rexresearch.com



Bagraev TAIMURAZOVICH, et al.

Human Regenerator







http://www.arabianbusiness.com/-10m-human-regenerator-makes-uae-debut-517859.html
12 September 2013

$10m Human Regenerator makes UAE debut
 
by
Salma Awwad

An anti-aging limited edition device known as ‘the Human Regenerator’ and kitted out in diamonds will be one of the vast portfolio of products that will go on display at an exhibition in the upcoming World Luxury Expo on September 27 in Abu Dhabi’s Emirates Palace.

Produced by the luxury high-tech company System4 Technologies GmbH, it will only be available upon order and the production is strictly limited to 50 devices per year with a price tag of $557,000.

The German company also offers it in a blinged out diamond encrusted version which it claims to be studded with 6880 Carats, or just less than 1.4 Kilos of small cut diamonds for a total of 172,000 unique gems. The price tag starts from a cool $9.8 million.

Weighing at 128kg, the bullet shaped cocoon pivots 90 degrees so your body is horizontal to the ground.



http://inventorspot.com/articles/go-abudhabi-get-younger-human-regenerator

Go To Abu Dhabi – Get A Little Younger With Human Regenerator

by Sidney Bittman

September 27, 2013 marks the annual World Luxury Expo in Abu Dhabi this year, and for a city internationally renowned for its miraculous innovations, the show certainly wasn’t a disappointment.

One of the most notable innovations though, may literally turn back time – but only on the outside. German company System4 Technologies GmbH unveiled its new “Human Regenerator,” claimed to be a “quantum-pulse-device that imitates the body’s natural frequencies and generates longitudinal waves.”

Put simply, this device uses a patented technology, which employs deposits of silicon and aluminum, to create anti-aging effects on the human body.

For years now, similar quantum-pulse devices have been used to help the body revert to its natural frequency in an attempt to achieve balance, but this is the first of its kind that suggests it may be able to help the body regenerate.

Of course, those looking to turn the clock back a few years might be frightened off by the price tag – the regular “Human Regenerator” is offered at $557,000, while a diamond encrusted version sells for $9.8 million. Like the MRI machine to the left, the "Human Regenerator" will allow patients to lie down during the procedure.

Fear not, though – like 3D printers in the last decade, these devices are used currently only by scientists and extreme hobbyists; but that’s not to say that in a few years they may be creeping into stores near you.



http://www.human-regenerator.com/



System4 Technologies GmbH.
Hermann-Koehl-Strasse 7.
D-28199 Bremen
Germany
p +49-421-9601/335
f +49-421-9601/338

The Human Regenerator is a Quantum-pulse Device that imitates and generates the cellular body's natural frequencies ranging between 0.0005 and 38.000 Hz within a field intensity of less than 1uTesla.

While common devices like Magnetic-Field Devices or Bioresonance Devices can only imitate a few % of the cellular body's natural frequencies, out scientists have succeeded to decode the predominant part of our body's cell frequencies and have integrated these into the Human Regenerator Module.

Through intenisive treatment with the body's own healthy frequencies the organism is regnerated ina natural way.

Furthermore, longitudinal waves are used as a filter to create more human-like waves, therefore adding pure positive energy to the body.

We have named our unique innovation Quantum-Cell-Code.



Patents

WO2007011267
EP1964590
RU2314844
METHOD FOR STIMULATING BASIC BIOCHEMICAL REACTIONS OF AN ORGANISM FOR TREATING AND REGENERATING TISSUES, A PANEL FOR TREATING AND REGENERATING TISSUES AND A RADIATOR  

