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SURVIVAL FACTOR IN NEOPLASTIC AND VIRAL
DISEASES
By
WILLIAM FREDERICK KOCH, Ph.D., M.D.
Supplement
PRACTICAL APPLICATION OF THE
FORMER CHAPTERS AND OTHER ESSENTIAL INFORMATION
One has seen that the reversal of pathogenesis of
microorganisms follows much the same pattern as the reversal
of neoplasia in tissue cells. Virulence is proportional to
pathogenicity in both, and their parasitism is a necessary
property depending on the degree of deficiency against which
survival is attempted. It is also an economic
provision that normal tissue survival arises in the successful
performance of the specific function of any form of life in its
contribution to the Great Biological Economy. Under this
circumstance, parasitism, pathogenicity and their virulences
are utterly impossible, as the pattern of activity is
determined by functional procedure and restoration of function
eliminates all three.
One has also seen that normal function depends on normal
structure, the key to which is the unhindered Carbonyl group
in the presence of molecular oxygen. Energy
production in any form of aerobic life can then proceed by
dehydrogenation, free radical production, peroxide free
radical production and the rest of the oxidative
progression.
It is axiomatic therefore, that where any one of the three
features, virulence, pathogenicity or parasitism is eliminated
by this basic corrective provision, all three are eliminated
as well. Clinical demonstrations were given in the
testimony of many physicians and veterinarians in the 1942 and
1946 Federal Court Trials by the Veterinarian Department of the
University of British Columbia, Canada, as well as by the
Ministry of Agriculture of that same province. Their testimony
showed that highly virulent hemolytic staphylococci lost their
toxicity and hemolytic properties together with the restoration
of the normal calcium balance and the restorative healing of the
parenchyma of seriously infected mammary gland structures
instead of by scar tissue. At the same time, a rapid return of
health followed after the Therapy of the text was given, and
most important of all, the rate of recuperation was proportional
to the rate of increase in the germs that had formerly produced
the disease. One concludes that the normal function of
bacteria cleaning out dead tissue debris had been restored by
the action of the activated Carbonyl group. The same
effects were observed in the healing of huge tubercular
cavities, the healing of fulminating and chronic terminal
Osteomyelitis, as well as, other infections. Toxicity tests done
before and after Treatment, of gangrenous mastitis in dairy
cows, showed that filtrates from the bacterial cultures taken
from untreated animals were fatally toxic, while those taken
from treated animal lesions were non-toxic.
To test the above principles, Dr. Dieter Reinstorff ran various
bacterial cultures of which the photographic plate pictures an
example. It served as a test for virulence. The inoculum was a
highly virulent hemolytic streptococcus taken from a child. At
two weeks after the inoculation of the test and the control
cultures, the latter showed rich growth while the test plate
showed no growth at all. The test plate was treated with 2
milliliters of the 10-(12) concentration of the Reagent. This
test for virulency is in accord with the loss of pathogenicity
after Treatment as reported above.
Treated culture at left, Control culture at right after two
weeks incubation.
REVERSAL OF VIRULENCE OF HEMOLYTIC STREPTOCOCCUS BY CONTACT
WITH GLYOXYLIDE SOLUTION, 10-(12) CONCENTRATION
It is also evident that the data shows that the
pathogenicity was not removed by a destructive reagent, but
rather by the corrective function of the activated Carbonyl
group. There was no longer any necessity for parasitism to
win survival and no forced effort at reproduction was
necessary to try to overcome a deficiency, for the
correction was already made by supplying the normal source
of energy for its created function and hence, pathogenicity
could not result. Similar patterns of recuperation
are observed clinically.
The delay in the occurrence of the first reaction to Treatment,
be it 24 hours, 36, 72 or more hours, or even days and weeks or
months (as in the case on Multiple Sclerosis of Mrs. R. P.)
after the Remedy is injected, presents the characteristics of
the induction period to a chain reaction, a free radical affair,
and hence shows that fundamentally the result of the activated
Carbonyl to be not an equimolecular affair, but an inductive
affair. It resembles the refractory period following a toxic
drug when sub-fatal, but when the tissues fail to respond to a
second or third dose all of which together are more than fatal
in amount, is given at the start all at once. The culture plate
is also an example, for the adaptation of the parasite to the
medium took two weeks to reach full bloom while the test plate
showed no growth. So the parasitic survival effort is likewise a
chain affair, another instance of the universality of free
radical phenomena in life processes. One should therefore
observe the response to the Treatment with the Carbonyl groups
of the text with careful attention before deciding that a dose
is inactive when visible changes of recovery do not show up
immediately.
MAGNETIC ASPECTS OF CARCINOGENESIS AND ITS REVERSAL
Ever since 1920, treated cancer patients in transit from
Western parts of the country to Detroit reported that they felt
much better after passing East of Ypsilanti, Michigan. The
reports were too numerous to ignore, so we investigated the
district between Detroit, Ypsilanti, Wayne and Redford. After
eliminating alpha, beta, gamma, and cosmic rays, we settled on
the magnetic flux of the district as responsible. The dip-needle
did not vary as much as 20 degrees from the horizontal but the
flux was stronger than that in unfavorable places.
We found many residents of the district who made rapid easy
recoveries from widespread neoplastic invasions of the vital
organs had reversals that were permanent and complete. So the
recovery process was favored as well as the feeling of well
being of the patients in transit. The soil was a rich, sandy,
black, shiny, loam with rich vegetation and many earthworms and
grubs, so we figured that the magnetic flux favored soil
building by the flora and fauna of that function. Centuries of
fertilization by animal excreta and decaying organic matter,
that supplied iron-porphyrin compounds from bile, blood and
flesh, with paramagnetic oxygen profited by the magnetic flux to
accelerate its soil building reactions. Foods raised here were
therefore the very best.
The cancer incidence was just as high and the neoplasms just as
malignant as ones found elsewhere. But the recoveries from
cancer by the Therapy of this text were exceptionally rapid and
easy. Both carcinogenesis and its reversal are free radical
affairs. The former is anoxic while the reversal stages use
paramagnetic oxygen and peroxide free radicals as its principle
actors. So, since oxygen is 4,000 times more magnetically
susceptible, like iron with which it coordinates, than most
other elements in the tissues, it concentrates with other
paramagnetic materials as calcium and iron in the activated
spots of the mitochondria to boost the reaction rates of
function and detoxicative oxidations.
Confirmatory are the boosting effects of magnetic storms that
occur with the sun’s rotation every 27 days, on both the rates
of neoplastic activity and the reversals to normal. Here again
the recoveries are boosted far beyond the pathogenic rates, and
no doubt for the same reasons, for in addition to the
paramagnetic oxygen and trace elements, the mitochondria hold
the activated Carbonyls and quinones and the necessary calcium
in their activated spots. These claims included in our Postulate
were opposed decades ago, but are now being confirmed by modern
microbiologists even those including the blocking effects of
guanidin. We hold that the electron mechanics of the double bond
of the Carbonyl and its activating ethylenic linkage are also
magnetically susceptible whereby their dehydrogenations are also
hastened. Antagonistic are mercuric salts, amines, and
sulphides, against which cyanide protects, though antagonizing
the cytochrome system, and tends to prevent neoplastic change. This
indicates that the primary pathology of cancer follows proton
withdrawal and blocks electron transport for it depends on
hypoxia. The curative progression depends on vigorous proton
withdrawal in the presence of oxygen and is aided by the
magnetic activation of free radicals.
SIGNIFICANCE OF THE ETHYLENE BRIDGE
In reality, the ethylenic linkage is not an electron donor,
but a weak withdrawer of electrons. When conjugated with a
Carbonyl group which is an active electron attractor, the
ethylenic electrons are mobilized toward the Carbonyl group,
and such substituents as CH(3) CH2CH3
CH(CH(3))2 and C(CH(3))3 which are
active releasers of electrons will, when located at the
opposite end of the double bond, supply their quota for
attraction to the Carbonyl group of the FCG system. In
addition, the Carbonyl group is negatively polarized with an
oxygen atom rating 3.5 electronegative units and a carbon atom
of 2.5 electronegative units. Only fluorine exceeds the
electro negativity of oxygen. Therefore, the Carbonyl
group of the FCG system as conjugated with an ethylenic
linkage serves as an active dehydrogenator of fuels and
pathogens that enter its field and the ethylenic linkage
serves as the bridge for the electronic migrations toward
the Carbonyl group. Where two or more Carbonyl group double
bonds are conjugated in series, the orbital mechanics
determine so heavy a concentration of electrons and electro
negativity at one of the groups, that it becomes a most
active dehydrogenator and, as in Triquinoyl, the strain
becomes so great that one group even becomes expellable to
form the more stable five member ring.
In addition, fuels and pathogens are especially equipped to
mobilize their critical hydrogen atoms. In glycogen and the
polysaccharides, the Carbonyl groups are inactivated and in the
monosaccharides the lactone structure alters the activity. When
the Carbonyl group is free; however, it attracts the electrons
away from the hydroxyl groups so that the hydrogen atoms tend
to be liberated with ease as protons. This mobilization is
seen when glucose or fructose are dissolved in heavy water. Here
it is found that the hydrogen atoms trade places freely at
random with the deuterium of the heavy water. Such mobility is
surprising in view of the fact that the bond energy of the OH
group is one of the highest for a covalent bond; namely, 110.2
Kilo-Calories and the bond length is one of the shortest, namely
0.95 A units. Thus one sees the power of mesomeric induction to
bring about reactivity without causing ionization. The same
applies to the C-H linkage.
Pathogens, like unsaturated fats, also invite dehydrogenations
in various degrees. Here we Postulate that a methylenic
group positioned alpha to a double bond of an ethylenic
linkage offers two activated hydrogen atoms; one is important
for the integration with the FCG system during the anoxia and
the other invites removal from the integrated pathogen by the
Carbonyl group of the curative Reagent. (This
dehydrogenation can also be accomplished by an appropriate free
radical). The activation of the pathogen’s hydrogen atom is
secured by withdrawing electrons from the alpha placed methylene
group by the substituents placed at the other end of the double
bond. Those that withdraw electrons are halogens, methoxyl,
hydroxyl, aldehyde, carbonyl, vinyl , phenyl, cyano
and sulphydryl as well as the imide groups. Here one sees
the possible place of iodine in activating the initiation of
physiological oxidation. The withdrawal of electrons from the
alpha positioned carbon-hydrogen or oxygen-hydrogen bond weakens
it to facilitate dehydrogenation. The
stage is thus set intrinsically in the pathogenesis for its
oxidative reversal. The pathology actually provides for its
correction. The philosophic implications deserve
thought.
The basic pathology in endocrine, viral and neoplastic
disease is; therefore, of the same pattern and depends upon
the electron passing powers of an ethylenic linkage to
activate the position alpha to it. The Carbonyl group is an
electron accumulator and the alpha methylene group an electron
donor.
