C. et al.; Lim, Y.Y.; Wong, S.K.; Lim, K.K.; Tan, S.P.; Lianto, F.S.; Yong, M.Y. (2009). "Effects of different drying methods on the antioxidant properties of leaves and tea of ginger species". Food Chemistry 113 (1): 166–172. doi:10.1016/j.foodchem.2008.07.090.
Materia Indica, 1826, Whitelaw Ainslie, M.D. M.R.A.S., via Google Books
Indian Spices. "Turmeric processing". kaubic.in.
a b Nagpal M, Sood S (2013). "Role of curcumin in systemic and oral health: An overview". J Nat Sci Biol Med 4 (1): 3–7. doi:10.4103/0976-9668.107253. PMC 3633300. PMID 23633828.
Tahira JJ et al (2010). "Weed flora of Curcuma longa". Pakistan J Weed Sci Res 16 (2): 241–6.
Dictionary.com Unabridged Based on the Random House Dictionary, © Random House, Inc. 2013. "Turmeric". Dictionary.com. 2012.
"Trade Related Intellectual Property Rights (TRIPs) and Farmers' Rights".
Royal Botanical Gardens, UK. "Turmeric – History". Plant Cultures. Royal Botanical Gardens.
Chattopadhyay, Ishita; Kaushik Biswas, Uday Bandyopadhyay, and Ranajit K. Banerjee (10 July 2004). "Turmeric and curcumin: Biological actions and medicinal applications". Current Science (Indian Academy of Sciences) 87 (1): 44–53. ISSN 0011-3891.
a b "Herbs at a Glance: Turmeric, Science & Safety". National Center for Complementary and Alternative Medicine (NCCAM), National Institutes of Health. 2012.
Curcuma longa A Modern Herbal, M Grieve.
Curcuma longa Linn. Description from Flora of China , South China Botanical Garden.
Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL (2006). "Curcumin content of turmeric and curry powders". Nutr Cancer 55 (2): 126–131. doi:10.1207/s15327914nc5502_2. PMID 17044766.
Is it Turmeric or Saffron?
Chaturvedi TP (2009). "Uses of turmeric in dentistry: an update". Indian J Dent Res 20 (1): 107–109. PMID 19336870.
Khalsa SVK. "Turmeric, The Golden Healer". healthy.net.
Prerna Singh (pp-19,2012). The Everything Indian Slow Cooker Cookbook. Google books.
Aggarwal BB, Sundaram C, Malani N, Ichikawa H (2007). "Curcumin: the Indian solid gold". Adv Exp Med Biol 595 (1): 1–75. doi:10.1007/978-0-387-46401-5_1. PMID 17569205.
Evans A (27 January 2012). "The amazing health benefits of turmeric". mother nature network. MNN Holdings, LLC.
"Turmeric". American Cancer Society. 7 December 2012.
"Clinical trials on turmeric". National Institutes of Health, Clinical Trials Registry. December 2013.
Mishra S, Palanivelu K (Jan–March, 2008). "The effect of curcumin (turmeric) on Alzheimer's disease: An overview". Ann Indian Acad Neurol 11 (1): 13–9. doi:10.4103/0972-2327.40220. PMC 2781139. PMID 19966973.
Boaz M, Leibovitz E, Bar Dayan Y, Wainstein J (2011). "Functional foods in the treatment of type 2 diabetes: olive leaf extract, turmeric and fenugreek, a qualitative review". Func Foods Health Dis 1 (11): 472–81.
Henrotin Y, Clutterbuck AL, Allaway D, et al. (February 2010). "Biological actions of curcumin on articular chondrocytes". Osteoarthr. Cartil. 18 (2): 141–9. doi:10.1016/j.joca.2009.10.002. PMID 19836480.
Gregory PJ, Sperry M, Wilson AF (January 2008). "Dietary supplements for osteoarthritis". Am Fam Physician 77 (2): 177–84. PMID 18246887.
"Health effects of Turmeric". Health effects of Herbs. University of Maryland Medical Center.
a b Singletary, K (2010). Potential Health Benefits of Turmeric. MSI.
Maitra, Anirban; Saraswati kumar (16 July 2013). "A Simple Spice That May Battle Cancer". John Hopkins Medicine. Summer 2013 (21).
Hylind, Linda. "Johns Hopkins Gazette reports on their study on turmeric". Chemicals in Curry and Onions May Help Stop Colon Cancer. American Cancer Society and National Institutes of Health.
Liu, Kai; Zhang, Datong; Chojnacki, Jeremy; Du, Yuhong; Fu, Haian; Grant, Steven; Zhang, Shijun (2013). "Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma". Organic & Biomolecular Chemistry 11 (29): 4757. doi:10.1039/C3OB40595H. PMID 23784627.
Ragasa C, Laguardia M, Rideout J (2005). "Antimicrobial sesquiterpenoids and diarylheptanoid from Curcuma domestica". ACGC Chem Res Comm 18 (1): 21–24.
http://www.ncbi.nlm.nih.gov/pubmed/20153625
Brennan, James (15 Oct 2008). "Turmeric". Lifestyle. The National.
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Ratzel, Friedrich. The History of Mankind. (London: MacMillan, 1896). URL: www.inquirewithin.biz/history/american_pacific/oceania/oceania-utensils.htm acces
Curcumin
Enol
form
Keto form
Enol
form
Keto formSkeletal formula
Enol form
Skeletal formula
Keto form
Ball-and-stick model
Ball-and-stick model
IUPAC name[hide]
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Other names[hide]
Diferuloylmethane; curcumin I; C.I. 75300; Natural Yellow 3
Identifiers
CAS number 458-37-7 Yes
PubChem 969516
ChemSpider 839564 Yes
UNII IT942ZTH98 Yes
ChEBI CHEBI:3962 Yes
ChEMBL CHEMBL116438
Molecular formula C21H20O6
Molar mass 368.38 g mol-1
Appearance Bright yellow-orange powder
Melting point 183 °C; 361 °F; 456 K
Curcumin (pronounced "Kur kyoo min")[1] is a diarylheptanoid. It is the principal curcuminoid of the popular South Asian spice turmeric, which is a member of the ginger family (Zingiberaceae). Turmeric's other two curcuminoids are desmethoxycurcumin and bis-desmethoxycurcumin. The curcuminoids are natural phenols that are responsible for the yellow color of turmeric. Curcumin can exist in several tautomeric forms, including a 1,3-diketo form and two equivalent enol forms. The enol form is more energetically stable in the solid phase and in solution.[2]
Curcumin can be used for boron quantification in the curcumin method. It reacts with boric acid to form a red-colored compound, rosocyanine.
Curcumin is brightly yellow colored and may be used as a food coloring. As a food additive, its E number is E100.[3]
Chemistry
Curcumin incorporates several functional groups. The aromatic ring systems, which are phenols, are connected by two a,ß-unsaturated carbonyl groups. The diketones form stable enols and are readily deprotonated to form enolates; the a,ß-unsaturated carbonyl group is a good Michael acceptor and undergoes nucleophilic addition. The structure was first identified in 1910 by J. Milobedzka, Stanislaw Kostanecki and Wiktor Lampe.[4]
Curcumin is used as an indicator for boron.[5]
Biosynthesis
The biosynthetic route of curcumin has proven to be very difficult for researchers to determine. In 1973 Roughly and Whiting proposed two mechanisms for curcumin biosynthesis. The first mechanism involved a chain extension reaction by cinnamic acid and 5 malonyl-CoA molecules that eventually arylized into a curcuminoid. The second mechanism involved two cinnamate units being coupled together by malonyl-CoA. Both mechanisms use cinnamic acid as their starting point, which is derived from the amino acid phenylalanine. This is noteworthy because plant biosyntheses employing cinnamic acid as a starting point are rare compared to the more common use of p-coumaric acid.[6] Only a few identified compounds, such as anigorufone and pinosylvin, use cinnamic acid as their start molecule.[7][8] An experimentally backed route was not presented until 2008. This proposed biosynthetic route follows both the first and second mechanisms suggested by Roughley and Whiting. However, the labeling data supported the first mechanism model in which 5 malonyl-CoA molecules react with cinnamic acid to form curcumin. However, the sequencing in which the functional groups, the alcohol and the methoxy, introduce themselves onto the curcuminoid seems to support more strongly the second proposed mechanism.[6] Therefore, it was concluded the second pathway proposed by Roughly and Whiting was correct.
Biosynthetic pathway of curcumin in Curcuma longa.[6]
Preliminary research for potential health effects
Research has identified curcumin as the agent responsible for most of the biological activity of turmeric.[9]
Laboratory research shows that curcumin is a pleiotropic molecule possibly capable of interacting with molecular targets involved in inflammation.[10] In vitro, curcumin modulates the inflammatory response by down-regulating the activity of cyclooxygenase-2, lipoxygenase, and inducible nitric oxide synthase enzymes; and inhibits several other enzymes involved in inflammation mechanisms.[11][12]
A systematic review of the use of curcumin based supplements for treating diabetic wounds found no significant positive outcome for human use.[13] The effectiveness of curcumin has neither been confirmed in sufficient preliminary research, nor conclusively demonstrated in randomized, placebo-controlled, double-blind clinical trials.[14]
A survey of the literature shows a number of other potential uses and that daily doses over a 3-month period of up to 12 grams proved safe.[15]
Clinical trials in humans are studying the effect of curcumin on various diseases, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis, arthritis and Alzheimer's disease.[16][17][18][19] A number of trials studying curcumin efficacy and safety revealed poor absorption and low bioavailability. Methods to possibly increase absorption and systemic bioavailability are under study, including combined administration with piperine and quercetin.[20]
Curcumin has also been shown to be a vitamin D receptor ligand "with implications for colon cancer chemoprevention." [21]
Bioavailability
In Phase I clinical trials, dietary curcumin was shown to exhibit poor bioavailability (i.e., low levels in plasma and tissues).[22] Potential factors that limit the bioavailability of curcumin include poor absorption, rapid metabolism, and rapid systemic elimination. Numerous approaches to increasing curcumin bioavailability have been explored, including the use of adjuvants like piperine.[22]
The bioavailability of curcumin ingested in foods may be increased as a result of cooking or dissolution in oil.[23]
Resistance
Overexpression of the ATP-binding cassette gene ABCA1 has been reported to confer resistance to curcumin in terms of NFkappaB activation that can be reversed by ABCA1 silencing.[24]
Potential risks and side effects
Kawanishi et al. remarked that curcumin, like many antioxidants, can be a "double-edged sword" where, in the test tube, carcinogenic and pro-oxidant effects may be seen in addition to anticancer and antioxidant effects.[25] Carcinogenic effects are inferred from interference with the p53 tumor suppressor pathway, an important factor in human colon cancer.[26] In vitro and in vivo studies suggest that curcumin can have carcinogenic effects.[27][28][29]
Clinical studies in humans with high doses (2–12 grams) of curcumin have shown few side effects, with some subjects reporting mild nausea or diarrhea.[30] More recently, curcumin was found to alter iron metabolism by chelating iron and suppressing the protein hepcidin, potentially causing iron deficiency in susceptible patients.[31] Further studies seem to be necessary to establish the benefit/risk profile of curcumin.[27]
There is no or little evidence to suggest curcumin is either safe or unsafe for pregnant women. However, there is still some concern medicinal use of products containing curcumin could stimulate the uterus, which may lead to a miscarriage, although there is not much evidence to support this claim. According to experiments done on rats and guinea pigs, there is no obvious effect (neither positive, nor negative) on the pregnancy rate or number of live or dead embryos.[32] Curcumin has embryotoxic and teratogenic effects on zebrafishes (Danio rerio) embryos.[33]
References
Notes
Dorland (2011-06-09). Dorland's Illustrated Medical Dictionary, 32nd Edition. ISBN 1455709859. Retrieved May 19, 2013. Published 2011.
Kolev, Tsonko M.; Velcheva, Evelina A.; Stamboliyska, Bistra A.; Spiteller, Michael (2005). "DFT and experimental studies of the structure and vibrational spectra of curcumin". International Journal of Quantum Chemistry 102 (6): 1069–79. doi:10.1002/qua.20469.
Food Standards Australia New Zealand. "Food Additives- Numerical List". Retrieved 2009-12-02.
Milob?dzka, J.; v. Kostanecki, St.; Lampe, V. (1910). "Zur Kenntnis des Curcumins". Berichte der deutschen chemischen Gesellschaft 43 (2): 2163–70. doi:10.1002/cber.191004302168.
"EPA Method 212.3: Boron (Colorimetric, Curcumin)".
a b c Kita, Tomoko; Imai, Shinsuke; Sawada, Hiroshi; Kumagai, Hidehiko; Seto, Haruo (2008). "The Biosynthetic Pathway of Curcuminoid in Turmeric (Curcuma longa) as Revealed by 13C-Labeled Precursors". Bioscience, Biotechnology, and Biochemistry 72 (7): 1789. doi:10.1271/bbb.80075.
Schmitt, Bettina; Hölscher, Dirk; Schneider, Bernd (2000). "Variability of phenylpropanoid precursors in the biosynthesis of phenylphenalenones in Anigozanthos preissii". Phytochemistry 53 (3): 331–7. doi:10.1016/S0031-9422(99)00544-0. PMID 10703053.
Gehlert, R.; Schoeppner, A.; Kindl, H. (1990). "Stilbene Synthase from Seedlings of Pinus sylvestris: Purification and Induction in Response to Fungal Infection" (pdf). Molecular Plant-Microbe Interactions 3 (6): 444–449. doi:10.1094/MPMI-3-444.
Aggarwal, Bharat B.; Sundaram, Chitra; Malani, Nikita; Ichikawa, Haruyo (2007). "Curcumin: the Indian solid gold". Advances in Experimental Medicine and Biology. Advan Exp Med Biol 595: 1–75. doi:10.1007/978-0-387-46401-5_1. ISBN 978-0-387-46400-8. PMID 17569205.
Gupta SC et al. (2011). "Multitargeting by curcumin as revealed by molecular interaction studies". Nat Prod Rep 28 (12): 1937–55. doi:10.1039/c1np00051a. PMC 3604998. PMID 21979811.
Abe Y, Hashimoto S, Horie T (1999). "Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages". Pharmacol Res 39 (1): 41–7. doi:10.1006/phrs.1998.0404. PMID 10051376.
Goel A, Kunnumakkara AB, Aggarwal BB (2008). "Curcumin as "Curecumin": from kitchen to clinic". Biochem Pharmacol 75 (4): 787–809. doi:10.1016/j.bcp.2007.08.016. PMID 17900536.
Maier, HM; Ilich, JZ; Kim, JS; Spicer, MT (2013). "Nutrition supplementation for diabetic wound healing: A systematic review of current literature". Skinmed 11 (4): 217–24; quiz 224–5. PMID 24053007.
Mancuso, C.; Barone, E. (2009). "Curcumin in clinical practice: myth or reality?". Trends in Pharmacological Science 30 (7): 333–334. doi:10.1016/j.tips.2009.04.004. PMID 19523696.
Goel, Ajay; Kunnumakkara, Ajaikumar B.; Aggarwal, Bharat B. (2008). "Curcumin as "Curecumin": From kitchen to clinic". Biochemical Pharmacology 75 (4): 787–809. doi:10.1016/j.bcp.2007.08.016. PMID 17900536. "Pilot phase I clinical trials have shown curcumin to be safe even when consumed at a daily dose of 12g for 3 months."
Hatcher, H.; Planalp, R.; Cho, J.; Torti, F. M.; Torti, S. V. (2008). "Curcumin: From ancient medicine to current clinical trials". Cellular and Molecular Life Sciences 65 (11): 1631–52. doi:10.1007/s00018-008-7452-4. PMID 18324353.
Yan, Jiao; Wilkinson, Di, Wang, Hatcher, Kock, D'Agostino, Jr, Knovich, Torti, Torti corresponding author (8 January 2009). "Red Cells, Iron, and Erythropoiesis Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator". Blood. 113(2): (Prepublished online 2008 September 24.): 462–469. doi:10.1182/blood-2008-05-155952. PMC 2615657. PMID 18815282.
"ClinicalTrials.gov: Current clinical trials on curcumin". US National Institutes of Health, Clinical Trial Registry. 2013.
Zhao, LN.; Chiu, SW.; Benoit, J.; Chew, LY.; Mu, Y. (Jun 2012). "The effect of curcumin on the stability of Aß dimers". J Phys Chem B 116 (25): 7428–35. doi:10.1021/jp3034209. PMID 22690789.
Shehzad A et al. (2010). "Curcumin therapeutic promises and bioavailability in colorectal cancer". Drugs of Today 46 (7): 523–32. doi:10.1358/dot.2010.46.7.1509560. PMID 20683505.
Bartik, L; Whitfield, GK; Kaczmarska, M; Lowmiller, CL; Moffet, EW; Furmick, JK; Hernandez, Z; Haussler, CA; Haussler, MR; Jurutka, PW (2010). "Curcumin: A novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention". The Journal of nutritional biochemistry 21 (12): 1153–61. doi:10.1016/j.jnutbio.2009.09.012. PMC 2891903. PMID 20153625.
a b Anand, P.; Kunnumakkara, A. B.; Newman, R. A.; Aggarwal, B. B. (2007). "Bioavailability of curcumin: problems and promises". Molecular Pharmaceutics 4 (6): 807–818. doi:10.1021/mp700113r. PMID 17999464.
Marczylo, T. H.; Verschoyle, R. D.; Cooke, D. N.; Morazzoni, P.; Steward, W. P.; Gescher, A. J. (2007). "Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine". Cancer Chemotherapy and Pharmacology 60 (2): 171–177. doi:10.1007/s00280-006-0355-x. PMID 17051370.
Bachmeier BE, Iancu CM, Killian PH, Kronski E, Mirisola V, Angelini G, et al. (2009). "Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells". Mol Cancer 8: 129–141. doi:10.1186/1476-4598-8-129. PMC 2804606. PMID 20030852.
Kawanishi, S.; Oikawa, S.; Murata, M. (2005). "Evaluation for safety of antioxidant chemopreventive agents". Antioxidants & Redox Signaling 7 (11–12): 1728–1739. doi:10.1089/ars.2005.7.1728. PMID 16356133.
Moos, P. J.; Edes, K.; Mullally, J. E.; Fitzpatrick, F. A. (2004). "Curcumin impairs tumor suppressor p53 function in colon cancer cells". Carcinogenesis 25 (9): 1611–1617. doi:10.1093/carcin/bgh163. PMID 15090465.
a b Burgos-Moron, E.; Calderón-Montaño, J. M.; Salvador, J.; Robles, A.; López-Lázaro, M. (2010). "The dark side of curcumin" (pdf). International Journal of Cancer 126 (7): 1771–1775. doi:10.1002/ijc.24967. PMID 19830693.
Dance-Barnes, S. T.; Kock, N. D.; Moore, J. E.; Lin, E. Y.; Mosley, L. J., et al. (2009). "Lung tumor promotion by curcumin". Carcinogenesis 30 (6): 1016–1023. doi:10.1093/carcin/bgp082. PMC 2691137. PMID 19359593.
López-Lázaro, M.; Kock, N. D.; Moore, J. E.; Lin, E. Y.; Mosley, L. J., et al. (2008). "Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent". Molecular Nutrition and Food Research 52 (Supplement 1): S103–S127. doi:10.1002/mnfr.200700238. PMID 18496811.
Hsu, C. H.; Cheng, A. L. (2007). "Clinical studies with curcumin". Advances in Experimental Medicine and Biology. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY 595: 471–480. doi:10.1007/978-0-387-46401-5_21. ISBN 978-0-387-46400-8. PMID 17569225.
Jiao, Y.; Wilkinson, J.; Di, X.; Wang, W.; Hatcher, H., et al. (January 2009). "Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator". Blood 113 (2): 462–469. doi:10.1182/blood-2008-05-155952. PMC 2615657. PMID 18815282.
Vijayalaxmi (1980). "Genetic effects of turmeric and curcumin in mice and rats". Mutation Research 79 (2): 125–132. doi:10.1016/0165-1218(80)90080-4. PMID 7432370.
Wu, J. Y.; Lin, C. Y.; Lin, T. W.; Ken, C. F.; Wen, Y. D. (2007). "Curcumin Affects Development of Zebrafish Embryo". Biol. Pharm. Bull 30 (7): 1336–1339. doi:10.1248/bpb.30.1336. PMID 17603177.
See also: Esatbeyoglu, Tuba; Huebbe, Patricia; Ernst, Insa M. A.; Chin, Dawn, et al.; Wagner, Anika E.; Rimbach, Gerald (2012). "Curcumin-From Molecule to Biological Function". Angewandte Chemie International Edition 51 (22): 5308. doi:10.1002/anie.201107724.
External links
Turmeric
Overview
Turmeric (Curcuma longa) has been used for 4,000 years to treat a variety of conditions. Studies show that turmeric may help fight infections and some cancers, reduce inflammation, and treat digestive problems, and it has gotten a lot of press lately.
But remember several facts when you hear news reports about turmeric. First, many studies have taken place in test tubes and animals, and turmeric may not work as well in humans. Second, some studies have used an injectable form of curcumin, the active substance in turmeric. Finally, some of the studies show conflicting evidence.
Turmeric is widely used in cooking and gives Indian curry its flavor and yellow color. It is also used in mustard and to color butter and cheese. Turmeric has been used in both Ayurvedic and Chinese medicine as an anti-inflammatory, to treat digestive and liver problems, skin diseases, and wounds.
Curcumin is also a powerful antioxidant. Antioxidants scavenge molecules in the body known as free radicals, which damage cell membranes, tamper with DNA, and even cause cell death. Antioxidants can fight free radicals and may reduce or even help prevent some of the damage they cause.
In addition, curcumin lowers the levels of two enzymes in the body that cause inflammation. It also stops platelets from clumping together to form blood clots.
Research suggests that turmeric may be helpful for the following conditions:
Indigestion or Dyspepsia
Curcumin stimulates the gallbladder to produce bile, which some people think may help improve digestion. The German Commission E, which determines which herbs can be safely prescribed in Germany, has approved turmeric for digestive problems. And one double-blind, placebo-controlled study found that turmeric reduced symptoms of bloating and gas in people suffering from indigestion.
Ulcerative colitis
Turmeric may help people with ulcerative colitis stay in remission. Ulcerative colitis is a chronic disease of the digestive tract where symptoms tend to come and go. In one double-blind, placebo-controlled study, people whose ulcerative colitis was in remission took either curcumin or placebo, along with conventional medical treatment, for 6 months. Those who took curcumin had a relapse rate much lower than those who took placebo.
Stomach Ulcers
Turmeric does not seem to help treat stomach ulcers. In fact, there is some evidence that it may increase stomach acid, making existing ulcers worse. (See "Precautions" section.)
Osteoarthritis
Because of its ability to reduce inflammation, researchers have wondered if turmeric may help relieve osteoarthritis pain. One study found that people using an Ayurvedic formula of herbs and minerals with turmeric, winter cherry (Withinia somnifera), boswellia (Boswellia serrata), and zinc had less pain and disability. But it’s impossible to know whether it was turmeric or one of the other supplements -- or all of them together -- that was responsible.
Heart Disease
Early studies suggested that turmeric may help prevent atherosclerosis, the buildup of plaque that can block arteries and lead to heart attack or stroke. In animal studies, an extract of turmeric lowered cholesterol levels and kept LDL "bad" cholesterol from building up in blood vessels. Because it stops platelets from clumping together, turmeric may also prevent blood clots from building up along the walls of arteries. But a double-blind, placebo-controlled study found that taking curcumin, the active ingredient in turrmeric, at a dose of up to 4 g per day did not improve cholesterol levels.
Cancer
There has been a great deal of research on turmeric's anti-cancer properties, but results are still very early. Evidence from test tube and animal studies suggests that curcumin may help prevent or treat several types of cancers, including prostate, breast, skin, and colon cancer. Its preventive effects may be because it is a strong antioxidant, protecting cells from damage. More research is needed. Cancer should be treated with conventional medications. Don’t use alternative therapies alone to treat cancer. If you choose to use complementary therapies along with your cancer treatment, make sure you tell all your doctors.
Bacterial and Viral Infections
Test tube and animal studies suggest turmeric may kill bacteria and viruses. But researchers don’t know whether it would work in people.
Uveitis
A preliminary study suggests curcumin may help treat uveitis, an inflammation of the eye’s iris. In one study of 32 people with chronic anterior uveitis, curcumin was effective as corticosteroids, the type of medication usually prescribed. More research is needed.
Plant Description
A relative of ginger, turmeric is a perennial plant that grows 5 - 6 feet high in the tropical regions of Southern Asia, with trumpet-shaped, dull yellow flowers. Its roots are bulbs that also produce rhizomes, which then produce stems and roots for new plants. Turmeric is fragrant and has a bitter, somewhat sharp taste. Although it grows in many tropical locations, the majority of turmeric is grown in India, where it is used as a main ingredient in curry.
Parts Used
The roots, or rhizomes and bulbs, are used in medicine and food. They are generally boiled and then dried, turning into the familiar yellow powder. Curcumin, the active ingredient, has antioxidant properties. Other substances in this herb have antioxidant properties as well.
Available Forms
Turmeric is available in the following forms:
Capsules containing powder
Fluid extract
Tincture
Because bromelain increases the absorption and anti-inflammatory effects of curcumin, it is often combined with turmeric products.
How to Take It
Pediatric
Turmeric supplements haven’t been studied in children, so there is no recommended dose.
Adult
The following are doses recommended for adults:
Cut root: 1.5 - 3 g per day
Dried, powdered root: 1 - 3 g per day
Standardized powder (curcumin): 400 - 600 mg, 3 times per day
Fluid extract (1:1) 30 - 90 drops a day
Tincture (1:2): 15 - 30 drops, 4 times per day
Precautions
The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, can trigger side effects and may interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider.
Turmeric in food is considered safe.
Turmeric and curcumin supplements are considered safe when taken at the recommended doses. However, taking large amounts of turmeric for long periods of time may cause stomach upset and, in extreme cases, ulcers. People who have gallstones or obstruction of the bile passages should talk to their doctor before taking turmeric.
If you have diabetes, talk to your doctor before taking turmeric supplements. Turmeric may lower blood sugar levels, and when combined with medications for diabetes could cause hypoglycemia (low blood sugar).
Although it is safe to eat foods with turmeric, pregnant and breastfeeding women should not take turmeric supplements.
Because turmeric may act like a blood-thinner, you should stop taking it at least 2 weeks before surgery. Tell your doctor and surgeon that you have been taking turmeric.
Possible Interactions
If you are being treated with any of the following medications, you should not use turmeric or curcumin in medicinal forms without first talking to your health care provider.
Blood-thinning Medications -- Turmeric may make the effects of these drugs stronger, raising the risk of bleeding. Blood-thinners include warfarin (Coumadin), clopidogrel (Plavix), and aspirin, among others.
Drugs that reduce stomach acid -- Turmeric may interfere with the action of these drugs, increasing the production of stomach acid:
Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Esomeprazole (Nexium)
Omeprazole
Lansoprazole (Prevacid)
Diabetes Medications -- Turmeric may make the effects of these drugs stronger, increasing the risk of hypoglycemia (low blood sugar).
Supporting Research
Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
Asai A, Miyazawa T. Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr. 2001;131(11):2932-2935.
Baum L, et al. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res. 2007;56(6):509-14.
Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:379-384.
Curcuma longa (turmeric). Monograph. Altern Med Rev. 2001;6 Suppl:S62-S66.
Darvesh AS, Aggarwal BB, Bishayee A. Curcumin and Liver Cancer: A Review. Curr Pharm Biotechnol. 2011 Apr 5. [Epub ahead of print]
Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Ghaffar A, Mayer EP. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol. 2007 Mar 1 [Epub ahead of print]
Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate. 2001;47(4):293-303.
Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate cancer. II. Curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein. Mol Urol. 2000;4(1):1-6.
Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, et al. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006 Nov;54(11):3452-64.
Gautam SC, Gao X, Dulchavsky S. Immunodilation by curcumin. Adv Exp Med Biol. 2007;595:321-41.
Gescher A J, Sharma R A, Steward W P. Cancer chemoprevention by dietary constituents: a tale of failure and promise. Lancet Oncol. 2001;2(6):371-379.
Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol. 2008;75(4):787-809.
Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.
Handler N, Jaeger W, Puschacher H, Leisser K, Erker T. Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. Chem Pharm Bull (Tokyo). 2007 Jan;55(1):64-71.
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57(13):1221-1227.
Jagetia GC, Aggarwal BB. "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007;27(1):19-35.
Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007 Apr 18; [Epub ahead of print]
Kim MS, Kang HJ, Moon A. Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells. Arch Pharm Res. 2001;24(4):349-354.
Krishnaswamy K. Traditional Indian spices and their health significance. Asia Pac J Clin Nutr. 2008;17 Suppl 1:265-8.
Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem. 2008;114(2):127-49.
Phan TT, See P, Lee ST, Chan SY. Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. J Trauma 2001;51(5):927-931.
Rakel D. Rakel: Integrative Medicine, 2nd ed. Philadelphia, PA: Saunders; 2008;80.
Rao CV. Regulation of COX and LOX by curcumin. Adv Exp Med Biol. 2007;595:213-26.
Sharma RA, Ireson CR, Verschoyle RD. Effects of dietary curcumin on glutathione S-Transferase and Malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels. Clin Cancer Res. 2001;7:1452-1458.
Sharma RA, Steward WP, Gescher AJ. Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol. 2007;595:453-70.
Shehzad A, Khan S, Shehzad O, Lee YS. Curcumin therapeutic promises and bioavailability in colorectal cancer. Drugs Today (Barc). 2010 Jul;46(7):523-32. Review.
Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol. 2007;595:127-48.
Su CC, Lin JG, Li TM, Chung JG, Yang JS, Ip SW, et al. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res. 2006 Nov-Dec;26(6B):4379-89.
Suryanarayana P, Satyanarayana A, Balakrishna N, Kumar PU, Reddy GB. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med Sci Monit. 2007;13(12):BR286-92.
White B, Judkins DZ. Clinical Inquiry. Does turmeric relieve inflammatory conditions? J Fam Pract. 2011 Mar;60(3):155-6. Review.
Zafir A, Banu N. Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats.
Eur J Pharmacol. 2007;572(1):23-31.
Turmeric (Curcuma longa) has been used for 4,000 years to treat a variety of conditions. Studies show that turmeric may help fight infections and some cancers, reduce inflammation, and treat digestive problems, and it has gotten a lot of press lately.
But remember several facts when you hear news reports about turmeric. First, many studies have taken place in test tubes and animals, and turmeric may not work as well in humans. Second, some studies have used an injectable form of curcumin, the active substance in turmeric. Finally, some of the studies show conflicting evidence.
Turmeric is widely used in cooking and gives Indian curry its flavor and yellow color. It is also used in mustard and to color butter and cheese. Turmeric has been used in both Ayurvedic and Chinese medicine as an anti-inflammatory, to treat digestive and liver problems, skin diseases, and wounds.
Curcumin is also a powerful antioxidant. Antioxidants scavenge molecules in the body known as free radicals, which damage cell membranes, tamper with DNA, and even cause cell death. Antioxidants can fight free radicals and may reduce or even help prevent some of the damage they cause.
In addition, curcumin lowers the levels of two enzymes in the body that cause inflammation. It also stops platelets from clumping together to form blood clots.
Research suggests that turmeric may be helpful for the following conditions:
Indigestion or Dyspepsia
Curcumin stimulates the gallbladder to produce bile, which some people think may help improve digestion. The German Commission E, which determines which herbs can be safely prescribed in Germany, has approved turmeric for digestive problems. And one double-blind, placebo-controlled study found that turmeric reduced symptoms of bloating and gas in people suffering from indigestion.
Ulcerative colitis
Turmeric may help people with ulcerative colitis stay in remission. Ulcerative colitis is a chronic disease of the digestive tract where symptoms tend to come and go. In one double-blind, placebo-controlled study, people whose ulcerative colitis was in remission took either curcumin or placebo, along with conventional medical treatment, for 6 months. Those who took curcumin had a relapse rate much lower than those who took placebo.