Inventor(s):     BAGRAEV NIKOLAI TAIMURAZOVICH [RU]; KLYACHKIN LEONID EFIMOVICH [RU]; MALYARENKO ANNA MIKHAILOVNA

Abstract

A method for stimulating the basic biochemical reactions of an organism at tissue treatment and regeneration, comprising exposure of skin areas to terahertz radiation in the range of 0.02 THz to 8 THz, the carrier of said radiation representing infrared radiation in the range of 1 to 56 [mu]m. The method can be embodied with the aim of a panel for tissue treatment and regeneration. The panel comprises n emitters in the form of silicon light emitting diodes generating terahertz radiation in the range of 0.02 THz to 8 THz. Maximal summary average luminosity flux of these emitters is calculated according to medical indications; the panel dimensions are calculated basing on the required exposure area that provides non-linear effect of regenerative influence intensification at simultaneous activation of light emitting diodes; the number of light emitting diodes on the panel is defined depending on the emitters aperture size. The panel is comprised of emitters. Each emitter represents a source of terahertz radiation in the form of semiconductor silicon light emitting diode, generating infrared radiation by means of emitting matrices of planar silicon structures, this infrared radiation being the carrier of terahertz radiation, whereas the substrate of an emitting matrix represents silicon quantum wells with p-type conductivity, self-ordered inside ultrafine diffusion boron profiles generated in the surface of single-crystalline silicon (100) wafers with n-type conductivity, and the emitting element represents quantum-dimensional p-n junction embodying a cascade of longitudinal silicon self-ordered quantum wells with p-type conductivity, crossed by modulated quantum wire, whereas this quantum-dimensional p-n junction is located inside self-ordered silicon microresonator. Terahertz radiation frequency is provided by selecting geometry of topographic image of ultrafine diffusion boron profiles surface in silicon, subject to fluctuations of surface deformation potential, which cause forming self-ordered silicon microresonators with distributed feedback in the plane of self-ordered quantum wells. Modulation depth is provided due to the rate of tension, applied both longitudinally and transversely to the diffusion profile plane.

[0001] The method for stimulating the basic biochemical reactions of an organism at tissue treatment and regeneration can be used in medicine for curing the diseases that feature disorder of cellular energy metabolism, attenuation of enzymatic processes, disorder of injured tissue regenerative function. This method of cure is used at therapy of tissue burning injuries resulted both from thermal and chemical exposure, as well as from penetrating hard radiation, e.g. y, , -radiation, that can result in malignant tumors and leucosis. The method can be used also at parodontosis and periodontitis treatment, during remission following local anaplastic face surgery, and for curing other diseases of the same class.

[0002] The known invention 'Method for exposing cells to electromagnetic radiation', patent No. RU 2197303, published 2003.01.27 , Int. CI. A61 N5/02, covers exposure to electromagnetic fields generated by the conductor electromagnetic field. The invention offers creation of wider range of electromagnetic radiation that promotes intact cells activity, causes destruction of malignant cells and capsulation on malignant tumors. However, exposure of cells to microwaves can bring to undesirable side effects since frequency range with regulated emissive power is not rigorously defined. This method does not allow for obtaining sufficiently wide range of electromagnetic field influencing living organism cells that would match near-resonance frequency of these cells oscillation.

[0003] The known invention 'Method for treatment of injured biological tissues by exposing lesion focus to physical agents', patent No. RU 2226412, published 2004.04.10 , Int. CI. A61 N5/02, describes exposure to high-frequency electromagnetic field generated by amplitude-modulated sine signal with carrier frequency in the range of 100 - 1000 kHz and modulation frequency continually changing within the range of 50 - 8000 Hz. The method offers increasing emission power that provides spread of current induced in biological tissue mainly throughout vessels and intertissue fissures, the cells being skirted. This results in improved curative effect due to acceleration of biological tissues regeneration. However, resonant oscillatory circuit does not provide resonance within the entire range of intracellular oscillating processes that covers frequency spacing from unit Hertz to terahertz. During exposure to electromagnetic waves of the suggested frequency, said exposure being limited to shallow penetration of millimeter waves, rays do not reach deeper layers of injured tissue, whereas membranes of both affected and intact cells in near-surface layers will destruct.