THE IMPORTANCE OF THE FREE RADICAL
Recently, Prof. Cheves Walling of Columbia University stated:
“Twenty-five years ago free radical chemistry interested only a
few gas-phase kineticists... It is remarkable that one set of
simple principles is basic to such a diverse group of processes
and products.” As our investigations show, the service of
free radical products and processes made it possible to
understand and reverse the pathogenesis of cancer and
liberate the host cell from fatal viral integration decades
earlier than 25 years ago, and in fact, concomitant with the
development of the plastic industry. Thus
the free radical occupies an important field in biological
processes as well.
(It is interesting to note that Dow Chemical Company and Dr.
Willard H. Dow first became aware of Dr. Koch’s free radical
research due to their independent study of the free radical as
it related to the development of plastics).
The free radical made possible an explanation of the Pasteur
Effect, and its reverse the Crabtree Effect, which in our
opinion is a means of measuring the contents of respiring
elements that conduct cell functions. Crabtree (1929)
showed that when glucose was added to cancer slices, the use of
oxygen was inhibited in favor of glycolysis, which was not the
case with normal tissues as liver and kidney cortex. Here
addition of glucose stimulated respiration. It was also shown
that such metabolically inert tissues as cartilage and kidney
medulla exhibited the Crabtree Effect much like cancer tissue.
Natal retina did also, until it matured and could function as an
oxidation mechanism. Thus, where and to what extent that
respiration is possible, addition of glucose will stimulate
oxygen use, and where this function is limited, glycolysis is
used to dispose of the added glucose, and the use of oxygen is
depressed to the extent that common factors engage in both
respiration and glycolysis. Thus cancer tissue has a limited
oxidation rate or capacity that it cannot increase under
stimulation, and is using to the limit all the time, thus
revealing the inability to supply further oxidative
facilities. What is the cause of this deficiency?
Aisenberg (1961) offered the two explanations that are
supported by data given in this text, (a) the diminished amount
of mitochondria in tumor cells, as Warburg also suggested; and
(b) the statement forwarded by Chance and Hess (1959) that the
respiratory elements are still present in normal amount, but are
under a restraining influence which blocks the oxidation ability
proportionately. This is exactly what our text has
demonstrated together with an explanation of both the
hindering mechanism’s chemistry and that of the liberation of
the oxidation mechanism. Thus our Thesis is supported again.
Not only the FCG’s of the various specific functions may be
concerned, but also the Carbonyl groups of the accessory factors
to the oxidation process, and the electron or hydrogen acceptors
as the quinones so recently discovered to exist in all living
cells. Their structures are essentially Carbonyl groups
activated by conjugation with double bonds of ethylenic
linkages. Similarly we find activated Carbonyl groups in the
keto-steroids, and the spent products of all such structures,
are hydrogenated and reduced to hydroxyl. In the case of the
ketosteroids the double bonds are also inactivated, and so the
molecule cannot be reversed to function again, but in the
case of the quinones the double bonds are not altered and
reversal with return of function is possible. Thus
Coenzyme Q can function as a coenzyme over and over again as an
electron transfer agent.
The quinone structure is also admirably adapted to such
function so as to meet the requirements of specificity in
oxidation-reduction potential and for selecting the specific
materials it will react with in each particular cell activity. The
substituents placed about the quinone’s double bonds give the
steric advantages and hindrances required for specific
reactions and for elevated or depressed negativity and
oxidation-reduction potentials of the Carbonyl groups.
Twenty years ago the most celebrated biochemists testified that
the quinone structure had no place in biological processes in
opposition to our Thesis. Today, we know otherwise and
the position of the free radical, which can now be proven by
electron spin resonance techniques, is demonstrated as
fundamental to all living processes.The present writer’s
Professor of Chemistry was the discoverer of the Free Radical,
Moses Gomberg. He developed his thesis as a pure piece of
philosophy, but he lived long enough to see it become the
basis of the plastic industry, and even learned of the first
adventures of this writer’s application of the free radical in
the interpretation and correction of pathologic states. We
join Prof. Walling in saluting the glorious work of Gomberg.
In our early work we found that polymerizing unsaturated free
radicals of low molecular weight stimulated cancer development
decidedly, whereas large inert polymers blocked cancer growth
and involution soon followed. Our conclusion was that the
carcinogen integrated with the host cell nucleus by a
co-polymerization process of free radical double bond
additions, whether the carcinogen is a polymerizing bacterial
toxin or a vegetating provirus, whose units were largely host
cell nuclear products; the symbiosis held through the mitotic
act. The small polymers offered more double bonds and free
radicals for hastening the mitosis point; whereas, the large
inert polymer blocked further additions as a terminator of the
chain. Moreover, the energy for the mitotic act was
provided by the polymerization and was not dependent on usual
sources as glycolysis or oxidation. Hence, the small free
radical additions provided more energetic cell division. Dehydrogenated
synthetic
carcinogens initiate the integration of either pathogen with
the mitotic mechanism’s FCG activating double bond when during
anoxia the free radical formed adds to one pole of this double
bond. The free radical formed thus at the other pole adds to
the critical ethylenic linkage of the pathogen producing a
free radical at the other pole that continues the
polymerization process that supplies the energy for
uncontrolled mitosis. This is why the synthetic carcinogen is
lost track of when the malignant change sets in. Such is
our explanation.
REVIEW OF CARCINOGENESIS AND ALLERGENESIS
As we have seen, the cause of cancer is a multiple affair
in which anoxia and two pathogens are the principal actors,
and the same pattern holds for the production of allergies.
The only difference is that in cancer the basic functional
cell unit attacked is the mitotic mechanism for cell
reproduction. In respiratory allergies, the secreting
mechanism, the contractile mechanism, and the energy producing
and receiving FCG’s as well as their activating double bonds are
involved. Where as in neurological allergies like epilepsy,
compulsory neuroses, and fixed ideas, the conductile energy
producing and receiving FCG systems of the activating double
bonds are attacked. We have classified cancer as an
allergy of the cell’s mitotic mechanism decades ago (Natural
Immunity, 1934, Christopher Publ. Co. - Koch).
The energy for excessive action of an allergy or neoplasia is
not received from the normal sources of oxidation nor even
glycolysis as Warburg suggested, for the FCG of energy
production and acceptance is blocked by the pathogenic
additions. We conclude that the energy comes from the
polymerization of one of the pathogens integrated with one
terminal of the FCG activating double bond as a free radical
addition. In the case of cancer and any other allergies, the
pathogen is a virus or a polymerizing toxin produced by
bacteria trapped in the scar of an old infection where
ischaemia protects it from oxidation. This pathogen
is the sustaining toxin that may be difficult to differentiate
from a virus, or bacteriophage living in symbiosis with the germ
and paralyzing its activity, instead of causing its lysis. When
it gains entrance into the blood stream and into the host cell,
its critical double bond adds to the distal pole of the FCG
activating double bond which has become a free radical through
addition of the free radical offered by the exciting or
sensitizing pathogen to the proximal pole. The sensitizing
or initiating pathogen may be a synthetic carcinogen that has
been dehydrogenated by the FCG during anoxia or the free
radical of an incompletely combusted metabolite, a
dehydrogenated sulfhydryl bacterial product, or a free radical
produced by sunrays in the polymerizing units of a maturing
pollen. The latter would be the initiating pathogen in hay
fever or asthma. When it adds to the distal pole of the FCG
activating double bond, the free radical formed at the other
pole can co-polymerize with the sustaining pathogen as just
stated whose energy liberated by polymerization forces the
excessive uncontrolled mitosis or other functions as an
allergy. The smaller the molecule, the greater the content
of double bonds, the more rapid the polymerization, and the
greater the amount of energy produced, and hence the more
intense the pathogenic action, be it an allergic affair or a
neoplasm. Also the smaller the molecule, the more energy is
shown by the free radical wandering in its domain, to force the
polymerizations.
The initiating toxin could be one of the sulfhydryl products of
certain bacteria trapped in occluded tonsilar crypts, the apical
infection of teeth, or some occluded scarred sinus of long
standing. Sulfhydryl readily forms free radicals on
dehydrogenation by the FCG, and it also has the ability to add
to double bonds of ethylenic linkages conjugated with Carbonyl
groups. It can thus interfere with oxidations in several
ways for it can inactivate the quinone type co-enzymes as
Co-enzyme Q-10, which is an electron carrier or transfer agent.
When one closes a culture of such bacteria taken from a focus of
infection just mentioned, it soon shows the development of
malodorous mercaptans. In like manner it may add to the FCG
activating system to initiate the pathogenesis.
To show that the focal infection of long standing is a
factor in carcinogenesis, a typical case history will suffice.
This woman was then 56 years of age and her case history was
included in the Testimony before the Federal Trade Commission in
1943, as a demonstration of the nature of the recovery process
after the Koch Reagent was given. The uterus and most of the
pelvis and lower abdomen were involved by a biopsy proven cancer
of the uterus, and the right breast also presented a massive
cancer of the simplex type which extended into the axilla. There
were numerous metastases to the skin as well when she received
the Koch Reagent in 1938. Recovery was in evidence within three
weeks and continued with reactions at the twelfth and
twenty-fourth weeks. At the end of the twenty-fourth week the
absorption of all growths was complete and an acute violent
inflammation of the tonsil and lymphatics of the neck on the
right side set in. She could neither swallow nor speak for about
a week, then it quickly subsided and she felt very well in all
respects. When describing her symptoms, she stated that she had
the very same symptoms some 20 years earlier, and her health was
never good afterwards. During that attack she could not speak
nor swallow. It was determined that both symptomatologies were
identical, except that in the recent attack the symptoms left
rapidly leaving her in exceptionally good health.
Here we have an example of the reversal of the pathogenesis
as the essence of the recovery process. The first symptom in
the initiation of the disease was the last symptom to be
brought to light and its causative pathology cleared away at
the wind-up of the correction process. The
interpretation is what we have offered since 1926. During
the recovery, the de-polymerization of the sustaining
pathogen was going on and finally when the growth was gone
the monomeric form of the toxin only was present to produce
the same symptoms as it did when the germ (and its virus)
infected the tonsilar area and produced the original
inflammation and its subsequent cicatrization. Both
inflammatory reactions to the monomeric form of the toxin were
identical except that the recovery reaction induced by the
corrective Reagent burned the infection away completely
including the toxins adsorbed in the protective scar tissue.
Since these were also burned away, the scar tissue became
obsolete and was absorbed like the neoplasms themselves. The
correction was therefore complete for no scar tissue was needed
after the toxin was burned away. The completion of the recovery
from diabetes with its gangrene conforms to the same pattern.
Here the block to FCG function of energy production and
acceptance left the islet cells unable to produce insulin and
the evolution of the pathology that followed included bacterial
infection of the ischaemic bones, which then underwent necrosis.
The recovery process removed the basis for this infection and
the infection left so the bones could be restored in minute
detail. The radiographs demonstrate this. The pathogenesis
patterns as outlined here need not be rigid and must conform to
the attending circumstances. They are in harmony with clinical
experience and the established facts of physiology and
chemistry, and are a guide to successful Treatment, which after
all was the goal of 50 years of investigation.