Stomach Ulcers
Turmeric does not seem to help treat stomach ulcers. In fact, there is some evidence that it may increase stomach acid, making existing ulcers worse. (See "Precautions" section.)
Osteoarthritis
Because of its ability to reduce inflammation, researchers have wondered if turmeric may help relieve osteoarthritis pain. One study found that people using an Ayurvedic formula of herbs and minerals with turmeric, winter cherry (Withinia somnifera), boswellia (Boswellia serrata), and zinc had less pain and disability. But it’s impossible to know whether it was turmeric or one of the other supplements -- or all of them together -- that was responsible.
Heart Disease
Early studies suggested that turmeric may help prevent atherosclerosis, the buildup of plaque that can block arteries and lead to heart attack or stroke. In animal studies, an extract of turmeric lowered cholesterol levels and kept LDL "bad" cholesterol from building up in blood vessels. Because it stops platelets from clumping together, turmeric may also prevent blood clots from building up along the walls of arteries. But a double-blind, placebo-controlled study found that taking curcumin, the active ingredient in turrmeric, at a dose of up to 4 g per day did not improve cholesterol levels.
Cancer
There has been a great deal of research on turmeric's anti-cancer properties, but results are still very early. Evidence from test tube and animal studies suggests that curcumin may help prevent or treat several types of cancers, including prostate, breast, skin, and colon cancer. Its preventive effects may be because it is a strong antioxidant, protecting cells from damage. More research is needed. Cancer should be treated with conventional medications. Don’t use alternative therapies alone to treat cancer. If you choose to use complementary therapies along with your cancer treatment, make sure you tell all your doctors.
Bacterial and Viral Infections
Test tube and animal studies suggest turmeric may kill bacteria and viruses. But researchers don’t know whether it would work in people.
Uveitis
A preliminary study suggests curcumin may help treat uveitis, an inflammation of the eye’s iris. In one study of 32 people with chronic anterior uveitis, curcumin was effective as corticosteroids, the type of medication usually prescribed. More research is needed.
Plant Description
A relative of ginger, turmeric is a perennial plant that grows 5 - 6 feet high in the tropical regions of Southern Asia, with trumpet-shaped, dull yellow flowers. Its roots are bulbs that also produce rhizomes, which then produce stems and roots for new plants. Turmeric is fragrant and has a bitter, somewhat sharp taste. Although it grows in many tropical locations, the majority of turmeric is grown in India, where it is used as a main ingredient in curry.
Parts Used
The roots, or rhizomes and bulbs, are used in medicine and food. They are generally boiled and then dried, turning into the familiar yellow powder. Curcumin, the active ingredient, has antioxidant properties. Other substances in this herb have antioxidant properties as well.
Available Forms
Turmeric is available in the following forms:
Capsules containing powder
Fluid extract
Tincture
Because bromelain increases the absorption and anti-inflammatory effects of curcumin, it is often combined with turmeric products.
How to Take It
Pediatric
Turmeric supplements haven’t been studied in children, so there is no recommended dose.
Adult
The following are doses recommended for adults:
Cut root: 1.5 - 3 g per day
Dried, powdered root: 1 - 3 g per day
Standardized powder (curcumin): 400 - 600 mg, 3 times per day
Fluid extract (1:1) 30 - 90 drops a day
Tincture (1:2): 15 - 30 drops, 4 times per day
Precautions
The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, can trigger side effects and may interact with other herbs, supplements, or medications. For these reasons, you should take herbs with care, under the supervision of a health care provider.
Turmeric in food is considered safe.
Turmeric and curcumin supplements are considered safe when taken at the recommended doses. However, taking large amounts of turmeric for long periods of time may cause stomach upset and, in extreme cases, ulcers. People who have gallstones or obstruction of the bile passages should talk to their doctor before taking turmeric.
If you have diabetes, talk to your doctor before taking turmeric supplements. Turmeric may lower blood sugar levels, and when combined with medications for diabetes could cause hypoglycemia (low blood sugar).
Although it is safe to eat foods with turmeric, pregnant and breastfeeding women should not take turmeric supplements.
Because turmeric may act like a blood-thinner, you should stop taking it at least 2 weeks before surgery. Tell your doctor and surgeon that you have been taking turmeric.
Possible Interactions
If you are being treated with any of the following medications, you should not use turmeric or curcumin in medicinal forms without first talking to your health care provider.
Blood-thinning Medications -- Turmeric may make the effects of these drugs stronger, raising the risk of bleeding. Blood-thinners include warfarin (Coumadin), clopidogrel (Plavix), and aspirin, among others.
Drugs that reduce stomach acid -- Turmeric may interfere with the action of these drugs, increasing the production of stomach acid:
Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Esomeprazole (Nexium)
Omeprazole
Lansoprazole (Prevacid)
Diabetes Medications -- Turmeric may make the effects of these drugs stronger, increasing the risk of hypoglycemia (low blood sugar).
Supporting Research
Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1-75.
Asai A, Miyazawa T. Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr. 2001;131(11):2932-2935.
Baum L, et al. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res. 2007;56(6):509-14.
Blumenthal M, Goldberg A, Brinckmann J. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000:379-384.
Curcuma longa (turmeric). Monograph. Altern Med Rev. 2001;6 Suppl:S62-S66.
Darvesh AS, Aggarwal BB, Bishayee A. Curcumin and Liver Cancer: A Review. Curr Pharm Biotechnol. 2011 Apr 5. [Epub ahead of print]
Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Ghaffar A, Mayer EP. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Regul Integr Comp Physiol. 2007 Mar 1 [Epub ahead of print]
Dorai T, Cao YC, Dorai B, Buttyan R, Katz AE. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate. 2001;47(4):293-303.
Dorai T, Gehani N, Katz A. Therapeutic potential of curcumin in human prostate cancer. II. Curcumin inhibits tyrosine kinase activity of epidermal growth factor receptor and depletes the protein. Mol Urol. 2000;4(1):1-6.
Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, et al. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006 Nov;54(11):3452-64.
Gautam SC, Gao X, Dulchavsky S. Immunodilation by curcumin. Adv Exp Med Biol. 2007;595:321-41.
Gescher A J, Sharma R A, Steward W P. Cancer chemoprevention by dietary constituents: a tale of failure and promise. Lancet Oncol. 2001;2(6):371-379.
Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol. 2008;75(4):787-809.
Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6.
Handler N, Jaeger W, Puschacher H, Leisser K, Erker T. Synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (COX-1) inhibitors. Chem Pharm Bull (Tokyo). 2007 Jan;55(1):64-71.
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57(13):1221-1227.
Jagetia GC, Aggarwal BB. "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007;27(1):19-35.
Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007 Apr 18; [Epub ahead of print]
Kim MS, Kang HJ, Moon A. Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells. Arch Pharm Res. 2001;24(4):349-354.
Krishnaswamy K. Traditional Indian spices and their health significance. Asia Pac J Clin Nutr. 2008;17 Suppl 1:265-8.
Pari L, Tewas D, Eckel J. Role of curcumin in health and disease. Arch Physiol Biochem. 2008;114(2):127-49.
Phan TT, See P, Lee ST, Chan SY. Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. J Trauma 2001;51(5):927-931.
Rakel D. Rakel: Integrative Medicine, 2nd ed. Philadelphia, PA: Saunders; 2008;80.
Rao CV. Regulation of COX and LOX by curcumin. Adv Exp Med Biol. 2007;595:213-26.
Sharma RA, Ireson CR, Verschoyle RD. Effects of dietary curcumin on glutathione S-Transferase and Malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels. Clin Cancer Res. 2001;7:1452-1458.
Sharma RA, Steward WP, Gescher AJ. Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol. 2007;595:453-70.
Shehzad A, Khan S, Shehzad O, Lee YS. Curcumin therapeutic promises and bioavailability in colorectal cancer. Drugs Today (Barc). 2010 Jul;46(7):523-32. Review.
Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol. 2007;595:127-48.
Su CC, Lin JG, Li TM, Chung JG, Yang JS, Ip SW, et al. Curcumin-induced apoptosis of human colon cancer colo 205 cells through the production of ROS, Ca2+ and the activation of caspase-3. Anticancer Res. 2006 Nov-Dec;26(6B):4379-89.
Suryanarayana P, Satyanarayana A, Balakrishna N, Kumar PU, Reddy GB. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med Sci Monit. 2007;13(12):BR286-92.
White B, Judkins DZ. Clinical Inquiry. Does turmeric relieve inflammatory conditions? J Fam Pract. 2011 Mar;60(3):155-6. Review.
Zafir A, Banu N. Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats.
Eur J Pharmacol. 2007;572(1):23-31.
Targeting Cancer Stem Cells by Curcumin and
Clinical Applications.
Yanyan Li, Tao Zhang
Yanyan Li, Tao Zhang
Abstract: Curcumin is a well-known dietary polyphenol derived from the rhizomes of turmeric, an Indian spice. The anticancer effect of curcumin has been demonstrated in many cell and animal studies, and recent research has shown that curcumin can target cancer stem cells (CSCs). CSCs are proposed to be responsible for initiating and maintaining cancer, and contribute to recurrence and drug resistance. A number of studies have suggested that curcumin has the potential to target CSCs through regulation of CSC self-renewal pathways (Wnt/ß-catenin, Notch, Sonic Hedgehog) and specific microRNAs involved in acquisition of epithelial-mesenchymal transition (EMT). The potential impact of curcumin, alone or in combination with other anticancer agents, on CSCs was evaluated as well. Furthermore, the safety and tolerability of curcumin have been well-established by numerous clinical studies. Importantly, the low bioavailability of curcumin has been dramatically improved through the use of structural analogues or special formulations. More clinical trials are underway to investigate the efficacy of this promising agent in cancer chemoprevention and therapy. In this article, we review the effects of curcumin on CSC self-renewal pathways and specific microRNAs, as well as its safety and efficacy in recent human studies. In conclusion, curcumin could be a very promising adjunct to traditional cancer treatments.
http://www.greenmedinfo.com/blog/600-reasons-turmeric-may-be-worlds-most-important-herb
http://www.greenmedinfo.com/substance/turmeric
Turmeric Database
by
Sayer Ji
by
Sayer Ji
[ Condensed Version ]
A combination of artichoke leaf, dandelion root, turmeric root and rosemary essential oil has therapeutic actions in relieving symptoms in functional dyspepsia.
Minerva Gastroenterol Dietol. 2010 Jun;56(2):93-9.
A combination of Saw Palmetto, Nettle, Curcumin and Quercetin significantly improves treatment outcome of prulifloxacin in bacterial prostatitis patients.
Int J Antimicrob Agents. 2009 Jun;33(6):549-53
A complex of curcumin and phosphatidylcholine is effective in reducing the symptoms of ostearthritis.
Altern Med Rev. 2010 Dec;15(4):337-44
A daily dose of 3.6 g curcumin achieves pharmacologically efficacious levels in the colorectum with negligible distribution of curcumin outside the gut.
Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5
.
A multi-herbal product called Protandim has significant antioxidant properties in human subjects.
Arzneimittelforschung. 2006;56(6):387-93
A standardized preparation of curcuminoids compares favorably with atorvastatin on endothelial dysfunction in association with reductions in inflammatory cytokines and markers of oxidative stress.
Drugs R D. 2008;9(4):243-50
An exclusion diet and nutraceutical therapy has significant therapeutic effects in juvenile Crohn's disease.
J Am Coll Nutr. 2009 Jun;28(3):277-85
Bioavailability Study: Piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
Planta Med. 1998 May;64(4):353-6
Bioflavonoid therapy with curcumin and quercetin improves cadaveric renal transplantation in humans.
Transplantation. 2005 Dec 15;80(11):1556-9
Chelidonium and turmeric root extract have a therapeutic effect on upper abdominal pain due to functional disorders of the biliary system.
Med Klin (Munich). 1999 Aug 15;94(8):425-30
Curcuma longa (turmeric) and tinospora cordifolia (guduchi) prevents antibiotic-induced liver damage in patients with tubercolosis.
World J Gastroenterol. 2008 Aug 14;14(30):4753-62
Curcumin acts as an adjuvant to imatinib in decreasing the NO levels and may help in the treatment of CML patients.
J Oncol Pharm Pract. 2011 Aug 15
Curcumin alleviates ethanol-induced oxidative damage in liver cells.
J Ethnopharmacol. 2010 Jan 18
Curcumin and Boswellia serrata are safe and tolerable and helped to improvethe levels of an inflammatory cytokine (IL-6).
J Complement Integr Med. 2013 ;10(1):1-10
Curcumin and capsaicin might represent an alternative approach to protect against vitiligo progression.
Antioxid Redox Signal. 2010 Jan 19
Curcumin appears safe and effective in maintaining remission in patients with quiescent ulcerative colitis.
Clin Gastroenterol Hepatol. 2006 Dec;4(12):1502-6
Curcumin appears to enhance clearance of amyloid-beta in Alzheimer's disease patients.
J Alzheimers Dis. 2006 Sep;10(1):1-7
Curcumin compares favorably with corticosteroid therapy in the management of chronic anterior uveitis.
Phytother Res. 1999 Jun;13(4):318-22
Curcumin exhibits anti-pre-cancer activity by increasing levels of vitamins C and E, and preventing lipid peroxidation and DNA damage.
J Oral Sci. 2010;52(2):251-6
Curcumin has a contractive effect on human gallbladder function.
J Bras Pneumol. 2006 Jan-Feb;32(1):66-74
Curcumin has anti-inflammatory properties in patients with postoperative inflammation.
Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):651-4
Curcumin has gall-bladder emptying properties.
Asia Pac J Clin Nutr. 2002;11(4):314-8
Curcumin has potential in the treatment of plasma cell dyscrasias.
Biologics. 2008 Mar;2(1):161-3
Curcumin has significant therapeutic activity in patients with pancreatic cancer.
Clin Cancer Res. 2008 Jul 15;14(14):4491-9
Curcumin has therapeutic effects in idiopathic inflammatory orbital pseudotumours.
Phytother Res. 2000 Sep;14(6):443-7
Curcumin has therapeutic value in patients with monoclonal gammopathy, a possible precursor to multiple myeloma.
Clin Cancer Res. 2009 Sep 15;15(18):5917-22
Curcumin has therapeutic value in the treatment of recurrent anterior uveitis of different etiologies.
Clin Ophthalmol. 2010;4:1201-6
Curcumin improves ulcerative proctitis and Crohn's disease in patient s with inflammatory bowel disease.
Dig Dis Sci. 2005 Nov;50(11):2191-3
Curcumin induces programmed cell death and inhibits proinflammatory prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis.
Int J Mol Med. 2007 Sep;20(3):365-72
Curcumin induces programmed cell death in human malignant gliobastoma cells - Article 2.
Neurosci Lett. 2006 Oct 16;407(1):53-8.
Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women.
Nutr Res. 2012 Oct ;32(10):795-9. Epub 2012 Oct 15
Curcumin is an effective treatment for HIV-associated diarrhea.
Dig Dis Sci. 2009 Oct;54(10):2188-91.
Curcumin is comparable to chlorhexidine as an anti-inflammatory mouthwash. Thus, it can be considered as an effective adjunct to mechanical periodontal therapy.
Oral Health Prev Dent. 2013 ;11(1):81-6.
Curcumin is safe and efficacious in treating major depressive disorder.
Phytother Res. 2013 Jul 6
Curcumin is safe in humans up to 8,000 mg/day when take by mouth for 3 months and has chemopreventive properties.
Anticancer Res. 2001 Jul-Aug;21(4B):2895-900.
Curcumin may enhance the therapeutic effect of gemcitabine in the treatment of advanced pancreatic cancer.
Curr Med Chem. 2009 Nov 24.
Curcumin may increase insulin production in healthy subjects.
Nutr J. 2010;9:43
Curcumin might have the potential to slow the disease process in patients with Monoclonal gammopathy...
Am J Hematol. 2012 May ;87(5):455-60.
Curcumin phytosome has a beneficial effect in diabetic microangiopathy.
Panminerva Med. 2011 Sep ;53(3 Suppl 1):43-9
Curcumin positively modulates blood lipids and reduces lipid peroxidation.
Arch Gerontol Geriatr. 2002 Feb;34(1):37-46
Curcumin protects DNA damage in a chronically arsenic-exposed population of West Bengal.
Hum Exp Toxicol. 2010 Jan 7. Epub 2010 Jan 7
Curcumin reduces arsenic-induced DNA damage in human subjects.
Eur J Cancer Prev. 2011 Mar;20(2):123-31.
Curcumin selectively induces programmed cell death in cutaneous T-cell lymphoma cell lines and in peripheral blood mononuclear cells (PBMCs).
J Invest Dermatol. 2010 Aug;130(8):2110-9
Curcumin suppresses inflammation in the mucosa of children and adults with inflammatory bowel disease.
Br J Nutr. 2009 Nov 2:1-9.
Curcumin suppresses of phosphorylase kinase activity which is correlated to a resolution of psoriasis.
Br J Dermatol. 2000 Nov;143(5):937-49
Curcuminoids may be used to ameliorate oxidative damage in patients with beta-thalassemia/Hb E disease.
Clin Biochem. 2010 Mar;43(4-5):424-9
Curcuminoids reduce the frequency of acute myocardial infarction after coronary artery bypass grafting.
Am J Cardiol. 2012 Jul 1 ;110(1):40-4
Curry consumption improves cognitive function in the elderly.
Am J Epidemiol. 2006 Nov 1;164(9):898-906
Dietary turmeric reduces breath hydrogen indicating it may be of value for treating halitosis.
Dig Dis Sci. 2009 Aug;54(8):1725-9
Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.
Nutr J. 2012 Sep 26 ;11(1):79
Dosage Study: A daily dose of 3.6 g of curcumin engendered 62% and 57% decreases in inducible PGE(2) production in blood samples...
Clin Cancer Res. 2004 Oct 15;10(20):6847-54.
Dosage Study: Turmeric extract can be administered safely to patients at doses of up to 2.2 g daily, equivalent to 180 mg of curcumin.
Clin Cancer Res. 2001 Jul;7(7):1894-900.
Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers.
J Assoc Physicians India. 2003 Nov ;51:1055-60.
Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers.
J Assoc Physicians India. 2003 Nov ;51:1055-60.
Fermented turmeric powder is well-tolerated and effective in subjects with elevated alanine transaminase levels.
BMC Complement Altern Med. 2013 ;13:58
High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus.
J Am Acad Dermatol. 2011 Sep 8
Lactoferrin and curcumin reduce infections in children with recurrent respiratory infections.
J Biol Regul Homeost Agents. 2009 Apr-Jun;23(2):119-24
Neem and Tumeric are a safe and effective topical treatment for scabies.
Trop Geogr Med. 1992 Jan;44(1-2):178-81.
Oral curcumin is safe and feasible in patients with pancreatic cancer.
Cancer Chemother Pharmacol. 2010 Sep 22. Epub 2010 Sep 22. PMID: 20859741
Oral curcumin may have therapeutic activity in the treatment of Déjérine-Sottas disease.
Pediatr Neurol. 2009 Oct;41(4):305-8. PMID: 19748054
Oral curcumin positively modulates blood lipid levels and lipid peroxidation.
Indian J Physiol Pharmacol. 1992 Oct;36(4):273-5. PMID: 1291482
Regular endurance exercise combined with daily curcumin ingestion may reduce LV afterload...
Am J Hypertens. 2012 Jun ;25(6):651-6. Epub 2012 Mar 15. PMID: 22421908
Review: Curcumin has therapeutic potential in multiple sclerosis.
Int Immunopharmacol. 2011 Mar;11(3):323-30. Epub 2010 Sep 8. PMID: 20828641
Safety & Dosage Review: Curcumin.
BMC Complement Altern Med. 2006;6:10. Epub 2006 Mar 17. PMID: 16545122
Soy isoflavones and curcumin suppress PSA levels in human subjects.
Prostate. 2010 Jul 1;70(10):1127-33. PMID: 20503397
The administration of low-dose curcumin showed a trend of reduction in total cholesterol level and LDL cholesterol...
Acta Med Indones. 2008 Oct;40(4):201-10. PMID: 19151449
The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas...
Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8. Epub 2006 Jun 6. PMID: 16757216
Tumeric has an anti-mutagenic activity on urinary mutagens in smokers.
Mutagenesis. 1992 Mar;7(2):107-9. PMID: 1579064
Turmeric and curcumin are therapeutic as topical agents in cancer therapy.
Tumori. 1987 Feb 28;73(1):29-31. PMID: 2435036
Turmeric compares favorably to chlorhexidine gluconate mouthwash in the prevention of plaque formation and gingivitis.
J Contemp Dent Pract. 2011 ;12(4):221-4. Epub 2011 Jul 1. PMID: 22186854
Turmeric extract appears to be as safe and effective as ibuprofen for the treatment of knee osteoarthritis.
Int J Mol Med. 2010 May;25(5):729-34. PMID: 19678780
Turmeric extract supplementation prevents UVB-induced skin aging.
Phytomedicine. 2009 Jul 3. PMID: 19577913
Turmeric may be effective in treating lung diseases.
Adv Exp Med Biol. 2007;595:379-405. PMID: 17569221
Turmeric may improve irritable bowel syndrome.
J Altern Complement Med. 2004 Dec;10(6):1015-8. PMID:15673996
Vitamin D3 and curcuminoids (turmeric) stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients.
J Alzheimers Dis. 2009 Jul;17(3):703-17. PMID: 19433889
Curcumin extract for prevention of type 2 diabetes.
Diabetes Care. 2012 Nov ;35(11):2121-7. Epub 2012 Jul 6. PMID: 22773702
Curcumin has been used to successfully treat infantile hemangioendothelioma of the liver.
Pediatr Blood Cancer. 2010 Aug;55(2):377-9. PMID: 20582974
"A Novel Curcumin-based Vaginal Cream Vacurin Selectively Eliminates Apposed Human Cervical Cancer Cells.:
Gynecol Oncol. 2012 Dec 9. Epub 2012 Dec 9. PMID: 23234806
"Curcumin ameliorates cisplatin-induced nephrotoxicity by inhibiting renal inflammation in mice."
J Biosci Bioeng. 2012 Dec 12. Epub 2012 Dec 12. PMID: 23245727
"Curcumin Attenuates Diabetic Neuropathic Pain by Downregulating TNF-a in a Rat Model."
Int J Med Sci. 2013 ;10(4):377-81. Epub 2013 Feb 20. PMID: 23471081
"Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis."
Biofactors. 2012 Dec 11. Epub 2012 Dec 11. PMID: 23233214
"Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice.'
Brain. 2012 Dec ;135(Pt 12):3551-66. PMID: 23250879
"Curcumin protects against the oxidative damage induced by the pesticide parathion in the hippocampus of the rat brain."
Nutr Neurosci. 2012 Feb 2. Epub 2012 Feb 2. PMID: 22333997
A combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis.
Food Chem Toxicol. 2010 Jan;48(1):390-5. Epub 2009 Oct 25. PMID: 19861145
A combination of nutrients improves cognitive functioning while decreasing Alzheimer disease neuropathology in an animal model.
PLoS One. 2010;5(11):e14015. Epub 2010 Nov 17. PMID: 21103342
A combination of turmeric, clarified butter (ghee) and hyaluronic acid stimulates gingival wound healing following surgery.
J Ethnopharmacol. 2008 Dec 8;120(3):335-41. Epub 2008 Sep 20. PMID: 18929638
A combined dosage of tetrahydrocurcumin and chlorogenic acid protects against experimentally induced type 2 diabetes in rats.
Mol Cell Biochem. 2010 Aug;341(1-2):109-17. Epub 2010 Mar 26. PMID: 20339905
A curcumin complex reduces acute lung injury severity.
Am J Respir Cell Mol Biol. 2012 Feb 3. Epub 2012 Feb 3. PMID: 22312018
A curcumin derivative restores membrane homeostasis disrupted after brain trauma.
Exp Neurol. 2010 Nov;226(1):191-9. Epub 2010 Sep 15. PMID: 20816821
A curcumin-artemisinin combination is effective for malaria.
Antimicrob Agents Chemother. 2006 May;50(5):1859-60. PMID: 16641461
A curcumin-free water extract of turmeric prevents chemically-induced mammary cancer in rats.
Cancer Lett. 1998 Jan 16;123(1):35-40. PMID: 9461015
A curcumin-free water extract of turmeric prevents chemically-induced mammary cancer in rats.
Cancer Lett. 1998 Jan 16;123(1):35-40. PMID: 9461015
A curcumin-phospholipid complex works synergistically to protect the livers of rats following chemical exposure.
Int J Pharm. 2007 Feb 7;330(1-2):155-63. Epub 2006 Sep 23. PMID: 17112692
A fermented turmeric extract exhibits anti-obesity properties.
J Sci Food Agric. 2012 Jan 25. Epub 2012 Jan 25. PMID: 22278718
A multi-herbal product called Protandim exhibits chemopreventive properties in a mouse model of skin cancer.
PLoS One. 2010;5(7):e11902. Epub 2010 Jul 30. PMID: 20689586
A multi-herbal product called Protandim has chemopreventive properties against skin cancer.
PLoS One. 2009;4(4):e5284. Epub 2009 Apr 22. PMID: 19384424
Suppressor Protein p53 Upregulation : CK(163) : AC(105), Vascular Cell Adhesion Molecule-1 Inhibitor : CK(94) : AC(24)
A multi-herbal product called Protandim prevents fibrosis and capillary loss and preserves right ventricular function in rats.
Circulation. 2009 Nov 17;120(20):1951-60. Epub 2009 Nov 2. PMID: 19884466
A poly-herbal formula named Protandim reduces oxidative stress in a mouse model of Duchenne muscular dystrophy.
J Diet Suppl. 2010 Jun 1;7(2):159-178. PMID: 20740052
A polyherbal formula containing Sea buckthorn (H. rhamnoides), Aloe and Turmeric (C. longa) possesses significant wound healing potential in both normal as well as chronic diabetic wounds.
Wound Repair Regen. 2008 Nov-Dec;16(6):784-90. PMID: 19128249
Age may play a significant role in the efficacy of chemoprevention of colon cancer by curcumin.
Nutr Cancer. 2004;48(1):37-43. PMID: 15203376
Aloe vera, turmeric and holy basil suppress the adverse effects associated with maternal fluoride exposure.
Indian J Exp Biol. 2010 Aug;48(8):830-6. PMID: 21341542
Andrographis and Hedyotis corymbosa in combination with curcumin have anti-malaria action.
Phytother Res. 2004 Feb;18(2):164-8. PMID: 19216765
Bioavailability is enhanced with a curcumin-phosphatidylcholine complex.
J Pharm Biomed Anal. 2006 Feb 24;40(3):720-7. Epub 2005 Nov 28. PMID: 16316738
Bioavailability Study: Phosphatidyl choline bound curcumin is superior to curcumin in isolation.
J Pharm Sci. 2011 May;100(5):1987-95. Epub 2010 Nov 24. PMID: 21374628
Boswellic acid and curcumin have chemopreventive properties on chemically-induced oral cancer.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Nov ;46(11):678-83. PMID: 22333308
Both curcumin and its metabolite tetrahydrocurcumin exert neuroprotection against chemically-induced neurotoxicity.
Inflammopharmacology. 2008 Apr;16(2):96-9. PMID: 18408903
Both curcumin and resveratrol show promise as anti-cachexia agents, whereas resveratrol performed better in this study.
Br J Cancer. 2004 Nov 1;91(9):1742-50. PMID: 15477867
Cadmium induced lipid peroxidation is abolished by curcumin treatment in the animal model.
Acta Neurol Scand Suppl. 1994;154:32-41. PMID: 15177643
Capsaicin and curcumin lower levels of an arthritis-associated glycoprotein in the sera of rats.
Mol Cell Biochem. 1997 Apr;169(1-2):125-34. PMID: 9089639
Carrageenan lambda type IV, cineole, curcumin, and eugenol provide significant protection in a mouse model of intravaginal HSV-2 challenge.
Antiviral Res. 1999 Jul;42(3):219-26. PMID: 10443534
Coenzyme Q10 and curcumin administration improves retinal histology by reversing the pathological changes due to chronic methanol...
J Med Assoc Thai. 2012 Apr ;95 Suppl 4:S76-81. PMID: 22696856
Combined curcumin and resveratrol reduces prostate cancer incidence in mice.
Int J Cancer. 2009 Jul 1;125(1):1-8. PMID: 19326431
Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on type 1 diabetic rats.
Gen Physiol Biophys. 2010 Mar;29(1):23-30. PMID: 20371877
Combining curcumin with guar gum may help increase its effectiveness in treating colon cancer.
Drugs Aging. 2007;24(11):945-55. PMID: 20614824
Compounds within turmeric suppress an increase in blood glucose levels in type 2 diabetic mice.
J Agric Food Chem. 2005 Feb 23;53(4):959-63. PMID: 15713005
Consumption of curcumin elevates fecal immunoglobulin A, an index of intestinal immune function, in rats fed a high-fat diet.
J Nutr Sci Vitaminol (Tokyo). 2010;56(1):68-71. PMID: 20354349
Consumption of some polyphenols reduces fecal deoxycholic acid and lithocholic acid, the secondary bile acids of risk factors of colon cancer.
J Agric Food Chem. 2009 Sep 23;57(18):8587-90. PMID: 19711910
Cucuma longa (Turmeric) and Spikenard (N. jatamansi) elevates the HDL-cholesterol/total cholesterol ratio and lowers triglycerides.
Indian J Physiol Pharmacol. 1988 Oct-Dec;32(4):299-304. PMID: 3215683
Cucumin and piperine in combination have a potent antigenotoxic effect...
Toxicol Mech Methods. 2008 Jan;18(9):691-6. PMID: 20020926
Curcumin works synergistically with paclitaxel to inhibit breast cancer in a mouse model.
Breast J. 2009 May-Jun;15(3):223-9. PMID: 19645775
Curcumin (from Turmeric) ameliorates Diabetic Nephropathy in Rats.
Clin Exp Pharmacol Physiol. 2006 Oct;33(10):940-5. PMID: 17002671
Curcumin (from Turmeric) and kolaviron (a compound from the seeds of Garcinia kola) ameliorate phthalate-induced testicular damage in rats.
Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):43-8. PMID: 17214610
Curcumin (from turmeric) and saikosaponin (from Bupleurum) protects against chemically induced liver fibrosis.
J Med Food. 2008 Jun;11(2):224-9. PMID: 18598162
Curcumin (from Turmeric) attenuates pulmonary inflammation and emphysema in mice.
Am J Physiol Lung Cell Mol Physiol. 2009 Apr;296(4):L614-23. Epub 2009 Jan 23. PMID: 19168576
Curcumin (from turmeric) circumvents chemoresistance and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in mice.
Mol Cancer Ther. 2009 Apr;8(4):959-70. PMID: 19372569
Curcumin (from Turmeric) has a protective effect against Middle Cerebral Artery Occlusion (MCAO)
Neurochem Res. 2008 Jun;33(6):1036-43. Epub 2008 Jan 18. PMID: 18204970
Curcumin (from Turmeric) in combination with Piperine may attenuate stress-induced depression.
Pharmacol Biochem Behav. 2008 Oct 25. [Epub ahead of print] PMID: 19000708
Curcumin (from Turmeric) positively modulates the HPA axis and neurotrophin factor expression in chronically stressed animals.
Brain Res. 2006 Nov 29;1122(1):56-64. Epub 2006 Oct 3. PMID: 17022948
Curcumin (from Turmeric) reduces amyloid beta plaque formation in an animal model of Alzheimers disease.
Neurochem Int. 2009 Mar-Apr;54(3-4):199-204. Epub 2008 Nov 30. PMID: 15590663
Curcumin (from Turmeric) reduces oxidative damage and amyloid plaque in a transgenic animal model of Alzheimers.
J Neurosci. 2001 Nov 1;21(21):8370-7. PMID: 11606625
Curcumin (from Turmeric) reduces oxidative injury associated with idiopathic pulmonary fibrosis.
Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(8):669-72. PMID: 16830828
Curcumin (Turmeric) may benefit Multiple Sclerosis by blocking an inflammatory mediator.