[0004] The suggested method is considered to be most close to invention 'Method for wave therapy', patent RU No. 2229906, published 2004.06.10 , Int. CI. A61 N5/02, A61N5/06, that describes exposure to electromagnetic radiation with concurrent smooth frequency variation in the entire range of actuating signal, said exposure covering frequency range of 30 GHz to 3 THz with radiation power 10<-11> - 10<-10> Wt. At the same time, influence of rays of said frequencies goes with resonant response of the organism and correction of disturbed homeostasis. However, resonant oscillatory circuit does not provide resonance within the entire range of intracellular oscillating processes. Besides, rays with mentioned frequency fail to reach deeper layers of injured tissue, and required therapeutic effectiveness cannot be obtained.

[0005] In order to stimulate the basic biochemical reactions of organism during tissue treatment and regeneration, essential is to provide photobiochemical reactions at molecular level that would bring cells (their molecules, atoms) into excited state due to externally supplied specified amount of energy with frequency close to resonant oscillatory frequency of cell membranes. Moreover, said intracellular oscillating processes feature a set of intrinsic characteristic frequencies. Besides, affected cells, e.g. malignant cells, as well as cells experienced thermal or chemical burn, feature shift of frequency range with respect to corresponding range of intact cells.

[0006] If cells are exposed to radiation in short range of frequencies, even if this provided frequency range is close to resonant oscillatory frequency of any of its membranes, it causes hard 'jutter' of other cell membranes and can lead to their destruction. Since a cell features intrinsic range of resonant frequency, both outer and inner membranes resonance should be provided. At the same time, biologically reasonable addition of energy promotes reaction of main transfer of proteins between cell membranes in both intracellular and intercellular space. This will be followed by destruction of affected cells membranes and their removal with blood flow.

[0007] Technical result of the suggested method comprises exposure of biological tissues to radiation in the entire range of terahertz frequencies, with concurrent increasing of the rays penetration that results in photo-stimulation of biochemical reactions due to coincidence of terahertz radiation frequency and resonant oscillatory frequency of intercellular (and intracellular) membranes and protein molecules. Hence, technical result comprises improvement of injured biological tissue healing efficiency by means of terahertz radiation exposure.

[0008] Technical result can be achieved by means of exposure to terahertz-ranged radiation, the carrier of the rays being radiation in infrared range of wavelengths. Carrier infrared radiation provides increase of terahertz frequencies penetration into biological tissues, that in turn contributes to improved efficiency of the photo-stimulating biochemical reactions due to coincidence of terahertz radiation frequency and resonant oscillatory frequency of the intercellular (and intracellular) membranes and protein molecules.

[0009] Technical result can be achieved as follows. Basic biochemical reactions of organism are being stimulated for biological tissues treatment and regeneration. The method comprises exposure of skin areas to terahertz radiation in the range of 0.02 to 8 THz, the carrier of the rays being infrared radiation in the range of 1 to 56 m.

[0010] Said method provides achieving of the technical result due to the main adenosine triphosphate aided reactions, which contribute to blood flow promotion, said reactions being as follows:
1. The basic exothermic reaction is transformation of adenosine triphosphate (ATP) into adenosine diphosphate (ADP) in a cell, released energy representing an enhancer for transformation of guanosine diphosphate (GDP) into guanosine triphosphate (GTP). Said reaction, that is responsible for intra- and extracellular protein transportation, runs due to ADP phase enzyme influence. Besides, the described reaction can be promoted by means of exposure to radiation in infrared range of wavelengths. However, efficiency of this reaction photo stimulating is rather low under conditions of continuous infrared radiation. Use of infrared radiation modulated in terahertz range and matched with intracellular oscillating processes frequencies (in resonance) improves photo-stimulated reactions efficiency by orders of magnitude greater. Besides, use of infrared radiation as a terahertz rays carrier significantly improves terahertz radiation penetration into biological tissues.

2. Reaction of oxygen transportation in myoglobin and hemoglobin, that features change of oxygen spin state during its trapping and drift from iron ion. This reaction is also controlled by ADP phase. Besides, this reaction efficiency is improved by infrared radiation. However, its influence efficiency can be low if radiation does not serve a carrier of terahertz rays with frequency corresponding to oscillatory frequency of heme pyridine ring.