GRAPHS SHOWING BLOOD SUGAR BEFORE AND AFTER TREATMENT
1,2,3, and 6 are cases that had no previous insulin or other
treatment. The rest are cases of longer standing that had
insulin and other anti-diabetic remedies, but could not tolerate
them and were not helped by them except transiently.
These cases show the immediate return of function of the islet
cells that still remain after the inhibiting toxin is removed,
and a slower return as reconstruction of islet cells are being
rebuilt as in Case No. 5 and 9.
Some cases await further blood tests to show this
reconstruction effect, such as Cases No. 4 and 8.
Before giving the SSR, the diet was changed to unlimited
carbohydrate fruits, vegetables, cereals and bread with all the
honey and molasses desired and the animal proteins were all
removed, as well as, all medications and insulin. Tea, coffee,
tobacco and alcohol were forbidden.
These patients were all sick in many different serious
ways, and their health returned fully after the Treatment, and in
the late cases the return of full health took plate before the
sugar came to its low point or the normal.
DYNAMIC PROPERTIES OF DOUBLE BOND
CLINICAL DEMONSTRATION PREDICTABILITY
One recalls that the conjugated double bond of a Carbonyl group
or of an ethylenic linkage activates many physiological
processes, pointed out in the text. These activations
demonstrate its value as an electron bridge, even in the high
energy carrying phosphate esters and especially the
enol-phosphate esters. Activation of the function of the
Carbonyl group in various capacities, as in the deaminations and
decarboxylations co-enzymed by pyridoxal phosphate are
demonstrated in their structural formula. However, no attention
has been given to this dynamic function of the double bond. Our
own Thesis made use of this action long before such ferments
were discovered. Thus, one recalls that the mobile electrons
of an ethylenic linkage activate both the dehydrogenating and
condensation processes of the FCG’s of energy production and
energy acceptance.In the pathogen, it activates the position
alpha thereto and determines its ability to integrate with the
host cell FCG’s and with their activating double bonds. And
after integration has taken place, it invites the oxidative
separation of the pathogen from the host cell. We saw that the
various unions were accomplished by azomethine condensations
and free radical additions, as mentioned in the text. In
Pyridoxal phosphate’s coenzyme services as in some other
recently discovered activities, the azomethine condensation is
now identifiable. All
such activations depend on the ability of the ethylenic double
bond to pass its mobile electrons on to the position alpha to
it, of course, as influenced by the substituents present in the
molecule. The double bond is therefore identified by the
fact that the condensations and cleavages take place at the
point alpha to it and it holds a critical value
physiologically, pathogenically and therapeutically.We can
also demonstrate the presence of this double bond in the
pathogen after integration has taken place, by causing
cleavage of the double bond itself, when we make use of its
identifying characteristics. The cleavage results in the
liberation of the host cell’s FCG from the pathogen. This is
demonstrated biologically by the cure of the disease.
The identifying characteristics are: (a) the greater
rigidity of the double bond against steric rotation, as
compared to the greater ease of rotation of the single
covalent bond in response to environmental influences; (b) the
ability to add a radical or atom at one pole or at both poles
in response to the number of atoms or radicals supplied; and
(c) when an addition is made at one pole, a free radical is
formed at the other pole. In the presence of molecular oxygen,
peroxide free radical formation and cleavage of the bond
follows with separation of the pathogen from the host cell’s
FCG system by forming two terminal Carbonyl groups. The
biological evidence is the rescue of the host cell with return
of its normal functional status. The pathogen is no longer
found.
The double bond is further identified since its
characteristic rigidity against rotation provides that the
distal pole will hold the same steric relation to the plane
of the double bond of the functional Carbonyl group (FCG) in
any particular disease or pathogenic integration.
Whereas if the bond were single, easy rotation in response to
various influences would place this pole in positions where
attacking atoms or radicals could not always reach it.
Therefore, the number of successful attacks would not be
predictable because of steric hindrance. The number of
successful attacks on the other hand, is predictable where the
bond is double because the steric advantage holds throughout
any particular pathogenic category. In other words, where the
double bond is concerned, if a successful attack is made once
in any disease category, it can be expected to be successful
in all other instances of the same disease, other things being
equal.
Different pathogens would be judged to present the distal
pole in the same steric relation to the FCG double bond, if a
predictable response is had in each of a series of diseases
caused by different pathogens. This fact has been realized. So
we conclude, that the Least Common Denominator both in the
pathogenesis and in its correction depends upon this ethylenic
linkage of the pathogen, and nature provides for the cure
right in the pathogenesis. It is easy to
conclude on this basis that animal life was originally free
from disease. Only one protective atomic value was needed. We
have shown in the text what it is, the SSR. Now we will
show by an alternate procedure what the curative process is and
thus corroborate our Postulate, and also the standard status of
the pathogen’s activating double bond.
For this demonstration, we used the following procedure, which
differs from the procedure used throughout the text. The latter,
one will recall, was the use of a highly activated DEHYDROGENATOR
CARBONYL GROUP, the SSR, which brought about a free
radical alpha to this double bond of activation of the pathogen
after integration. The sequence was peroxide free radical
production and cleavage alpha to the double bond. Now instead of
an oxidizing agent, a HYDROGENATOR, a reducing agent of high
activity is used to add hydrogen to the distal pole of this
double bond by preference, when given in sufficiently high
dilution and which adds to both poles when given in adequate or
saturating concentration. For steric reasons, Hydrogen is a
better carrier of the free radical that makes the additions than
any complex group of atoms.
When a dilution of one part to a billion or higher is given,
only one pole, the distal pole, is reduced and a free radical is
formed at the other pole. This free radical goes through the
regular sequence of adding molecular oxygen to become a peroxide
free radical that causes cleavage of the double bond itself with
production of two Carbonyl groups, one belonging to the FCG and
the other being terminal in the pathogen, as an activator of
further oxidation. Biologically the results are restored FCG
function and cure.
Further as the double bond can add two atoms of hydrogen, one
at each pole, and thus become resistant to oxidative attack when
sufficient reducing Reagent is given, the integration with the
host cell is made permanent and the disease remains. In serious
vital diseases, in animals as Hog Cholera, fatality resulted in
100% of cases treated with concentrations of one part to a
million. The same was true in Aftosa, dog distemper, and some
bacterial infections after poisoning with a tetanus toxin. In
animals and man with the high dilution of one part to a trillion
and higher, rapid corrections were had in all diseases treated,
predictably. These include anterior poliomyelitis, malaria,
cancer, and the acute crises of coronary occlusion with
infarction, chicken pox and in some hereditary degenerations of
serious degree.
Thus by steric and bi-pole evidences, the double bond of
activation of the pathogen is demonstrated after integration has
taken place and its part played, in both the pathogenesis and in
the restoration of normalcy, are also seen.
It is helpful to contrast this action with that of the SSR of
the text, since the latter is a dehydrogenator and directly an
Oxidizing Agent, while the action of the reducing agent is
indirectly an oxidation, but only when used in very high
dilution. The SSR shows corrective effects in every dilution
from one to a million up to one to a trillion and higher.
Here only one action can take place and that is the removal of a
hydrogen atom alpha to the activating double bond. This
dehydrogenation is followed by the usual sequence of peroxide
free radical formation and cleavage alpha to the double bond,
and liberation of the host cell. Thus only a curative action can
be had when the concentration is needlessly high, as one part
per million, the recovery reactions are uselessly too
uncomfortably vigorous, without anything being gained over the
recovery had by a reasonably dilute dose. The recovery gained by
the reducing agent requires an appreciation of the basic
chemistry involved. When correctly conducted, it is just the
same as when the Oxidizing Agent, the SSR, is used. A few cases
will show this. They will be greatly condensed to give the main
facts.
ANTERIOR POLIOMYELITIS PARALYTIC
Miss N. L., trained nurse, age 33, took ill August 16, 1947
with the prodromal symptoms, headache, nausea, terrible leg and
back pains and leg stiffness. On August 19, at 4 p.m., both legs
from hips to toes were paralyzed, could not support her, and the
pains were worse. I saw her at 11:30 that night. There were no
tendon reflexes in the legs, no knee jerk. When a pencil point
was jabbed forcefully into the soles of her feet, there was no
effort at withdrawal, and no muscle contractions could be felt.
This is the best test of all. The fever was only 102.5°F. The
spine was getting stiffer and the neck also, so the disease was
spreading. The injection of 2 cc. of the one to a trillion
dilution of the Reducing Agent was given in the right triceps
muscle. Results: On the next morning at 8, the mother phoned
that the girl could move her legs, slept some and ate a little.
At midnight, I saw her again. She could walk, felt pretty well,
and was hungry. In two more days, she was ready to work. All
reflexes were normal.
MALARIA, CHRONIC MALIGNANT TYPE
Mr. L.M., age 36, gas station attendant, World War II veteran,
contracted malaria in the Pacific area, treated in Veteran’s
hospitals for many months, but without results. Attacks still
came. After one on June 13, 1947 he was given an injection of 2
cc. of the one to a trillion solution of the Reducing agent.
Result: No more attacks in the two years that followed under our
observation. His health returned very nicely. The history states
this was a falciform infection.
CANCER
Mrs. F., age 58. The history claimed full diagnosis of cancer
at the Henry Ford Hospital, with hopeless prognosis. Examination
showed a weak cachectic woman with an abdomen greatly enlarged
with hard irregular tumefaction and a pelvis so involved the
landwarks were completely obliterated. Hemorrhage and drainage
from vagina and rectum and the enormous involvement, with the
great anemia, indicated she could not survive many days. We did
not wait for the biopsy report, as we considered the situation
hopeless and made a clinical diagnosis only. The Reducing A gent
was given 2 cc of the one to a trillion dilution on August 17,
1947. In a month’s time drainage, pain, bleeding and functions
had improved. She gradually recovered according to reports. She
moved to California. The last report came in August 1961,
stating that she fully regained her health and is still well.
CORONARY OCCLUSION
Mrs. S., age 74, with a long history of arterial sclerosis and
aortic insufficiency, usually carrying a blood pressure of
200/100, had a severe coronary attack in June 1960. The SSR was
given before true infarction could happen and the recovery was
immediate. The ECG showed no infarction. The following year on
June 27, 1961 she had a very severe attack. She was hospitalized
and given every possible aid while under the oxygen tent, but
without favorable response. The situation rapidly deteriorated,
B.P. 190/100, great pulmonary edema, thin weak pulse at 130 P/M,
great dyspnoea, general cyanosis, chest pain and she was at the
point of collapse when the Reagent was injected in the triceps
muscle, 2 cc. of the one to a trillion dilution. The response
was immediate. The house physician took the pulse while the
injection was being given to check the change that followed. The
needle was a No. 12 bore, one inch long, to accommodate the
rapid injection. Just after the needle was withdrawn, a part of
a minute after the injection was made, the pulse immediately
changed to 60 per minute, the dyspnoea ceased, the cyanosis
faded away, and as fast as the blood pressure could be taken it
was found to be 140/80. She was comfortable in a minute. The
house physician was “shocked.” The next morning the ECG was
taken, amid showed nodal fibrillation, extensive infarction of
the Septum, and ischaemia extending over the lateral wall of the
left ventricle. Another ECG taken a week later showed marked
improvement with diminution of the area of infarction. The day
following the crisis the Blood Pressure was back to its normal
for her, 180/100. Her health remains what is considered good for
her.