J Immunol. 2002 Jun 15;168(12):6506-13. PMID: 12055272
Curcumin acts as immunorestorer in tumor-bearing host.
Cancer Res. 2007 Jan 1;67(1):362-70. PMID: 17210719
Curcumin alleviates dystrophic muscle pathology in mdx mice.
Mol Cells. 2008 Jun 30;25(4):531-7. Epub 2008 May 6. PMID: 18460899
Curcumin alleviates matrix metalloproteinases associated with inflammation during eradication of H. pylori infection.
PLoS One. 2011;6(1):e16306. Epub 2011 Jan 21. PMID: 21283694
Curcumin ameliorates acute thioacetamide-induced hepatotoxicity.
J Gastroenterol Hepatol. 2006 Feb;21(2):358-66. PMID: 16509859
Curcumin ameliorates aflatoin-induced toxicity in serum of mice.
Acta Pol Pharm. 2008 May-Jun;65(3):339-43. PMID: 18646553
Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice.
Acta Pol Pharm. 2008 Jul-Aug;65(4):415-9. PMID: 19051581
Curcumin ameliorates aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice.
Acta Pol Pharm. 2007 Sep-Oct;64(5):413-6. PMID: 18540160
Curcumin ameliorates aflatoxin-induced lipid-peroxidation in liver and kidney of mice.
Acta Pol Pharm. 2008 Mar-Apr;65(2):195-202. PMID: 18666425
Curcumin ameliorates aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice.
Acta Pol Pharm. 2007 Nov-Dec;64(6):497-502. PMID: 18323242
Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa.
Fertil Steril. 2008 Sep;90(3):775-80. Epub 2007 Dec 27. PMID: 18163997
Curcumin ameliorates aflatoxin-induced toxicity.
Poult Sci. 2008 Jun;87(6):1125-30. PMID: 18493001
Curcumin ameliorates arterial dysfunction and oxidative stress with aging.
Exp Gerontol. 2012 Nov 7. Epub 2012 Nov 7. PMID: 23142245
Curcumin ameliorates chemically-induced liver damage and fibrosis in rats.
Ann Hepatol. 2011 Oct 1 ;10(4):516-30. PMID: 21911894
Curcumin ameliorates cognitive deficits and neurodegeneration in a rat model of sporadic dementia of Alzheimer's type (SDAT).
Eur Neuropsychopharmacol. 2009 Sep;19(9):636-47. Epub 2009 Mar 28. PMID: 19329286
Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.
Eur J Pharmacol. 2010 Oct 10;644(1-3):106-12. Epub 2010 Jul 24. PMID: 20667451
Curcumin ameliorates endotoxin-induced experimental hepatoxicity in rodents.
Clin Exp Immunol. 2006 Aug;145(2):313-21. PMID: 16879252
Curcumin ameliorates ethanol and nonethanol experimental pancreatitis.
Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G85-95. PMID: 12488237
Curcumin ameliorates experimentally induced ulcerative colitis.
Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID: 17276891
Curcumin ameliorates high glucose-induced adverse changes to the aortic endothelium of rats.
Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82. Epub 2009 May 19. PMID: 19473193
Curcumin ameliorates kidney failure in nephrectomized rats.
Am J Physiol Renal Physiol. 2009 May;296(5):F1146-57. Epub 2009 Feb 18. PMID: 19225048
Curcumin ameliorates kidney lesions associated with diabetes.
Mol Cell Biochem. 1998 Apr;181(1-2):87-96. PMID: 9562245
Curcumin ameliorates lung inflammation induced by Klebsiella pneumoniae and may be a useful adjuvant in antibiotic therapy.
J Med Microbiol. 2010 Jan 7. Epub 2010 Jan 7. PMID: 20056776
Curcumin ameliorates memory deficits associated with diabetes in the rat.
Age (Dordr). 2009 Mar;31(1):39-49. Epub 2008 Oct 8. PMID: 19234767
Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.
Int J Cancer. 2010 Sep 13. Epub 2010 Sep 13. PMID: 20839263
Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in rats.
Ital J Biochem. 2004 Jul;53(2):82-6. PMID: 15646012
Curcumin ameliorates sodium arsenite induced biochemical perturbations in rats.
Food Chem Toxicol. 2008 Nov;46(11):3506-11. Epub 2008 Sep 2. PMID: 18809455
Curcumin ameliorates sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs.
Molecules. 2009;14(3):1098-110. Epub 2009 Mar 10. PMID: 19049818
Curcumin ameloriates experimental autoimmune encephalomyelitis through inhibition of IL-17 production.
Int Immunopharmacol. 2009 May;9(5):575-81. Epub 2009 Feb 3. PMID: 19539560
Curcumin and tetrahydrocurcumin have antihyperlipidemic properties in experimental type 2 diabetic rats.
JPEN J Parenter Enteral Nutr. 1986 Sep-Oct;10(5):530-2. PMID: 17994458
Curcumin and a curcumin copper complex has a radioprotective effect in mouse livers.
J Radiat Res (Tokyo). 2007 May;48(3):241-5. Epub 2007 Apr 27. PMID: 17464095
Curcumin and caffeic acid phenethyl ester decrease intestinal tumors in an animal model of familial adenomatous polyposis.
Carcinogenesis. 2000 May;21(5):921-7. PMID: 10783313
Curcumin and CAPE may reduce chemotherapy-induced mucosal barrier injury.
Leukemia. 2004 Feb;18(2):276-84. PMID: 14671640
Curcumin ameliorates aflatoxin-induced lipid-peroxidation in liver and kidney of mice.
Acta Pol Pharm. 2008 Mar-Apr;65(2):195-202. PMID: 18666425
Curcumin ameliorates aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice.
Acta Pol Pharm. 2007 Nov-Dec;64(6):497-502. PMID: 18323242
Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa.
Fertil Steril. 2008 Sep;90(3):775-80. Epub 2007 Dec 27. PMID: 18163997
Curcumin ameliorates aflatoxin-induced toxicity.
Poult Sci. 2008 Jun;87(6):1125-30. PMID: 18493001
Curcumin ameliorates cognitive deficits and neurodegeneration in a rat model of sporadic dementia of Alzheimer's type (SDAT).
Eur Neuropsychopharmacol. 2009 Sep;19(9):636-47. Epub 2009 Mar 28. PMID: 19329286
Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.
Eur J Pharmacol. 2010 Oct 10;644(1-3):106-12. Epub 2010 Jul 24. PMID: 20667451
Curcumin ameliorates endotoxin-induced experimental hepatoxicity in rodents.
Clin Exp Immunol. 2006 Aug;145(2):313-21. PMID: 16879252
Curcumin ameliorates ethanol and nonethanol experimental pancreatitis.
Am J Physiol Gastrointest Liver Physiol. 2003 Jan;284(1):G85-95. PMID: 12488237
Curcumin ameliorates experimentally induced ulcerative colitis.
Int Immunopharmacol. 2007 Mar;7(3):333-42. Epub 2006 Dec 18. PMID: 17276891
Curcumin ameliorates high glucose-induced adverse changes to the aortic endothelium of rats.
Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82. Epub 2009 May 19. PMID: 19473193
Curcumin ameliorates kidney failure in nephrectomized rats.
Am J Physiol Renal Physiol. 2009 May;296(5):F1146-57. Epub 2009 Feb 18. PMID: 19225048
Curcumin ameliorates kidney lesions associated with diabetes.
Mol Cell Biochem. 1998 Apr;181(1-2):87-96. PMID: 9562245
Curcumin ameliorates lung inflammation induced by Klebsiella pneumoniae and may be a useful adjuvant in antibiotic therapy.
J Med Microbiol. 2010 Jan 7. Epub 2010 Jan 7. PMID: 20056776
Curcumin ameliorates memory deficits associated with diabetes in the rat.
Age (Dordr). 2009 Mar;31(1):39-49. Epub 2008 Oct 8. PMID: 19234767
Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.
Int J Cancer. 2010 Sep 13. Epub 2010 Sep 13. PMID: 20839263
Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in rats.
Ital J Biochem. 2004 Jul;53(2):82-6. PMID: 15646012
Curcumin ameliorates sodium arsenite induced biochemical perturbations in rats.
Food Chem Toxicol. 2008 Nov;46(11):3506-11. Epub 2008 Sep 2. PMID: 18809455
Curcumin ameliorates sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs.
Molecules. 2009;14(3):1098-110. Epub 2009 Mar 10. PMID: 19049818
Curcumin ameloriates experimental autoimmune encephalomyelitis through inhibition of IL-17 production.
Int Immunopharmacol. 2009 May;9(5):575-81. Epub 2009 Feb 3. PMID: 19539560
Curcumin and tetrahydrocurcumin have antihyperlipidemic properties in experimental type 2 diabetic rats.
JPEN J Parenter Enteral Nutr. 1986 Sep-Oct;10(5):530-2. PMID: 17994458
Curcumin and a curcumin copper complex has a radioprotective effect in mouse livers.
J Radiat Res (Tokyo). 2007 May;48(3):241-5. Epub 2007 Apr 27. PMID: 17464095
Curcumin and caffeic acid phenethyl ester decrease intestinal tumors in an animal model of familial adenomatous polyposis.
Carcinogenesis. 2000 May;21(5):921-7. PMID: 10783313
Curcumin and CAPE may reduce chemotherapy-induced mucosal barrier injury.
Leukemia. 2004 Feb;18(2):276-84. PMID: 14671640
Curcumin attenuates acute adriamycin myocardial toxicity in rats.
Br J Pharmacol. 1998 Jun;124(3):425-7. PMID: 9647462
Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats.
Transplant Proc. 2010 Apr;42(3):744-7. PMID: 20430162
Curcumin attenuates alcohol toxicity.
J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386
Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.
Biol Pharm Bull. 2003 Jul;26(7):1021-4. PMID: 12843631
Curcumin attenuates aluminum-induced functional neurotoxicity in rats.
Pharmacol Biochem Behav. 2009 Jul;93(1):31-9. Epub 2009 Apr 17. PMID: 19376155
Curcumin attenuates an inflammatory response and improved the meiotic maturation of oocytes...
Fiziol Zh. 2010;56(4):96-101. PMID: 20968042
Curcumin attenuates cadmium-induced tisse damage in mice.
J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010
Curcumin attenuates cerebral edema following traumatic brain injury in mice.
J Neurochem. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20132469
Curcumin attenuates chronic fatigue syndrome in a mouse experimental model.
Immunobiology. 2009;214(1):33-9. Epub 2008 Jun 17. PMID: 19159825
Curcumin attenuates Concanavalin A-induced liver injury in mice.
Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522
Anti-Inflammatory Agents : CK(1230) : AC(433), Hepatoprotective : CK(580) : AC(281)
Curcumin attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.
BMC Pharmacol. 2005;5:15. Epub 2005 Oct 15. PMID: 16225695
Curcumin attenuates damage associated with cardiac ischemia/reperfusion.
J Surg Res. 2005 May 1;125(1):109-16. PMID: 15836859
Curcumin attenuates diabetic encephalopathy in rats.
Eur J Pharmacol. 2007 Dec 8;576(1-3):34-42. Epub 2007 Aug 14. PMID: 17822693
Curcumin attenuates diet-induced hypercholesterolemia in rats.
Med Sci Monit. 2005 Jul;11(7):BR228-234. Epub 2005 Jun 29. PMID: 15990684
Curcumin attenuates dimethylnitrosamine-induced liver injury in rats.
Food Chem Toxicol. 2008 Apr;46(4):1279-87. Epub 2007 Sep 26. PMID: 18006204
Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.
Food Chem Toxicol. 2006 Sep;44(9):1443-8. Epub 2006 May 20. PMID: 16814915
Curcumin attenuates high-fat-diet induced blood lipid elevation and oxidation.
Wei Sheng Yan Jiu. 2000 Jul;29(4):240-2. PMID: 12520931
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385
Curcumin attenuates inflammation in experimental colitis.
Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11. PMID: 19002562
Curcumin attenuates ischemia-reperfusion injury in rat testis.
Fertil Steril. 2009 Jan;91(1):271-7. Epub 2008 Jan 28. PMID: 18222428
Curcumin attenuates isoproterenol induced myocardial necrosis in rats.
Mol Cell Biochem. 1999 Jul;197(1-2):31-7. PMID: 10485321
Curcumin attenuates lipopolysaccharide-induced renal inflammation.
Biol Pharm Bull. 2011;34(2):226-32. PMID: 21415532
Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.
J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470
Curcumin attenuates acute adriamycin myocardial toxicity in rats.
Br J Pharmacol. 1998 Jun;124(3):425-7. PMID: 9647462
Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats.
Transplant Proc. 2010 Apr;42(3):744-7. PMID: 20430162
Curcumin attenuates alcohol toxicity.
J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386
Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.
Biol Pharm Bull. 2003 Jul;26(7):1021-4. PMID: 12843631
Curcumin attenuates aluminum-induced functional neurotoxicity in rats.
Pharmacol Biochem Behav. 2009 Jul;93(1):31-9. Epub 2009 Apr 17. PMID: 19376155
Curcumin attenuates an inflammatory response and improved the meiotic maturation of oocytes...
Fiziol Zh. 2010;56(4):96-101. PMID: 20968042
Curcumin attenuates cadmium-induced tisse damage in mice.
J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010
Curcumin attenuates cerebral edema following traumatic brain injury in mice.
J Neurochem. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20132469
Curcumin attenuates chemically induced colitis.
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G235-43. Epub 2003 Mar 13. PMID: 12637253
Curcumin attenuates chronic fatigue syndrome in a mouse experimental model.
Immunobiology. 2009;214(1):33-9. Epub 2008 Jun 17. PMID: 19159825
Curcumin attenuates Concanavalin A-induced liver injury in mice.
Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522
Curcumin attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.
BMC Pharmacol. 2005;5:15. Epub 2005 Oct 15. PMID: 16225695
Curcumin attenuates damage associated with cardiac ischemia/reperfusion.
J Surg Res. 2005 May 1;125(1):109-16. PMID: 15836859
Curcumin attenuates diabetic encephalopathy in rats.
Eur J Pharmacol. 2007 Dec 8;576(1-3):34-42. Epub 2007 Aug 14. PMID: 17822693
Curcumin attenuates diet-induced hypercholesterolemia in rats.
Med Sci Monit. 2005 Jul;11(7):BR228-234. Epub 2005 Jun 29. PMID: 15990684
Curcumin attenuates dimethylnitrosamine-induced liver injury in rats.
Food Chem Toxicol. 2008 Apr;46(4):1279-87. Epub 2007 Sep 26. PMID: 18006204
Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.
Food Chem Toxicol. 2006 Sep;44(9):1443-8. Epub 2006 May 20. PMID: 16814915
Curcumin attenuates high-fat-diet induced blood lipid elevation and oxidation.
Wei Sheng Yan Jiu. 2000 Jul;29(4):240-2. PMID: 12520931
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385
Curcumin attenuates inflammation in experimental colitis.
Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11. PMID: 19002562
Curcumin attenuates ischemia-reperfusion injury in rat testis.
Fertil Steril. 2009 Jan;91(1):271-7. Epub 2008 Jan 28. PMID: 18222428
Curcumin attenuates isoproterenol induced myocardial necrosis in rats.
Mol Cell Biochem. 1999 Jul;197(1-2):31-7. PMID: 10485321
Curcumin attenuates lipopolysaccharide-induced renal inflammation.
Biol Pharm Bull. 2011;34(2):226-32. PMID: 21415532
Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.
J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470
Curcumin attenuates acute adriamycin myocardial toxicity in rats.
Br J Pharmacol. 1998 Jun;124(3):425-7. PMID: 9647462
Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats.
Transplant Proc. 2010 Apr;42(3):744-7. PMID: 20430162
Curcumin attenuates alcohol toxicity.
J Pharm Pharm Sci. 2004 Aug 20;7(2):274-83. Epub 2004 Aug 20. PMID: 15367386
Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs.
Biol Pharm Bull. 2003 Jul;26(7):1021-4. PMID: 12843631
Curcumin attenuates aluminum-induced functional neurotoxicity in rats.
Pharmacol Biochem Behav. 2009 Jul;93(1):31-9. Epub 2009 Apr 17. PMID: 19376155
Curcumin attenuates an inflammatory response and improved the meiotic maturation of oocytes...
Fiziol Zh. 2010;56(4):96-101. PMID: 20968042
Curcumin attenuates cadmium-induced tisse damage in mice.
J Appl Toxicol. 2006 May-Jun;26(3):207-12. PMID: 16345010
Curcumin attenuates cerebral edema following traumatic brain injury in mice.
J Neurochem. 2010 Feb 1. Epub 2010 Feb 1. PMID: 20132469
Curcumin attenuates chemically induced colitis.
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G235-43. Epub 2003 Mar 13. PMID: 12637253
Curcumin attenuates chronic fatigue syndrome in a mouse experimental model.
Immunobiology. 2009;214(1):33-9. Epub 2008 Jun 17. PMID: 19159825
Curcumin attenuates Concanavalin A-induced liver injury in mice.
Int Immunopharmacol. 2012 Jan ;12(1):151-7. Epub 2011 Dec 2. PMID: 22138522
Curcumin attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys.
BMC Pharmacol. 2005;5:15. Epub 2005 Oct 15. PMID: 16225695
Curcumin attenuates damage associated with cardiac ischemia/reperfusion.
J Surg Res. 2005 May 1;125(1):109-16. PMID: 15836859
Curcumin attenuates diabetic encephalopathy in rats.
Eur J Pharmacol. 2007 Dec 8;576(1-3):34-42. Epub 2007 Aug 14. PMID: 17822693
Curcumin attenuates diet-induced hypercholesterolemia in rats.
Med Sci Monit. 2005 Jul;11(7):BR228-234. Epub 2005 Jun 29. PMID: 15990684
Curcumin attenuates dimethylnitrosamine-induced liver injury in rats.
Food Chem Toxicol. 2008 Apr;46(4):1279-87. Epub 2007 Sep 26. PMID: 18006204
Curcumin attenuates gentamicin-induced kidney oxidative damage in rats.
Food Chem Toxicol. 2006 Sep;44(9):1443-8. Epub 2006 May 20. PMID: 16814915
Curcumin attenuates high-fat-diet induced blood lipid elevation and oxidation.
Wei Sheng Yan Jiu. 2000 Jul;29(4):240-2. PMID: 12520931
Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction.
Arch Toxicol. 2008 Jul;82(7):471-81. Epub 2007 Nov 30. PMID: 18060385
Curcumin attenuates inflammation in experimental colitis.
Mol Cell Biochem. 2009 Feb;322(1-2):127-35. Epub 2008 Nov 11. PMID: 19002562
Curcumin attenuates ischemia-reperfusion injury in rat testis.
Fertil Steril. 2009 Jan;91(1):271-7. Epub 2008 Jan 28. PMID: 18222428
Curcumin attenuates isoproterenol induced myocardial necrosis in rats.
Mol Cell Biochem. 1999 Jul;197(1-2):31-7. PMID: 10485321
Curcumin attenuates lipopolysaccharide-induced renal inflammation.
Biol Pharm Bull. 2011;34(2):226-32. PMID: 21415532
Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats.
J Egypt Natl Canc Inst. 2008 Jun;20(2):141-8. PMID: 20029470
Curcumin attenuates ovalbumin-induced airway inflammation.
Biochem Biophys Res Commun. 2008 Oct 17;375(2):275-9. Epub 2008 Aug 13. PMID: 18706396
Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA).
Mol Cell Biochem. 2009 Apr;324(1-2):157-64. Epub 2009 Jan 23. PMID: 19165575
Curcumin attenuates oxidative stress and inflammatory response in the early phase after partial hepatectomy...
J Surg Res. 2010 Mar;159(1):497-502. Epub 2008 Dec 31. PMID: 19321178
Curcumin attenuates renal fibrosis in rat obstructive nephropathy.
Urology. 2006 Feb;67(2):440-6. PMID: 16461119
Curcumin attenuates retinal oxidative stress and inflammation in diabetes.
Nutr Metab (Lond). 2007;4:8. Epub 2007 Apr 16. PMID: 17437639
Curcumin attenuates the development of allergic airway inflammation and hyper-responsiveness.
J Ethnopharmacol. 2010 Jul 17. Epub 2010 Jul 17. PMID: 20643202
Curcumin attenuates the inflammatory response in collagen-induced arthritis.
Int Immunopharmacol. 2010 May;10(5):605-10. Epub 2010 Feb 23. PMID: 20188213
Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice.
Carcinogenesis. 2009 Nov;30(11):1949-56. Epub 2009 Sep 30. PMID: 17300872
Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat.
Nutrition. 2008 Nov-Dec;24(11-12):1133-8. Epub 2008 Aug 26. PMID: 18752929
Curcumin attenuates the virulence of Pseudomonas aeruginosa .
J Agric Food Chem. 2008 Mar 26;56(6):1955-62. Epub 2008 Feb 20. PMID: 18284200
Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.
Eur J Pharmacol. 2006 May 1;536(3):256-61. Epub 2006 Mar 13. PMID: 16584726
Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice.
Antioxid Redox Signal. 2009 Jan;11(1):35-45. PMID: 18752423
Curcumin blocks chronic morphine analgesic tolerance and positively modulates brain chemistry.
Neuroreport. 2009 Jan 7;20(1):63-8. PMID: 19033880
Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis.
Kidney Int. 2005 Nov;68(5):2042-9. PMID: 16221204
Curcumin blocks HIV protease inhibitor rotonavir-induced vascular dysfunction in porcine coronary arteries.
J Am Coll Surg. 2005 Jun;200(6):820-30. PMID: 15922191
Curcumin blocks sepsis-induced muscle proteolysis.
Mediators Inflamm. 2008;2008:317851. PMID: 18389075
Curcumin can alleviate alveolitis and pulmonary fibrosis induced by bleomycin in rats.
Zhonghua Jie He He Hu Xi Za Zhi. 2007 Mar;30(3):197-201. PMID: 17572999
Curcumin can ameliorate cerebral pathological changes in the event of ischemic brain injury.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jun;29(6):1153-5. PMID: 19726347
Curcumin can be an alternative therapy for protecting lung transplantation-associated injury...
Crit Care Med. 2008 Apr;36(4):1205-13. PMID: 18379247
Curcumin can decrease inflammation in an experimental model of fibrosis.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 May;25(5):399-401. PMID: 19426594
Curcumin can decrease pulmonary arterial pressure, improve pulmonary vessel remodeling and inhibit the deposition of collagen I in pulmonary arterioles.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006 Aug;22(3):257-61. PMID: 21158062
Curcumin can induce apoptosis of pulmonary fibroblasts in rats with bleomycin-induced pulmonary fibrosis.
Zhonghua Jie He He Hu Xi Za Zhi. 2009 Jan;32(1):37-41. PMID: 19484960
Curcumin can inhibit tumour growth in a xenograft animal model in vivo.
Phytother Res. 2010 Jan 13;24(2):189-192. Epub 2010 Jan 13. PMID: 20077433
Curcumin can reduce inflammation and offset some of the performance deficits associated with eccentric exercise-induced muscle damage.
Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2168-73. Epub 2007 Mar 1. PMID: 17332159
Curcumin can significantly protect neurons against cerebral ischemia.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007 May;23(2):184-8. PMID: 21179765
Curcumin can stimulate developmental and adult hippocampal neurogenesis, and a biological activity that may enhance neural plasticity and repair.
J Clin Psychopharmacol. 2000 Dec;20(6):680-4. PMID: 18362141
Curcumin co-treatment seems to prevent oxidative damage and found to delay the development of cataract.
Indian J Exp Biol. 2004 Jun;42(6):601-3. PMID: 15260112
Curcumin compares favorably to the drug dexamethasone in a rat model of lung injury.
Cancer Lett. 2003 Mar 31;192(2):145-9. PMID: 18799504
Curcumin compares favorably with bisdemethoxycurcumin in a gastric ulcer model system.
Phytomedicine. 2009 Apr;16(4):342-51. Epub 2009 Feb 1. PMID: 19188055
Curcumin could improve cardiac function in heart failure.
Zhonghua Xin Xue Guan Bing Za Zhi. 2010 Apr;38(4):369-73. PMID: 20654087
Curcumin could improve heart function, diminish infarct size and reverse the abnormal changes in the activities of serum lactate dehydrogenase and creatine kinase MB in rats after myocardial infarction.
Pharmacol Res. 2010 Feb;61(2):142-8. Epub 2009 Sep 9. PMID: 19747544
Curcumin counteracts the aluminium-induced ageing-related alterations in the rat brain.
Biogerontology. 2009 Aug;10(4):489-502. Epub 2008 Nov 20. PMID: 19020987
Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.
Gastroenterology. 2006 Jan;130(1):120-6. PMID: 20622013
Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis.
Int J Cancer. 2010 Sep 7. Epub 2010 Sep 7. PMID: 20824699
Curcumin demonstrates therapeutic properties in an animal model of Alzheimer disease.
J Pharmacol Exp Ther. 2008 Jul;326(1):196-208. Epub 2008 Apr 16. PMID: 18417733
Curcumin dispalys anti-proliferartive and anti-angiogenic properties on tumors.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Oct;35(10):1029-36. PMID: 21051827
Curcumin displays therapeutic value in an animal model of irritable bowel syndrome.
AAPS PharmSciTech. 2009;10(3):752-62. Epub 2009 Jun 3. PMID: 19495987
Curcumin eliminates leptin's effect on liver fibrogenesis.
Endocrinology. 2009 Jul;150(7):3011-20. Epub 2009 Mar 19. PMID: 19299451
Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells which are associated wtih liver fibrosis.
Lab Invest. 2009 Nov;89(11):1275-90. Epub 2009 Sep 7. PMID: 19736547
Curcumin enhances adriamycin-induced human liver-derived hepatoma G2 cell death.
Eur J Pharm Sci. 2011 Jun 14 ;43(3):125-31. Epub 2011 Apr 14. PMID: 21514382
Curcumin enhances neurogenesis and cognition in aged rats.
PLoS One. 2012 ;7(2):e31211. Epub 2012 Feb 16. PMID: 22359574
Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation.
PLoS One. 2010;5(10):e13264. Epub 2010 Oct 11. PMID: 20845461
Curcumin enhances the effect of cisplatin in suppression of head and neck squamous cell carcinoma.
Mol Cancer Ther. 2010 Oct;9(10):2665-75. PMID: 20937593
Curcumin enhances wound healing in animals.
Phytother Res. 2008 Jul;22(7):970-2. PMID: 9776860
Curcumin enhances wound healing in diabetic rats.
Wound Repair Regen. 1999 Sep-Oct;7(5):362-74. PMID: 10564565
Curcumin exerts an anti-hyperlipidemic effect against nicotine-induced lung toxicity...
J Med Food. 2005;8(2):246-50. PMID: 16117619
Curcumin exerts neuroprotective effects against homocysteine intracerebroventricular injection-induced cognitive impairment and oxidative stress in rat brain.
Exp Neurol. 2010 Oct;225(2):237-9. Epub 2010 Jul 11. PMID: 20553189
Curcumin exerts pain-killing effects in a mouse model of neuropathic pain.
Neuropharmacology. 2012 Feb ;62(2):843-54. Epub 2011 Sep 19. PMID: 21945716
Curcumin exerts stimulatory influence on the secretory function of the thyroid gland in young rats....
Folia Histochem Cytobiol. 2008;46(2):205-11. PMID: 18519239
Curcumin exhibits anti-bacterial activity against Helicobacter pylori infection.
Antimicrob Agents Chemother. 2009 Apr;53(4):1592-7. Epub 2009 Feb 9. PMID: 19204190
Curcumin exhibits anti-cancer activity in an animal mode of intestinal cancer.
Carcinogenesis. 2001 May;22(5):821-5. PMID: 11323404
Curcumin exhibits anti-gastrointestinal cancer activity in rats.
Cancer Sci. 2006 Sep;97(9):896-904. Epub 2006 Jun 29. PMID: 16805852
Curcumin exhibits anti-liver cancer activity.
Int J Pharm. 2010 Nov 15;400(1-2):211-20. Epub 2010 Sep 8. PMID: 20813175
Curcumin exhibits anti-malarial activity in a mouse model.
Biochem Biophys Res Commun. 2005 Jan 14;326(2):472-4. PMID: 15582601
Curcumin exhibits anti-melanoma activity.
Phytother Res. 2003 Mar;17(3):217-21. PMID: 19260281
Curcumin exhibits antidepressant properties.
Pharmacol Biochem Behav. 2005 Sep;82(1):200-6. PMID: 16171853
Curcumin exhibits chemopreventive properties in hematogenous breast cancer metastases in immunodeficient mice.
Cell Physiol Biochem. 2007;19(1-4):137-52. PMID: 17310108
Curcumin exhibits cholesterol lowering properties.
Nutr Res Pract. 2010 Jun;4(3):191-5. Epub 2010 Jun 28. PMID: 20607063
Curcumin exhibits hepatoprotective properties against selenium toxicity.
Indian J Physiol Pharmacol. 2005 Jan;49(1):111-4. PMID: 15881869
Curcumin exhibits inhibitory effects liver fibrosis associated with injury.
Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G20-30. Epub 2003 Mar 26. PMID: 12660143
Curcumin exhibits neuroprotective properties when given 4h post-ischemia in the rat thromboembolic stroke models.
Behav Brain Res. 2008 Nov 21;193(2):289-97. Epub 2008 Jun 19. PMID: 18611416
Curcumin exhibits potentially therapeutic properties in a rat experimental model of endometriosis.
Maturitas. 2007 Mar 20;56(3):322-31. Epub 2006 Nov 13. PMID: 21069258
Curcumin exhibits radioprotective properties and inhibits acute and chronic effects of gamma radiation exposure.
Int J Radiat Oncol Biol Phys. 2002 Jul 1;53(3):735-43. PMID: 12062620
Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster.
Planta Med. 1997 Oct;63(5):465-6. PMID: 20645870
Curcumin extends lifespan in Caenorhabditis elegans.
Mech Ageing Dev. 2011 Aug 9. Epub 2011 Aug 9. PMID: 21855561
Curcumin formulated with phosphatidylcholine furnishes higher systemic levels of parent agent than unformulated curcumin.
Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7. Epub 2006 Oct 19. PMID: 17051370
Curcumin has a beneficial effect on acute lung injury induced by oleic acid in rats.
Zhongguo Zhong Yao Za Zhi. 2008 Sep;33(17):2141-5. PMID: 19066061
Indian J Pharmacol. 2012 Jan ;44(1):73-7. PMID: 22345874
Curcumin has a cardioprotective effect against myocardial ischemia.
Int J Biochem Cell Biol. 2004 Oct;36(10):1967-80. PMID: 15203111
Curcumin has a chemopreventive effect on chemically-induced esophageal cancer.
Jpn J Cancer Res. 2000 Sep;91(9):893-8. PMID: 11011116
Curcumin has a corrective effect on the expression of genetic defects associated with cystic fibrosis in an animal model.
Lab Invest. 2010 May 10. Epub 2010 May 10. PMID: 15105504
Curcumin has a curative effect on liver fibrosis in rats.
Zhong Yao Cai. 2007 Nov;30(11):1421-5 PMID: 18323214
Curcumin has a cytoprotective and immunomodulating effect in rats subjected to carbon tetrachloride-induced oxidative stress.
Br J Rheumatol. 1994 Sep;33(9):847-52. PMID: 18340409
Curcumin has a detoxifiying and antioxidant effect in rats experimentallly exposed to mercury.
Cont Lens Anterior Eye. 2009 Dec 21. Epub 2009 Dec 21. PMID: 20229497
Curcumin has a immunomodulatory effect in host macrophages and NK cells which results in a tumoricidal effect.
FEBS Lett. 2000 Oct 13;483(1):78-82. PMID: 11033360
Curcumin has a liver protecting effect against aflatoxin B(1)-induced liver injury.
Arch Toxicol. 2010 May;84(5):389-96. Epub 2010 Jan 30. PMID: 20112103
Curcumin has a neuroprotective effect against homocysteine-induced cognitive impairment and oxidative stress in the rat.