3. Excitation of protein alpha helix hydrogen bonds is also initiated by ADP phase influence. Besides, hydrogen bonds excitation is due to infrared radiation as well. Use of infrared radiation modulated in terahertz range and matched with intracellular oscillating processes frequencies (in resonance) improves photo-stimulated reactions efficiency by orders of magnitude greater.

[0011] Moreover, alleged technical result can be realized only under condition of increased depth of radiation penetration within specified frequency range.

[0012] When energy is accumulated in a cell, soliton mechanism of power exchange between excited protein molecules starts.

[0013] In the process of exposure to terahertz radiation with the use of infrared radiation as a carrier, the above processes has been controlled by means of regulating summary (cumulative) average luminosity flux (mWt/m<2> ) and duration of exposure.

[0014] Clinical results given below are the examples illustrating improved efficiency of injured tissue treatment by means of exposure to terahertz radiation.

Example 1.

[0015] The patient at the age of 28, diagnosis: second-degree burn of chest. Burnt area was exposed to electromagnetic radiation with frequency 0.048 THz. Infrared radiation with wavelength 1 - 56 m was used as a carrier. Course of treatment comprised daily exposure during 22.5 min, 10 days in total. Radiation exposure was performed with the same emitter. Blood circulation at the area of the wound was controlled according to the method of intact cutaneous covering rheography at the distance 1-3 mm from the edge of the wound. The following parameters have been considered at rheographic results examination:

1) rheographic index (normal value 0.07-0.09),
2) index of vessels tonic contraction (normal value 15-18%),
3) index of vessels peripheral resistance (normal value 70-80%).Prior to treatment, rheographic parameters made as follows: rheographic index = 0.4, index of vessels tonic contraction = 22, index of vessels peripheral resistance = 91. After treatment, rheographic parameters made as follows: rheographic index = 0.09, index of vessels tonic contraction =16, index of vessels peripheral resistance = 86.

Example 2.

[0016] The patient at the age of 35, diagnosis: first-degree burn of forearm.
Burnt area was exposed to electromagnetic radiation with frequency 7.01 THz. Infrared radiation with wavelength 1 - 56 m was used as a carrier. Course of treatment comprised daily exposure during 22.5 min, 10 days in total. Radiation exposure was performed with the same emitter.

[0017] Prior to treatment, rheographic parameters made as follows: rheographic index = 0.03, index of vessels tonic contraction = 23, index of vessels peripheral resistance = 89. After treatment rheographic parameters made as follows: rheographic index = 0.07, index of vessels tonic contraction = 17, index of vessels peripheral resistance = 79.

[0018] Basing on the performed clinical testing, improved efficiency of healing tissues injured in the result of thermal action has been confirmed, the results having been controlled by means of rheographic observation of blood circulation in injured tissue.

Fig. 1 a, b shows diagrams of decrease of vessels peripheral resistance index down to normal value versus summary average luminosity flux and summary duration of exposure correspondingly.



Fig. 2 a, b shows diagrams of decrease of vessels tonic contraction index down to normal value versus summary average luminosity flux and summary duration of exposure correspondingly.



Fig. 3 a, b shows diagrams of increase of rheographic index up to normal value versus summary average luminosity flux and summary duration of exposure correspondingly.



[0019] During examination of the results of investigation the following parameters has been considered: 1) rheographic index (normal value 0.07-0.09), 2) index of vessels tonic contraction (normal value 15-18%), and 3) index of vessels peripheral resistance (normal value 70-80%).

[0020] Thus, significant improvement of injured tissues healing efficiency due to photo-stimulation of biochemical reactions resulted from coincidence of terahertz radiation frequency and resonant oscillatory frequency of intercellular (and intracellular) membranes and protein molecules, that in turn provides removal of affected cells from organism by intensified blood flow, has been proved. Application of the suggested method resulted in both acceleration of injured tissue healing and absence of complications in the form of inflammatory process and respective vascular disorders.