During the first attack the blood was extremely jelled so that
the ischaemia of the heart muscle gave the same symptoms as a
thrombosis, since the blood was not flowing. But on receiving
the SSR, the blood colloids were quickly charged and good
dispersion restored the fluidity for normal movement. Infarction
was prevented. During the second attack, the jelling of the
colloids went on long enough to injure the vessel intimae and
true clotting took place over a wide area and besides, a still
wider area was ischaemic from extensive blood jelling. Wherever
the true clot had not interrupted the circulation, the
dispersion was restored and a good flow assured. The periphery
of the infracted area showed so much improvement within a week,
that one could conclude, that much of the integrated toxin was
really removed. The speed of the restoration to normal in both
instances was the same and in each instance depended on the
separation of the pathogen from the FCG of all the cells
concerned. Dr. Jayme Treiger attended her in both attacks.
CHICKEN POX
Dr. Treiger reports on 14 cases of Chicken Pox treated during
an epidemic in 1961. Twelve cases gave immediate responses so
that the lesions did not progress any further after Treatment
with the reducing agent, but started to involute right away.
Between 24 to 48 hours, the recoveries were complete. The other
two cases recovered between 5 days and a week. Thus the virus
was instantaneously removed from the tissue cell’s FCG, in the
first 12 cases. The results in the two cases that failed to
respond to the Reagent were also predictable, since they did not
follow the regime and ate such antagonistic foods as smoked ham.
As in measles, where the recoveries require about 12 hours after
the patient has been treated, the response is predictable and
the scientific basis of the Therapy is thereby established.
HEREDITARY GENERAL ATROPHY-IDIOCY
A girl of 11 years of age, with the intelligence of a child of
one year could walk before she was three years old, but not
afterward. Her arms, legs and body were atrophied, but not her
head although her brain failed to develop. She had convulsions
every day of her life until July 1, 1961 when the Reducing Agent
was given. On that day, she had convulsions and was unconscious
all day until Dr. J. Treiger injected the Remedy. After the
injection, the convulsions stopped and she had no more until
during thesixth week reaction, when one mild convulsion took
place. There has been a steady improvement in her health during
the 2 months that followed the Treatment, up to this date
(9/1/61).
DIABETES WITH GANGRENE
Dr. Julian Baldor reports the following case of diabetes with
gangrene. Mr. A. C., age 71, had been diabetic for five years.
He had had many high blood sugar analyses and insulin
injections, but a steady decline in health: On January 5, 1961,
he had a severe crisis; blood sugar 375 mgm.%, high fever, much
pain in the right foot and was approaching coma. Gangrene of the
fifth toe set in. Following toe amputation on February 12, 1961,
fever continued and there was a rapid spread of the gangrene to
involve the entire foot with numerous fistulae on the dorsum and
plantar surface. Further amputation was considered, but because
of the virulence of the gangrene, it was considered useless,
even though done above the knee.
The Reagent was given on March 18, 1961. Two days later, on
March 20, 1961, Radiograph I of the right foot was taken showing
bone destruction from diabetic gangrene. After Treatment,
improvement followed. On March 30, 1961, without insulin his
blood sugar was 124 mgm.%. No medication was required. In eight
weeks, the lesions were healed, the edema was gone and healing
of the destroyed bone tissue in exact normal detail was observed
in the Radiographs. Radiograph II, taken on June 3, 1961, shows
bone reconstruction where the gangrene had formerly destroyed
the bony structures. Only where amputation removed the bone was
no reconstruction possible. His foot became normal, all fistulae
were healed, function was good and he is able to walk normally.
On August 25, 1961, his blood sugar was 80 mgm.% and his health
remains good. He is a good demonstration of the reversal of the
pathogenesis.
We have fully reviewed the established theoretical chemistry
basic to our Postulate, and have seen how it is exemplified in
Nature’s biochemical systems. We have seen how the double bond
is postulated to serve in the production and correction of
ALLERGY AND ESTABLISHES A LEAST COMMON DENOMINATOR IN DISEASE
CONDITIONS.
The reversal of the pathogenesis has been observed many
times in the reconstruction of bone that was destroyed by
cancer. In this process soft bone is formed first and after
its shape and dimensions conform to the normal with the
fragments drawn to their normal positions, the soft
bone calcifies and is hardened so it can function normally.
The original normal structure is thus restored as seen in the
Radiographs. Soft tissues as the vocal cords, the uterus and the
stomach wall, have also been observed to reconstruct to good,
normal functioning. Thus the pathogenesis was reversed in its
totality. So it is not unreasonable to suppose that if the
FCG of the tissue cells and of the reticulo endothelial system
possesses an O/R potential equal to or superior than that of
the SSR, disease changes, as we know them today, could never
be initiated nor propagated. Was man so equipped when the
Creator pronounced him perfect in the beginning? And what has
unnaturally produced foods and other features of civilization
have to do with our present status?
Without doubt it has to do with the anoxia that makes possible
the integration of foreign material with the host cell’s
functional mechanism, for the eating of meat was never
prescribed by the Creator, and wherever dead animal tissue is
found, be it in the ground or in the colon, the germs that
putrefy it into fertilizer for plants are there and the toxic
amines are one of the products. These cause the jelling of
cellular, blood and lymph colloids that block the circulation
and combine with and inactivate the Carbonyl groups that should
initiate the oxidation progressions and serve the electron
transport from substrate to oxygen. Sulfhydryl compounds add to
quinones and interfere similarly.
Then how often can the functional mechanism, as we have
outlined it, take on a pathogenic free radical and accommodate
the oxidative cleavage to get rid of the pathogen and function
normally again? In the case at hand, the diabetes has not
returned and the leg and foot tissues remain normal, as he lives
on a clean vegetable-fruit-cereal diet. Moreover, there are
other sequelae to diabetes that offer data that answer this
question, for example, diabetic retinitis. Here the basic
cellular pathology is the same, which can be estimated by the
delicate sense of vision. Also in myelogenous and demyelinating
diseases of the nervous system, the pathology can be estimated
as it comes and also as it is caused to leave under the
Treatment of this text.
In all cases, the toxic amines, sulphides, etc., produced in
the putrid colon, strike the endothelial cells and intima of the
small blood vessels first to cause them to swell and multiply
while the tissue colloids are jelled to a hyalin substance, all
of which tend to shut off the circulation and oxygen to the
functional elements and allow the pathogenic integrations that
constitute the specific diseases. This can be seen in daily
practice and two cases that recently appeared for consultation,
illustrate them very well. One is a case of diabetic retinitis,
where the pathogen stepped in as supplied by a toxic colon and
was separated out when the Oxidation Therapy of the text was
employed, again returned upon neglect of colon hygiene and then
again responded to additional Treatment. The other is a case of
multiple sclerosis, which shows the true course of the
pathogenesis as responsive to a putrid colon.
DIABETIC RETINITIS
A few pertinent facts will suffice. Mrs. J. C. C., age 39
years, was under good insulin management for 12 years for
diabetes discovered after a stillbirth. The vision did not start
to deteriorate until a year later when the glycemia was found to
be 350 mgm.%. Put on Protamin, zinc insulin and restinon, the
glycemia dropped to 280mgms.%. A good cardiologist found the
circulation to be grossly normal, the B.P. 14/8, pulse 90 b.p.m.
Blood examination on 9/10/64, showed a glycemia of 216 mgms. %
and at this time the distinguish light from dark faintly. She
was given a dose of the 6x dilution of Parabenzoquinone and 18
days later, the dose was repeated. In a few days, a reaction set
in with vision entirely absent for a day. Thereafter, the vision
improved steadily so that at the end of 3 months, she could read
large newspaper print and got around very well. She then
deserted her vegetarian regime and indulged freely in the animal
proteins she enjoyed so well and the retinitis returned, but
vision was still practical enough to get around. Treatment was
again instituted, as before, and the response was satisfactory
to her, she reports. However, she did not return for vision
tests.
MULTIPLE SCLEROSIS
Demyelization of the pyramidal tracts is the visible pathology,
with gliosis and axon degeneration in advanced cases. The case
history facts of the following case under Treatment at present
shows that the chemical pathology lays primarily in the
functional elements and the demyelization, is secondary or
concomitant. The course of the recovery process demonstrates
this.
Mrs. R. P., age 40, first started to show paralysis of the
lower limbs late in the fall of 1963, following an intestinal
infection that was diagnosed as typhoid fever but probably was a
different infection, as she had typhoid at the age of eleven,
followed by falling of the hair during convalescence. This
latter “typhoid” attacked her in October 1963, and its terrible
headaches kept repeating every day thereafter between 11 a.m.
and 11 p.m. with a fever of 37.5 to 38, until she was placed on
our colon cleansing diet and lavages and given the
Parabenzoquinone injection on August 3, 1965. It was during this
two years of poisoning that the paralysis developed, and then
reversed toward normalcy under our “get rid of the pathogen”
system.
The diagnosis, multiple sclerosis, was made by the experts at
the Lahey Clinic and at Massachusetts General Hospital, Boston,
with the usual prognosis summed up in a letter by Dr. Chas.
Fager and Dr. Norcross as follows: “Spastic type of paraparesis
affecting the lower limbs quite symmetrically, worse in the
distal segments than proximally, associated with pathological
reflexes in the toes and absent abdominal reflexes. For the most
part the long sensory tracts testing was normal except for
slight impairment of vibrational sensation in the feet. In the
upper extremities and mandible, the reflexes were also
hyperactive but from a neurological standpoint, there were no
other abnormalities, no evidence of any cranial nerve, optic
nerve, cerebellar or upper extremity dysfunction. I am sorry we
have nothing further to offer but this seems clearly to be a
case of demyelinating disease of the spinal cord for which,
unfortunately, there is no specific treatment.” The
cerebrospinal fluid showed a Gamma globulin of 12.25 mgms. % and
there was an eosinophils of 17%. They recommended heavy animal
protein diet for strength.
The recovery course showed that after the two weeks of colon
cleansing on a fruit-vegetable juice diet and the injection of
the two cc of a one to a million dilution of Benzoquinone and
then a regular vegetarian diet; reversal of the pathogenesis
followed the rule of the first to come was the last to go, and
vice versa. The headaches and fevers left immediately, only to
return during the reaction periods the third day, the third week
and the sixth week for an hour or so. But the point, for which
we recite this case, is that within one-half hour after the
injection of the Reagent, she had a reaction of fibrillation of
the muscles that control the toes of the left foot. This lasted
for 20 minutes and returned for similar periods several times
that day and continued to come for a few days when the reaction
also started, in the same way, in the muscles of the right foot.