Pharmacol Biochem Behav. 2010 Oct;96(4):378-85. Epub 2010 Jul 6. PMID: 20619287
Curcumin has a neuroprotective effect in arsenic-induced neurotoxicity in rats.
Neurotoxicology. 2010 Sep;31(5):533-9. Epub 2010 May 11. PMID: 20466022
Curcumin has a neuroprotective effect in brain trauma.
Neuroscience. 2009 Jul 21;161(4):1037-44. Epub 2009 Apr 21. PMID: 19393301
Curcumin has a neuroprotective effect in hypoxia ischemia brain tissue injury.
J Nat Prod. 2009 Apr;72(4):725-31. PMID: 19397204
Curcumin has a neuroprotective effect in in middle cerebral artery occlusion induced focal cerebral ischemia in rats.
Life Sci. 2004 Jan 9;74(8):969-85. PMID: 14672754
Curcumin has a neuroprotective effect on 6-hydroxydopamine-induced Parkinsonism in rats.
Exp Neurol. 2010 Oct;225(2):237-9. Epub 2010 Jul 11. PMID: 20951685
Curcumin has a neuroprotective effect on focal cerebral ischemic rats by preventing blood-brain barrier damage.
Chemotherapy. 2010;56(1):60-5. Epub 2010 Mar 19. PMID: 17303117
Curcumin has a novel synergistic effect with the drug cyclosporine as an immunosuppressive.
Transplant Proc. 2003 Jun;35(4):1603-5. PMID: 12826232
Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats.
Fundam Clin Pharmacol. 2005 Aug;19(4):473-7. PMID: 16011735
Curcumin has a potent preventive action against radiation-induced breast cancer initiation.
Carcinogenesis. 2000 Oct;21(10):1835-41. PMID: 11023541
Curcumin has a potent preventive activity during the DES-dependent promotion stage of radiation-induced mammary tumorigenesis.
Carcinogenesis. 1999 Jun;20(6):1011-8. PMID: 10357781
Curcumin has a preventive effect on different aspiration material-induced lung injury in rats.
Pediatr Surg Int. 2009 Jan;25(1):83-92. Epub 2008 Nov 12. PMID: 19002695
Curcumin has a preventive effect on experimental acute pancreatitis in mouse.
Indian J Med Res. 2011 Nov ;134(5):717-24. PMID: 22199113
Curcumin has a prophylactic effect on hepatic fibrosis.
Zhonghua Gan Zang Bing Za Zhi. 2006 May;14(5):337-40. PMID: 16732906
Curcumin has a protective effect after spinal cord injury.
J Surg Res. 2009 Aug 5. Epub 2009 Aug 5. PMID: 20018302
Curcumin has a protective effect against against intracerebral streptozotocin induced impairment in memory and cerebral blood flow.
Life Sci. 2010 Jan 16;86(3-4):87-94. Epub 2009 Nov 17. PMID: 19925811
Curcumin has a protective effect against aluminium toxicity in rats as measured by behavioral and biochemical alterations.
Behav Brain Res. 2009 Jul 16. PMID: 19616038
Curcumin has a protective effect against hyperlipidemia and insulin resistance in high-fat-fed hamsters.
J Am Diet Assoc. 2005 Jun;105(6):967-70. PMID: 18940397
Curcumin has a protective effect against lsoproterenol-induced mycardial infarction.
Biochem Pharmacol. 1996 Jan 12;51(1):47-51. PMID: 8534267
Curcumin has a protective effect against nicotine-induced genotoxicity on rat liver.
Eur J Pharmacol. 2008 Jul 7;588(2-3):151-7. Epub 2008 Apr 15. PMID: 18508046
Curcumin has a protective effect in experimentally induced colitis.
Br J Pharmacol. 2003 May;139(2):209-18. PMID: 12770926
Curcumin has a protective effect on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats.
Exp Toxicol Pathol. 2010 Apr 2. Epub 2010 Apr 2. PMID: 20363603
Curcumin has a protective effect on lindane induced reproductive toxicity in male Wistar rats.
Bull Environ Contam Toxicol. 2010 Apr;84(4):378-84. Epub 2010 Feb 25. PMID: 20182699
Curcumin has a protective effect on myocardial ischemia reperfusion injury.
Zhong Yao Cai. 2005 Oct;28(10):920-2. PMID: 16479932
Curcumin has a similar effect to hydrocortisone in preventing bleomycin-induced pulmonary fibrosis.
J Ethnopharmacol. 2007 Jun 13;112(2):292-9. Epub 2007 Mar 13. PMID: 17434272
Curcumin has a synergistic effect with cisplatin against fibrosarcoma.
Pharmacol Res. 1999 Mar;39(3):175-9. PMID: 10094841
Curcumin has an ameliorative effect against acute cadmium toxicity on male reproductive system in rats.
Andrologia. 2012 Jan 18. Epub 2012 Jan 18. PMID: 22257170
Curcumin has an ameliorative effect on the seminiferous epithelium metronidazole-treated mice.
Toxicol Pathol. 2010;38(3):366-71. Epub 2010 Mar 9. PMID: 20215582
Curcumin has an insulin releasing effect in rat-isolated pancreatic islets.
Angiology. 2010 Aug;61(6):557-66. Epub 2010 Apr 14. PMID: 20395228
Curcumin has analgesic properties.
Phytother Res. 2009 Apr;23(4):507-12. PMID: 19051211
Curcumin has analgesic properties.
Pak J Biol Sci. 2008 Jan 15;11(2):312-4. PMID: 18817212
Curcumin has anti-aging and neuroprotective effects in aged rat brain regions.
Biogerontology. 2006 Apr;7(2):81-9. PMID: 16802111
Curcumin has anti-anxiety properties.
Brain Res. 2010 Sep 17;1352:167-75. Epub 2010 Jul 12. PMID: 20633542
Curcumin has anti-cataractogenic properties.
Chem Biol Interact. 2009 Oct 7;181(2):202-9. Epub 2009 May 27. PMID: 19481068
Curcumin has anti-thrombotic properties.
Biochem Pharmacol. 1999 Oct 1;58(7):1167-72. PMID: 10484074
Curcumin has anti-ulcer activity in experimental gastric ulcer in rats.
Biomed Environ Sci. 2009 Dec;22(6):488-95. PMID: 20337222
Curcumin has anti-umorigenic and hormone-suppressive effects against pituitary tumors.
Endocr Relat Cancer. 2009 Dec;16(4):1339-50. Epub 2009 Sep 2. PMID: 19726538
Curcumin has anticancer, chemosensitization and radiosensitization effects in prostate cancer.
Cancer Res. 2007 Mar 1;67(5):1988-96. PMID: 17332326
Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice.
Phytother Res. 2008 Dec;22(12):1660-4. PMID: 18661468
Curcumin has antidepressant properties that compare favorably to the drugs imipramine and fluoxetine.
Acta Pol Pharm. 2011 Sep-Oct;68(5):769-75. PMID: 21928724
Curcumin has antidepressant-like effects in chronic unpredictable mild stress of rats.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):435-49. Epub 2009 Jan 22. PMID: 19302828
Curcumin has antihyperalgesic properties.
J Dent Res. 2010 Feb;89(2):170-4. Epub 2009 Dec 29. PMID: 20040737
Curcumin has antinociceptive (pain-killing) properties associated with ATP-sensitive potassium channels.
Korean J Pain. 2012 Oct ;25(4):221-7. Epub 2012 Oct 4. PMID: 23091682
Curcumin has beneficial effects in experimental dementia.
Naunyn Schmiedebergs Arch Pharmacol. 2010 Jun;381(6):529-39. Epub 2010 Apr 6. PMID: 20369229
Jun 01, 2010
Curcumin has chemopreventive properties during the promotion/progression stages of colon cancer.
Cancer Res. 1999 Feb 1;59(3):597-601. PMID: 9973206
Curcumin has lipid lowering properties in diabetic rats.
Mol Cell Biochem. 1997 Jan;166(1-2):169-75. PMID: 9046034
Curcumin has neuroprotective effect on transient focal cerebral ischemia in rats.
Brain Res. 2008 Sep 10;1229:224-32. Epub 2008 Jul 8. PMID: 18640105
Curcumin has neuroprotective effects against a fungal toxin.
Methods Find Exp Clin Pharmacol. 2007 Jan-Feb;29(1):19-25. PMID: 17344940
Curcumin has positive immunomodulatory effects on mouse schistosomiasis.
Immunobiology. 2009;214(8):712-27. Epub 2009 Feb 26. PMID: 19249123
Curcumin has potent liver preservation properties in an isolated perfusion model.
Transplantation. 2006 Oct 15;82(7):931-7. PMID: 17038909
Curcumin has potent therapeutic activity in the amelioration of alcoholic neuropathy in rats.
Neurosci Lett. 2012 Jan 16. Epub 2012 Jan 16. PMID: 22281447
Curcumin has potential anti-epileptic effects.
Indian J Physiol Pharmacol. 2009 Jan-Mar;53(1):39-46. PMID: 19810575
Curcumin has protective effects against hepatic ischemia/reperfusion injury.
World J Gastroenterol. 2007 Apr 7;13(13):1953-61. PMID: 17461496
Curcumin has schistosomicidal potential against Schistosoma japonicum.
J Asian Nat Prod Res. 2012 Oct 23. Epub 2012 Oct 23. PMID: 23088385
Curcumin has therapeutic effects in chemically-induced colitis.
World J Gastroenterol. 2006 Jun 28;12(24):3848-53. PMID: 16804969
Curcumin has variable immunomodulatory effects.
J Huazhong Univ Sci Technolog Med Sci. 2005;25(2):137-40. PMID: 16116955
Curcumin holds promise as an agent to prevent or treat central nervous system complications in diabetes.
J Biomed Sci. 2010;17:43. Epub 2010 May 31. PMID: 20513244
Curcumin improves bone microarchitecture and enhances mineral density in transgenic mice.
Phytomedicine. 2011 Jan 15;18(2-3):205-13. Epub 2010 Jul 16. PMID: 20637579
Curcumin improves early functional results after experimental spinal cord injury.
Acta Neurochir (Wien). 2010 Sep;152(9):1583-90; discussion 1590. Epub 2010 Jun 10. PMID: 20535508
Curcumin improves insulin resistance in skeletal muscle of rats.
Nutr Metab Cardiovasc Dis. 2010 Mar 12. Epub 2010 Mar 12. PMID: 20227862
Curcumin improves learning and memory ability in a mouse Alzheimer's disease experimental model.
Chin Med J (Engl). 2008 May 5;121(9):832-9. PMID: 18701050
Curcumin improves left ventricular function in pressure overloaded rabbits.
Biol Pharm Bull. 2004 Feb;27(2):198-202. PMID: 14758033
Curcumin improves memory and learning dysfunction in rats.
Eur J Gastroenterol Hepatol. 2002 Nov;14(11):1271-4. PMID: 18394334
Curcumin improves outcomes and attenuates focal cerebral ischemic injury.
Neurochem Res. 2010 Mar;35(3):374-9. Epub 2009 Sep 23. PMID: 19774461
Curcumin improves sclerosing cholangitis in mice.
Gut. 2010 Apr;59(4):521-30. PMID: 20332524
Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 in rats.
Life Sci. 2009 Jul 3;85(1-2):1-10. Epub 2009 Apr 5. PMID: 19345695
Curcumin improves survival in mice with tumors.
Tohoku J Exp Med. 2002 Aug;197(4):221-7. PMID: 12434997
Curcumin improves the metabolic status in diabetic conditions.
Phytother Res. 2007 Apr;21(4):395-7. PMID: 8609907
Curcumin improves vascular function and alleviates oxidative stress in endotoxaemia in mice.
J Clin Invest. 2008 Mar;118(3):868-78. PMID: 19540224
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species.
Cancer Lett.2006 Jul 28;239(1):144-50. Epub 2005 Nov 21 PMID: 16770527
Curcumin in combination with EPA and DHA work synergistically to reduce inflammation.
Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8. PMID: 19744468
Curcumin in combination with visible light inhibits tumor growth in a xenograft tumor model.
Int J Cancer. 2009 Mar 15;124(6):1422-8. PMID: 19035461
Curcumin increases glucose uptake in skeletal muscle.
Neurosci Lett. 2009 Nov 20;465(3):238-41. Epub 2009 Sep 16. PMID: 19765405
Curcumin induces a tolerogenic response in an animal model of colitis.
Eur J Immunol. 2009 Nov;39(11):3134-46. PMID: 19839007
Curcumin induces programmed cell death and inhibits growth of human Burkitt's lymphoma in xenograft mouse model.
J Nutr. 2009 Jul;139(7):1339-46. Epub 2009 Jun 3. PMID: 19326074
Curcumin induces recovery from hepatic injury.
Indian J Biochem Biophys. 2008 Oct;45(5):317-25. PMID: 19069843
Curcumin inhibit tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo.
Jpn J Cancer Res. 1998 Apr;89(4):361-70. PMID: 9617340
Curcumin inhibition of JNKs prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease...
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Curcumin inhibits adenoid cystic carcinoma.
Mol Pharmacol. 2010 Oct 19. Epub 2010 Oct 19. PMID: 20959361
Curcumin inhibits amyloid-petpide induced changes associated with the progression of Alzheimer's disease.
J Neurochem. 2004 Dec;91(5):1199-210. PMID: 15569263
Curcumin inhibits ascites tumor growth in mice.
Mol Cell Biochem. 2005 May;273(1-2):57-67. PMID: 16013440
Curcumin inhibits bladder tumor growth in a mouse model.
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Curcumin inhibits bleomycin-induced pulmonary fibrosis in rats.
Br J Pharmacol. 2000 Sep;131(2):169-72. PMID: 10991907
Curcumin inhibits chemically-induced colonic lesions.
Carcinogenesis. 1993 Nov;14(11):2219-25. PMID: 8242846
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Food Chem Toxicol. 2000 Nov;38(11):991-5. PMID: 11038236
Curcumin inhibits chemically-induced skin cancer promotion in the mouse model.
Cancer Res. 2010 Aug 1;70(15):6368-76. Epub 2010 Jul 20. PMID: 3139287
Curcumin inhibits chemically-induced skin cancer.
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Curcumin inhibits chemically-induced tumor initiation.
Carcinogenesis. 1992 Nov;13(11):2183-6. PMID: 1423891
Curcumin inhibits colon polyp formation.
Br J Cancer. 2003 May 6;88(9):1480-3. PMID: 12778080
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.
Carcinogenesis. 2009 Nov;30(11):1949-56. Epub 2009 Sep 30. PMID: 19793800
Curcumin inhibits endometrial cancer and works synergistically with the aromatase inhibitor letrozole.
Int J Gynecol Cancer. 2009 Oct;19(7):1248-52. PMID: 19823063
Curcumin inhibits experimental collitis via anti-angiogenic and anti-inflammatory properties.
J Pharm Pharmacol. 2009 Mar;61(3):311-21. PMID: 19222903
Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury.
Am J Physiol Lung Cell Mol Physiol. 2010 Jan 8. Epub 2010 Jan 8. PMID: 20061443
Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice.
Eur J Pharmacol. 2012 Oct 11. Epub 2012 Oct 11. PMID: 23063543
Curcumin Inhibits Imiquimod-Induced Psoriasis-Like Inflammation by Inhibiting IL-1beta and IL-6 Production in Mice.
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Curcumin inhibits leukemia cells in mice.
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Curcumin inhibits lipid peroxidation and cholesterol levels in mice.
Indian J Physiol Pharmacol. 1992 Oct;36(4):239-43. PMID: 1291474
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Curcumin inhibits muscle wasting in colon tumor bearing mice.
Br J Nutr. 2009 Oct;102(7):967-75. Epub 2009 Apr 27. PMID: 19393114
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental fatty liver in mice.
Mech Ageing Dev. 2003 Dec;124(10-12):1025-34. PMID: 15582125
Curcumin inhibits nitric oxide production.
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Curcumin inhibits proliferation and induces programmed cell death in leukemic cells...
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J Agric Food Chem. 2008 Sep 24;56(18):8418-26. Epub 2008 Aug 30. PMID: 19055861
Curcumin inhibits prostate cancer growth.
Prostate. 2001 Jun 1;47(4):293-303. PMID: 11398177
Curcumin inhibits prostate cancer tumors.
Peptides. 2009 Dec;30(12):2357-64. Epub 2009 Sep 20. PMID: 19772879
Curcumin inhibits radiation-impaired healing of excisional wounds in mice.
J Wound Care. 2004 Mar;13(3):107-9. PMID: 15045805
Curcumin inhibits radiation-induced changes in the liver.
J Radiol Prot. 2001 Dec;21(4):361-70. PMID: 11787891
Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock.
Clin Exp Pharmacol Physiol. 2010 Sep;37(9):939-44. Epub 2010 May 28. PMID: 20528978
Curcumin inhibits the growth of choroidal melanoma.
Cancer Biol Ther. 2011 Jan 15;11(2):229-35. Epub 2011 Jan 15. PMID: 21084858
Curcumin inhibits the growth of HTLV-1 infected T-cell tumors implanted into mice...
Int J Cancer. 2006 Feb 1;118(3):765-72. PMID: 16106398
Curcumin inhibits the growth of pancreatic cancer in a mouse experimental model.
Anticancer Res. 2009 Jun;29(6):1895-9. PMID: 19528445
Curcumin inhibits the increase of glutamate, hydroxyl radicals and PGE2 in the hypothalamus
Eur J Pharmacol. 2008 Sep 28;593(1-3):105-11. Epub 2008 Jul 15. PMID: 18664365
Curcumin inhibits the proliferation of human oral cancer cells.
Am J Chin Med. 2010;38(2):343-58. PMID: 20387230
Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.
Cancer Res. 2008 Sep 15;68(18):7283-92. PMID: 18794115
Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats.
Int Immunopharmacol. 2006 Aug;6(8):1233-42. Epub 2006 Apr 7. PMID: 16782535
Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts.
Mol Nutr Food Res. 2010 Aug;54(8):1192-201. PMID: 20087857
Curcumin inhibits tumor implantation and growth in the mouse bladder tumor model.
J Urol. 2001 Oct;166(4):1498-501. PMID: 11547120
Curcumin inhibits tumorigenesis in mice.
Phytother Res. 2009 Nov;23(11):1524-30. PMID: 9591190
Curcumin intervention ameliorates the AFB(1) induced toxicity.
J Ethnopharmacol. 2010 Feb 17;127(3):641-4. Epub 2009 Dec 14. PMID: 20015472
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Curcumin is a potential glucose-lowering agent and antioxidant in type 2 diabetic mice.
Phytother Res. 2008 Feb;22(2):180-4. PMID: 18398869
Curcumin is a potential radio-enhancer in head and neck cancer.
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Curcumin is an in vivo inhibitor of angiogenesis.
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Curcumin is effective in the prevention of radiation-induced oral mucositis.
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Curcumin is efficacious for chronic nonbacterial prostatitis in rats.
Zhonghua Nan Ke Xue. 2010 Jan;16(1):84-8. PMID: 20180411 Jan 01, 2010
Curcumin is more effective than prednisone at suppressing bleomycin-induced pulmonary fibrosis in rats.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008 May;26(5):257-61. PMID: 18727865
Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats.
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Curcumin is superior to drug therapies for preventing scopolamine-induced memory impairment.
Fitoterapia. 2011 Jan 26. Epub 2011 Jan 26. PMID: 21277954
Curcumin limits the fibrogenic evolution of experimental fatty liver.
Lab Invest. 2010 Jan;90(1):104-15. Epub 2009 Nov 9. PMID: 19901911
curcumin may be an effective strategy to combat the genotoxicity of arsenic.
Asian Pac J Cancer Prev. 2010;11(1):239-47. PMID: 20593964
Curcumin may be useful as an angiogenic inhibitor in the treatment of corneal diseases that show neovascularization.
Ophthalmologica. 2008;222(3):178-86. Epub 2008 May 22. PMID: 18497527
Curcumin may contribute to ameliorating alcohol withdrawal symptoms.
Cell Mol Neurobiol. 2007 Dec;27(8):997-1006. Epub 2007 Sep 11. PMID: 17846884
Curcumin may contribute to preventing memory loss.
Biochem Pharmacol. 2009 Apr 1;77(7):1254-65. Epub 2008 Dec 31. PMID: 19161989
Curcumin may have a beneficial effect in degenerative aortic aneurysms.
Ann Vasc Surg. 2006 May;20(3):360-8. Epub 2006 May 19. PMID: 16779518
Curcumin may have a preventive role in the treatment of diabetic retinopathy.
Biochem Biophys Res Commun. 2007 Sep 21;361(2):528-32. Epub 2007 Jul 23. PMID: 17662242
Curcumin may have a therapeutic role in reducing the adverse effects of hyperandrogenemia on the ovary and metabolism.
Reprod Sci. 2009 Jun;16(6):539-50. Epub 2009 Mar 20. PMID: 19304795
Curcumin may have beneficial anti-angiogenic and protective properties in kidneys of diabetics.
J Med Assoc Thai. 2010 Feb;93 Suppl 2:S1-8. PMID: 21302394
Curcumin may have therapeutic value for controlling allergic responses resulting from exposure to allergens such as latex.
Clin Mol Allergy. 2007;5:1. Epub 2007 Jan 25. PMID: 17254346
Curcumin may have therapeutic value for treatment of diabetes-associated hepatic fibrogenesis.
Mol Cell Endocrinol. 2010 Dec 30. Epub 2010 Dec 30. PMID: 21195127
Curcumin may have therapeutic value in Alzheimer disease prevention.
Cancer Lett. 2009 Nov 24. Epub 2009 Nov 24. PMID: 11755008
Curcumin may have therapeutic value in colon cancer prevention.
Oncogene. 1999 Oct 28;18(44):6013-20. PMID: 10557090
Curcumin may have therapeutic value in patients prone to vascular thrombosis and requiring anti-arthritic therapy.
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Curcumin may have therapeutic value in the prevention of cardiovascular complications associated with diabetes.
Nutr Metab (Lond). 2006;3:27. Epub 2006 Jul 18. PMID: 16848894
Curcumin may have therapeutic value in the treatment of hyperlipidemia.
J Med Food. 2005;8(2):256-60. PMID: 16117621
Curcumin may have therapeutic value in treating aortic stenosis, left ventricular dysfunction and myocardial fibrosis.
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Curcumin may have therapeutic value in treating scleroderma.
Am J Respir Cell Mol Biol. 2004 Jul;31(1):28-35. Epub 2004 Jan 23. PMID: 14742295
Curcumin may increase muscle tone in urinary bladder.
Evid Based Complement Alternat Med. 2008 Sep;5(3):281-7. PMID: 20172017
Curcumin may inhibit cardiac hypertrophy and myocardial infarction.
Lab Invest. 2009 Oct 19. PMID: 18292806
Curcumin may offer protective effects against methotrexate-induced rat enteritis by lowering the intestinal mucosal permeability.
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):119-21. PMID: 18227041
Curcumin may play a role in preventing diabetes-induced cardiomyopathy.
Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E1119-26. Epub 2008 Apr 15. PMID: 18413674
Curcumin may play a therapeutic role in treating depression.
Psychopharmacology (Berl). 2008 Dec;201(3):435-42. Epub 2008 Sep 3. PMID: 18766332
Curcumin may play its therapetuic role by leveling down the content of extracellular matrix in rats with pulmonary fibrosis induced by bleomycin.
Zhongguo Zhong Yao Za Zhi. 2006 Apr;31(7):570-3. PMID: 16780161
Curcumin may protect against sepsis.
Crit Care Med. 2006 Jul;34(7):1874-82. PMID: 16715036
Curcumin may protect the aging brain from oxidative stress.
Int J Dev Neurosci. 2010 Aug;28(5):351-7. Epub 2010 Apr 18. PMID: 20403421
Curcumin may provide an ideal lead molecule for the prevention and treatment of TTR amyloidosis.
Biochim Biophys Acta. 2012 Oct 13. Epub 2012 Oct 13. PMID: 23069388
Curcumin may provide an ideal therapeutic agent in the treatment of heart failure.
J Clin Invest. 2008 Mar;118(3):868-78. PMID: 18292809
Curcumin may reduce adverse effects associated with stress.
Domest Anim Endocrinol. 2010 Nov;39(4):231-9. Epub 2010 Jul 30. PMID: 20920780
Curcumin may reduce pain by activation of both opioid and non opioid mechanisms.
Pak J Biol Sci. 2007 Aug 1;10(15):2583-6. PMID: 19070135
Curcumin may stimulate recovery from spinal cord injury.
J Neurosurg Spine. 2012 Feb 10. Epub 2012 Feb 10. PMID: 22324804
Curcumin might be an effective antifibrotic drug in the treatment of chronic kidney disease.
Kidney Int. 2004 Jul;66(1):112-20. PMID: 15200418
Curcumin might increase the effect of vitamin C in protecting the function of endothelial cells..
Clin Hemorheol Microcirc. 2006;35(4):481-9. PMID: 17148847
Curcumin might significantly decrease the level of insulin resistance and leptin resistance caused by the high fat diet.
J Atheroscler Thromb. 2009;16(6):870-7. Epub 2009 Dec 22. PMID: 19176142
Curcumin modulates the immune response associated with LPS-induced periodontal disease in rats, indicating its potential therapeutic value.
Innate Immun. 2011 Jan 17. Epub 2011 Jan 17. PMID: 21242275
Curcumin oil has a protective effect against cisplatin-induced nephrotoxicity.
J Agric Food Chem. 2007 Dec 12;55(25):10150-5. Epub 2007 Nov 15. PMID: 18001039
Curcumin oil has anti-platelet effects in an experimental model of myocardial ischemia-reperfusion and thrombosis.
Thromb Res. 2011 Feb;127(2):111-8. Epub 2010 Dec 8. PMID: 21144557
Curcumin positively modulates leukocyte and platelet adhesion and improves survival in mouse sepsis.
Microcirculation. 2010 Aug;17(6):407-16. PMID: 20690979
Curcumin potentiates the activity of the chemotherapy agent gemcitabine in vitro and in vivo animal models of pancreatic cancer.
Cancer Res. 2007 Apr 15;67(8):3853-61. PMID: 17440100
Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer.
Cancer Res. 2009 Dec 1;69(23):8958-66. Epub 2009 Nov 10. PMID: 19903839
Curcumin potentiates the antitumor effects of gemcitabine in an animal model of human bladder cancer...
Biochem Pharmacol. 2010 Jan 15;79(2):218-28. Epub 2009 Aug 12. PMID: 19682434
Curcumin preserves pancreatic islet cell survival and transplantation efficiency.
Life Sci. 2008 Jan 16;82(3-4):182-9. Epub 2007 Nov 21. PMID: 18093618
Curcumin pretreatment has a beneficial effect on wound healing in mice whole-body exposed to various doses of gamma-radiation.
Chemosphere. 2009 Mar;74(9):1145-51. Epub 2009 Jan 13. PMID: 15172199
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Radiat Oncol. 2010 Nov 22;5(1):111. Epub 2010 Nov 22. PMID: 19913070
Curcumin prevents adriamycin nephrotoxicity in rats.
Br J Pharmacol. 2000 Jan;129(2):231-4. PMID: 10694226
Curcumin prevents advanced glycation induced complications of diabetes.
Biochem Pharmacol. 1998 Dec 15;56(12):1607-14. PMID: 9973181
Curcumin prevents alcohol-induced liver disease in rats.
Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G321-7. Epub 2002 Aug 28. PMID: 12388178
Curcumin prevents and reverses cirrhosis induced by bile duct obstruction.
Fundam Clin Pharmacol. 2008 Aug;22(4):417-27. PMID: 18705752
Curcumin prevents and/or delays diabetic complications associated with brain.
J Agric Food Chem. 2008 Nov 12;56(21):9905-10. Epub 2008 Oct 2. PMID: 20637830
Curcumin prevents cardiac remodeling secondary to chronic renal failure in rats.
Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H975-84. Epub 2010 Jul 2. PMID: 20601462
Curcumin prevents chemically-induced colitis in mice.
Gastroenterology. 2002 Dec;123(6):1912-22. PMID: 12454848
Curcumin prevents chemically-induced colitis.
Scand J Gastroenterol. 2009;44(2):187-94. PMID: 18830899
Curcumin prevents chemically-induced colitis.
World J Gastroenterol. 2005 Mar 28;11(12):1747-52. PMID: 15793857
Curcumin prevents chemically-induced liver cancer.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):439-42. Epub 2006 Dec 15. PMID: 10657978
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Cancer Lett. 2001 Jun 10;167(1):33-8. PMID: 11323096
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Mutat Res. 2000 Feb 16;465(1-2):131-7. PMID: 10708978
Curcumin prevents colon carcinogenesis.
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Phytother Res. 1999 Nov;13(7):571-4. PMID: 10548748
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Free Radic Biol Med. 2010 Feb 15;48(4):483-92. Epub 2009 Dec 10. PMID: 19932168
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Hepatology. 2010 May;51(5):1555-66. PMID: 20222050
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J Nat Med. 2009 Oct;63(4):415-20. Epub 2009 Jun 25. PMID: 19554395
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Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1329-36. Epub 2006 Apr 14. PMID: 19917353
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Indian J Med Res. 1995 Jan;101:31-5. PMID: 7883281
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Food Chem Toxicol. 2009 Jul;47(7):1480-4. Epub 2009 Apr 2. PMID: 19345714
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Int J Radiat Oncol Biol Phys. 2002 Jan 1;52(1):212-23. PMID: 11777641
Curcumin prevents radiation-induced thymic lymphoma in mice.
J Environ Pathol Toxicol Oncol. 2007;26(4):273-9. PMID: 18197825
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Catheter Cardiovasc Interv. 2009 Nov 15;74(6):881-8. PMID: 19496118
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Curr Eye Res. 2010 Feb;35(2):122-9. PMID: 20136422
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Nutr Cancer. 2012 Jan ;64(1):72-9. Epub 2011 Dec 15. PMID: 22172229
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Dig Dis Sci. 2007 Nov;52(11):2993-8. Epub 2007 Apr 11. PMID: 17429738
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Life Sci. 2000;66(2):PL21-8. PMID: 10666014
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Curr Neurovasc Res. 2012 Jan 16. Epub 2012 Jan 16. PMID: 22272768
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Biochim Biophys Acta. 2007 Jun;1770(6):989-96. Epub 2007 Feb 22. PMID: 17383825
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Fertil Steril. 2009 Feb;91(2):597-601. Epub 2008 Feb 21. PMID: 18291380
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Ital J Biochem. 2004 Jul;53(2):61-6. PMID: 15646009
Curcumin protects against alcohol and PUFA-induced lipid peroxidation.
Phytother Res. 2003 Sep;17(8):925-9. PMID: 13680826
Curcumin protects against amiodarone-induced pulmonary fibrosis in rats.
Br J Pharmacol. 2003 Aug;139(7):1342-50. PMID: 12890714
Curcumin protects against atherosclerosis in a mouse model.
J Physiol Pharmacol. 2005 Dec;56(4):627-35. PMID: 16391419
Curcumin protects against bleomycin-induced damages in pulmonary functions in rats
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J Pharm Pharmacol. 2007 Jun;59(6):849-56. PMID: 19285535
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Life Sci. 2006 Apr 4;78(19):2188-93. Epub 2005 Nov 8. PMID: 16288784
Curcumin protects against chemically-induced neurotoxicity in mice.
Anticancer Res. 1998 Sep-Oct;18(5A):3487-91. PMID: 20054649
Curcumin protects against chemically-induced oxidative stress in the brain.
Eur Rev Med Pharmacol Sci. 2006 Jul-Aug;10(4):157-61. PMID: 16910344
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Int J Cancer. 2005 Mar 20;114(2):190-4. PMID: 10813555
Curcumin protects against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver.
J Appl Microbiol. 2009 Jun;106(6):2086-95. Epub 2009 Mar 9. PMID: 16691314
Curcumin protects against cisplatin-induced oxidative injury in rat testis.
Hum Reprod. 2009 Jul;24(7):1717-25. Epub 2009 Mar 11. PMID: 19279034
Curcumin protects against colchicine-induced cognitive dysfunction and oxidative stress in rats.