[0021] A panel for tissue treatment and regeneration

[0022] The invention relates to medicine and medical equipment. The panel can be used as a device for considerable acceleration of energy transfer due to extension of injured tissue exposed area in emergency cases, when significant increase of healing surface is necessary (when large area is affected) under conditions of the same duration of a patient exposition and achieving rapid healing response. Otherwise, lingering pain shock can cause irreversible processes, e.g. coma. In particular, the apparatus can be used at shock therapy.

[0023] The known invention 'Apparatus for exposing biological objects to EHF-ranged electromagnetic field', patent RU No. 2032430 published 1995.04.10 , Int. CI. A61N5/02, describes the apparatus comprising n emitters with fixed electromagnetic radiation frequency, capable of frequency modulation and continuous operation, n making 2 < n < 5. Each of n emitters design provides for their spatial arrangement. EHF-ranged radiation ensures resonance as regards cell resonant frequency spectrum. However, it does not ensure resonance or coincidence with characteristic frequencies within the entire range of intracellular oscillating processes, which can cause complications. Besides, each emitter of the suggested apparatus is discretely tuned to its intrinsic frequency, and the entire apparatus does not provide the required range of radiation frequencies when large affected area is exposed. Moreover, the apparatus does not provide a quantity of excitation sources inside biological tissues; hence, it does not cause bursting effect of intracellular diffusion processes.

[0024] The suggested technical decision is considered to be most close to invention 'Apparatus for physical therapy', patent RU No. 2238773, published 2004.10.27 , Int. CI. A61 N5/02, which describes the apparatus comprising a power supply unit, M sources of electromagnetic oscillation, M modulators and a power amplifier. Each source of electromagnetic oscillation represents a self-excited oscillator tuned to its intrinsic carrier frequency selected in the range of 100 - 1000 kHz. However, these sources do not provide terahertz frequency of radiation. Besides, since each emitter is discretely tuned to its intrinsic frequency, the apparatus does not provide the required range of radiation frequencies, which would ensure resonance or coincidence with characteristic frequencies within the entire range of intracellular oscillating processes within the entire affected area. Moreover, the apparatus does not provide a quantity of excitation sources inside biological tissues; hence, it does not cause bursting effect of intracellular diffusion processes.

[0025] It is common knowledge that the entire spectrum of oscillation frequencies in a cell single parts, e.g. inner and outer cell membranes as well as protein molecules, is defined by intrinsic range of resonant frequencies. At the same time, values of resonant frequencies of a single cell parts differ considerably. However, it is impossible to transfer the required amount of energy of necessary range inside injured tissues since terahertz radiation features low penetrability.

[0026] Said circumstance calls for necessity of broader ranges of radiation frequencies with significant depth of their penetration inside tissues. Otherwise, the required healing effect in deep layers of injured tissues will be impossible to achieve, since transfer of biologically reasonable amount of energy that would promote reaction of protein main exchange between cell membranes in inter- and intracellular space, will not be performed. On the other side, significant increase of summary average luminosity flux during exposure can cause further affecting the outer layers of tissue. Besides, the process will get complicated by wide area of lesion. In bad cases, when wide and deep tissue areas are affected, the required healing effect is impossible to achieve with the use of a single emitter of terahertz rays, its carrier being radiation in infrared range of wavelengths.

[0027] In emergency cases, when it is essential to maintain duration of a patient exposing to radiation and achieve healing effect within the period at the most of healing minor injured tissue areas, i.e. to achieve bursting intracellular and intercellular diffusion processes responsible for protein transfer, a quantity of sources of cell excitation should be applied. It is impossible just to increase summary average luminosity flux of a single radiation emitter since significant increase of summary average luminosity flux will cause membranes destruction both in affected and intact cells. Besides, since infrared radiation will not penetrate into deep layers of injured tissue within the entire area, this will also decrease curative effect due to impossibility of stimulating the basic biochemical reactions within the entire area of injured tissue.