These fibrillations traveled from the feet to the calves and
then after the sixth week, to the thighs and slightly to the
abdominal muscles and as they left the feet and calves, the use
of these muscles lost most of their spasticity, gained much more
control so she could walk to the chair, sit down and get up
again easily without help, as was previously required by two
attendants and her balance became almost normal. After the sixth
week reaction, her improvement slowed down so that by the ninth
week it was stationary. This meant, that necessary elements to
the tissue reconstruction were exhausted and one had to wait
until the deficiencies could be overcome. Such recuperation
takes time and in one case, had to wait for one and a half years
after Treatment in a man whose multiple sclerosis was developing
for 15 years and was completely hemiplegic for 4 years before he
received his dose of GLYOXYLIDE. Then after a year and a half,
restoration set in and in the course of 4 months he could walk
across the room with a little support. In this case during the
recuperation, his legs jerked every third week for a few days
and then improvement set in resembling somewhat the
fibrillations referred to above. So in the case of this woman,
time must be given to accomplish whatever changes are necessary
for further progress.
Time factors cannot be predicted!
It will be recalled that at the beginning of Treatment, the
woman was running high fever with intense migraines for many
months, until the two weeks of comparative starvation with colon
washings, cleansed her system of the load of the debris from the
forced meat diet that had stuffed the mitochondrial spaces and
covered their surfaces, so that the necessary electric
potentials and diffusion facilities were obliterated and normal
function was prevented. Then after the Treatment within several
hours, she was freed of the headache, the fever disappeared and
the toe muscles twitched, etc. To me, this meant that the
mitochondria were unloading their metabolic debris and in time
they were able to function with improvement, until the period of
exhaustion set in. Another fast was recommended along with colon
cleansing to prepare her for the further progress, she required.
There can be no doubt about the mitochondria being injured by
her prolonged toxic condition, as favored by viral and toxic
invasions, the extent of which one is not able to estimate.
However, the SALUTARY effect of fasting in all chronic diseases
must be emphasized and a brilliant case in mind, will
illustrate. It is a woman of about fifty years of age who had an
enormous cancer of the right breast, that had metastasized to
all quarters of the lungs causing difficult, painful, breathing
and also metastasized to the brain so that she was paralyzed,
quite generally blind, unable to take nutrition and then
proceeded to fall into a coma, for about ten days before the
cardiologist was called to strengthen her heart. On seeing the
full situation, he gave the Treatment of the text, giving a dose
of Parabenzoquinone in one arm and a combined solution of
Glyoxal and Methyl Glyoxal (one of the original forms of
Glyoxylide) into the other arm. The heart responded immediately
and continued to become normal; the breast, lung and brain
neoplastic invasions absorbed so that in eleven weeks, when I
saw her, she was perfectly normal, up and about and free from
all traces of the disease. Soon thereafter, she took a trip to
Sao Paulo as any normal person. Subsequent X-ray investigations
showed she was free of all traces of the disease.
Now then, what was the secret of her brilliant response? It was
the prolonged fast she had been forced to follow when she was
entirely helpless. This unloaded the mitochondria of their
metabolic debris, so that the oxidations instituted by the
pathogens and integrated with the mitochondria, could be burned
away without further impediment. Never force feed, but fast the
patient!
INSOMNIA
Whether insomnia is an allergy of the waking centers in the
mesocephalon, or an inhibition of the sleeping centers has not
been decided, so far as I know. But it makes little difference.
For wherever the interfering pathogen is integrated, it has
proved subject to oxidative removal and freeing of the center,
within a matter of a few days, so that normal sleep became the
habit. One case of insomnia lasted twelve years without sleep,
in spite of all of the best efforts by the therapists. He
recovered, permanently, in less than a week after one dose of
Benzoquinone. Another case was of two years standing and also
recovered, in a few days, following a dose of the same Reagent.
One must conclude, therefore, that sleep is a function in which
energy is used and the oxidation mechanism supplies it.
Interference with this energy production, as by toxic
amines and sulphides, lead to schizophrenic and paranoid states,
hallucinations and compulsions, mentioned only a few times in this
text. But there are many others who responded more quickly and
with perfect sanity. One therefore concludes, that the integration
of the pathogen in nerve tissue is weak and readily ruptured by
the high oxidation potential of the Koch Reagents and the
pathogens would then be products of bacterial action generated in
the colon, as for example, by the Tryptophan changes leading to
rearrangements of the pyrrol ring to produce lysergic and
reserpine types of products, as well as plenty of others.
Heart muscle has not entirely lost its nerve characteristics
in its differentiation and so its higher tendency to survive
oxidation defects influenced the decision to test out heart
muscle, as a carrier of the glyoxal derivatives, used in the
1919 Official A.M.A. Investigation. Its cure rate, between
(60% to 80%) in terminal cancer, was falsely reported by the
A.M.A. The report, published in the Medical Record of
October 30, 1920, demonstrated a similar curative action in
heart muscle. And on this fact, was built the larger serial
systems of Carbonyl groups mentioned in Chapter 13, of this
text. Further activation of Carbonyl by conjugation
with ethylenic double bonds confirmed the truth that highly
negatively charged Carbonyl groups, in correctly constructed
molecules, are the guardians of perfect tissue function.
VISIBLE DEMONSTRATION OF REVERSAL OF THE PATHOGENESIS
Radiograph I, taken on March 18, 1961, of the right foot
showing bone destruction from diabetic gangrene
(top photo). >
Radiograph No. II taken on June 3, 1961, of the same foot showing
bone reconstruction where the gangrene had formerly destroyed
the bony structures (bottom photo).
Radiograph III, of Mrs. A. C.’s right foot taken in December
1961, about 9 months after Treatment.
A little more discussion should be given to the easy rotation of
the single covalent bond and also, its ability to be fixed in
one plane by mutual polar attractions and repulsions of
component atomic groups, in both the host cell and the
integrated pathogen. This rigidity exhibited by each species, in
each of its viral infections, has been observed as a constant
feature and would be the only explanation available, if we
assume that the pathogenic integration takes place by an
addition at one position in the host cell’s FCG’s activating
double bond.
The additions of the two pathogens, the initiating and
the supporting pathogen(s) cannot be formulated with
exactness as the chemical structures are not known with
exactness; we have arrived as far as we have by Postulates
and check-up of each Postulate, all of which were based on
sound chemical principles. With this reservation in
mind, we may also formulate the integration of both pathogens
with the critical atomic group of the host cell’s energy
producing and receiving mechanisms, as directed by the polarity
forces, exhibited by the double bond and its substituents. This
cannot be claimed to be absolute for we do not know the atomic
groupings sufficiently for an absolute diagram. However, any
utility in a conclusion reached by a Postulate is just as good a
utility as that reached by cold fact, for it is the utility we
need now to face the cancer and viral plagues we fret about or
are not willing to tackle. The utility of an explanation is some
reward.
We have observed that Hog Cholera fails in 100% of cases, to
respond to the serial system of Carbonyl groups that Hog Aftosa,
Cow Aftosa and rabies respond to very satisfactorily. Many
epidemics of Aftosa in cattle have responded 100% to this
Reagent. On the other hand, Aftosa does not respond to
Benzoquinone nor does rabies respond to diphenoquinone, to which
100% of Hog Cholera has responded to in more than one epidemic.
So the species pathogen integration for each disease is set. A
diagram in one plane only can be given on paper and will have to
be interpreted by the reader with reference to other planes. The
substituent groups R, R’ R” cannot be given in detail for they
are not known. However, the signs will have to be understood
to carry the polarity values that cause the fixation of the
single covalent bond that joins the two parties, as we
outlined before. What we can show is how the polarity values
of the critical atomic groups of the autonomous host and of
the parasitic pathogen, favor the pathogenesis and also the
separation of the host’s critical atomic group from the
pathogen which, undergoes a stepwise oxidation. There is,
however, more than one question that is not answered by the
diagram. Further data must first be won. The main question
answered is how and why the Reducing Agent is successful in
all of the pathogenic integrations, regardless of species or
viral type. This, one can see, is due to the firmness of the
double bond against rotation since, the cleavage is had
between its two terminals and they remain fixed with reference
to each other. The diagram also indicates the fixation
of the single covalent bond that combines the pathogen and
host cell, in each specific disease integration, so as to
offer steric hindrance to successful attack by certain
reagents and steric advantage to others; this is confirmed by
clinical experience. This fixation is, of course,
electrostatic.
CRITICAL ATOMIC GROUP OF PATHOGEN, ESSENCE OF PARASITISM
The pathogen may integrate with the host cell’s FCG by the
condensation via its amine group and block FCG function or
pour polymerization energy into it, to force an allergy or a
neoplasia. This does not need to be diagramed, as only one
pathogen is required. Blocked functions as in diabetes or mental
suspensions following the toxic amine carrying antibiotics, are
examples. But neoplasms as caused by butter-yellow and
diacetylaminofluorene require a supporting carcinogen to supply
the energy for mitosis. Where the amine condenses with the
FCG to form an azomethine double bond and initiate neoplasia,
a nitrogen free radical would be expected to mediate the
carcinogenesis. 
The polarity of C(4) is positive like C(6) through withdrawal
of electrons by R’ and C(7), which thus become negative. R’could
contain halogens, nitrile, etc.
CRITICAL ATOMIC GROUP OF THE FUNCTIONAL ENERGY PRODUCTION
AND ENERGY ACCEPTING SYSTEMS ESSENCE OF AUTONOMY
The polarity of the Carbonyl group (12) is strongly negative
through the electrons it has withdrawn from the double bond and
C(13) is also negative because of lying in the orbit, the
Carbonyl electrons that polarizes the electrons to the pole
nearest to it and removing them from the distal pole which makes
C(14) positive, comparatively. The methyl functions at C(15)
contribute electrons via the double bond to the Carbonyl group.
R” carries groups like R and R’ of the pathogen that determine
the line-up of the two when they integrate and the polarities of
the critical atomic groups’ atoms determine which make the
unions or additions to the double bonds. C(4) being positive
tends to expel H(5) for easy removal by the Carbonyl group (12)
forming the free radical that makes the addition of C(4) to the
negative pole of the FCG’s activating double bond at C(13).
Thereby, a free radical is produced at C(14) which adds to the
negative pole C(7) of a fresh molecule of the pathogen to start
the polymerization chain which continues as an end to end
addition, yielding the energy that supports the allergy or the
neoplasia.
THE INTEGRATION OF PATHOGEN AND HOST CELL CRITICAL ATOMIC
GROUPS AND THEIR SEPARATIONS
The polymerization continues at C(6) free radical.
To rupture the integration oxidatively, the Therapy
dehydrogenator removes H(3) of the initiating pathogen producing
a free radical that adds molecular oxygen to become a peroxide
free radical that cleaves C(4) from C(6) producing a Carbonyl
group at the latter. C(4) also becomes a Carbonyl group and by
being positive remains attached to the negative C (13). By
gaining a Carbonyl group the pathogen looses its parasitism
and becomes autonomous.