Hum Exp Toxicol. 2012 Jan 19. Epub 2012 Jan 19. PMID: 22262262
Curcumin protects against copper-induced genotoxicity.
Anticancer Res. 1998 Nov-Dec;18(6A):4083-90. PMID: 17998598
Curcumin protects against cyclophosphamide-induced haemorrhagic cystitis.
Biochem Biophys Res Commun. 2004 Apr 16;316(4):1065-72. PMID: 19413659
Curcumin protects against cypermethrin-induced oxidative stress in rats.
Exp Toxicol Pathol. 2010 Dec 2. Epub 2010 Dec 2. PMID: 21130633
Curcumin protects against d-galactose-induced senescence in mice.
J Asian Nat Prod Res. 2011 Jan;13(1):42-55. PMID: 21253949
Curcumin protects against doxorubicin (adriamycin)-induced toxicity in rats.
J Med Food. 2009 Apr;12(2):394-402. PMID: 19459743
Curcumin protects against encephalopathy in the animal model.
Mutat Res. 2008 Dec 8;657(2):105-10. Epub 2008 Aug 22. PMID: 19000058
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J Huazhong Univ Sci Technolog Med Sci. 2006;26(6):678-81. PMID: 17357487
Curcumin protects against experimental liver injury in mice.
Zhongguo Zhong Yao Za Zhi. 2003 Aug;28(8):756-8, 793. PMID: 15015361
Curcumin protects against familial adenomatous polyposis and decreases intestinal bleeding as compared to NSAID drugs.
Biol Pharm Bull. 2009 Mar;32(3):382-8. PMID: 12050094
Curcumin protects against gamma radiation-induced ileal mucosal damage.
Arch Toxicol. 2009 Jun;83(6):609-17. Epub 2008 Aug 27. PMID: 18754102
Curcumin protects against Haloperidol-associated neurotoxicity.
J Altern Complement Med. 2004 Dec;10(6):1015-8. PMID: 21076901
Curcumin protects against hemorrhage/resuscitation injury.
Shock. 2003 Feb;19(2):150-6. PMID: 12578124
Curcumin protects against hepatic and renal injury.
Microsc Res Tech. 2009 Dec 18. Epub 2009 Dec 18. PMID: 20025056
Curcumin protects against indomethacin-induced gastric injury.
Anticancer Drugs. 2009 Oct;20(9):757-69. PMID: 16631530
Curcumin protects against ischaemia/reperfusion insult in rat forebrain.
Pharmacol Res. 2002 Sep;46(3):273-9. PMID: 12220971
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World J Urol. 2008 Jun;26(3):285-91. Epub 2008 Mar 29. PMID: 18373094
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Nutr Cancer. 2001;39(1):148-53. PMID: 8858558
Curcumin protects against lead neurotoxicity in rats.
Hum Exp Toxicol. 2003 Dec;22(12):653-8. PMID: 14992327
Curcumin protects against lipid peroxidation and oxidative stress during nicotine-induced toxicity.
Toxicol Mech Methods. 2004;14(6):339-43. PMID: 20021100
Curcumin protects against methionine-induced hyperlipidemia and hyperhomocysteinemia in rats.
Indian J Exp Biol. 2008 Jul;46(7):534-40. PMID: 18807758
Curcumin protects against myocardial oxidative damage induced by isoproterenol in rats.
Hum Exp Toxicol. 2007 Dec;26(12):933-8. PMID: 18375636
Curcumin protects against necrotizing enterocolitis in neonatal rats.
Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):132-6. PMID: 20199731
Curcumin protects against nicotine-induced lung toxicity by modulating the extent of lipid peroxidation and augmenting antioxidant defense system.
Pol J Pharmacol. 2004 Sep-Oct;56(5):581-6. PMID: 15591646
Curcumin protects against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters.
Int J Parasitol. 2011 Jan 21. Epub 2011 Jan 21. PMID: 21256849
Curcumin protects against oxidative insult induced by pentylenetetrazol in epileptic rats.
Methods Find Exp Clin Pharmacol. 2010 May;32(4):227-32. PMID: 20508869
Curcumin protects against seizures and cognitive impairment in a drug-induced epileptic rat model.
Life Sci. 2010 Sep 16. Epub 2010 Sep 16. PMID: 20840851
Curcumin protects against the anti-rejection drug cyclosporine-induced nephrotoxicity.
Gen Physiol Biophys. 2010 Mar;29(1):85-94. PMID: 20371885
Curcumin protects against the development of diabetic nephropathy, in a diabetic rat experimental model.
Br J Pharmacol. 2008 Mar;153(6):1225-31. Epub 2008 Jan 21. PMID: 18204486
Curcumin protects against vancomycin-induced kidney damage in rats.
Exp Toxicol Pathol. 2010 Sep 8. Epub 2010 Sep 8. PMID: 20832269
Curcumin protects bleomycin-induced lung injury in rats.
Pharm Res. 2008 Sep;25(9):2181-9. Epub 2008 Apr 25. PMID: 9250724
Curcumin protects intestinal mucosal barrier function of rat enteritis.
PLoS One. 2010;5(9):e12969. Epub 2010 Sep 24. PMID: 20885979
Curcumin protects pancreatic islet cells and chemically-induced type 1 diabetes.
Br J Pharmacol. 2008 Nov;155(5):702-13. Epub 2008 Aug 11. PMID: 18695642
Curcumin protects pre-oligodendrocytes from activated microglia...
Brain Res. 2010 Jun 21;1339:60-9. Epub 2010 Apr 24. PMID: 20403340
Curcumin protects rat brains against focal ischemia.
Brain Res. 2009 Jul 28;1282:133-41. Epub 2009 May 13. PMID: 19445907
Curcumin protects rat myocardium against isoproterenol-induced ischemic injury.
J Cardiovasc Pharmacol. 2010 Apr;55(4):377-84. PMID: 20125031
Curcumin protects rats against acetaminophen-induced hepatorenal damages and shows synergistic activity with N-acetyl cysteine.
Eur J Pharmacol. 2010 Feb 25;628(1-3):274-81. Epub 2009 Nov 15. PMID: 19919835
Curcumin protects retinal cells from light-and oxidant stress-induced cell death...
Free Radic Biol Med. 2009 Mar 1;46(5):672-9. Epub 2008 Dec 24. PMID: 19121385
Curcumin protects testicle cells of mice from damage induced by chronic alcohol administration.
Med Sci Monit. 2008 Nov;14(11):BR237-42. PMID: 18971866
Curcumin protects the liver against aflatoxin-induced changes.
Poult Sci. 2009 Dec;88(12):2620-7. PMID: 19903961
Curcumin protects the mmune system and body weight gain on rats intoxicated with 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD).
Immunopharmacol Immunotoxicol. 2010 Mar;32(1):99-104. PMID: 19821784
Curcumin protects the rat liver from chemically-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation.
Mol Pharmacol. 2008 Feb;73(2):399-409. Epub 2007 Nov 15. PMID: 18006644
Curcumin reduced the side effects of mitomycin C in the treatment of breast cancer.
Cancer Sci. 2009 Nov;100(11):2040-5. Epub 2009 Jul 23. PMID: 19703194
Curcumin reduces adjuvant-induced c-reactive protein and inflammation.
Immunopharmacol Immunotoxicol. 2003 May;25(2):213-24. PMID: 12784914
Curcumin reduces burn progression in rats.
Acad Emerg Med. 2007 Dec;14(12):1125-9. PMID: 18045885
Curcumin reduces gallstone formation and biliary cholesterol concentration in mice.
Indian J Med Res. 1992 Oct;96:288-91. PMID: 1459671
Curcumin reduces high blood sugar and vascular inflammation in an animal model of type 1 diabetes.
Antioxid Redox Signal. 2009 Feb;11(2):241-9. PMID: 18976114
Curcumin reduces indomethacin-induced damage in the rat small intestine.
Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID: 17351913
Curcumin reduces injury progression in a rat comb burn model.
J Burn Care Res. 2011 Jan-Feb;32(1):135-42. PMID: 21088615
Curcumin reduces intestinal inflammation and polyps, indicating its potential value for preventing colon cancer.
J Interferon Cytokine Res. 2010 Oct 15. Epub 2010 Oct 15. PMID: 20950131
curcumin reduces markers of liver damage in rats treated with heated sunflower oil or ethanol.
Vet Ital. 2010 Jan-Mar;46(1):83-92. PMID: 20391370
Curcumin reduces nitric oxide formation and associated inflammation in the rat mammary gland.
J Exp Biol. 2009 Jan;212(Pt 2):163-8. PMID: 11020339
Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.
Mol Nutr Food Res. 2009 Oct;53(10):1316-28. PMID: 19753608
Curcumin reduces oxidative stress associated with exposure to an environmental pollutant.
Toxicol Ind Health. 2011 Jan 18. Epub 2011 Jan 18. PMID: 21245202
Curcumin reduces pathogenesis in hamster-opisthorchiasis.
Southeast Asian J Trop Med Public Health. 2009 Nov;40(6):1208-15. PMID: 20578454
Curcumin reduces periductal fibrosis in liver fluke-infected in hamsters.
Eur J Pharmacol. 2010 Jul 25;638(1-3):134-41. Epub 2010 Apr 24. PMID: 20420820
Curcumin reduces pertussis-induced infectious brain edema in rats.
Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 14723822
Curcumin reduces pulmonary tumorigenesis in transgenic mice.
Mol Nutr Food Res. 2011 Jul ;55(7):1036-43. Epub 2011 May 2. PMID: 21538854
Curcumin reduces rat hepatic fibrosis.
Zhonghua Gan Zang Bing Za Zhi. 2007 Oct;15(10):753-7. PMID: 17963602
Curcumin reduces the accumulation of collagen IV and fibronectin in the glomeruli...
Clin Cancer Res. 2009 Feb 15;15(4):1123-5. PMID: 15339499
Curcumin reduces the adverse effects of hyperinsulinemia associated with type 2 diabetes
Clin Breast Cancer. 2010 Jun;10(3):224-9. PMID: 19841616
Curcumin regresses tumors as well as protects the host from tumor-induced immunosuppression and toxicity.
Cancer Detect Prev. 2005;29(5):470-8. Epub 2005 Sep 26. PMID: 16188398
Curcumin regulates the shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis.
Acta Pharmacol Sin. 2006 Aug;27(8):1071-7. PMID: 16867261
Curcumin retards the growth of intestinal polyps in a mouse model of familial adenomatous polyposis.
Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID: 16387490
Curcumin reverses amyloid pathology and associated neurotoxicity in a mouse model of Alzheimer disease.
J Neurochem. 2007 Aug;102(4):1095-104. Epub 2007 Apr 30. PMID: 17472706
Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.
Neuropharmacology. 2009 Sep;57(4):463-71. Epub 2009 Jun 21. PMID: 19540859
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts.
Cell Mol Immunol. 2010 Jul;7(4):306-15. Epub 2010 Mar 22. PMID: 20305684
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation.
Clin Cancer Res. 2008 Apr 1;14(7):2128-36. PMID: 18381954
Curcumin showed significant nephroprotective effects against Sodium Fluoride induced toxicity upon kidneys.
Biol Trace Elem Res. 2012 Mar ;145(3):369-74. Epub 2011 Sep 7. PMID: 21901432
Curcumin significantly attenuates carotid artery neointima formation.
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):85-90. Epub 2005 Oct 20. PMID: 16239599
Curcumin reduces gallstone formation and biliary cholesterol concentration in mice.
Indian J Med Res. 1992 Oct;96:288-91. PMID: 1459671
Curcumin reduces high blood sugar and vascular inflammation in an animal model of type 1 diabetes.
Antioxid Redox Signal. 2009 Feb;11(2):241-9. PMID: 18976114
Curcumin reduces indomethacin-induced damage in the rat small intestine.
Cancer Res. 2010 Nov 15;70(22):9218-23. Epub 2010 Oct 26. PMID: 17351913
Curcumin reduces injury progression in a rat comb burn model.
J Burn Care Res. 2011 Jan-Feb;32(1):135-42. PMID: 21088615
Curcumin reduces intestinal inflammation and polyps, indicating its potential value for preventing colon cancer.
J Interferon Cytokine Res. 2010 Oct 15. Epub 2010 Oct 15. PMID: 20950131
curcumin reduces markers of liver damage in rats treated with heated sunflower oil or ethanol.
Vet Ital. 2010 Jan-Mar;46(1):83-92. PMID: 20391370
Curcumin reduces nitric oxide formation and associated inflammation in the rat mammary gland.
J Exp Biol. 2009 Jan;212(Pt 2):163-8. PMID: 11020339
Curcumin reduces oxidative and nitrative DNA damage associated with fluke infection.
Mol Nutr Food Res. 2009 Oct;53(10):1316-28. PMID: 19753608
Curcumin reduces oxidative stress associated with exposure to an environmental pollutant.
Toxicol Ind Health. 2011 Jan 18. Epub 2011 Jan 18. PMID: 21245202
Curcumin reduces pathogenesis in hamster-opisthorchiasis.
Southeast Asian J Trop Med Public Health. 2009 Nov;40(6):1208-15. PMID: 20578454
Curcumin reduces periductal fibrosis in liver fluke-infected in hamsters.
Eur J Pharmacol. 2010 Jul 25;638(1-3):134-41. Epub 2010 Apr 24. PMID: 20420820
Curcumin reduces pertussis-induced infectious brain edema in rats.
Biopharm Drug Dispos. 2006 Dec;27(9):407-20. PMID: 14723822
Curcumin reduces pulmonary tumorigenesis in transgenic mice.
Mol Nutr Food Res. 2011 Jul ;55(7):1036-43. Epub 2011 May 2. PMID: 21538854
Curcumin reduces rat hepatic fibrosis.
Zhonghua Gan Zang Bing Za Zhi. 2007 Oct;15(10):753-7. PMID: 17963602
Curcumin reduces the accumulation of collagen IV and fibronectin in the glomeruli...
Clin Cancer Res. 2009 Feb 15;15(4):1123-5. PMID: 15339499
Curcumin reduces the adverse effects of hyperinsulinemia associated with type 2 diabetes
Clin Breast Cancer. 2010 Jun;10(3):224-9. PMID: 19841616
Curcumin regresses tumors as well as protects the host from tumor-induced immunosuppression and toxicity.
Cancer Detect Prev. 2005;29(5):470-8. Epub 2005 Sep 26. PMID: 16188398
Curcumin regulates the shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis.
Acta Pharmacol Sin. 2006 Aug;27(8):1071-7. PMID: 16867261
Curcumin retards the growth of intestinal polyps in a mouse model of familial adenomatous polyposis.
Eur J Cancer. 2006 Feb;42(3):415-21. Epub 2006 Jan 4. PMID: 16387490
Curcumin reverses amyloid pathology and associated neurotoxicity in a mouse model of Alzheimer disease.
J Neurochem. 2007 Aug;102(4):1095-104. Epub 2007 Apr 30. PMID: 17472706
Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress.
Neuropharmacology. 2009 Sep;57(4):463-71. Epub 2009 Jun 21. PMID: 19540859
Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts.
Cell Mol Immunol. 2010 Jul;7(4):306-15. Epub 2010 Mar 22. PMID: 20305684
Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation.
Clin Cancer Res. 2008 Apr 1;14(7):2128-36. PMID: 18381954
Curcumin showed significant nephroprotective effects against Sodium Fluoride induced toxicity upon kidneys.
Biol Trace Elem Res. 2012 Mar ;145(3):369-74. Epub 2011 Sep 7. PMID: 21901432
Curcumin significantly attenuates carotid artery neointima formation.
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):85-90. Epub 2005 Oct 20. PMID: 16239599
Curcumin's induction of enzymes involved in the detoxification of the electrophilic products of lipid peroxidation may contribute to the anti-inflammatory and anti-cancer activities of curcumin.
Int J Biochem Cell Biol. 1998 Apr;30(4):445-56. PMID: 9675878
Curcumin's inhibition of intestinal tumors is associated with changes in the intestinal immune cell profile.
J Surg Res. 2000 Apr;89(2):169-75. PMID: 10729246
Curcumin's neuroprotective properties may be due to its anticholinesterase, antioxidant activity and brain insulin receptor modulating activities.
Pharmacol Res. 2010 Mar;61(3):247-52. Epub 2009 Dec 21. PMID: 20026275
Curcumin, a NF-kappaB inhibitor, stimulates muscle regeneration after traumatic injury.
Am J Physiol. 1999 Aug;277(2 Pt 1):C320-9. PMID: 10444409
Curcumin, beta-carontein and hesperidin prevent chemically-induced oral cancer.
Cancer Res. 1994 Sep 1;54(17):4653-9. PMID: 8062259
Curcumin, capsaicin and garlic attenuate adverse blood changes associated with a cholesterol-enriched diet.
Br J Nutr. 2005 Jan;93(1):81-91. PMID: 15705229
Curcumin, capsaicin and garlic have a beneficial influence on erythrocyte integrity in high-fat fed rats.
J Nutr Biochem. 2006 Jul;17(7):471-8. Epub 2005 Oct 25. PMID: 16263255
Curcumin, capsaicin and garlic inhibit adverse blood and liver changes associated wtih a high-fat diet in rats.
Ann Nutr Metab. 2004 Sep-Oct;48(5):314-20. Epub 2004 Oct 1. PMID: 15467281
Curcumin, capsaicin and garlic reduce adverse changes in red blood cells associated with hypercholesterolemia.
Mol Cell Biochem. 2002 Jul;236(1-2):155-61. PMID: 12190115
Curcumin, capsaicin, and garlic have a beneficial effect in the red blood cells and liver of cholesterol fed rats.
Acta Pharmacol Sin. 2007 Oct;28(10):1559-65. PMID: 15296079
Curcumin, ellagic acid and bixin attenuate radiation induced toxicity.
Indian J Exp Biol. 1996 Sep;34(9):845-7. PMID: 9014516
Curcumin, ellagic acid and bixin provide protection against chromosome damage produced by radiation.
J Exp Clin Cancer Res. 1998 Dec;17(4):431-4. PMID: 10089063
Curcumin, resveratrol and melatonin protect against cadmium-induced oxidative damage.
Toxicology. 2006 Aug 15;225(2-3):150-6. Epub 2006 May 26. PMID: 16806632
Curcumin, silymarin and N-acetylcysteine protect against antitubercular drug-induced hepatotoxicity.
Hum Exp Toxicol. 2012 Feb 8. Epub 2012 Feb 8. PMID: 22318308
Curcumin-free turmeric extract inhibits chemically-induced gastric tumors in mice.
Cancer Lett. 1997 Sep 16;118(1):79-85. PMID: 9310263
Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR human oral cancer cells.
Int J Oncol. 2013 Oct ;43(4):1141-50. Epub 2013 Aug 5. PMID: 23917396
Curcumin-manganese complexes have enhanced antioxidant activity.
Free Radic Biol Med. 2003 Dec 15;35(12):1632-44. PMID: 14680686
Curcuminoid supplementation ameliorates cardiac autonomic imbalance in high-fat-fed rats, probably due to its lipid-lowering effect.
Nutrition. 2009 Jul-Aug;25(7-8):870-8. Epub 2009 Apr 23. PMID: 19398300
Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease.
Neuroscience. 2010 Sep 1;169(3):1296-306. Epub 2010 Jun 9. PMID: 20538041
Curcuminoids exhibit anti-allergy activity.
Bioorg Med Chem. 2004 Nov 15;12(22):5891-8. PMID: 15498665
Curcuminoids exhibit anti-spasmodic activity in pig ileum and rat uterus.
CNS Drugs. 2007;21 Suppl 1:39-43; discussion 45-6. PMID: 12930003
Curcuminoids inhibit chemically-induced tumor promotion.
Carcinogenesis. 1995 Oct;16(10):2493-7. PMID: 7586157
Curcuminoids inhibit chemically-induced tumor promotion.
Carcinogenesis. 1995 Oct;16(10):2493-7. PMID: 7586157
Curcuminoids may suppress liver inflammation associated with endotoxemia.
Shock. 2002 May;17(5):399-403. PMID: 12022761
Curcuminoids positively modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain.
Free Radic Res. 2008 Nov;42(11-12):999-1005. PMID: 19031318
Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male rats.
J Agric Food Chem. 2007 Feb 7;55(3):1039-44. PMID: 17263510
Curry feeding inhibits cancer in a cell-transplanted mouse model.
Asia Pac J Clin Nutr. 2007;16(1):30-9. PMID: 17215178
Curumin reduces inflammation associated with Angiostrongylus cantonensis-induced eosinophilic meningitis.
J Helminthol. 2007 Mar;81(1):1-5. PMID: 17381860
Dietary constituents inhibit chemically-induced DNA and hemoglobin adductions associated with cancer.
Appl Radiat Isot. 2003 Mar;58(3):291-8. PMID: 12595006
Dietary curcumin and capsaicin have hypolipidemic and antioxidant effects.
Life Sci. 2001 Dec 7;70(3):253-67. PMID: 17960446
Dietary curcumin attenuates glioma growth.
Clin Cancer Res. 2010 Dec 1;16(23):5781-95. PMID: 21138870
Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition.
Exp Neurol. 2006 Feb;197(2):309-17. Epub 2005 Dec 20. PMID: 16364299
Dietary curcumin has a chemopreventive effect on inflammation-induced colorectal carcinogenesis in mice.
Mol Nutr Food Res. 2011 Feb;55(2):259-67. Epub 2010 Sep 16. PMID: 20848615
Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.
Radiat Res. 2010 May;173(5):590-601. PMID: 20426658
Dietary curcumin inhibits chemically induced gastric cancer in mice.
Carcinogenesis. 1998 Aug;19(8):1357-60. PMID: 9744529
Dietary curcumin inhibits forestomach, duodenal, and colon carcinogenesis in mice.
Cancer Res. 1994 Nov 15;54(22):5841-7. PMID: 7954412
Dietary curcumin prevents colon carcinogenesis.
Cancer Res. 1995 Jan 15;55(2):259-66. PMID: 7812955
Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity.
Endocrinology. 2008 Jul;149(7):3549-58. Epub 2008 Apr 10. PMID: 18403477
Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue.
J Nutr. 2001 Nov;131(11):2932-5. PMID: 11694621
Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in male mice, indicating its protective value against chemical carcinogenesis and toxicity.
Pharmacol Toxicol. 2003 Jan;92(1):33-8. PMID: 12710595
Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and angiogenesis.
Anticancer Res. 2013 Sep ;33(9):3603-9. PMID: 24023285
Embelin and curcumin have a beneficial effect against oxidative tissue damage during chemically-induced hepatocarinogenesis in rats.
Mol Cell Biochem. 2006 Mar;284(1-2):49-55. Epub 2006 Feb 14. PMID: 16477385
Embelin and curcumin have a chemopreventive effect against chemically-induced liver cancer.
Fitoterapia. 2005 Sep;76(6):549-55. PMID: 16009505
Fucoxanthin, lutein and tetrahydrocurcumin may have chemopreventive effects against colon carcinogenesis.
Carcinogenesis. 1998 Jan;19(1):81-5. PMID: 9472697
Garlic and turmeric restore endothelial function in rats.
Life Sci. 2005 Jul 8;77(8):837-57. Epub 2005 Apr 14. PMID: 15964306
Grape seed extract, black seed extract and curcumin ameliorate tamoxifen-induced liver injury.
Hepatogastroenterology. 2007 Jan-Feb;54(73):320-4. PMID: 21046982
Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease.
Mutat Res. 2009 Feb 10;661(1-2):25-34. Epub 2008 Nov 6. PMID: 19027755
Melatonin and curcumin protect against ndomethacin-induced acute gastric ulceration.
Free Radic Biol Med. 2006 Sep 15;41(6):911-25. Epub 2006 Apr 30. PMID: 16934674
Melatonin, curcumin, quercetin, and resveratrol ameliorate chemically-induced kidney damage.
Neuro Endocrinol Lett. 2007 Dec;28(6):739-44. PMID: 18684806
NAC and curcumin protect against malathion-induced toxicity in human peripheral blood mononuclear cells.
Toxicol In Vitro. 2009 Oct;23(7):1319-25. Epub 2009 Jul 14. PMID: 19607909
Nanocapsulated curcumin acts as an oral chemopreventive formulation against chemically-induced hepatocellular carcinoma in rat.
Chem Biol Interact. 2011 Dec 16. Epub 2011 Dec 16. PMID: 22197969
Nitric oxide modulation is involved in the protective effect of curcumin in ameliorating sleep deprivation-induced behavioral alterations and oxidative damage.
IEEE Trans Biomed Eng. 1997 Oct;44(10):909-20. PMID: 18586477
Nutritional antioxidants such as green tea polyphenols and tetrahydrocurcumin may beneficially modify the life span of animals.
Biogerontology. 2007 Oct;8(5):567-73. Epub 2007 May 22. PMID: 17516143
Omega-3 fatty acids, black seed oil and curcuminoids have a therapeutic role in gastritits in an animal model.
Eur J Nutr. 2007 Oct;46(7):391-6. Epub 2007 Sep 20. PMID: 18368490
Oral administration of curcumin reduces intestinal inflammation in a mouse model of irritable bowel syndrome.
Dig Dis Sci. 2010 May;55(5):1272-7. Epub 2009 Jun 10. PMID: 19513843
Oral curcumin inhibits skin carcinogenesis in mice.
Cancer Lett. 1997 Jun 24;116(2):197-203. PMID: 9215864
Oral curcumin may have chemopreventive properties against colorectal cancer.
Cancer Res. 2001 Feb 1;61(3):1058-64. PMID: 11221833
Oral curcumin may have therapeutic activity in treating inherited peripheral neuropathies.
Am J Hum Genet. 2007 Sep;81(3):438-53. Epub 2007 Aug 3. PMID: 17701891
Oral curcumin protects against chemically-induced skin cancer in mice.
BMC Cancer. 2001;1:1. Epub 2001 Jan 17. PMID: 11231886
Piperine and Curcumin (from Turmeric) attenuates Cadmium induced immunotoxicity.
Biometals. 2008 Dec;21(6):649-61. Epub 2008 Jun 20. PMID: 18566892
Pre-treatment with curcumin enhances oral bioavailability of docetaxel in rats.
Int J Pharm. 2010 Oct 31;399(1-2):116-20. Epub 2010 Aug 18. PMID: 20727390
Pretreatment of curcumin attenuates coagulopathy and renal injury in LPS-induced endotoxemia.
J Endotoxin Res. 2007;13(1):15-23. PMID: 17621542
Pretreatment with NAC and curcumin inhibit staphylococcal enteroxin A-induced fever in rabbits.
Mol Cell Biochem. 2004 Jul;262(1-2):177-85. PMID: 15532722
Quercetin and curcumin inhibit ischemic kidney injury.
Transplantation. 1998 Jul 27;66(2):147-52. PMID: 9701255
Quercetin and curcumin protect against paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat.
Food Chem Toxicol. 2010 Nov;48(11):3246-61. Epub 2010 Sep 4. PMID: 20804811
Quercetin, curcumin, ginseng and rutin exhibit anti-cancer activity in an animal model of colon cancer.
Arch Neurol. 2003 Feb;60(2):194-200. PMID: 15831530
Red sage and curcumin exhibit anti-liver fibrotic properties.
Chin J Integr Med. 2006 Sep;12(3):207-11. PMID: 17005083
Resveratrol and curcumin may combine with insulin in attenuating diabetic neuropathic pain.
Phytother Res. 2007 Mar;21(3):278-83. PMID: 17199240
Resveratrol and curcumin reduce inflammation associated with acute small intestinal inflammation.
PLoS One. 2010;5(12):e15099. Epub 2010 Dec 3. PMID: 21151942
Safety Study: Curcumin may not be safe during pregnancy.
Int J Mol Sci. 2010;11(8):2839-55. Epub 2010 Aug 2. PMID: 21152277
Saffron, garlic and curcumin protect against yclophosphamide induced genotoxicity in mice.
Asia Pac J Clin Nutr. 2004;13(3):292-4. PMID: 15331343
Sulforaphane and curcumin protect against malathion toxicity.
Eur Rev Med Pharmacol Sci. 2012 Jul ;16 Suppl 3:144-8. PMID: 22957429
Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer.
Mol Cancer Ther. 2010 Aug;9(8):2255-64. Epub 2010 Jul 20. PMID: 20647339
Tea and curcumin inhibit chemically-induced oral cancer.
Carcinogenesis. 2002 Aug;23(8):1307-13. PMID: 12151348
Tea and curcumin inhibit chemically-induced oral cancer.
Prog Neuropsychopharmacol Biol Psychiatry. 1994 Sep;18(5):915-24. PMID: 12572355
Tetrahydrocurcumin and rutin have cardioprotective properties in a rat model of myocardial infarction
Pharmazie. 2009 Feb;64(2):132-6. PMID: 19320287
Tetrahydrocurcumin displays antihyperlipidaemic effect in addition to its antidiabetic effect in type 2 diabetic rats.
Basic Clin Pharmacol Toxicol. 2006 Aug;99(2):122-7. PMID: 16918712
Tetrahydrocurcumin has a lipid lowering effects in a rat model of diabetes.
Chem Biol Interact. 2010 Dec 5;188(3):643-50. Epub 2010 Aug 7. PMID: 20696151
Tetrahydrocurcumin has a protective effect on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats.
Basic Clin Pharmacol Toxicol. 2007 Oct;101(4):241-5. PMID: 17845505
Tetrahydrocurcumin has antioxidant and anti-diabetic activity in streptozotocin-nicotinamide induced diabetic rats.
Life Sci. 2006 Sep 27;79(18):1720-8. Epub 2006 Jun 9. PMID: 16806281
Tetrahydrocurcumin increases the number of total cellular insulin binding sites resulting in a significant increase in plasma insulin.
J Biosci. 2008 Mar;33(1):63-72. PMID: 18376071
Tetrahydrocurcumin normalizes blood glucose and causes a marked improvement of altered carbohydrate metabolic enzymes in diabetic animals.
J Basic Clin Physiol Pharmacol. 2005;16(4):257-74. PMID: 16438392
Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats.
J Med Food. 2007 Jun;10(2):323-9. PMID: 17651069
Tetrahydrocurcumin protect against chloroquine induced liver toxicity.
J Pharm Pharm Sci. 2005;8(1):115-23. Epub 2005 Apr 30. PMID: 15946605
Tetrahydrocurcumin protects against oxidative damage associated with chemical exposure.
Basic Clin Pharmacol Toxicol. 2006 Nov;99(5):329-34. PMID: 17076682
Tetrahydrocurcumin protects against oxidative stress in cholesterol-fed rabbits.
J Atheroscler Thromb. 2002;9(5):243-50. PMID: 12409634
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J Basic Clin Physiol Pharmacol. 2005;16(1):1-15. PMID: 16187483
Tetrahydrocurcumin protectsagainst erythromycin estolate-induced lipid peroxidation in rats.
J Basic Clin Physiol Pharmacol. 2005;16(1):1-15. PMID: 16187483
The combination of epigallocatechin gallate and curcumin suppresses ER alpha-breast cancer cell growth in vitro and in vivo.
Int J Cancer. 2008 May 1;122(9):1966-71. PMID: 18098290
The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma.
J Nutr Biochem. 2011 Jul 18. Epub 2011 Jul 18. PMID: 21775121
Topical curcumin attenuates photoaging in mice.
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Tumeric and curcumin may prevent or delay the development of cataract.
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Tumeric oil ameliorates the neurological functional deficits and infarct and edema volumes in the rat model of embolic stroke.
BMC Complement Altern Med. 2008 Sep 30;8:55. PMID: 18826584
Turmeric (Curcuma wenyujin) induces programmed cell death and inhibits proliferation in human cervical cancer cells in vitro and in vivo.
Integr Cancer Ther. 2010 Feb 11. Epub 2010 Feb 11. PMID: 20150221
Turmeric and catechin are effective chemopreventive agent.
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Turmeric and curcumin appear to be beneficial in preventing diabetes-induced oxidative stress in rats.
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Turmeric and curcumin have anti-diabetic actions.