[0028] The more extensive is the injured area, the wider is the range of intrinsic characteristic frequencies spread in a single cell. Therefore, a single radiation source exposure contributes to significant decrease of probability of each cell rapid exciting due to biologically reasonable addition of terahertz radiation, since probability of rapid resonant coincidence with characteristic frequencies within the entire affected area decreases.

[0029] In emergency cases, when not only efficient healing is required but also healing process must not prolong, terahertz radiation exposure with the use of a quantity of sources of radiation is applied, the rays' carrier being radiation in infrared range of wavelengths.

[0030] All said radiation sources must be tuned in the way that would prevent exceeding permissible value of summary average luminosity flux of all emitters that is defined by biologically reasonable amount of energy added to injured tissue. In order to achieve the required bursting healing effect, it is necessary both to stimulate biochemical reactions of the organism quickly and to provide fast removal of destructed cell membranes from injured area by intensified blood flow. The aforesaid is in particular relative to emergency cases of hazard to the patient's life, when energy transfer throughout the entire organism needed to be intensified considerably. In this case, the required bursting healing effect cannot be achieved without simultaneous transfer of energy from a quantity of the sources of excitation. The mechanism of energy accumulation and transfer by the cells is still understood incompletely. However, it is known that simultaneous several sources of radiation exposure results in soliton effect of protein transfer that promotes healing effect. Constant value of biological rate of protein exchange between cells, as well as mechanism of energy transfer; prevent fast healing with the use of a single radiation emitter.

[0031] Hence, technical result comprises improvement of efficiency of injured tissues healing by means of terahertz radiation exposure, said efficiency improvement being provided by means of creation of a quantity of the cell excitation sources at a large area, these excitation sources matching the entire range of cell membranes characteristic frequencies; said technical result further comprising non-linear effect of regenerative influence intensification.

[0032] Alleged technical result can be achieved by means of the apparatus described below. A panel for tissue treatment and regeneration comprises n emitters representing silicon light emitting diodes that generate terahertz radiation in the range of 0.02 to 8 THz, the carrier of said radiation being infrared radiation in the range of 1 to 56 m and said emitters' summary average luminosity flux being calculated according to medical indications. The panel dimensions are to be defined basing on the required exposure area that provides non-linear effect of regenerative influence intensification at simultaneous activation of light emitting diodes, and the number of light emitting diodes on the panel is defined according to the emitters angular aperture size. In particular, the number of the emitters should be defined with summary average luminosity flux not exceeding 300 mWt/m<2> . Dimensions of the panel active zone should be defined basing on the injured area size, as well as on values of power and aperture size of a single source of radiation. A number of segments that incorporate uniformly spaced units of radiation emitters constitute the panel. Besides, light emitting diodes can be activated both in groups and following specified order, e.g. due to exposing hard-to-reach body parts.

[0033] Maximum number of emitters should be calculated according to medical indications, the panel dimensions should be defined basing on the required exposure area, and the number of light emitting diodes on the panel should be defined according to the area and depth of tissue injury. When light emitting diodes are activated simultaneously, non-linear effect of the regenerative influence intensification provides both antishock action and effective healing of injured tissues throughout extensive areas without significant prolongation of healing period.

[0034] Particular implementation of the panel features 108 emitters, dimensions (W x L) 0.6 x 1.8 m<2> , and 10 cm space between light emitting diodes.
Clinical testing was performed using emitters with power 0.3 Wt/m<2> .
Summary average luminosity flux made 300mWt/m<2> .

Description of the Figures

[0035]
Fig. 1 shows the panel fixed on the rack permitting regulation of its height above an exposed surface, side view and rear view;




Fig. 2 shows bottom view of the panel constituted by three emitter units, each incorporating 36 light emitting diodes.



[0036] Description of principle of apparatus operation.