The polymerization bond between C(14) of the host’s FCG
activating double bond and C(7) of the pathogen invites cleavage
as C(14) which is positive in polarity and tends to release its
H atom to the action of a dehydrogenator of appropriate
qualities, as offered in the Therapy Reagent. A free radical is
formed there and a peroxide free radical results in the presence
of oxygen that cleaves C(14) from C(7) of the pathogen forming
two terminal Carbonyl groups. The Functional System of the
host cell thus now holds a cluster of three Carbonyl groups to
serve its dehydrogenating function as activators and
as dehydrogenators. This is a quite formidable array, via its
orbital mechanics. The Carbonyl group won by the pathogen,
attracts electrons from the methylene group alpha to it and
thus releases its hydrogen atom to any dehydrogenator at hand,
as the cytochrome or ferrous-ferric electron acceptor systems
and so a new Carbonyl group is formed at each terminal again,
a process that can be repeated until the pathogen is burned
out of the way.
SEPARATION OF THE INTEGRATION VIA THE REDUCING AGENT
The Reducing Agent is constructed to yield a hydrogen free
atom, which C(7) of the pathogen being of high negative
polarity, immediately combines. A free radical is thus formed
at the C(6) pole, which being of positive polarity,
immediately combines the molecular oxygen in which it is
bathed to form a peroxide free radical that splits the double
bond to form a Carbonyl group at C(6). The Carbonyl
group withdraws electrons from C(4), which is already positive
and makes it release H(3) to any ordinary dehydrogenator, as
before mentioned. The initiating pathogen is thus removed and
the FCG system gains a Carbonyl group joined to its functional
mechanism. Another Carbonyl group is gained at C(14) by the
progressive oxidation of the integrated supporting pathogen,
starting at the closest C(4) to the newly formed Carbonyl
group, which now reinforces the FCG, so it is amply able to
remove the H(5), which is already repelled by the positive
polarity of C(4). C(4) thus becomes a Carbonyl group as a
result of the usual sequence of free radical action. Likewise,
so does C(6) that draws off the electrons from C(7) so that it
tends to release its hydrogen atom to the ordinary hydrogen
acceptors and become a Carbonyl group that, in like manner,
causes C(14) to release its hydrogen and become a Carbonyl
group. Now the FCG is a triple Carbonyl group affair with
properties, as just described, resulting from the action of
the oxidation process instituted through the Therapy
dehydrogenator. Whatever toxin debris is present in the FCG,
is readily burned away by the high power of the triple
Carbonyl system of the FCG as a dehydrogenator. The rapid
action of the recovery process in cases where the Reducing
Agent was used in dilutions of one part per trillion, may be
explained on the basis of the procedure just outlined. The
polio case, the coronary case and the diabetes case being
typical examples.
The processes just outlined must be considered in any
investigation of cancer, allergy and infection, as they use
the most basic of chemical phenomena, as we understand
chemistry today. Whether the outlines given are the
actual processes that take place is not easy to prove without
much work. However, they lay out the paths to be followed
in any basic investigations of the subject and they were
fruitful to us in our limited approach. The results cannot
be overlooked, as such results have never been known before in
the whole history of medicine unless, of course, we are
scientific enough to factually examine the superior results of
Divine Miracle Healing as reported by Nobel Laureate Alexis
Carrell, which he compared to his tissue culture data and
which yielded some enlightening conclusions that cannot be
scientifically brushed aside, though they follow Laws of
Nature we are not as yet able to understand. The cases we
present follow basic cycles and laws that we have observed
whether interpretable or not.
MITOCHONDRIA AND THEIR CLINICAL ASPECTS
Complicated as the mitochondria are now shown to be by
modern methods, the patterns detailed are far too simple to
account for their complex performances. And while our
observations are made on the intact patient via case history and
physical examinations, we were able thereby to outline decades
ago what the microbiologists are demonstrating today. The
clues gained from our parathyroidectomy experiments were
indeed fortunate not only in teaching us the effects of
activated amine groups in bringing about anoxia, but also
the mechanism whereby they blocked the use of oxygen and the
operation of the Pasteur Effect. These clues, followed in a
step by step process, led to the Conclusion that the
direction of flow of electrons over the double bond bridge,
whether to or from an alpha placed Carbonyl, amine or
methylene group, determines the resulting normal,
pathogenic, or corrective process. Other guides for
determining the most likely reaction sites and courses in
oxidation reduction substitution affairs, were the loosening up
of hydrogen-carbon, hydrogen-oxygen, and hydrogen-nitrogen
bonds, by the electron mechanics of neighboring groups, as in
the hydroxyl of the phosphate and the exposed amine group of the
adenine and the methylene (2) group conjugated with the ring
oxygen of the ribose fraction of the ATP. The same earmarks of
energy transfer agency admit creatine, phosphate, guanosine
criphosphate and the whole series of substituted quinones to the
energy transmission belt, each holding its specific position in
each particular function, and the ketosteroids may also be
included. Each must be identified with its clinical signs of
deficiency, as the basis of a rational therapy.
Another simple principle in chemistry recalled by the
clinical events, is that the energy liberated by exergonic
reactions, must be disposed of or the reaction will be
blocked. It usually passes into and energizes another
process or is lost as heat. Intrinsic in the mitochondria is the
function-trophic balance whereby the gene pattern of its
architecture is maintained. So it appears that the energy, in
the working mechanism, is inadequate to use and is shunted into
trophic processes that build up the mechanism until it is able
to use supplied energy efficiently. In a sense, the need for the
function determines the amount of energy offered and the
mechanism either uses it, is built up by it, or passes it into
the mitotic mechanism in cells that can reproduce. No
reproducing cells, as the anterior horn cells, undergo
mitochondrial reconstruction and Nissle substance rebuilding,
needed to meet the functional demands after the obstructing
virus or carcinogen is oxidatively removed. Thereby, the trophic
neurons are enabled to again resume the development of tissues
that were destroyed by cancer, or were stopped from developing
during a symbiotic polio infection, as the case histories show.
Retarded growth of a limb may thus be corrected 20 years
after the polio infection took place, even returning to a
nearly normal state.
PROVEN REVERSIBILITY OF CANCER
And this leads to the question posed by Warburg as to the
irreversibility of cancer which we show exists only so long
as the carcinogen is integrated with the cell’s energy
producing and receiving mechanisms for function and mitosis,
and which is reversed by oxidatively removing the integrated
carcinogen, virus, etc. The case histories of the
text are good examples.
America’s most noted expert surgeons and pathologists, at our
proudest institutions, made the diagnoses utilizing all the
facilities for making a firm diagnosis, in the regular course of
business. Only a few examples are used here, but they are
enough. Besides, the American Medical Association and its
Wayne County Medical Society officially, but begrudgingly,
proved that cancer is fully and permanently reversible in
1919 when they investigated this Therapy on “five undoubted
cases of cancer” treated in the terminal stages, as is
fitting for such a test. Three weeks after
the Treatments were given, several patients started to
improve so rapidly that the Official Committee began to
panic and closed the investigation, sending the patients
back to their distant homes with the instruction that
further Treatments would not be allowed! In spite of the
committee’s actions, follow-up medical documentation on
three of the five patients showed that they all continued to
recover until they were again normal with full reversal of
the pathogenesis, and permanently so. A fourth
patient made such a rapid recovery from a generalized von
Recklinghausen neurosarcoma that had invaded his entire body,
that when the uncountable tumors began to rapidly dissolve away,
the Committee warned the patient that if he received another
Koch Treatment, he would melt away just like his tumors and so
he had better return home for safety’s sake. He lost no time in
doing so. It was not possible to follow him personally
thereafter, as he lived over 300 miles away. So I cannot
personally state that I found him cured like the others. However,
five years later, patients continued to come from his
hometown because of the good results they observed in his
case and unless he were cured, he certainly could not have
survived over a few months from the time of Treatment. Certainly
a recovery rate of 60% or 80% of cases treated in the
terminal stage is not, “nothing came of it”, as was
officially reported. Moreover, five years later, when I
presented the follow up documentations of the curative
results to the Wayne County Medical Society and requested
that they correct their misleading report, they persistently
refused.
The full and permanent reversibility of far advanced
cancer was also firmly, factually and with uncontradictable
evidence, proven in two Federal Court Trials of daily
sessions, each lasting five months, in 1942 and 1946. And at
their conclusions, the Food and Drug Administration was
forced to withdraw their false charges stating that the
Remedy of this text was ineffective. The answer to the
Warburg question is established, “Cancer is fully
reversible, permanently and completely so.”
ELECTRON TRANSPORT, SUPPLEMENTARY STATEMENT 1964
Continuing the discussion from Chapter 9 of the text on
Coenzyme Q10, a supplementary statement is required. In 1953
when the first edition was written, nothing was known by the
author about the Ubiquinones and in 1959, when the
present text was written, all that was known by the writer, was
included in Chapter 9. But up to the present day, an enormous
amount of literature has been developed, contributed to by
biochemists in the leading research centers throughout the
world. Since they give practical information yielded by
precise methods and instruments, not even dreamed of when this
Postulate was formulated, they confirm this Thesis throughout
and the student will profit by reviewing some of the facts. This
is not a review of the entire subject, but only some of the
outstanding facts as well as our interpretations, which are
helpful to the conduct of the Therapy.
Because of the intriguing nucleophilic properties of
Parabenzoquinone, and the facts stated in the early pages of
this text regarding the parathyroidectomy experiments, it
was chosen with other activated Carbonyl groups, as in the
alpha-keto-aldehydes, triquinoyl, and other polymers of
O=C=C=O, as a key for investigating and demonstrating the
principles whereby pathogens could be dehydrogenated and
thus detoxicated before and after they had integrated with
the host cell’s energy producing and receiving mechanisms,
and of course, to open up the electron transport where a
bottle-neck blocked the metabolism. It is of special
interest here that the Benzoquinone nucleus now offers a
historical background that supports the demonstrations we have
made over the past half of a century. For it is the nucleus of
the Coenzyme Q series, the Ubiquinones, that are so named
because of their universal distribution in all aerobic cells,
animal, plant, and microbial. Their intensive investigations
over the past few years show that the chemical properties, we
relied upon to develop our Postulate, are actually used
biologically by all aerobic cells. This is in contrast to
the swornTestimony of leading biochemists in 1942-1946 who
claimed, based upon their broad general knowledge and great
education, that the quinone structure, as well as calcium,
oxygen and its catalysis, had no significant place in health
or in the treatment of disease, of course, in opposition to
our Thesis. In the Preface to the 1963 edition of
the ANNUAL REVIEW OF BIOCHEMISTRY, Szent Gyorgyi gives
biochemists some moral advice they may weigh profitably.