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Turmeric and myrrh protect against liver oxidative damage and genotoxicity induced by lead acetate in mice.
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Turmeric extract and curcumin reduce the development of animal tumors.
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Turmeric extract protects against carcinogen and benzo[a]phyrene-induced mutagenicity, genotoxicity and carcinogenicity.
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Maturitas. 2008 Feb 20;59(2):137-48. Epub 2008 Mar 4. PMID: 10625938
Curcumin inhibits cervical cancer associated HPV-infection.
Br J Nutr. 2007 Oct;98(4):720-6. Epub 2007 Aug 1. PMID: 15514944
Curcumin inhibits chemically-induced oxidative stress associated with a tumor-promoting agent.
Carcinogenesis. 1994 Aug;15(8):1717-21. PMID: 8055654
Curcumin inhibits cholesterol uptake.
Lipids Health Dis. 2010;9:40. Epub 2010 Apr 19. PMID: 20403165
Curcumin inhibits chronic myelogenous leukemia cells (K562).
J Altern Complement Med. 2007 Nov;13(9):985-7. PMID: 15182583
Curcumin inhibits cortisone-induced cytoxicity in vitro.
Basic Clin Pharmacol Toxicol. 2009 Mar;104(3):236-40. Epub 2009 Jan 20. PMID: 19175364
Curcumin inhibits cyclooxygenase and matrix metalloproteinase-8 expression associated with breast cancer progrression.
Antioxid Redox Signal. 2005 Nov-Dec;7(11-12):1612-20. PMID: 16356124
Curcumin inhibits cyclooxygenase-2 expression in human colon cancer cells.
Cancer Lett. 2001 Oct 30;172(2):111-8. PMID: 11566484
Curcumin inhibits cytokines associated with allergic diseases.
Biochem Pharmacol. 1997 Oct 1;54(7):819-24. PMID: 9353136
Curcumin inhibits EBV reactivation in vitro.
Mol Carcinog. 2002 Mar;33(3):137-45. PMID: 11870879
Curcumin inhibits embryonal carcinoma.
Int J Nurs Pract. 2010 Oct;16(5):454-60. PMID: 11686235
Curcumin inhibits endotoxin-associated changes in rat genes.
J Pharmacol Exp Ther. 2003 Dec;307(3):1205-12. Epub 2003 Oct 13. PMID: 14557382
Curcumin inhibits epidermal growth factor receptor activity in human epidermoid cancer cells.
Biochim Biophys Acta. 1994 Dec 30;1224(3):597-600. PMID: 7803521
Curcumin inhibits esophageal activation in response to acid.
Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G388-98. Epub 2008 Dec 12. PMID: 19074641
Curcumin inhibits Ewing sarcoma.
Med Oncol. 2010 Dec;27(4):1096-101. Epub 2009 Oct 27. PMID: 19859844
Curcumin inhibits gastrointestinal hormone (e.g., neurotensin)-induced chemokine expression and cell migration associated with human colon cancer cell progression.
Clin Cancer Res. 2006 Sep 15;12(18):5346-55. PMID: 17000667
Curcumin inhibits glucose production in isolated mice hepatocytes.
Diabetes Res Clin Pract. 2008 May;80(2):185-91. Epub 2008 Jan 24. PMID: 18221818
Curcumin inhibits glutamate-induced excitoxicity in vitro.
Mol Cell Biochem. 2007 Apr;298(1-2):187-94. Epub 2006 Nov 25. PMID: 17131042
Curcumin inhibits gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection.
Biol Chem. 2005 May;386(5):481-90. PMID: 15927892
Curcumin inhibits growth and induces programmed cell death in human ovarian cancer cell lines.
Chin J Integr Med. 2006 Jun;12(2):126-31. PMID: 16800992
Curcumin inhibits growth and sensitizes ovarian cancer cells to cisplatin-mediated killing.
Carcinogenesis. 1982;3(11):1331-8. PMID: 12447990
Curcumin inhibits growth, induces cell cycle arrest and programmed cell death in human prostatic stromal cells.
Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(16):2022-5. PMID: 19086645
Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT.
Int J Mol Med. 2012 Nov ;30(5):1021-8. Epub 2012 Aug 20. PMID: 22922731
Curcumin inhibits head and neck cancer cell proliferation.
Int J Cancer. 2006 Sep 15;119(6):1268-75. PMID: 16642480
Curcumin inhibits head and neck squamous cell cancer cells.
Int J Cancer. 2004 Sep 20;111(5):679-92. PMID: 15252836
Curcumin inhibits Helicobacter pylori.
Anticancer Res. 2002 Nov-Dec;22(6C):4179-81. PMID: 12553052
Curcumin inhibits hepatic fibrogenesis.
Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G113-23. Epub 2006 Sep 7. PMID: 16959952
Curcumin inhibits hepatitis B virus.
FEBS Lett. 2010 Jun 3;584(11):2485-90. Epub 2010 Apr 29. PMID: 20434445
Curcumin inhibits hepatitis C virus replication.
FEBS Lett. 2009 Dec 17. PMID: 20026048
Curcumin inhibits histiocytoma tumor cells.
FEBS Lett. 1999 Aug 6;456(2):311-4. PMID: 10456330
Curcumin inhibits HIV-1 integrase activity.
Biochem Pharmacol. 1995 Apr 18;49(8):1165-70. PMID: 7748198
Curcumin inhibits human colon cancer cell growth.
Oncogene. 2006 Jan 12;25(2):278-87. PMID: 16170359
Curcumin inhibits human leukemia cells.
Biochim Biophys Acta. 1996 Nov 15;1317(2):95-100. PMID: 8950193
Curcumin inhibits human malignant astrocytoma cell lines.
J Neurooncol. 2005 Sep;74(2):105-11. PMID: 16193380
Curcumin inhibits human ovarian cancer cell migration.
Cancer Chemother Pharmacol. 2008 Oct;62(5):857-65. Epub 2008 Jan 23. PMID: 18214481
Curcumin inhibits human pancreatic cancer cell growth.
Cancer. 2002 Sep 15;95(6):1206-14. PMID: 12216086
Curcumin inhibits human pancreatic cancer cell growth.
Cancer. 2004 Nov 15;101(10):2351-62. PMID: 15476283
Curcumin inhibits Human T-cell leukemia virus type I (HTLV-I).
Cancer Sci. 2006 Apr;97(4):322-7. PMID: 16630125
Curcumin inhibits hypoxia induced proliferation and collagen I synthesis.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Jul;41(4):621-5. PMID: 20848782
Curcumin inhibits hypoxia-induced angiogenesis associated wtih tumor progression.
Oncol Rep. 2006 Jun;15(6):1557-62. PMID: 16685395
Curcumin inhibits IMP dehydrogenase, a target for anticancer and antiviral chemotherapy agents.
Biosci Biotechnol Biochem. 2010;74(1):185-7. Epub 2010 Jan 7. PMID: 20057137
Curcumin inhibits in vitro MCP-1 release from mouse pancreatic islets, indicating it may have anti-rejection properties.
Transplant Proc. 2006 Nov;38(9):3035-8. PMID: 17112893
Curcumin inhibits inflammation associated with secretion of inflammatory chemokines.
Food Chem Toxicol. 2010 Jan;48(1):47-52. Epub 2009 Sep 18. PMID: 19766691
Curcumin inhibits inflammation-induced bone resportion that is frequently associated with cancers such as metastatic breast cancer and multiple myeloma.
Ann Rheum Dis. 1995 Jun;54(6):491-3. PMID: 15128775
Curcumin inhibits inflammation.
Food Chem Toxicol. 2006 Dec;44(12):1989-96. Epub 2006 Jul 12. PMID: 7786295
Curcumin inhibits inflammatory processes associated with skin cancer promotion.
Carcinogenesis. 2003 Sep;24(9):1515-24. Epub 2003 Jul 4. PMID: 12844482
Curcumin inhibits integrin (alpha6beta4)-dependent breast cancer cell motility and invasion.
Cancer Prev Res (Phila). 2008 Oct;1(5):385-91. PMID: 19138983
Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human non-small cell lung cancer cells.
Biochem Biophys Res Commun. 2005 Aug 26;334(2):313-8. PMID: 16005433
Curcumin inhibits invasion and metastasis in colorectal cancer.
Biosci Rep. 2011 Jan 14;31(3):185-97. PMID: 20815812
Curcumin inhibits invasive ductal carcinoma of the breast in the cell model.
Chem Biol Interact. 2010 Feb 12;183(3):455-61. Epub 2009 Nov 26. PMID: 19944674
Curcumin inhibits ionizing radiation-induced proliferation of human neuroblastoma cells.
Gynecol Endocrinol. 2010 Feb 23. Epub 2010 Feb 23. PMID: 21236599
Curcumin inhibits keloid formation in fibroblasts.
Arch Dermatol Res. 2010 Dec;302(10):717-24. Epub 2010 Aug 18. PMID: 20717830
Curcumin inhibits LDL cholesterol induced hepatic stellate cell activation associated with fatty liver and liver fibrosis.
Endocrinology. 2009 Dec;150(12):5384-94. Epub 2009 Oct 6. PMID: 19808779
Curcumin inhibits leiomyoma (fibroid) cell proliferation and fibronection expression.
Fertil Steril. 2009 May;91(5 Suppl):2177-84. Epub 2008 Jun 13. PMID: 18555241
Curcumin inhibits leptin-induced hepatic stellate cell activation.
Br J Pharmacol. 2010 Nov;161(5):1137-49. PMID: 20977462
Curcumin inhibits leukemia cell proliferation.
J Surg Res. 2010 Aug 6. Epub 2010 Aug 6. PMID: 12938514
Curcumin inhibits leukemia cell proliferation.
Acta Pharmacol Sin. 2003 Nov;24(11):1155-60. PMID: 14627502
Curcumin inhibits ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation associated with tumor cell growth.
Carcinogenesis. 1995 Aug;16(8):1741-5. PMID: 7634398
Curcumin inhibits lipid peroxidation and protein oxidation in rat liver mitochondria.
Biochim Biophys Acta. 2006 Jan;1760(1):70-7. Epub 2005 Oct 3. PMID: 16236451
Curcumin inhibits lipopolysaccharide-activated primary microglia.
Int Rev Neurobiol. 2009;88:297-334. PMID: 16934299
Curcumin inhibits lipopolysaccharide-induced inflammation.
Int Immunopharmacol. 2010 Jul;10(7):760-8. Epub 2010 Apr 22. PMID: 20399909
Curcumin inhibits lipoxygenase, indicating it possesses anti-inflammatory and anti-cancer properties.
Int J Mol Med. 2000 Nov;6(5):521-6. PMID: 11029517
Curcumin inhibits liver cancer cell gowth.
Zhonghua Gan Zang Bing Za Zhi. 2002 Dec;10(6):449-51. PMID: 12502450
Curcumin inhibits liver cancer cell invasiveness.
Comp Biochem Physiol B Biochem Mol Biol. 2000 Oct;127(2):213-22. PMID: 9663426
Curcumin inhibits liver fibrogenesis.
Int Immunopharmacol. 2005 Mar;5(3):555-69. PMID: 15683851
Curcumin inhibits liver tumor angiogenesis and growth.
Clin Hemorheol Microcirc. 2006;34(1-2):109-15. PMID: 16543625
Curcumin inhibits lung cancer by inducing programmed cell death and cell cycle arrest.
Cancer Lett. 2008 Dec 8;272(1):77-90. Epub 2008 Aug 12. PMID: 18701210
Curcumin inhibits lung cancer cells.
Mol Biol Rep. 2010 Mar;37(3):1627-32. Epub 2009 May 15. PMID: 19444642
Curcumin inhibits mantle cell lymphoma through a number of pathways.
Biochem Pharmacol. 2005 Sep 1;70(5):700-13. PMID: 16023083
Curcumin inhibits melanoma proliferation by arresting growth and induces programmed cell death.
Melanoma Res. 2004 Jun;14(3):165-71. PMID: 15179184
Curcumin inhibits metastatic breast cancer cells.
Front Oncol. 2012 ;2:161. Epub 2012 Nov 15. PMID: 23162792
Curcumin inhibits metastatic melanoma cells.
Cancer Lett. 2004 Aug 10;211(2):235-42. PMID: 15219947
Curcumin inhibits metastatic progression of breast cancer cells.
Mol Biol Rep. 2011 Sep 24. Epub 2011 Sep 24. PMID: 21947854
Curcumin inhibits migration and invasion of hepatic stellate cells by reducing MMP-2 expression and activity
Zhonghua Gan Zang Bing Za Zhi. 2009 Nov;17(11):835-8. PMID: 19958643
Curcumin inhibits multi drug resistance associated protein (MRP1) in retinoblastoma cells.
Bioinformation. 2012 ;8(1):13-9. Epub 2012 Jan 6. PMID: 22359429
Curcumin inhibits multi-drug resistance gene expression in human leukemic cells.
Arch Pharm Res. 2006 Oct;29(10):866-73. PMID: 17121181
Curcumin inhibits multi-drug resistant leukemia cells.
Mol Cell Biochem. 2012 Jan ;360(1-2):253-60. Epub 2011 Sep 22. PMID: 21938404
Curcumin inhibits multi-drug resistant pancreatic cancer.
Cancer Chemother Pharmacol. 2010 Nov 30. Epub 2010 Nov 30. PMID: 21116627
Curcumin inhibits murine neuroblastoma cells.
Neuro Endocrinol Lett. 2007 Apr;28(2):204-12. PMID: 17435663
Curcumin inhibits neuroglial cell proliferation and growth associated with neurodegenerative diseases.
Neuro Endocrinol Lett. 2003 Dec;24(6):469-73. PMID: 15073579
Curcumin inhibits nicotine-induced toxicity.
J Med Food. 2004;7(4):467-71. PMID: 15671691
Curcumin inhibits osteoclastogenesis, indicating its potential benefit in preventing and/or attenuating osteoporosis.
Mol Cells. 2008 Nov 30;26(5):486-9. PMID: 18719352
Curcumin inhibits ox-LDL stimulated vascular smooth muscle cell proliferation associated with arteriosclerosis.
Zhongguo Zhong Yao Za Zhi. 2006 Mar;31(6):500-3. PMID: 16722385
Curcumin inhibits ox-LDL-induced cholesterol accumulation associated with atherosclerosis.
Appl Environ Microbiol. 2008 Jul;74(14):4564-6. Epub 2008 May 23. PMID: 18430363
Curcumin inhibits pancreatic cancer cell and tumor growth.
J Biol Chem. 2010 Aug 13;285(33):25332-44. Epub 2010 Jun 9. PMID: 20538607
Curcumin inhibits pancreatic cancer cell growth and acts as a chemosensitizing agent.
Mol Pharmacol. 2009 Jul;76(1):81-90. Epub 2009 Apr 24. PMID: 19395473
Curcumin inhibits pancreatic cancer cell growth.
Cancer. 2006 Jun 1;106(11):2503-13. PMID: 16628653
Curcumin inhibits pancreatic cancer cell proliferation.
Eur J Cancer. 2009 Mar;45(5):874-80. Epub 2009 Feb 3. PMID: 19196508
Curcumin inhibits pancreatic cancer cells.
Am J Clin Nutr. 2010 Jan 13. Epub 2010 Jan 13. PMID: 20121547
Curcumin inhibits pathological processes initiated by Helicobacter pylori.
Biochem Biophys Res Commun. 2004 Apr 16;316(4):1065-72. PMID: 15044093
Curcumin inhibits phosphalipase D activity, indicating its potential role as an anti-inflammatory and anti-carcinogenic.
FEBS Lett. 1997 Nov 10;417(2):196-8. PMID: 9395294
Curcumin inhibits programmed cell death in breast cancer cells.
J Biol Chem. 2005 May 20;280(20):20059-68. Epub 2005 Feb 28. PMID: 15738001
Curcumin inhibits proliferation of multiple myeloma cells.
J Immunol. 2003 Oct 1;171(7):3863-71. PMID: 14500688
Curcumin inhibits prostate cancer cells.
Int J Cardiol. 1995 May;49(3):191-9. PMID: 12682902
Curcumin inhibits PSA expression in prostate cancer cell lines.
Yao Xue Xue Bao. 2005 Sep;40(9):800-3. PMID: 16342680
Curcumin inhibits PSA gene expression in prostate cancer cells.
J Androl. 2008 Nov-Dec;29(6):661-8. Epub 2008 Jul 31. PMID: 18676361
Curcumin inhibits ral squamous cell carcinoma cells.
Trop Med Int Health. 2010 Oct;15(10):1148-55. Epub 2010 Aug 17. PMID: 12359752
Curcumin inhibits Rift Valley Fever virus replication in human cells.
J Biol Chem. 2012 Jul 30. Epub 2012 Jul 30. PMID: 22847000
Curcumin inhibits telomerase activity and induces programmed cell death in cancer cells.
Mutat Res. 2006 Apr 11;596(1-2):81-90. Epub 2006 Jan 30. PMID: 16445949
Curcumin inhibits telomerase activity in breast ancer cells.
J Urol. 2011 Feb;185(2):719-24. Epub 2010 Dec 18. PMID: 12104041
Curcumin inhibits telomerase activity in human cancer cell lines.
Int J Mol Med. 2006 Aug;18(2):227-31. PMID: 16820928
Curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells.
J Cell Biochem. 2012 Nov 28. Epub 2012 Nov 28. PMID: 23192708
Curcumin inhibits telomerase expression associated with tumorigensis.
Cancer Lett. 2010 Apr 1;290(1):76-86. Epub 2009 Sep 13. PMID: 19751963
Curcumin inhibits the activation of NF-kappaB associated with cancer progression.
Bioorg Med Chem. 2006 Apr 1;14(7):2450-61. Epub 2005 Dec 7. PMID: 16338138
Curcumin inhibits the formation of capillary-like tubes by rat lymphatic endothelial cells.
Cancer Lett. 2007 Jun 28;251(2):288-95. Epub 2007 Jan 2. PMID: 17197075
Curcumin inhibits the growth and induces programmed cell death in B cell lymphoma cells.
Clin Immunol. 1999 Nov;93(2):152-61. PMID: 10527691
Curcumin inhibits the growth of breast cancer through the manipulation of the arachidonate metabolism.
BMC Cancer. 2007;7:138. Epub 2007 Jul 25. PMID: 17651499
Curcumin inhibits the growth of human colon cancer cells.
Korean J Gastroenterol. 2005 Apr;45(4):277-84. PMID: 15843753
Curcumin inhibits the growth of human gastric cancer cells and shows synergistm with 5-fluorouracil.
J Med Food. 2004;7(2):117-21. PMID: 15298755
Curcumin inhibits the growth of ovary cancer cells.
J Clin Psychiatry. 2007;68 Suppl 10:4-7. PMID: 12520734
Curcumin inhibits the invasion and induces programmed cell death in human breast cancer cells.
Arch Pharm Res. 2001 Aug;24(4):349-54. PMID: 11534770
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.
Int J Cancer. 2006 Aug 15;119(4):757-64. PMID: 16550606
Curcumin inhibits the migration and invasion of human and lung cancer cells.
Cancer Lett. 2009 Nov 28;285(2):127-33. Epub 2009 May 23. PMID: 19477063
Curcumin inhibits the proliferation and induces programmed cell death of hepatic stellate cells.
Braz J Med Biol Res. 2009 Dec;42(12):1173-8. Epub 2009 Nov 13. PMID: 19918672
Curcumin inhibits the proliferation and migration of breast cancer cells.
Int J Mol Med. 2009 Apr;23(4):469-75. PMID: 19288022
Curcumin inhibits the proliferation of Burkitt cancer cells.
J Huazhong Univ Sci Technolog Med Sci. 2006;26(2):199-201, 210. PMID: 16850746
Curcumin inhibits the proliferation of colonic cancer cells.
Zhonghua Nei Ke Za Zhi. 2009 Sep;48(9):760-3. PMID: 20079215
Curcumin inhibits the proliferation of human liver cancer cells.
Int J Mol Med. 2010 Nov;26(5):673-8. PMID: 20878089
Curcumin inhibits the proliferation of leukemia cells.
Hunan Yi Ke Da Xue Xue Bao. 2000 Jun 28;25(3):216-8. PMID: 12212145
Curcumin inhibits the proliferation of vascular smooth muscle cells, indicating its value in cardiovascular diseases.
Biochem Biophys Res Commun. 2009 Feb 6;379(2):277-82. Epub 2008 Dec 25. PMID: 19101502
Curcumin inhibits the survival of multiple myeloma cells.
Blood. 2004 Apr 15;103(8):3175-84. Epub 2003 Dec 18. PMID: 15070700
Curcumin inhibits TNF and VCAM mediated inflammatory processes.
Biochem Pharmacol. 1998 Mar 15;55(6):775-83. PMID: 9586949
Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma.
J Clin Invest. 2009 May;119(5):1322-34. doi: 10.1172/JCI37385. Epub 2009 Apr 20. PMID: 17545551
Curcumin inhibits tyrosine kinase activity associated breast cancer cell promotion.
Clin Cancer Res. 1999 Jul;5(7):1884-91. PMID: 10430096
Curcumin inhibits ultraviolet light induced HIV gene expression.
Mol Cell Biochem. 2003 Dec;254(1-2):289-97. PMID: 14674708
Curcumin inhibits up-regulation of tumor necrosis factor alpha and reverses experimentally induced insulin resistance in adipocytes.
Biomed Environ Sci. 2009 Feb;22(1):32-9. PMID: 19462685
Curcumin inhibits uterine leiomyoma cell proliferation.
Gynecol Endocrinol. 2010 Jul 30. Epub 2010 Jul 30. PMID: 20672906
Curcumin inhibits UV radiation mutagenesis and SOS gene induction.
Ann Oncol. 2000 Dec;11(12):1537-43. PMID: 7477054
Curcumin inhibits xanthine oxidase.
Nutrition. 2006 Jun;22(6):593-9. PMID: 19800788
Curcumin is a histone deacetylase inhibitor.
Biochem Pharmacol. 2005 Apr 15;69(8):1205-13. PMID: 15794941
Curcumin is a nitric oxide scavenger.
Gynecol Oncol. 2004 Sep;94(3):760-8. PMID: 9120760
Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase.
FEBS Lett. 1994 Mar 14;341(1):19-22. PMID: 7511111
Curcumin is a potent inhibitor of glutathione S-transferase activity in human melanoma cells.
Chem Biol Interact. 1996 Oct 21;102(2):117-32. PMID: 8950226
Curcumin is a potent radiosensitizer and may act by overcoming the effects of radiation-induced NFkappaB mediated pro-survival gene expression in neuroblastoma.
Cancer Biol Ther. 2008 Apr;7(4):569-76. Epub 2008 Jan 7. PMID: 18305409
Curcumin is a potential candidate for prevention and treatment of hepatic fibrosis.
Biochem J. 2004 Nov 15;384(Pt 1):149-57. PMID: 15320868
Curcumin is a potential candidate for treatment of tubulointerstitial fibrosis.
Am J Nephrol. 2010;31(4):332-41. Epub 2010 Feb 17. PMID: 20160437
Curcumin is a potential inhibitor of human laryngeal squamous carcinoma cell invasion and metastasis.
J Am Coll Nutr. 2007 Dec;26(6):704S-12S. PMID: 17341208
Curcumin is a potentially promising compound for the treatment of Adult T-cell leukemia.
Leuk Res. 2006 Mar;30(3):313-21. Epub 2005 Sep 12. PMID: 16157375
Curcumin is a promising anticandidal of clinical interest.
Can J Microbiol. 2011 Mar;57(3):204-10. PMID: 21358761
Curcumin is a radiosensitizer of human cervical tumor cells.
Mol Pharmacol. 2008 May;73(5):1491-501. Epub 2008 Feb 5. PMID: 18252805
Curcumin is a radiosensitizer of squamous cell carcinoma cells.
Otolaryngol Head Neck Surg. 2005 Feb;132(2):317-21. PMID: 15692547
Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II.
Bioorg Med Chem. 2012 Oct 15 ;20(20):6040-7. Epub 2012 Aug 30. PMID: 22989913
Curcumin is an inhibitor of cancer.
J Am Coll Nutr. 1992 Apr;11(2):192-8. PMID: 1578097
Curcumin is an inhibitor of p300 histone acetylatransferase capable of blocking prostate cancer cells.
Med Chem. 2006 Mar;2(2):169-74. PMID: 16787365
Curcumin is an iron chelator. - Article 1.
Free Radic Biol Med. 2006 Apr 1;40(7):1152-60. PMID: 16545682
Curcumin is an iron chelator. - Article 2.
J Eur Acad Dermatol Venereol. 2004 Nov;18(6):649-53. PMID: 18815282
Curcumin is beneficial for improving Type 2 diabetes complications and assists in preventing oxidative stress and inflammation.
Br J Pharmacol. 2012 Mar 27. Epub 2012 Mar 27. PMID: 22452372
Curcumin is capable of inducing programmed cell death in gastric cancer cells.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov ;27(11):1227-30. PMID: 22078453
Curcumin is cytotoxic to cervical cancer cells.
Mol Cell Biochem. 2009 May;325(1-2):107-19. Epub 2009 Feb 4. PMID: 19191010
Curcumin is effective in blocking lipopolysaccharide-induced loss of muscle mass.
J Cell Biochem. 2007 Mar 1;100(4):960-9. PMID: 17131360
Curcumin may act as a chemosensitizer in multi-drug resistant cancer.
Zhongguo Zhong Yao Za Zhi. 2010 Sep;35(18):2460-3. PMID: 21141501
Curcumin may act as a chemosensitizing agent in multidrug resistant cancer cells.
Biochem Pharmacol. 2002 Aug 15;64(4):573-82. PMID: 12167476
Curcumin may act as a chemosensitizing agent.
Adv Exp Med Biol. 2007;595:269-300. PMID: 17569216
Curcumin may act as a photosensitizer and chemotherapeutic agent in nasopharyngeal carcinoma.
J Environ Pathol Toxicol Oncol. 2006;25(1-2):205-15. PMID: 16566718
Curcumin may attenuate diabetic complications.
FEBS Lett. 2009 Nov 19;583(22):3637-42. Epub 2009 Oct 20. PMID: 19850041
Curcumin may attenuate lead and cadmium-induce neurotoxicity.
Anesth Analg. 2001 Oct;93(4):912-6. PMID: 14729307
Curcumin may be a potential radiosensitizing agent for enhanced antiangiogenic effect in colorectal cancer radiation therapy.
Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G865-77. Epub 2010 Mar 18. PMID: 20299603
Curcumin may be a powerful candidate for developing preventive agents for cancer metastasis.
Oncol Rep. 2010 Mar;23(3):665-70. PMID: 20127004
Curcumin may be applied as an effective and novel sunscreen drug for the protection of photoinflammation.
Exp Mol Med. 2005 Jun 30;37(3):186-92. PMID: 16000872
Curcumin may be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response.
Int Immunopharmacol. 2012 Jan ;12(1):302-11. Epub 2011 Oct 29. PMID: 22036766
Curcumin may be used as a chemosensitizer to make the retinoblastoma cells more sensitive to the effects of chemotherapy.
Curr Eye Res. 2009 Oct;34(10):845-51. PMID: 19895312
Curcumin may be used as a novel intravaginal spermicidal agent for contraception and HIV prevention.
Contraception. 2003 Sep;68(3):219-23. PMID: 14561543
Curcumin may be useful to prevent changes of atherosclerosis and post-angioplasty restenosis.
Br J Pharmacol. 1998 Jul;124(6):1029-40. PMID: 9720770
Curcumin may block brain tumor formation.
Brain Res. 2009 Feb 10. Epub 2009 Feb 10. PMID: 19368804
Curcumin may contribute to accelerated wound healing.
Pathophysiol Haemost Thromb. 2010 Nov 12. Epub 2010 Nov 12. PMID: 21071923
Curcumin may contribute to overcoming chemoresistance of FOLFOX.-surviving colon cancer cells.
Vet Med (Praha). 1989 Aug;34(8):467-74. PMID: 20332435
Curcumin may decrease the progression of glomerulosclerosis.
Zhonghua Er Ke Za Zhi. 2003 Nov;41(11):822-6. PMID: 14728887
Curcumin may down-regulate genes associated with cancer progression in prostate cancer.
Cancer Biol Ther. 2008 Sep;7(9):1427-35. Epub 2008 Sep 4. PMID: 18719366
Curcumin may enhance the chemotherapeuic efficacy of all-trans retinoic acid against human promyelocytic leukemia cells.
Oncol Res. 1997;9(1):19-29. PMID: 9112257
Curcumin may facilitate chemoprevention via direct binding to, and activation of, vitamin D receptor (VDR).
J Nutr Biochem. 2010 Dec;21(12):1153-61. Epub 2010 Feb 12. PMID: 20153625
Curcumin may have a role to play in modulating pathological scar formation.
J Cell Mol Med. 2009 Apr;13(4):712-25. Epub 2008 Apr 10. PMID: 18410527
Curcumin may have a therapeutic role in the treatment of cystic fibrosis.
Nutr Cancer. 1992;18(2):181-9. PMID: 16424149
Curcumin may have a therapeutic role in hyperplastic scars.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Dec;29(12):1100-3. PMID: 20214332
Curcumin may have a therapeutic role in reducing diabetic complications.
J Biosci. 2003 Dec;28(6):715-21. PMID: 14660871
Curcumin may have a therapeutic role in Th1-mediated immune diseases.
Br J Pharmacol. 1999 Sep;128(2):380-4. PMID: 10510448
Curcumin may have a therapeutic role in the treatment of autoimmune diseases.
Eur J Pharmacol. 2011 Jan 10;650(1):451-7. Epub 2010 Oct 13. PMID: 20950605
Curcumin may have a therapeutic role in the treatment of osteoarthritis.
Osteoarthritis Cartilage. 2010 Feb;18(2):141-9. Epub 2009 Oct 8. PMID: 19836480
Curcumin may have an anti-malarial effect by inducing cell death in infected erythrocytes.
Cell Physiol Biochem. 2009;24(3-4):133-40. Epub 2009 Aug 3. PMID: 19710527
Curcumin may have anti-aging properties.
Mol Nutr Food Res. 2010 Oct 11. Epub 2010 Oct 11. PMID: 20938987
Curcumin may have anti-malarial properties.
Bone. 2010 Nov;47(5):926-37. Epub 2010 Aug 7. PMID: 19329310
Curcumin may have anti-obesity properties.
J Nutr Biochem. 2010 Dec 27. Epub 2010 Dec 27. PMID: 21189228
Curcumin may have anti-tumor properties in cervical cancer.
Phytother Res. 2008 Sep 23. PMID: 19058955
Curcumin may have chemosensitizing properties in the treatment of human ovarian cancer.
Cell Prolif. 2009 Apr;42(2):195-206. Epub 2009 Feb 18. PMID: 19236381
Curcumin may have inhibitory activity against HIV-1 protease and integrase.
Am J Clin Nutr. 1995 Mar;61(3):585-9. PMID: 15950462
Curcumin may have positive epigenetic effects in high prostate cancer.
AAPS J. 2011 Dec ;13(4):606-14. Epub 2011 Sep 22. PMID: 21938566
Curcumin may have potential therapeutic uses in the prevention and treatment of endometriosis.
Phytother Res. 2011 Dec 20. Epub 2011 Dec 20. PMID: 22183741
Curcumin may have therapeutic potential for bladder cancer patients via anti-inflammatory, antioxidant and anti-carcinogenic activities.
Oncol Rep. 2006 May;15(5):1225-31. PMID: 16596191
Curcumin may have therapeutic value against amyloid diseases.
Biol Chem. 2009 Oct;390(10):1057-61. PMID: 19558331
Curcumin may have therapeutic value in allergic diseases.
J Allergy Clin Immunol. 2008 May;121(5):1225-31. Epub 2008 Apr 18. PMID: 18394691
Curcumin may have therapeutic value in Alzheimer disease.
Brain Res. 2010 Nov 18;1361:115-23. Epub 2010 Sep 16. PMID: 20840842
Curcumin may have therapeutic value in cancer as a proteasome inhibitor.
Int J Mol Med. 2010 Oct;26(4):447-55. PMID: 20818481
Curcumin may have therapeutic value in cardiomyopathies.
J Cardiovasc Pharmacol. 2010 Feb;55(2):176-83. PMID: 19935077
Curcumin may have therapeutic value in chronic myelocytic leukemia (CML).
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):572-6. PMID: 15498113
Curcumin may have therapeutic value in cystic fibrosis.
Trends Mol Med. 2004 Oct;10(10):473-5. PMID: 15464445
Curcumin may have therapeutic value in Hemolytic-Uremic Syndrome.
Biol Pharm Bull. 2006 Jul;29(7):1470-5. PMID: 16819191
Curcumin may have therapeutic value in HIV infection.
Mol Nutr Food Res. 2010 Feb 19. Epub 2010 Feb 19. PMID: 15383533
Curcumin may have therapeutic value in inflammatory conditions of the central nervous system.
J Neuroinflammation. 2005 Feb 25;2(1):8. Epub 2005 Feb 25. PMID: 15733321
Curcumin may have therapeutic value in inhibiting B-Cell over-activity.
Phytomedicine. 2009 Oct;16(10):982-8. Epub 2009 Mar 20. PMID: 19303754
Curcumin may have therapeutic value in polycystic kidney disease.
Eur J Pharmacol. 2011 Mar 1;654(1):92-9. Epub 2010 Dec 24. PMID: 21187084
Curcumin may have therapeutic value in the prevention of transplant-associated organ injury and rejection.
Biochem Biophys Res Commun. 2003 Sep 5;308(4):950-5. PMID: 12927811
Curcumin may have therapeutic value in the treatment of endometriosis.
Indian J Biochem Biophys. 2009 Feb;46(1):59-65. PMID: 19374255
Curcumin may have therapeutic value in treating human chronic myelogenous leukemia due to its ability to regulate NF-kappB genes and pathways.
Ann N Y Acad Sci. 2009 Aug;1171:436-47. PMID: 19723087
Curcumin may have therapeutic value in treating human liposarcoma.
Phytomedicine. 2005 Nov;12(10):715-22. PMID: 21282356
Curcumin may have therapeutic value in treating hyaline membrane disease.
Life Sci. 2001 Dec 7;70(3):253-67. PMID: 12005259
Curcumin may have therapeutic value in Wilson disease.
Hepatology. 2009 Dec;50(6):1783-95. PMID: 19937698
Curcumin may improve outcome in chemotherapy-refractory Natural killer/T-cell lymphoma (NKTL).
Br J Haematol. 2005 Oct;131(1):59-66. PMID: 16173963
Curcumin may inhibit breast cancer cell proliferation through down-regulating the NFkappaB inducing genes.
Phytomedicine. 2009 Oct;16(10):916-22. Epub 2009 Jun 12. PMID: 19524420
Curcumin may inhibit Coxsackievirus
J Virol. 2007 Apr;81(7):3142-50. Epub 2007 Jan 17. PMID:17229707
Curcumin may inhibit oxidative stress including LDL cholesterol oxidation.
J Enzyme Inhib Med Chem. 2010 Oct;25(5):720-9. PMID: 20163327
Curcumin may offer a therapeutic advantage in the clinical management of refractory bladder cancer.
Cancer Prev Res (Phila). 2011 Oct ;4(10):1698-709. Epub 2011 Aug 11. PMID: 21836020
Curcumin may overcome resistance in leukemia cells.
Int J Cancer. 2006 Oct 15;119(8):1811-8. PMID: 16721786
Curcumin may play a protective effect in primary cultured rat prefrontal cortical neurons against iAbeta-induced cytotoxicity.
Neurosci Lett. 2010 Aug 9;480(1):21-4. PMID: 20638958
Curcumin may play a protective role against oxidative stress in islet transplantation outcomes.
Pancreas. 2009 May;38(4):454-60. PMID: 19188863
Curcumin may play a role in suppressing hepatic fibrinogenesis.
Lab Invest. 2008 May;88(5):529-40. Epub 2008 Mar 10. PMID: 18332871
Curcumin may play a therapeutic role in diseases of the bone associated with osteoclastogenesis and bone lysis.
J Cancer Res Clin Oncol. 2009 Feb;135(2):173-9. Epub 2008 Sep 3. PMID: 18766375
Curcumin may play a therapeutic role in heart failure.
J Food Sci. 2007 Oct;72(8):S612-7. PMID: 20467147
Curcumin may prevent and treat muscle wasting.
Nutrition. 2009 Feb;25(2):125-9. Epub 2008 Nov 22. PMID: 19028079
Curcumin may prevent ferric nitrilotriacetate (Fe-NTA) induced toxicity and cancer.
J Cutan Pathol. 2009 Oct;36(10):1053-62. Epub 2009 Jan 27. PMID: 12616605
Curcumin may protect against amyloid-beta-stimulated inflammation associated wtih Alzheimer disease.
J Alzheimers Dis. 2010;20(4):1189-99. PMID: 20413894
Curcumin may provide an ideal therapeutic agent for patients with Hodgkin's lymphoma which does not have the side effects associated with multi-drug chemotherapy.
Int J Cancer. 2008 Jul 1;123(1):56-65. PMID: 18386790
Curcumin may provide an ideal therapy for metabolic syndrome.
Biofactors. 2012 Dec 13. Epub 2012 Dec 13. PMID: 23239418
Curcumin may provide an ideal therapy to down-regulate epidermal growth factor receptor activity.
J Mol Recognit. 2012 Nov ;25(11):623-9. PMID: 23108622
Curcumin may reduce carcinogenesis by binding to (and inhibiting) lipoxygenase.
Int J Mol Med. 2003 Jul;12(1):17-24. PMID: 12792803
Curcumin may reduce inflammation in the pancreas.
Mol Biol Rep. 2009 Nov;36(8):2329-32. Epub 2009 Jan 21. PMID: 19156536
Curcumin may represent a novel therapeutic agent targeting endothelial activation in inflammatory bowel disease.
Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G259-68. Epub 2009 Jun 11. PMID: 19520742
Curcumin may sensitize cancer cells to chemotherapy.
Mol Cancer Ther. 2006 Apr;5(4):952-61. PMID: 16648566
Curcumin may slow aging.
Curr Pharm Des. 2010;16(7):884-92. PMID: 20388102
Curcumin may support the regeneration of articular cartilage.
Arthritis Res Ther. 2010;12(4):R127. Epub 2010 Jul 1. PMID: 20594343
Curcumin may work synergistically with antifungal drugs to reverse multidrug resistance in Candida cells.
Antimicrob Agents Chemother. 2009 Aug;53(8):3256-65. Epub 2009 May 26. PMID: 19470507
Curcumin may work synergistically with taxane chemotherapy for hormone-refractory prostate cancer treatment.
Nutr Cancer. 2010;62(2):148-53. PMID: 20099188
Curcumin might have therapeutic potential for treating dry eye disease.
Exp Eye Res. 2010 Mar;90(3):437-43. Epub 2009 Dec 23. PMID: 20026325
Curcumin might provide a novel therapeutic strategy for treating gliomas.
Biochem Biophys Res Commun. 2005 Nov 18;337(2):510-6. Epub 2005 Sep 21. PMID: 16198311
Curcumin modulates cell cycle in leukemia cells and enhances programmed cell death.
J Tongji Med Univ. 2000;20(2):123-5. PMID: 12845723
Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism, indicating it may have therapeutic value in the condition.
J Biol Chem. 2007 Feb 16;282(7):4533-44. Epub 2006 Dec 18. PMID: 17178710
Curcumin participates in reversing multi-drug resistance in cancer cells.
Zhonghua Xue Ye Xue Za Zhi. 2006 Apr;27(4):254-8. PMID: 16875558
Curcumin potentiates antitumor activity of l-asparaginase in acute lymphoblastic leukemia.
Leuk Lymphoma. 2012 Jan 25. Epub 2012 Jan 25. PMID: 22185211
Curcumin potentiates the apoptotic effects of chemotherapeutic agents in drug resistant human bladder cancer cells.
Mol Cancer Ther. 2007 Mar;6(3):1022-30. PMID: 17363495
Curcumin potentiates the pro-apoptotic effects of sulindac sulfone in colorectal cancer.
Expert Opin Investig Drugs. 2010 Apr;19 Suppl 1:S117-24. PMID: 20374023
Curcumin potently induces programmed cell death in colon cancer cells
Br J Nutr. 2005 Jun;93(6):835-44. PMID: 19723094
Curcumin pretreatment may have clinical potential in hepatic transplantation.
Transplantation. 2006 Feb 27;81(4):623-6. PMID: 16495813
Curcumin prevents acrylamide-induced DNA damage in liver cells.
Wei Sheng Yan Jiu. 2009 Jul;38(4):392-5. PMID: 19689063
Curcumin prevents benzo[a]pyrene-induced DNA adduct formation.
Cancer Lett. 1995 Sep 4;96(1):71-80. PMID: 7553610
Curcumin prevents chemically-induced inflammation in gastrointestinal lines associated with cancer promotion.
J Invest Dermatol. 2009 Feb;129(2):468-75. Epub 2008 Aug 14. PMID: 10190560
Curcumin prevents cholesterol oxidation, indicating its therapeutic value in attenuating atherosclerosis and lesion formation.
Prostaglandins Other Lipid Mediat. 2009 Nov;90(1-2):13-20. Epub 2009 Jun 21. PMID: 19549571
Curcumin prevents DNA damage associated with benzo[a]pyrene exposure.
Mutat Res. 2004 Feb 14;557(2):203-13. PMID: 14729375
Curcumin prevents dopaminergic neuronal death.
Rejuvenation Res. 2010 Feb;13(1):55-64. PMID: 20230279
Curcumin prevents Epstein-Barr virus induced Post-Transplant Lymphoproliferative disorder (PTLD).
Am Surg. 1998 Jan;64(1):47-51; discussion 51-2. PMID: 9457037
Curcumin prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries.
Biol Pharm Bull. 2001 Sep;24(9):1091-2. PMID: 15622377
Curcumin prevents human dendritic cell response to immune stimulants, indicating it may have value as an immunosuppresant.
Biochem Biophys Res Commun. 2008 Sep 26;374(3):431-6. Epub 2008 Jul 17. PMID: 18639521
Curcumin prevents nitrite-induced methemoglobin formation.
FEBS Lett. 1992 Apr 20;301(2):195-6. PMID: 1314741
Curcumin prevents progestin-induced breast cancer cell promotion.
Menopause. 2008 May-Jun;15(3):570-4. PMID: 18467956
Curcumin prevents the migration of nasopharyngeal cancer cells.
Anticancer Res. 2010 Jul;30(7):2851-6. PMID: 20683022
Curcumin prevents TNF-alpha induced endothelial dysfunction.
Thromb Res. 2005;115(5):417-26. Epub 2004 Nov 14. PMID: 15733976
Curcumin prevents tumor-induced T cell apoptosis.
Behav Brain Res. 2011 Mar 24. Epub 2011 Mar 24. PMID: 17392282
Curcumin promotes programmed cell death in multidrug-resistant human lung cancer cells.
Biochem Biophys Res Commun. 2010 Aug 13;399(1):1-6. Epub 2010 Jul 11. PMID: 20627087
Curcumin promotes programmed cell death in esophageal squamous carcinoma cell lines.
Ai Zheng. 2008 Jun;27(6):566-70. PMID: 18570726
Curcumin promotes programmed cell death in human lung adenocarcinoma cells.
J Sep Sci. 2009 Apr;32(7):955-64. PMID: 20878113
Curcumin promotes programmed cell death of cisplain-resistant human lung carcinoma cells.
Zhongguo Fei Ai Za Zhi. 2010 Apr;13(4):301-6. PMID: 20677554
Curcumin promotes programmed cell death, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma.
Transl Oncol. 2010 Apr;3(2):99-108. PMID: 20360934
Curcumin protects 6-hydroxydopamine (6-OHDA)-induced neuronal death associated with Parkinson disease.
Biochem Pharmacol. 2009 Jul 15;78(2):178-83. Epub 2009 Apr 8. PMID: 19464433
Curcumin protects against adverse changes associated with neuronal hypoxia.
Asia Pac J Clin Nutr. 2003;12(1):50-60. PMID: 18461445
Curcumin protects against beta-amyloid-induced toxicity.
Food Chem Toxicol. 2008 Aug;46(8):2881-7. Epub 2008 Jun 4. PMID: 18573304
Curcumin protects against cerebral ischemia-induced neuronal cell death.
J Neurosci Res. 2005 Oct 1;82(1):138-48. PMID: 16075466
Curcumin protects against chemically induced cell death.
Apoptosis. 2006 Jun;11(6):943-53. PMID: 16547587
Curcumin protects against chemically-induced cataract formation in rat lenses.
Am J Clin Nutr. 1996 Nov;64(5):761-6. PMID: 8901798
Curcumin protects against chemically-induced neuronal damage.
Acta Pharmacol Sin. 2004 Dec;25(12):1606-12. PMID: 15569404
Curcumin protects against chemically-induced Parkinsonism in a cell model.
Pharmacol Res. 2011 Jan 12. Epub 2011 Jan 12. PMID: 21237271
Curcumin protects against copper injury.
Psychiatry Res. 1999 Nov 29;88(3):227-32. PMID: 18082042
Curcumin protects against gastric ulcers by blocking H2 histamine receptors.
Biol Pharm Bull. 2005 Dec;28(12):2220-4. PMID: 16327153
Curcumin protects against glutamate excitotoxicity.
Brain Res. 2008 May 19;1210:84-91. Epub 2008 Apr 16. PMID: 18420184
Curcumin protects against hydrogen peroxide induced cytotoxicity.
Hum Exp Toxicol. 2010 May 20. Epub 2010 May 20. PMID: 20488840
Curcumin protects against methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells.
Acta Pharmacol Sin. 2006 Sep;27(9):1192-8. PMID: 16923340
Curcumin protects against mutagenic heterocyclic amines found in cooked food.
Indian J Exp Biol. 2002 Dec;40(12):1365-72. PMID: 12974398
Curcumin protects against smoke-induced DNA damage.
Metabolism. 2002 Jul;51(7):887-92. PMID: 1937145
Curcumin protects against staurosporine toxicity in rat neurons.
Neurosci Bull. 2012 Oct ;28(5):606-10. Epub 2012 Oct 3. PMID: 23054638
Curcumin protects cardiac cells against ischemia-reperfusion injury.
Free Radic Biol Med. 2008 Sep 15;45(6):839-46. Epub 2008 Jun 20. PMID: 18638545
Curcumin protects dopaminergic cells from Parkinson disease-associated 6-hydroxydopamine-induced neurotoxicity.
Neurosci Lett. 2011 Feb 11;489(3):192-6. Epub 2010 Dec 15. PMID: 21167259
Curcumin protects dopaminergic neuron against lipopolysaccharide induced neurotoxicity.
Neurochem Res. 2008 Oct;33(10):2044-53. Epub 2008 Mar 27. PMID: 18368483
Curcumin protects hepatic stellate cells against leptin-induced activation, indicating its therapeutic value in fatty and fibrotic liver conditions.
Endocrinology. 2010 Sep;151(9):4168-77. Epub 2010 Jul 21. PMID: 20660066
Curcumin protects the brain against drug-induced neurotoxicity, indicating it may have value in preventing neurological disorders such as Parkinson disease.
Antioxid Redox Signal. 2007 Mar;9(3):399-408. PMID: 17184173
Curcumin provides antioxidant and anti-inflammatory therapeutic benefits in the treatment of chronic inflammatory lung diseases.
Mol Nutr Food Res. 2008 Sep;52(9):987-94. PMID: 18327875
Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model.
BMC Neurosci. 2010;11:57. Epub 2010 Apr 30. PMID: 20433710
Curcumin reduces angiotensin II-mediated cardiomyocyte growth via LOX-1 inhibition.
J Cardiovasc Pharmacol. 2010 Apr;55(4):417-24. PMID: 20422739
Curcumin reduces chemo-resistance of melanoma cells to tamoxifen.
Cancer Biol Ther. 2011 Jan 29;11(2). Epub 2011 Jan 29. PMID: 21088500
Curcumin reduces cisplatin-induced neurotoxicity.
Neurotoxicology. 2012 Oct 2. Epub 2012 Oct 2. PMID: 23036615
Curcumin reduces DNA adduct formation in human lung cancer cells.
Toxicol In Vitro. 2003 Jun;17(3):323-33. PMID: 12781211
Curcumin reduces inflammation and carcinogensis associated with arachidonic acid metabolism.
J Nutr. 2009 Jul;139(7):1273-8. Epub 2009 May 20. PMID: 15073046
Curcumin reduces lipopolysaccharide-indced nitric oxide synthetase activity.
Int Immunopharmacol. 2011 Feb;11(2):179-86. Epub 2010 Nov 20. PMID: 21094287
Curcumin reduces multi-drug resistance in uterine cancer cells.
Oncol Rep. 2008 Oct;20(4):731-5. PMID: 18813811
Curcumin reduces NF-kappa B factor activation associated with anticancer drugs.
Endocr Relat Cancer. 2009 Dec;16(4):1339-50. Epub 2009 Sep 2. PMID: 12007574
Curcumin reduces the expression of malignancy-associated Bcl-2 in breast cancer cells.
Med Oncol. 2010 Dec;27(4):1114-8. Epub 2009 Nov 12. PMID: 19908170
Curcumin reduces the programmed cell death associated with toxic bile acids in liver injury during cholestasis.
Biochem Biophys Res Commun. 2006 Feb 17;340(3):800-6. Epub 2005 Dec 20. PMID: 16380075
Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells.
Liver Int. 2009 Jan;29(1):63-72. Epub 2008 May 19. PMID: 18492020
Curcumin restores corticosteroid function in monocytes exposed to oxidants, thus overcoming cortisone resistance.
Am J Respir Cell Mol Biol. 2008 Sep;39(3):312-23. Epub 2008 Apr 17. PMID: 18421014
Curcumin reverse multi-drug resistance in multiple myeloma cells.
Ann Hematol. 2010 Apr;89(4):399-404. Epub 2009 Sep 15. PMID: 19756599
Curcumin reverse multidrug resistance of osteosarcoma cells.
Wei Sheng Yan Jiu. 2011 Jan;40(1):103-6. PMID: 21434326
Curcumin reverses chemoresistance of human gastric cancer cells.
Oncol Rep. 2011 Aug 2. Epub 2011 Aug 2. PMID: 21811763
Curcumin reverses the multidrug resistance of a human multiple myeloma cell line.
Zhonghua Xue Ye Xue Za Zhi. 2009 Jan;30(1):33-7. PMID: 19563033
Curcumin selectively inhibits and induces programmed cell death in B-cell lymphoma cells.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Nov;24(11):1003-6. PMID: 15609600
Curcumin selectively inhibits tumor cells.
Mol Cancer Ther. 2004 Sep;3(9):1101-8. PMID: 15367704
Curcumin selectively targets immortalized normal, leukoplakia, and malignant oral cells.
Cancer Prev Res (Phila). 2010 Mar;3(3):331-8. Epub 2010 Feb 9. PMID: 20145189
Curcumin sensitizes cervical cancer cells to curcumin-induced programmed cell death.
J Biol Chem. 2005 Feb 25;280(8):6301-8. Epub 2004 Dec 7. PMID: 15590651
Curcumin sensitizes lung cancer cells to cisplatin-induced programmed cell death.
Phytother Res. 1999 Jun;13(4):318-22. PMID: 19283527
Curcumin sensitizes prostate cancer cells to programmed cell death.
J Pharmacol Exp Ther. 2007 May;321(2):616-25. Epub 2007 Feb 8. PMID: 17289836
Curcumin sensitizes prostate cancer cells to tumor necrosis factor-related programmed cell death.
Mol Cancer Ther. 2004 Jul;3(7):803-12. PMID: 15252141
Curcumin shows promising anticryptosporidial activity.
Parasitol Res. 2009 Oct;105(4):1155-61. Epub 2009 Jun 26. PMID: 19557435
Curcumin significantly inhibits the growth and induces programmed cell death in human ovarian cancer cell lines. - Article 1
Cell Biol Int. 2006 Mar;30(3):221-6. Epub 2005 Dec 22. PMID: 16376585
Curcumin significantly inhibits the growth and induces programmed cell death in human ovarian cancer cell lines. - Article 2
J Huazhong Univ Sci Technolog Med Sci. 2004;24(1):55-8. PMID: 15165116
Curcumin slows proliferation in the infant acute monocytic leukemia cell line.
Cell Physiol Biochem. 2011 ;28(6):1169-80. Epub 2011 Dec 16. PMID: 22179005
Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity.
J Immunotoxicol. 2007 Apr;4(2):85-96. PMID: 15582996
Curcumin stimulates glucose uptake in myotube (muscle) cells.
J Cell Physiol. 2010 Jun;223(3):771-8. PMID: 20205235
Curcumin stimulates programmed cell death in melanoma cells.
Apoptosis. 2008 Jul;13(7):904-14. PMID: 18493855
Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.
J Pharmacol Exp Ther. 2010 Oct;335(1):114-23. Epub 2010 Jul 6. PMID: 20605902
Curcumin supplementation by reducing vascular inflammation may prevent diabetic complications.
J Nutr Biochem. 2010 Jul 21. Epub 2010 Jul 21. PMID: 20655188
Curcumin supplementation may prevent the cellular dysfunction associated with diabetes.
Free Radic Biol Med. 2006 Jul 1;41(1):92-6. Epub 2006 Mar 30. PMID: 16781457
Curcumin suppresses breast cancer cells growth.
FEBS J. 2010 Aug;277(16):3437-48. Epub 2010 Jul 14. PMID: 20646066
Curcumin suppresses cigarette smoke-induced promotion of human non-small cell lung cancer cell growth.
Carcinogenesis. 2003 Jul;24(7):1269-79. Epub 2003 May 9. PMID: 12807725
Curcumin suppresses colon cancer cells.
World J Gastroenterol. 2009 Mar 21;15(11):1346-52. PMID: 19294764
Curcumin suppresses growth and chemoresistance of human glioblastoma cells.
J Neurochem. 2007 Jul;102(2):522-38. PMID: 17596214
Curcumin suppresses head and neck cancer cell growth.
Arch Otolaryngol Head Neck Surg. 2009 Feb;135(2):190-7. PMID: 19221248
Curcumin suppresses hepatic stellate cell genes, indicating its therapeutic value for hepatitic fibrosis.
Am J Physiol Gastrointest Liver Physiol. 2006 May;290(5):G883-93. Epub 2005 Nov 23. PMID: 16306131
Curcumin suppresses HPV oncoproteins and HPV upregulation associated wtih benzo[a]pyrene exposure.
Mol Carcinog. 2011 Jan;50(1):47-57. PMID: 21061268
Curcumin suppresses human breast cancer cell growth.
Chem Biol Interact. 2009 Oct 7;181(2):263-71. Epub 2009 Jun 30. PMID: 19573523
Curcumin suppresses human promyelocytic leukemia cells.
J Biochem Mol Biol. 2002 May 31;35(3):337-42. PMID: 12297018
Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression associated with inflammation.
J Pharmacol Sci. 2004 Mar;94(3):325-8. PMID: 15037818
Curcumin suppresses melanogenesis in melanoma cells.
Int J Mol Med. 2010 Jul;26(1):101-6. PMID: 20514428
Curcumin suppresses mouse pituitary corticotroph tumor cells.
PLoS One. 2010;5(4):e9893. Epub 2010 Apr 13. PMID: 20405005
Curcumin suppresses oral carcinogenesis.
Int J Cancer. 2010 Jul 1;127(1):9-20. PMID: 20127863
Curcumin suppresses proliferation and induces programmed cell death in human multiple myeloma cells.
Blood. 2003 Feb 1;101(3):1053-62. Epub 2002 Sep 5. PMID: 12393461
Curcumin suppresses proliferation and invasion in human gastric cancer cells.
Cancer Biol Ther. 2009 Jul;8(14):1360-8. Epub 2009 Jul 13. PMID: 19448398
Curcumin suppresses protein kinase C and nuclear oncogene expression associated with cancer progression.
Arch Pharm Res. 2004 Jul;27(7):683-92. PMID: 15356994
Curcumin suppresses SV40-immortalized bladder cancer cells.
Anticancer Res. 2007 Mar-Apr;27(2):737-40. PMID: 17465196
Curcumin suppresses the growth and induces programmed cell death in bladder cancer cells, in vitro.
Zhong Yao Cai. 2004 Nov;27(11):848-50. PMID: 15810596
Curcumin suppresses the inflammatory response of brain microglial cells.
J Immunol. 2003 Dec 1;171(11):6072-9. PMID: 14634121
Curcumin suppresses transcription factor Egr-1.
Thromb Res. 2000 Feb 15;97(4):179-89. PMID: 10674404
Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells.
Acta Pharmacol Sin. 2007 Jan;28(1):105-10. PMID: 17184589
Curcumin synergistically potentiates the anti-cancer effects of celecoxib in pancreatic cancer cells.
Biomed Pharmacother. 2005 Oct;59 Suppl 2:S276-80. PMID: 16507392
Curcumin synergizes the growth inhibitory properties of Indian toad skin-derived factor in colon cancer cells.
Phytother Res. 2007 Sep;21(9):895-7. PMID: 19331178
Curcumin synergizes with resveratrol to inhibit colon cancer.
J Endocrinol. 2003 Jan;176(1):163-8. PMID: 19838927
Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression.
Int J Clin Oncol. 2013 May 11. Epub 2013 May 11. PMID: 23666561
Curcumin treatment protects rat retinal neurons against excitotoxicity.
Exp Brain Res. 2005 Dec;167(4):641-8. Epub 2005 Aug 3. PMID: 16078027
Curcumin work synergistically with a PI3K inhibitor to induce cell death in breast cancer cellis.
Biochem Biophys Res Commun. 2010 Apr 9;394(3):476-81. Epub 2010 Feb 6. PMID: 20138829
Curcumin works synergistically with antifungal drugs.
FEMS Yeast Res. 2010 Aug 1;10(5):570-8. Epub 2010 Apr 23. PMID: 20528949
Curcumin works synergistically with bortezomib in multiple myeloma.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun ;19(3):684-8. PMID: 21729550
Curcumin works synergistically with celecoxib to potentiate a growth-inhibitory and pro-apoptotic in osteoarthritis synovial adherent cells.
Rheumatology (Oxford). 2006 Feb;45(2):171-7. Epub 2005 Oct 25. PMID: 16249246
Curcumin works synergistically with copper to damage leukemia cells.
Molecules. 2009;14(12):5328-38. Epub 2009 Dec 17. PMID: 20032896
Curcumin works synergistically with cyclophosmide to reverse multi-drug resistance of a human lymphoma cell line.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Aug;16(4):804-8. PMID: 18718065
Curcumin works synergistically with drugs as an anti-fibrotic agent in liver fibrosis.
Zhong Yao Cai. 2003 Nov;26(11):795-8. PMID: 14989060
Curcumin works synergistically with EGF-receptor protein to inhibit the growth of colon cancer cells.
Nutr Cancer. 2006;55(2):185-94. PMID: 17044774
Curcumin works synergistically with insulin on muscle cell glucose metabolism.
Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2366-73. Epub 2010 Jun 1. PMID: 20561944
Curcumin works synergistically with light to inhibit bacterial growth.
Arch Microbiol. 1989;151(2):183-5. PMID: 2655550
Curcumin works synergistically with paclitaxel to overcome multidrug resistance in tumor cells.
Mol Pharm. 2009 May-Jun;6(3):928-39. PMID: 19278222
Curcumin works synergistically with the chemotoxic agent FOLFOX to eliminate colon caner stem cells.
Transl Oncol. 2009 Dec;2(4):321-8. PMID: 19956394
Curcumin's (Turmeric) inhibition of HPV oncogenes is cytotoxic to cervical cancer cells.
Mol Carcinog. 2006 May;45(5):320-32. PMID: 16526022
Curcumin's ability to inhibit VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells indicate it may have value in irritable bowel syndrome and cancer.
Gut. 2008 Nov;57(11):1509-17. Epub 2008 Jul 2. PMID: 18596194
Curcumin's anti-inflammatory properties are related to its ability to inhibit the neutrophil response.
Agents Actions. 1989 Nov;28(3-4):298-303. PMID: 2556903
Curcumin's blood sugar lowering effect may be due to its inhibitory effect on hepatic gluconeogenesis.
Biochem Biophys Res Commun. 2009 Oct 16;388(2):377-82. Epub 2009 Aug 8. PMID: 19665995
Curcumin's higher binding affinity for iron and copper rather than zinc may contribute to its protective effect in Alzheimer's disease.
J Alzheimers Dis. 2004 Aug;6(4):367-77; discussion 443-9. PMID: 15345806
Curcumin's induction of programmed cell death in human leukemia cells is associated with inhibition of telomerase activity.
Mol Cell Biochem. 2007 Mar;297(1-2):31-9. Epub 2006 Nov 10. PMID: 17096185
Curcumin's proapoptotic and antidegranulation effect make it a potential candidate for the therapy of neutrophil-induced lung injury and sepsis.
Crit Care Med. 2005 Nov;33(11):2571-8. PMID: 16276182
Curcumin's various benefits may be associated with its role as a Glycogen synthase kinase-3beta (GSK-3beta) Inhibitor.
J Enzyme Inhib Med Chem. 2009 Jun;24(3):771-8. PMID: 18720192
Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets.
Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):223-7. PMID: 7784468
Curcumin, a multi-functional chemopreventive agent, blocks growth of colon cancer cells.
J Mol Histol. 2004 Mar;35(3):301-7. PMID: 15339049
Curcumin, a potent anti-tumor reagent, is a novel histone deacetylase inhibitor regulating B-Cell lymphoma cell line proliferation.
Acta Pharmacol Sin. 2005 May;26(5):603-9. PMID: 15842781
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages.
Biochem Biophys Res Commun. 1995 Jan 17;206(2):533-40. PMID: 7530002
Curcumin, an antioxidant and anti-inflammatory agent protects endothelial cells against oxidative stress.
Biol Pharm Bull. 2006 Apr;29(4):670-4. PMID: 10889462
Curcumin, EGCG and resveratrol inhibit inflammation.
Mutat Res. 2001 Sep 1;480-481:243-68. PMID: 11506818
Curcumin, resveratrol and EGCG may have a therapeutic role in proliferative vitreoretinopathy (PVR).
Curr Eye Res. 2010 Nov;35(11):1021-33. PMID: 20958191
Curcumin, resveratrol and flavonoids act as anti-inflammatory, cyto- and DNA-protective dietary compounds.
Toxicology. 2009 Nov 10. Epub 2009 Nov 10. PMID: 19903510
Curcumin, Resveratrol and Gingerol decrease prostate inflammation
Carcinogenesis. 2007 Jun;28(6):1188-96. Epub 2006 Dec 6. PMID: 17151092
Curcumin, resveratrol and vanillin protects against DNA damage.
Minerva Med. 1988 May;79(5):387-90. PMID: 12561251
Curcumin-induced cell death of ovarian carcinoma has a known mechnism.
Mol Carcinog. 2010 Jan;49(1):13-24. PMID: 19676105
Curcumin-induced suppression of adipogenic differentiation, indicating its therapeutic role in obesity.
Am J Physiol Cell Physiol. 2010 Jun;298(6):C1510-6. Epub 2010 Mar 31. PMID: 20357182
Curcuminoids (from Turmeric) are effective in treating multi-drug resistance cancer cell lines.
Biochem Pharmacol. 2004 Nov 15;68(10):2043-52. PMID: 15476675
Curcuminoids are cytotoxic to human ovarian cancer cells.
J Nat Prod. 1998 Dec;61(12):1531-4. PMID: 9868158
Curcuminoids are potent inhibitors of lipid peroxidation.
J Pharm Pharmacol. 1994 Dec;46(12):1013-6. PMID: 7714712
Curcuminoids have anti-tumor and antioxidant activity.
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Curcuminoids inhibit multidrug resistance-associated protein.