The specific place in metabolism held by the Ubiquinones
depends upon the way in which the Benzoquinone nucleus is
dressed up by its substituents so as to fit some specific
function, as a key in a lock. What we showed was that the
properties, so used in a particular position, can be used
generally when the dressing is removed, that is, when it is
stripped of its steric hindrances. In other words, when
the substituents are replaced by hydrogen atoms as in
Benzoquinone.
The structural formula of Coenzyme Q10, in Chapter 9, shows a
methyl substituent at position 2 of the quinone nucleus, an
isoprenoid side chain at position 3 and methoxyl groups at
positions 5 and 6. The isoprenoid side-chains of different
Ubiquinones have different lengths. Those in man and higher
animals have ten carbon atoms and are named Co Q10. Lower forms
have from 6 to 9, as the suffix in each case indicates. This
side chain gives the quinone greater lipoid solubility and plays
a part in the chromanol change made possible by the position of
its first double bond. It does not alter the redox potential of
98.8 milivolts, which is to be attributed to electrons received
by the Carbonyl group from the other substituents. The
coenzyme is therefore a specific dehydrogenator and electron
carrier and is placed between the flavoproteins and
cytochromes in the electron transport chain on the way to
oxygen. It is also agreed that it does not serve on the main
transport path, but on a different undetermined pathway.
One might suggest also that it acts on a very special substrate
as well. It therefore serves the general immunity only in a very
restricted way. Other highly activated Carbonyl groups
present with it in heart muscle lipids are far more important
as we have seen. Since the average human cadaver contains
about one gram of Co Q10, but because it is present in the urine
in health and disease in amounts far greater than catalytic
doses, its high substitution is in agreement with its restricted
protective value, in contrast with the general high protection
offered by the naked Benzoquinone structure. The same facts hold
for the serial systems of Carbonyl groups.
As Coenzyme Q occurs in 5 times the quantity as other members
of the electron transporting chain in some tissues, it must have
other functions besides the simple electron transport, although
it is present in proportion to both the capacity and continuity
of oxidation. So with its neat redox potential, one would assume
that it serves as a dehydrogenator of a special grade. Since it
is known to undergo chromanol change, as does both vitamin K and
vitamin E, in order to serve as a phosphorylator, it is shown
that this latter function is also tied up with the Carbonyl
group. All three substances are known to enhance sperm motility,
to serve in blood coagulation, and to serve in the
phosphorylation of ADP to ATP.
However, long before these functions were known, this writer
used the naked Benzoquinone nucleus, which does not undergo
chromanol change, to not only enhance sperm activity in bulls
but to restore their total fertility. It was used not only to
stop a hemorrhage immediately but also to restore the colloidal
dispersion of the blood so it flowed freely after such gelling
had been caused by the presence of guanidine bases and other
toxic amines. Thus it prevented coronary thrombosis, cerebral
apoplexy, etc. The section, “Practical Application of the
Former Chapters and Other Essential Information,”
illustrates the inexplicable speed by which the blood flow was
restored by the more active of the Carbonyl structures, as well
as, the reducing substance. Likewise, the naked un-substituted
quinone can serve as a phosphorylating agent in a very neat and
efficient process, when as it is reduced by its dehydrogenating
function, may add phosphoric acid with withdrawal of hydrogen
and by losing another electron, is thereby re-oxidized to the
quinone structure as it hands over its phosphate group to ADP. Thus
it prepares to go through another cycle of dehydrogenating
and phosphorylating as an example of highest efficiency with
which nothing in the Krebs Cycle can compare.
Echinochrome-A, a quinone secreted by the Sea Urchin egg’s to
mobilize and attract the sperm for fertilization is proven to be
active by Kuhn and Wallenfels in dilutions as high as one part
for two billion parts of water. Also, Kuhn and Moweus showed, at
approximately the same time during the 1940’s, that the female
gamete of certain algae mobilized the male gamete by secreting
Crocin, a carotenoid which presents a Carbonyl group activated
by conjugation with a series of ethylenic double bonds in
equally high dilutions. Thus Nature presents a pattern
whereby a Carbonyl serves as an initiator and transferor of
energy oxidatively in order to serve many functions; the
unrestricted “core” of which forms the basis of the Therapy
of this text.The Ubiquinones are just one class, and the
ketosteroids are another. Coenzyme Q is part of the liver
oxidase system that catalyses the burning of certain aliphatic
and aromatic aldehydes. It is also present in succinic oxidase
and is found in richest amount in the lipid fraction of heart
muscle, — all since 1955, while its structure was definitely
determined before 1960.
However, this writer had experience with it and other Carbonyl
groups as early as 1917 on finding a lipoid soluble agent in the
cephalin fraction of heart muscle, which could be inactivated by
adding guanidine. So on the basis that cancer cells were
lacking in functional capacity, it was used to treat far
advanced cases of cancer to learn if it would correct the
deficiency. Biopsies from the tumors after parenteral
treatment was given, however, showed no return to normal cell
structure, but a calcification followed by coagulation in only
the tumor cells, which were then invaded by capillaries and
absorbed like a blood clot. I therefore named it “Tissue
Thrombin” in a paper published by the Medical Record
of New York on October 30, 1920. Then at the
request of the Journal of the American Medical Association,
the Medical Record refused to publish any follow-up
papers. The Editor of the Medical Record personally
informed this writer that the pressure, which would be brought
to bear upon his publication if he disobeyed their directive,
would totally incapacitate this scientific magazine. The obvious
conclusion was that the medical profession was not free to
receive future information, because of the monopolistic impasse
imposed by those in control of the American Medical Association.
Forty years later, in the 1964 Annual Review of
Biochemistry, Warburg states, in his Preface, that he
found quinone to show slight curative value in mice with Ehrlich
ascites cell cancer, but it proved too toxic for practical use.
He depended on large doses to produce hydrogen peroxide as
the destructive agent, instead of utilizing catalytic doses to
initiate dehydrogenations and free radical progressions, which
we have established in the text and in our Court Testimony to
be entirely harmless and efficient in the true cure of cancer
and other serious affairs. Warburg also reports the
successful use of L and D- glyceraldehyde in the cure of Erlich
ascites cell cancer, both with equal effects, in spite of the
fact that the L form is more efficient as an inhibitor of
fermentation in cancer cells; thus indicating that the effect is
not enzymatic, and claiming the mode of action is unknown. In
both instances, Warburg overlooks the properties of the
Carbonyl group, which we have demonstrated in our literature
to be highly curative when activated by conjugation with other
Carbonyl groups as in pyruvic aldehyde.
For decades, an intentional blockage to the
advancement of cancer research imposed by the American
Medical Association and the U.S. Government has resulted in
the prevention of valuable scientists, such as Warburg, from
learning about and building upon our findings.
A most significant clinical fact is the presence of Co Q10
in the lipoid fraction of the mitochondrial membranes
together with cholesterol, lecithin and cephalin. Here with
variations, cholesterol occurs in about equal amount to the sum
of the other two. In liver, the lecithin and cephalin are each
about 40% of the total, while in succinate CoQ Reductase, the
cephalin fraction is only half as much as the lecithin fraction,
24% and 48%, respectively. Since it is also known that the
reduction of CoQ accounts for only about one third of the
oxidized substrate, one concludes, that other
dehydrogenators, like our FCG, must carry the major part of
this function within as well as outside of the mitochondrial
membranes.
The most intriguing fact, however, is that the amine groups of
lecithin choline each carry two substituent methyl groups, while
the hydrogen atoms of the cephalin ethanol amines are free and
unsubstituted, so they can condense with the Carbonyl groups
under discussion, to form labile azomethine bases which are
thereby protected from forming permanently, inactivated,
condensations with guanidine and other toxic amines. An example
of the other value of the Cephalin Schiff Bases, is their
ability to carry the coenzyme right to the substrate when the
phosphate of cephalin is transferred to ADP followed by the
ready liberation of the Carbonyl structure, which is then free
to start another cycle. Lecithin, in this respect, would serve
in contrast as a vehicle. Here we find the explanation of
some clinical facts that assign cephalin a role in the
immunity mechanism.
In many years of medical practice, one has seen among members of
families with tuberculosis, that those who ate the fat of the
meat did not have nor acquire the infection, but those who had
the infection, never ate the fat. No doubt, the cephalin in the
fat protected the functional Carbonyl groups all the way from
the intestinal lumen to the mitochondrial membranes, as stated
above, so they could initiate oxidations in the fatty capsules
of the tubercle germs, if that be necessary, or at least correct
their faulty metabolism as described in Chapter 18. Two
additional observations are: the reduction in weight of obese
patients following a dose of the Carbonyl structures of the
text, and the restoration to normal of the very erratic
cholesterol counts found in the blood of cancer patients, by
restoring adequate dehydrogenation potentials within the
mitochondrial membranes, where fats and cholesterol are burned.
Further, the efficient burning of acetate chains prevents the
excessive production of cholesterol. It appears that not the
eating of fats, but the paralysis of the oxidation facilities
here mentioned, is the cause of arterial disease. This was our
conclusion in Case 56.
All aerobic germs possess Ubiquinones. This means they have
Carbonyl activation through conjugation with ethylenic linkages
that serve the dehydrogenation function. They can also be
inactivated as described. We Postulated, that such
activated Carbonyl groups produce free radicals followed by
peroxide free radicals in the substrate to be oxidized; that
they actually do produce free radicals, is now proven by
electron spin resonance spectroscopy.Our Postulate is thus
supported in this respect, so that when a germ’s
dehydrogenating power is crippled, it cannot obtain energy
for survival in the normal way by making harmless oxidation
products, but instead produces such toxic products as toxic
amines and hemolysins, which cause disease.It is not
surprising, therefore, that after contact with the Reagents of
this text, the dehydrogenating power would be restored and is
again able to oxidize to harmless materials, the toxic
products it had formerly produced. Note the examples in
Chapter 9, where gangrenous mastitis of high toxicity in dairy
cattle recovered rapidly after a dose of the Reagent, with rapid
healing, loss of toxicity and concomitantly, a rapid increase in
the number of germs. The same holds true for the rapid cure of
terminal cases of fulminating tubercular pneumonia and cases
with huge cavitations. Chapter 18 contains cases that reference
the above statement. The time element gives the clue and culture
studies confirm it.
In line with this explanation, a recent report from a physician
in the frozen North, where an epidemic of fulminating pneumonia
was raging, sometimes complicated with measles or scarlet fever,
states the following, “I had to use five doses to save the lives
of five small children with fulminating pneumonia, who certainly
would have died without it. The results in these cases were
spectacular (about five hours in each case cured them).” Such
are the usual experiences. Carbonyl, free radicals and
molecular oxygen are the principles. Electron spin
resonance techniques show that all aerobic tissues contain free
radicals, so long as they are alive. (Schoffa 1964) Cancer cells
are shown to contain less free radicals than normal tissues.
This is of course in proportion to their anaplasia and inability
to function oxidatively. Any increase in free radical content
above that of normal tissue must be attributed to the
polymerizing of the carcinogen in proportion to its malignancy,
and as activated by magnetic influences, magnetic storms, etc.
These techniques show also that gamma rays are able to destroy
Carbonyl groups and thus, tend to make the tissue metabolism of
the malignant order, as in Warburg’s Oxygen Starvation
Techniques and with complete reversibility, for the addition of
quinones or other Carbonyl structures (mentioned in the text)
restore the normal oxidative progression, when oxygen is also
admitted. This is another confirmation of our Thesis that
the Pasteur Effect is a function of the Carbonyl group, and
unless the functional Carbonyl group is present to
dehydrogenate, when oxygen is admitted, the Pasteur Effect
will not be observed. Inactivation of bacteria,
reduction of inflammation by gamma rays and negative
consequences from the use of modern toxic amine antibiotics, may
be considered also under this heading.
Intimately connected with the function of Carbonyl groups as
activated by conjugation with other Carbonyl groups or ethylenic
double bonds stands: copper, zinc and the divalent paramagnetic
cations of calcium, magnesium, manganese and iron. Copper is
mainly diamagnetic, its oxide being weakly paramagnetic. Still
its presence is essential to the action of polyphenol oxidase,
vitamin C, the Ubiquinones and for the utilization of iron in
hemoglobin and other activities. We found copper, as supplied by
the waters of the Great Lakes, as essential to the best success
of our Reagents in the treatment of cancer for nearly half a
century. Where the tissues held a good quota, such successes as
illustrated in, “The Integration of Pathogen and Host Cell
Critical Atomic Groups and Their Separations” were the
rule. Here we have given a few recent confirmations of our
Thesis from leading research centers that certify our
Theoretical basis, long established by the clinical results.
THE O=P GROUPS COMPLEMENTS CARBONYL, AIDS IN RECOVERY
Before the historic work of Coris, Lipmann and some others had
elucidated the energy carrying phosphate esters during the
1930s, we took interest in the hydrogen attracting
powers of the O=P group of phosphoric acid, to compare this
double bond with the O=C group, chemically and clinically. We
had observed the dampening effects of hydroxyl and amine groups
on Carbonyl action, and by analogy figured that the three
hydroxyl groups of phosphoric acid must reduce the
dehydrogenating powers of the O=P group. At that time, the
electronegative units of neither the Carbonyl nor the oxygen
phosphorous double bond had been estimated. But the
dehydrogenating facility, as hindered by hydroxyl and amine
groups, was very evident. Today one can measure their
effects mathematically, and it is seen that while the Carbonyl
group offers 6 electronegative units, the O=P group runs a
close second, with 5.6 such units. The position of the O=P
group is therefore to be reckoned in the oxidation process as
something more than a passive unit in the phosphorylation
energy passing function.
One may appreciate the repelling effect of hydroxyl on the
electron attraction power of the O=P group by analogy, when one
recalls its effect in maleic acid, as compared with the
anhydride on the attracting power of the Carbonyl groups.
Similar effects are seen where chlorine replaces hydroxyl as in
acetyl chloride. A similar effect should be considered in the
increase of energy carrying power of pyrophosphate, by
condensing two molecules of orthophosphate. Likewise, the
increase in the attracting power of the Carbonyl group produced
by conjugation with unsaturated groups, as in maleic acid as
compared with malic acid, and by the increase of O/R power of
diphenoquinone as compared with paraquinone. The effects of
un-saturation and anhydride formation, all of which are
dehydration affairs, influence Carbonyl and phosphoryl in
affecting their electro-negativity.
To test this proposal, one combines rich, hydroxyl carrying
molecules, as glucose or fructose, with phosphoric acid under
forceful dehydration and un-saturating conditions to produce
their polymeric unions. The resulting increase in
oxidation-reduction potential did not reach that where Carbonyl
is involved, still the energy carrying power was tremendously
increased in a way that was useful in the reconstruction of
injured tissues and in restoring bacteria from their pathogenic
states. Bacteria lost their pathogenicity and virulence, as is
demonstrated by bacterial plate cultures, similar to that shown
in the Supplement, “Practical Application Of The Former
Chapters And Other Essential Information,” and by clinical
observations in Chapter 15 and Chapter 18. One concludes,
that bacteria and tissue cells regained the energy utilization
powers required for their normal metabolism and function and
thus, their parasitism and pathogenicity was lost. Since
the recuperation of tissue cells and of bacteria is
accomplished by the Carbonyl structures of the text, as
observed in other case reports of the text, it is concluded
that energy was produced and transferred into the same
functional structures by both the Carbonyl and the phosphoryl
double bond structures under similar means of activation.That
both groups serve complementary to each other with Carbonyl
holding the initial position, is seen in cases where both
types were administered to the patient and followed by an
increase in the recovery rate. It is also to be noted that
the Reagents were given in such high dilution that the amounts
represented only 10-(12) grams per dose, which obviously is not
an injurious dose, but instead could only be a catalytic
constructive dose. The conclusion therefore follows that
the bacteria and tissue cells are restored to their normal
places in the biological economy by these two atomic groups
and that disease germs, in active and suppressed focal
infection, loose their pathogenicity whether they are
arsenic fast, antibiotic resistant, or otherwise
unresponsive to medications, like many trypanosomes, thus
showing that the position of Carbonyl and phosphoryl action
is different from that of the current anti-germ agents and
their high position in biology is assured.
USEFUL REMEDIES FOR CLEANSING THE MITOCHONDRIA
As was seen, the origin of tissue intoxication via the
decarboxylated amino acids and sulphides, as found in the putrid
colon and chronic focal infections, as infected tooth roots,
infected sinuses and diverticulae. The colon can be cleansed by
the use of pure linseed oil, taken every day at amounts
of a soup spoonful once or twice a day or oftener. The oil must
be un-oxidized for otherwise it forms irritant peroxides. It
offers three sets of double bonds, which probably present free
radicals that activate molecular oxygen which detoxicate
bacteria and their products. It makes a good salad oil, but must
be protected from exposure to air.
Catalase combines with peroxides to form a peroxide complex,
which reacts with the toxin substrates, and possibly also with
unburned food residues to produce oxidation products, as for
example, ethyl alcohol is oxidized to aldehyde. If large amounts
of peroxide are at hand, it dehydrogenates hydrogen peroxide to
form molecular oxygen, that is when more H(2)O(2) than any toxic
substrate, is present to be burned. It should be used first in
small doses in such cases as cancer victims, for the catalase
content is reduced in such persons and the amount of peroxide
used should be increased as the ability to produce more catalase
increases, as for example, during the recovery from cancer under
the Treatment of the text. Ordinarily, one drop of the 10%
solution of H(2)O(2) per 50 kilos of body weight used but once a
day, is recommended as a safe procedure. However, one
has
observed angiospasms of a dangerous type in persons where a dose
of ten times as much had been used.
PSYCHIC EFFECTS ON PATHOGENESIS
Psychic influences on the recovery process are of utmost
importance since the ischemia and its anoxia consequent to
sympathetic-adrenal action on blood vessels of neoplastic and
infected lesions can block the recovery process. This is because
oxygen is essential to it. Therefore, inquiry must be made in
every case under Treatment to learn if a subconscious conflict
needs to be identified, analyzed, harmonized and eliminated, so
that no psychosomatic effect can emerge to hinder the blood
supply to any lesion. This is important.
Conscious fear-induced protective vasomotor reflexes are
coordinated and controlled to meet the need. Subconscious
fear-induced sympathetic-adrenal produced ischemia is not
adapted to protection, is uncontrolled, and may strike any area
of irritation, injury, or an area associated with a guilt
complex. It may produce fatal ischemic crises through anoxia
that favors carcinogenic or viral integrations with the tissue
cells. Aside from viral agents, the pathogens are generally
produced in old scarred-in focal infections, as stated in the
text. Being free radical products in anoxic foci, they
polymerize through the neurotoxic state and then on to the
carcinogenic state after which, the neurotoxic symptoms
disappear only to return transiently during the reversal
process from the neoplastic state back to the original form
of the toxin, as were originally produced during the initial
acute state of the infection. Then as the oxidation
continues through the action of the Therapy agent, the germ,
its toxin and its protective scar are eliminated. The
disease is thus cured completely from its very inception
when the blood supply is good. However, there
are the ischemic psychosomatic effects on existing lesions
referred to above as caused by submerged
concepts of guilt. The vigor of the ischemia
so produced and its persistence, are proportional to the depth
of the conflict. Persons holding to higher moral standards, show
greater depths of the conflict and proportionately greater
psychosomatic sequelae. Whereas those who do not carry the
negative guilt and are able to excuse, justify or shift
culpability, will not submerge negative feelings to the
subconscious and set up conflict of sufficient violence to bring
on the psychosomatic effect, or if they do, the sequel will be
delayed and not as violent.
NATURALLY OCCURING ANTICARCINOGEN QUINONES
While searching in Nature for plants that present chromophore
groups of the order we have proven to be anti-carcinogenic,
namely Carbonyl as reinforced by conjugation with ethylenic
linkages or by adjacent Carbonyl groups, as stated in the text,
three were found, one in Australia and Africa, and two in
Brazil. All are naphthoquinones of para and ortho structure
existing isomerically and interchangeably. Energy is gained by
the change from para to ortho structure and probably the sun and
soil provide the agencies for it. None of the African or
Australian pigments have been identified with medicinal
activity. And still we may do so simply on the basis of the
Carbonyl arrangements in each, as they all conform, including
the Brazilian product, to the laws we have identified with
anti-carcinogenic activity. The Brazilian pigment has not been
identified as to structure except by ourselves, since we find it
to be both the para and ortho forms of a naphthoquinone in
isomerism, in two different trees. Here they can be extracted
from the inner bark, and are named the Pau d’Arco Amarilo and
Roxo, for the paraquinone and orthoquinone forms respectively.
Both are proven to be curative in cancer and other diseases,
the ortho form being most active in conformance to our Thesis.
Both are of lower oxidation-reduction potentials than the
Synthetic Agents we offer in the text, and run from 0.3 to 0.9
volts lower than our Reagents including: Glyoxal, Methyl
Glyoxal, Rhodizonic acid, Triquinoyl, Compound C and the long
straight chains of Carbonyl groups of the text, simple
Parabenzoquinone and Diphenoquinone. They hence have a
much-limited field of activity and are adapted to continued use
over long periods by mouth, in which form they meet the needs of
primitive people. However, as civilization has changed disease
systems, the Synthetic Products we have used for the past fifty
years, which were kept from the sufferer by bureaucratic and
commercial interests, must be awaited by present and future
generations. It will be of interest also that Rhodizonic acid,
being stabilized and though reduced in activity by the two
hydroxyl groups, is of use when taken by mouth and will thus
serve those who cannot afford professional assistance. The
structural patterns of the others can be represented by that of
the Australian pigment Lamatol or the African Lapachol with but
slight changes in their side-chains.
The Brazilian pigments run very similar and all must have about
equal medicinal values, as the others will be found to have.