Cancer Chemother Pharmacol. 2006 Feb;57(3):376-88. Epub 2005 Jul 14. PMID: 16021489
Curcuminoids inhibits breast cancer cell proliferation.
Pharmacol Res. 2010 Nov 25. Epub 2010 Nov 25. PMID: 9714342
Curcuminoids masy promote neuritogenesis.
J Agric Food Chem. 2012 Jan 11 ;60(1):433-43. Epub 2011 Dec 22. PMID: 22145830
Curcuminoids may enhance the efficacy of chemotoxic drugs.
Mol Cancer Ther. 2006 Aug;5(8):1995-2006. PMID: 16928820
Curcuminoids may provide an ideal solution to overcoming chemoresistance.
Mol Med Report. 2012 Sep 27. Epub 2012 Sep 27. PMID: 23023936
Curcuminoids may reduce the risk of hypertension and cardiovascular diseases.
Int J Food Sci Nutr. 2012 Jan 23. Epub 2012 Jan 23. PMID: 22263555
Curcuminoids prevent experimentally induced neuronal damage in the rat hippocampus.
Life Sci. 2006 Mar 13;78(16):1884-91. Epub 2005 Nov 2. PMID: 16266725
Curcuminoids protect against endothelial diseases caused by oxidative damages.
Exp Mol Med. 2006 Aug 31;38(4):393-400. PMID: 16953118
Curcuminoids protect against neuronal cell death in an Alzheimer disease model.
Neurosci Lett. 2001 Apr 27;303(1):57-61. PMID: 11297823
Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices.
Synapse. 2010 Oct 20. Epub 2010 Oct 20. PMID: 20963814
Curcuminoids suppress the growth and induce programmed cell death in glioblastoma multiforme cells.
J Agric Food Chem. 2010 Oct 13;58(19):10639-45. PMID: 20822178
Curcuminoids suppress the growth of pharynx and nasopharyngeal cancer cells.
J Agric Food Chem. 2009 May 13;57(9):3765-70. PMID: 19317462
Curcuminoids, particularly curcumin, can improve the symptoms of allergic diseases, such as anaphylaxis and itching.
Arch Pharm Res. 2009 Dec;32(12):1783-7. Epub 2010 Feb 17. PMID: 20162408
Curcuminoids-loaded lipid nanoparticles exhibit anti-malarial activity.
Colloids Surf B Biointerfaces. 2010 Nov 1;81(1):263-73. Epub 2010 Jul 17. PMID: 20688493
Curcumoids inhibit matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells.
Arch Pharm Res. 2010 Jul;33(7):989-98. Epub 2010 Jul 27. PMID: 20661707
Curcumol, isolated from Curcuma phaeocaulis (R. Curcumae) induces programmed cell death in human lung cancer cells.
Med Oncol. 2010 Feb 3. Epub 2010 Feb 3. PMID: 20127426
Demethoxycurcumin induces programmed cell death in human glioma cells.
Biochem Biophys Res Commun. 2009 Jul 10;384(4):420-5. Epub 2009 May 5. PMID: 19422808
Demethoxycurcumin suppresses migration and invasion of human breast cancer cell line.
Eur J Pharmacol. 2010 Feb 10;627(1-3):8-15. Epub 2009 Oct 7. PMID: 19818349
Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses in microglia cells.
Int Immunopharmacol. 2010 Mar;10(3):331-8. Epub 2009 Dec 16. PMID: 20018257
Dietary omega-3 fatty acids, curcumin and capsaicin lower the release of lysosomal enzymes and eicosanoids in rat peritoneal macrophages associated with inflammation.
Mol Cell Biochem. 2000 Jan;203(1-2):153-61. PMID: 10724344
EGCG and curcumin have chemopreventive synergism in normal, premalignant and malignant human oral epithelial cells.
Carcinogenesis. 1998 Mar;19(3):419-24. PMID: 9525275
EGCG and curcumin suppress Alzheimer disease associated beta amyloid production.
Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H715-21. Epub 2005 Mar 18. PMID: 18695518
Ellagic acid and curcumin may inhibit cancer through preventing the over-expression of glutathione S-transferases.
Food Chem Toxicol. 2007 Feb;45(2):286-95. Epub 2006 Aug 30. PMID: 17046132
Epicatechin enhances the anti-cancer activity of curcumin in human lung cancer cells.
Cancer Prev Res (Phila). 2010 Aug;3(8):953-62. Epub 2010 Jul 6. PMID: 20606042
Epigenetic Reactivation of RANK in Glioblastoma Cells by Curcumin: Involvement of STAT3 Inhibition.
DNA Cell Biol. 2013 Apr 27. Epub 2013 Apr 27. PMID: 23621850
Ethanol extracts of A. hypogaea (peanut), C. longa (turmeric), and P. maritimum could be considered a new natural agent against the Acanthamoeba cyst.
Parasitol Res. 2011 Dec 7. Epub 2011 Dec 7. PMID: 22146994
Garcinol (Garcinia indica) and curcumin (Turmeric) induce programmed cell death in human leukemia cells.
J Agric Food Chem. 2001 Mar;49(3):1464-74. PMID: 11312881
Genistein and curcumin block migratory and invasive phenotypes within mouse skin cells.
Nutr Cancer. 2000;37(1):49-54. PMID: 10965519
Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies indicating it may help to alleviate autoimmune diseases.
Mol Nutr Food Res. 2010 Aug;54(8):1202-9. PMID: 20146265
Hexahydrocurcumin has a cytotoxic effect against human colorectal cancer cells.
Nat Prod Commun. 2011 Nov ;6(11):1671-2. PMID: 22224285
High dose of curcumin might be an effective anti-angiogenic drug in the treatment against tumor.
Mol Pharmacol.2007 Dec;72(6):1508-21. Epub 2007 Sep 14. PMID: 16151260
Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophages by curcumin.
Eur J Pharmacol. 1999 Nov 19;384(2-3):191-5. PMID: 10611441
Liposome-encapsulated curcumin exhibits anti-cancer activity in pancreatic cancer.
Cancer. 2005 Sep 15;104(6):1322-31. PMID: 16092118
Liposome-encapsulated curcumin suppresses neuroblastoma growth.
Surgery. 2012 Jan 26. Epub 2012 Jan 26. PMID: 22284765
MGN-3 and curcumin exhibit synergistic anti-cancer activity on human multiple myeloma cell lines.
Neoplasma. 2011;58(2):118-23. PMID: 21275460
NAC and curcumin ameliorate pesticide-induced oxidative DNA damage in human peripheral blood mononuclear cells.
Environ Monit Assess. 2010 Nov 4. Epub 2010 Nov 4. PMID: 21049288
Natural curcuminoids exhibit alpha-glucosidase inhibitory activity.
Eur J Med Chem. 2006 Feb;41(2):213-8. Epub 2006 Jan 4. PMID: 16387392
Natural plant compounds may have preventive and therapeutic applications against the growth of breast tumors induced by environmental estroge
Environ Health Perspect. 1998 Dec;106(12):807-12. PMID: 9831541
Phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane have a synergistic effect in the inhibition of inflammation.
Pharm Res. 2009 Jan;26(1):224-31. Epub 2008 Oct 8. PMID: 18841446
Phosphatidylcholine bound curcumin is a lipoxygenase inhibitor.
Lipids. 1998 Dec;33(12):1223-8. PMID: 9930409
Polyphenols such as curcumin and EGCG from green tea may chelate out iron from the Alzheimers brain.
Prog Neurobiol. 2007 Aug;82(6):348-60. Epub 2007 Jun 19. PMID: 17659826
Preventive compounds curcumin and piperine are capable of targeting breast stem cells.
Breast Cancer Res Treat. 2010 Aug ;122(3):777-85. Epub 2009 Nov 7. PMID: 19898931
Prophylactic use of curcumin may effectively rescue pancreatic islets from damage without affecting the normal function of these cellular structures.
BJU Int. 2002 Jun;89(9):829-34. PMID: 17900558
Resveratrol and curcumin may attenuate Chlamydia-associated induced atherosclerosis.
Biochem Biophys Res Commun. 2005 Jul 22;333(1):21-7. PMID: 15939398
Review: Anti cancer effects of curcumin.
Cell Div. 2008;3:14. Epub 2008 Oct 3. PMID: 18834508
Review: antiangogenic effect of selected phytochemicals.
Pharmazie. 2010 Jan;65(1):57-63. PMID: 20187580
Review: Curcumin content of turmeric and curry powders.
Nutr Cancer. 2006;55(2):126-31. PMID: 17044766
Review: Curcumin has a number of potential therapeutic properties for Alzheimer diseaes.
Mutat Res. 2009 Oct 13. Epub 2009 Oct 13. PMID: 19966973
Review: Curcumin has potential value in the treatment of inflammatory bowel disease.
J Lab Clin Med. 1997 Dec;130(6):576-84. PMID: 19519446
Review: Curcumin has therapeutic potential in the treatment of head & neck cancers.
Mol Cancer. 2011 Feb 7;10(1):12. Epub 2011 Feb 7. PMID: 21299897
Review: Curcumin may be an ideal anti-cancer therapy due to is role in positively modulating the machineries of cell survival, proliferation, invasion, and angiogenesis.
Mol Cell Biochem. 2010 Mar;336(1-2):85-95. Epub 2009 Oct 14. PMID: 19826768
Review: curcumin may be an ideal epigenetic agent.
Cancer. 2010 Oct 15;116(20):4670-6. PMID: 20597137
Review: Curcumin may have therapeutic value in obesity.
Pediatr Rehabil. 2004 Oct-Dec;7(4):245-60. PMID: 21091916
Review: Curcumin selectively kills tumor cells.
Scand J Prim Health Care. 1998 Mar;16(1):37-9. PMID: 19590964
Review: Potentials of curcumin as an antidepressant.
ScientificWorldJournal. 2009;9:1233-41. Epub 2009 Nov 1. PMID: 19882093
Safety Study: A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats.
Food Chem Toxicol. 2007 Jan;45(1):64-9. Epub 2006 Aug 7. PMID: 16987575
Six dietary constituents inhibit nicotine-DNA adduct formation.
Food Chem Toxicol. 2003 Jul;41(7):1045-50. PMID: 12804663
Spice constituents such as quercetin and curcumin inhibit LDL cholesterol oxidation.
Mol Cell Biochem. 2002 Jan;229(1-2):19-23. PMID: 11936843
Targeting Cancer Stem Cells by Curcumin and Clinical Applications.
Cancer Lett. 2014 Jan 23. Epub 2014 Jan 23. PMID: 24463298
Tea, rosemary and turmeric inhibit inflammation.
Cancer Lett. 1995 Sep 4;96(1):23-9. PMID: 7553604
Testoterone enhances curcumin's anti-prostate cancer activity.
Cancer Sci. 2011 Feb;102(2):468-71. Epub 2010 Dec 7. PMID: 21134073
Tetrahydrocurcumin inhibits cell migration and invasion in fibrosarcoma cells.
Acta Pharmacol Sin. 2008 Jul;29(7):853-60. PMID: 18565284
Tetrahydrocurcumin may contribute to overcoming multi-drug resistance of human cancers.
Mol Cell Biochem. 2007 Feb;296(1-2):85-95. Epub 2006 Sep 8. PMID: 16960658
Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.
Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 10803946
Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.
Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 10803946
The anti-breast cancer activity of curcumin may be due in part to its down-regulation of insulin-like growth factor.
Life Sci. 2007 May 16;80(23):2161-9. Epub 2007 Apr 21. PMID: 17499312
The dietary polyphenols trans-resveratrol and curcumin interact with cannabinoid receptors indicating their potential role in treating obesity and/or drug dependence.
Biosci Biotechnol Biochem. 1996 Jun;60(6):1000-5. PMID: 19359525
The natural compounds berberine, curcumin and picroliv are able to suppress the progression of virally induced leukemia.
J Exp Ther Oncol. 2008;7(4):275-84. PMID: 19227007
The natural Nuclear factor-kappaB inhibitor curcumin may help to overcome drug resistance in human pancreatic cancer.
Mol Cancer Ther. 2006 Sep;5(9):2251-60. PMID: 16985059
The phytoestrogens quercetin, baicalein, genistein, epigallocatechin gallate (EGCG), and curcumin are effective inhibitors of prostate tumor cell growth.
Nutr Cancer. 2004;49(2):200-8. PMID: 15489213
The plant extracts curcumin, quercetin, green tea, balcalein, and luteolin offer protection and promote healing of neurological tissues
Surg Neurol Int. 2012 ;3:19. Epub 2012 Feb 15. PMID: 22439110
The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.
Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831
The polyphenols, epigallocatechin gallate, and catechin hydrate significantly attenuate quinolinic acid-induced excitotoxicity in human neurons.
FEBS J. 2010 Jan;277(2):368-82. Epub 2009 Dec 10. PMID: 20015232
The role of cancer stem cells in the anti-carcinogenicity of curcumin.
Mol Nutr Food Res. 2013 Jul 31. Epub 2013 Jul 31. PMID: 23900994
Theophylline and curcumin may restore corticosteroid insensitivity.
Expert Opin Ther Targets. 2007 Jun;11(6):745-55. PMID: 17504013
There is strong evidence to support the use of curcumin in retinal diseases, Crohn's disease and disorders related to the spinal cord.
Arch Otolaryngol Head Neck Surg. 2004 Dec;130(12):1381-6. PMID: 15262811
Topic turmeric may have photoprotective properties.
J Cosmet Dermatol. 2011 Dec ;10(4):260-5. PMID: 22151933
Topical application of curcumin (from Turmeric) may have therapeutic value in the treatment of scleroderma, psoriasis and skin cancer.
Adv Exp Med Biol. 2007;595:343-57. PMID: 17569219
Topical application of curcumin was useful in reducing experimental corneal neovascularization and can be used to inhibit angiogenesis in the cornea.
Curr Eye Res. 2010 Apr;35(4):274-80. PMID: 20373893
Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells.
Support Care Cancer. 2010 May 14. Epub 2010 May 14. PMID: 20467756
Topical curcumin with visible light may have therapeutic value in skin cancer.
J Invest Dermatol. 2007 Aug;127(8):1992-2000. Epub 2007 Apr 5. PMID: 17410200
Trichostatin A works synergistically with curcumin to inhibit human leukemia cells.
Pharmazie. 2006 Aug;61(8):710-6. PMID: 16964716
Tumeric contains compounds such as tumerones and curlone separate and distinct from curcumin which exhibit antibacterial activity.
J Agric Food Chem. 1999 Oct;47(10):4297-300. PMID: 10552805
Turmeric and curcumin inhibit aflatoxin induced hemolysis.
Evid Based Complement Alternat Med. 2010 Jan 4. Epub 2010 Jan 4. PMID: 17665866
Turmeric and curcumin protect against gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells.
Teratog Carcinog Mutagen. 1999;19(1):9-18. PMID: 10321406
Turmeric and ginger work synergistically to suppress prostate cancer cell lines.
J Basic Clin Physiol Pharmacol. 2012 Oct 12 ;0(0):1-8. Epub 2012 Oct 12. PMID: 23072849
Turmeric and green tea have significant apoptic effects in chronic lymphocytic leukemia.
Clin Cancer Res. 2009 Feb 15;15(4):1123-5. PMID: 19228716
Tetrahydrocurcumin protect against radiation-induced lipid peroxidation.
Appl Physiol Nutr Metab. 2009 Dec;34(6):1093-7. PMID: 10803946
The anti-breast cancer activity of curcumin may be due in part to its down-regulation of insulin-like growth factor.
Life Sci. 2007 May 16;80(23):2161-9. Epub 2007 Apr 21. PMID: 17499312
The dietary polyphenols trans-resveratrol and curcumin interact with cannabinoid receptors indicating their potential role in treating obesity and/or drug dependence.
Biosci Biotechnol Biochem. 1996 Jun;60(6):1000-5. PMID: 19359525
The natural compounds berberine, curcumin and picroliv are able to suppress the progression of virally induced leukemia.
J Exp Ther Oncol. 2008;7(4):275-84. PMID: 19227007
The natural Nuclear factor-kappaB inhibitor curcumin may help to overcome drug resistance in human pancreatic cancer.
Mol Cancer Ther. 2006 Sep;5(9):2251-60. PMID: 16985059
The phytoestrogens quercetin, baicalein, genistein, epigallocatechin gallate (EGCG), and curcumin are effective inhibitors of prostate tumor cell growth.
Nutr Cancer. 2004;49(2):200-8. PMID: 15489213
The plant extracts curcumin, quercetin, green tea, balcalein, and luteolin offer protection and promote healing of neurological tissues
Surg Neurol Int. 2012 ;3:19. Epub 2012 Feb 15. PMID: 22439110
The plant polyphenols curcumin, carnosic acid, and silibinin may work synergistically to inhibit acute myeloid leukemia cells.
Nutr Cancer. 2010 Aug;62(6):811-24. PMID: 20661831
The polyphenols, epigallocatechin gallate, and catechin hydrate significantly attenuate quinolinic acid-induced excitotoxicity in human neurons.
FEBS J. 2010 Jan;277(2):368-82. Epub 2009 Dec 10. PMID: 20015232
The role of cancer stem cells in the anti-carcinogenicity of curcumin.
Mol Nutr Food Res. 2013 Jul 31. Epub 2013 Jul 31. PMID: 23900994
Theophylline and curcumin may restore corticosteroid insensitivity.
Expert Opin Ther Targets. 2007 Jun;11(6):745-55. PMID: 17504013
There is strong evidence to support the use of curcumin in retinal diseases, Crohn's disease and disorders related to the spinal cord.
Arch Otolaryngol Head Neck Surg. 2004 Dec;130(12):1381-6. PMID: 15262811
Topic turmeric may have photoprotective properties.
J Cosmet Dermatol. 2011 Dec ;10(4):260-5. PMID: 22151933
Topical application of curcumin (from Turmeric) may have therapeutic value in the treatment of scleroderma, psoriasis and skin cancer.
Adv Exp Med Biol. 2007;595:343-57. PMID: 17569219
Topical application of curcumin was useful in reducing experimental corneal neovascularization and can be used to inhibit angiogenesis in the cornea.
Curr Eye Res. 2010 Apr;35(4):274-80. PMID: 20373893
Topical curcumin can inhibit deleterious effects of upper respiratory tract bacteria on human oropharyngeal cells.
Support Care Cancer. 2010 May 14. Epub 2010 May 14. PMID: 20467756
Topical curcumin with visible light may have therapeutic value in skin cancer.
J Invest Dermatol. 2007 Aug;127(8):1992-2000. Epub 2007 Apr 5. PMID: 17410200
Trichostatin A works synergistically with curcumin to inhibit human leukemia cells.
Pharmazie. 2006 Aug;61(8):710-6. PMID: 16964716
Tumeric contains compounds such as tumerones and curlone separate and distinct from curcumin which exhibit antibacterial activity.
J Agric Food Chem. 1999 Oct;47(10):4297-300. PMID: 10552805
Turmeric and curcumin inhibit aflatoxin induced hemolysis.
Evid Based Complement Alternat Med. 2010 Jan 4. Epub 2010 Jan 4. PMID: 17665866
Turmeric and curcumin protect against gamma-radiation-induced chromosome aberrations in Chinese hamster ovary cells.
Teratog Carcinog Mutagen. 1999;19(1):9-18. PMID: 10321406
Turmeric and ginger work synergistically to suppress prostate cancer cell lines.
J Basic Clin Physiol Pharmacol. 2012 Oct 12 ;0(0):1-8. Epub 2012 Oct 12. PMID: 23072849
Turmeric and green tea have significant apoptic effects in chronic lymphocytic leukemia.
Clin Cancer Res. 2009 Feb 15;15(4):1123-5. PMID: 19228716
PATENTS
Process for extracting curcumin
CN103254050
The invention provides a process for extracting curcumin by a carbon dioxide supercritical extraction method. According to the process, curcumin is extracted from ginger by taking a supercritical carbon dioxide liquid as an extractant and 95% ethanol as an entrainer. The method adopted is simple in flow and convenient to operate. Separation is realized at the same time in the extraction process, and the method has no bad effect on production personnel and the environment. The yield and purity of curcumin are high.
Preparation method for extracting purified curcumin-related compounds from turmeric
CN103193610
The invention discloses a preparation method for extracting purified curcumin-related compounds from turmeric. The process comprises the following steps of: performing water washing and crushing on the turmeric, performing multi-stage countercurrent extraction by using alcohol-amino acid water, performing chromatography through a macroporous resin column, performing gradient elution by using ethanol-water, collecting eluate, performing decompression, evaporation and concentration, and performing vacuum drying to obtain active ingredients, namely curcumin, demethoxycurcumin and bisdemethoxycurcumin. The preparation method disclosed by the invention has the advantages that the alcohol-amino acid water is used for performing the multi-stage countercurrent extraction, the used macroporous resin can be utilized repeatedly, water and ethanol are taken as solvents, the preparation method is economic, simple and convenient, high-purity curcumin, demethoxycurcumin and bisdemethoxycurcumin can be conveniently obtained, the purity of each monomer compound is above 95%, the sample recovery rate is above 75%, the process flow is short, the operability is strong, the consumption of the solvents is low, the extraction rate is high, the stability of the extraction solution is good, obtained products can be widely used for the fields of medicines, foods and the like, and the preparation method is suitable for mass production.
High-yield water-based curcumin extraction method
CN103130629
The invention relates to a high-yield water-based curcumin extraction method which comprises the following steps: (1) grinding curcuma, soaking with an alkaline water solution of 0-40 DEG C, stirring, extracting, then adding antioxidant, centrifuging, extracting 1-2 times, taking the supernatant, and adding acid to precipitate; and (2) adding an alcohol solution to dissolve the precipitate, centrifuging, adding water to obtain an alcohol dissolving liquid, purifying, concentrating, and drying to obtain curcumin. The curcumin content extracted by the invention can be up to 95%; the extraction and purification yield is more than 80%; and by taking water as extraction solvent, the method is economic, convenient and safe. Thus, the method provided by the invention is a high-yield and low-cost production process.
Method for extracting curcumin from turmeric
CN102617316
The invention relates to a method for extracting curcumin from turmeric. The method is characterized by comprising the following steps that: the turmeric is cleanly cleaned and is then crushed into turmeric powder, the turmeric powder and extraction solvents are mixed according to a certain proportion and are then subjected to backflow extraction, next, the separation is carried out under certain conditions to remove heavy metals, and finally, the precipitates are separated and crystallized to obtain curcumin.; Compared with the prior art, the method has the advantages that the heavy metal separation and purification flow process is simple and short, the risk of secondary pollution caused by the additional addition of absorption agents or absorption media is avoided, and the heavy metal residue of products can be purified to a degree that the lead content is lower than 1.0PPM, the cadmium content is lower than 1.0 PPM, the mercury content is lower than 0.10 PPM, and the arsenic content is lower than 0.10PPM.
Method for extracting and separating high-purity curcumin with low heavy-metal residues from turmeric
CN102603505
The invention discloses a method for extracting and separating high-purity curcumin with low heavy-metal residues from turmeric. The method comprises the following steps of: firstly cleaning, drying and crushing turmeric into turmeric powder, and mixing the turmeric powder with an extraction solvent proportionally, heating, stirring and extracting; mixing extractive solutions, filtrating and separating, removing the filter residue to obtain filtrate, and concentrating the filtrate; cooling the remaining concentrated liquid, mixing the liquid with a crystallization solvent proportionally, and carrying out static crystallization in a suitable temperature range and filtrating the mixture to obtain wet crystal product; and finally mixing the crystallization solvent with water proportionally to prepare a mixed solvent, mixing the wet crystal product with the mixed solvent proportionally and recrystallizing, and separating to obtain high-purity curcumin with low heavy-metal residues. The technology provided by the invention can reduce the heavy metal content as much as possible while retaining effective natural ingredients of traditional Chinese medicine at the same time, and the technology has significant meaning in improving the standard system of safety control for traditional Chinese medicine, breaking the foreign technical barriers and really pushing traditional Chinese medicine to go onto the world market.
Method for extracting and separating curcumin and curcuma oil from carcuma longa
CN102408320
The invention discloses a method for extracting and separating curcumin and curcuma oil from carcuma longa, which comprises the following steps of: grinding the carcuma longa into carcuma longa powder with particle size of 80-100 meshes; taking ethanol water solution as extractant for dynamic countercurrent extraction of the carcuma longa powder to obtain extraction solution, and concentrating to obtain concentrated solution; and adding the concentrated solution with plant oil extraction solvent for liquid-liquid extraction to obtain light phase containing curcuma oil and heavy phase containing curcumin. Compared with the prior art, the invention takes the ethanol water solution as the extractant and extracts the curcumin and the curcuma oil from the carcuma longa by employing the dynamic countercurrent extraction method, and the method has the advantages of simple operation, moderate extraction condition, low usage amount of solvent, short extraction time, few impurities in extraction solution and high extraction efficiency.
Process method for microwave assistant supercritical extraction of active ingredients of curcuma
CN102100875
The invention discloses a process method for microwave assistant supercritical extraction of active ingredients of curcuma. In the method, the active ingredients, namely curcumin and fat soluble curcuma oil, of curcuma are extracted by the synergistic action of the microwave technology and the supercritical technology. The process method mainly comprises the following steps of: performing microwave intermittent sudden heating and then carbon dioxide (CO2) supercritical extraction; separating CO2 and curcuma oil in an analyzing kettle; and adding water or ethanol into curcuma residue in a solid-to-liquid weight ratio of 1:7-14, and performing microwave action, twice soaking, filtration, condensation and spray drying to obtain the curcumin.; The process method solves the problem that in the prior art, only single active ingredient can be extracted or the compositions of the extract are not balanced, and realizes the extraction of two main active ingredients, namely curcuma oil and curcumin, of the curcuma at the same time, and the yield is over 8 percent and 13 percent respectively. The process method is the physical method and has the advantages of no product pollution, high purity, low cost, simple process and easy mass production.
Extracting method for curcumin
CN101831199
The invention discloses an extracting method for curcumin, comprising the following steps: pulverizing curcuma; pelleting the pulverized curcuma under the condition of introducing steam; and extracting particles obtained by pelleting with leach liquor. Since turmeric roots contain a large amount of starch which can be gelatinized in a manner of introducing steam for heating and has stickiness, thus the turmeric powder can be more compactly combined, has large rigidity, and is not easy to break; the prepared particles are provided with many micropores, and the solvent is easy to permeate, thus the extraction rate is high; and in addition, the gaps among the particles are larger than the gaps among the powdery materials, thus the solvent is more easy to permeate and the rate of filtration is high, thereby improving the extraction rate, the rate of filtration and the production efficiency.
Curcumin purification technique
CN101774899
The invention relates to a curcumin purification technique. The technique adopts fresh curcuma longa as material, the curcuma longa is ground, squeezed and filtered, ethyl ether is added for extraction, so that volatile oil is removed, and after separation and purification conducted by way of cation exchange resin, membrane concentration and alumina column chromatography and recrystallization conducted by way of methanol, the product is obtained. The method has the advantages of high product purity, simple operation, high throughput and easy industrialized production.
Purification technology of curcumin compound
CN101768061
The invention discloses a purification technology of a curcumin compound. Turmeric medicine serves as a raw material to be smashed and extracted by petroleum ether in a backflow mode; residue is subjected to ultrasound assistant extraction after warm immersing by sodium salicylate alcoholic solution; macroporous resin is added into extract to be separated and purified; mixture is eluted by acetone-2% glacial acetic acid (50:50); curcumin, demethoxy curcumin and bisdemethoxy curcumin fraction are respectively collected; reagent is recovered and is respectively dissolved by a small quantity of acetone; water of which the amount is three times of acetone is quickly added to be decentralized; and supernate is removed, and the mixture is precipitated, frozen and dried to obtain the product.
Curcumin A as well as preparation method thereof and applications to preparing medicaments for treating cardiovascular and cerebrovascular diseases
Method for preparing curcumin, demethoxycurcumin and bisdemethoxycurcumin
CN101585757
The present invention discloses a method for preparing curcumin, demethoxycurcumin and bisdemethoxycurcumin, which comprises the following steps: continuously executing countercurrent extraction to the turmeric with the methanol-acid solution or ethanol-acid solution, after filtering the extracted solution, condensing into the oleoresin with the relative density of 0.9-1.2; placing the oleoresin on the chromatographic separation medium for gradient elution, and after fraction-collecting the eluent, respectively obtaining the curcumin crystal, demethoxycurcumin crystal and bisdemethoxycurcumin crystal after condensing. The invention adopts a technique in which HZ-816, HZ-818 or HZ-801 is used as the chromatographic separation medium and the alcohol-water is used as the elution solvent.; Three monomeric compounds of curcumin, demethoxycurcumin and bisdemethoxycurcumin are simultaneously obtained. The purity of each monomeric compound is more than 95%, and the recovery rate of the sample is more than 70%. The method of the invention further has the advantages of less intercrossing of compounds in the separation process, short flow path, strong operability, low consumption of the solvent, high extraction rate and excellent stability of the extraction solution. Furthermore the obtained product can be widely applied for the fields of medicament, food, etc., and is suitable for large-scale production.
Method for extracting refined curcumin and curcuma oil from curcuma
CN101445440
The invention relates to a method for extracting refined curcumin and curcuma oil from curcuma. The method comprises the following steps: the curcuma is cleaned, dried in the shade, crushed into 30-40 mesh curcuma powder, low-carbon alcohol and alkyl hydrocarbon are made into a mixed solvent at the volume ratio of 1:1-3, the curcuma powder and the mixed solvent are mixed at a weight ratio of 1:3-5 for extraction twice; the extracts are merged, filtered, separated and removed from dregs, the obtained filtrate is condensed, the concentration level is controlled at 60-90%, and the solvent is recovered; a separating agent containing 0-3% salt is added to the residual concentrated solution, the addition amount of the separating agent is 0.5-2 times of the volume of the concentrated solution, the obtained mixture is kept standing for demixing after evenly stirred; a supernatant is separated and condensed, and the alkyl hydrocarbon is recovered to obtain the curcuma oil; a subnatant is adsorbed by a macroporous absorbent resin, flushed to remove water soluble impurities, and eluted with a desorbent, the solvent is condensed and recovered to crystallize the curcumin, thus obtaining the curcumin with the content more than 95%.
Method for extracting and separating curcuma oil
CN101407743
The invention relates to a method for extracting and separating turmeric oil, which comprises the step of extracting the turmeric oil from curcumas by using supercritical CO2, and is characterized in that the method also comprises the following steps: adopting first-step molecular distillation to separate curcumin and grease in the turmeric oil obtained by using the supercritical CO2 method; obtaining almost colorless turmeric essential oil under the conditions of operating pressure of 10 to 20Pa, distillation temperature of 70 to 90 DEG C, the rotation speed of a blade applicator of 200 to 300r/min and distillates of more than 75.0 percent. Adopting supercritical CO2 extraction and two-level molecular distillation, the method can effectively keep the natural ingredients of the turmeric oil, without bringing any pollution to the environment.; In addition, the method also realizes the separation of oxygenous sesquiterpene from sesquiterpene in the turmeric oil, which can be used directly as raw materials in the fields such as the cosmetics, food and pharmacy where different amounts of the oxygenous sesquiterpene and the sesquiterpene are needed.
Method for extracting and separating turmeric effective ingredient curcumin
CN101468944
The invention discloses a method for extracting and separating curcumin as an effective constituent of turmeric, which belongs to the extraction and separation of traditional Chinese medicine effective constituents and technical application. The structural formula of the compound is as shown in a figure. The method for extracting and separating curcumin comprises the steps of grinding turmeric, adding alkali liquid for cold extraction, filtering, performing column chromatography through macroporous resin, performing gradient elution by use of ethanol and water, collecting eluent, reducing pressure, evaporating, concentrating and vacuum-drying the eluent, and obtaining the effective constituent, namely curcumin. The method has the advantages that the macroporous resin used in the method can be repeatedly utilized, and the method is economical and simple by taking water and ethanol as solvents, can conveniently obtain the extract with the effective constituent content not lower than 90 percent, and is easy to industrialize.