[0037] The panel comprises light emitting diodes with specified radiation parameters. In cases of large area of burns, dimensions of the panel emitting area should be defined according to dimensions and location of injured areas. For instance, three emitter units can be switched on either simultaneously or selectively. Another factor defining the number and selection of activated emitters on the panel is time of distribution and time of excitation transfer from the source of excitation to cells of the organism. Depending on the height of radiation emitter and surface geometry, summary average luminosity flux of all activated radiation sources is defined; this summary average luminosity flux must not exceed maximal permitted value of luminosity flux basing on biological indications. Besides, in order to achieve non-linear effect of regenerative influence intensification, necessary radiation density per 1 cm<2> of tissue surface should be defined.

[0038] Since biological rate of energy accumulation and exchange between cells must not exceed the same at exposing to a single radiation source, concurrent stimulation of basic biological reactions on several areas is required. This significantly increases probability of terahertz radiation resonant coincidence with cell characteristic frequencies, and bursting effect of these reactions stimulation is this way achieved. Thus, in emergency cases of hazard to a patient's life due to pain shock such exposure can provide healing of large areas of injured tissues after 10 sessions, i.e. not longer than at smaller injured areas. This ensures the decrease of hazard to the patient's life.

[0039] Basing on the known exposure area of a single radiation emitter, angle aperture, summary average luminosity flux and geometric sequence of light emitting diodes activating can be determined accounting for the height of the radiation emitter.

Results of clinical testing

Example 1.

[0040] The patient at the age of 39, diagnosis: second- and first-degree multiple burns of the abdomen bottom and both legs.
The whole underpinning was exposed to electromagnetic radiation of frequency 0.025 THz. Infrared radiation with wavelength 1 - 56 m was used as a carrier. Course of treatment comprised daily exposure during 22.5 min, 10 days in total. Prior to treatment, rheographic parameters made as follows: rheographic index = 0.05, index of vessels tonic contraction = 21, index of vessels peripheral resistance = 90. After treatment, rheographic parameters made as follows: rheographic index = 0.1, index of vessels tonic contraction = 16, index of vessels peripheral resistance = 78.

Example 2.

[0041] The patient at the age of 43, diagnosis: second-degree multiple burns of the back and the right leg.
All injured areas were simultaneously exposed to electromagnetic radiation of frequency 1.2 THz. Infrared radiation with wavelength 1 - 56 m was used as a carrier. Course of treatment comprised daily exposure during 22.5 min, 10 days in total.

Prior to treatment, rheographic parameters made as follows: rheographic index = 0.03, index of vessels tonic contraction = 22, index of vessels peripheral resistance = 89. After treatment, rheographic parameters made as follows: rheographic index = 0.07, index of vessels tonic contraction = 17, index of vessels peripheral resistance = 79.

[0042] Thus, supervision of patients with large injured areas showed that the period of healing in the result of simultaneous exposure to several radiation emitters with summary average luminosity flux equal to a single emitter summary average luminosity flux was the same as the period of small injured tissue area healing in the result of exposure to a single radiation emitter. This effect can be explained by improved efficiency of injured tissues healing due to exposure of a quantity of excitation sources to terahertz radiation within the entire range of cell parts characteristic frequencies and non-linear effect of regenerative influence intensification.

Emitter for tissue treatment and regeneration

[0043] The invention relates to semiconductor devices intended for light emitting, in particular to light-emitting diodes with p-n junction as the main source of radiation. The invention can be applied in medical equipment intended for realizing the method for stimulating the basic biochemical reactions of organism at tissue treatment and regeneration.

[0044] The known invention 'Apparatus for microwave therapy', patent RU No. 2134597, published 1999.08.20 , Int. CI. A61N5/00 A61 N5/02, describes an apparatus comprising emitter and current amplifier, placed in a metal thimble with cover, said cover representing dielectric partition, said thimble representing the screen, said emitter featuring frequency of 2.5+0.1 THz and digital noise generator featuring frequency range of 0.2 - 3.0 Hz. The apparatus comprises microresonator analog and permits use of both low frequency and high frequency radiation. However, the apparatus design is complicated, and it does not use quantum-dimensional heterostructures.

[0045] The known invention 'Cyan laser diode', patent RU No. 2127478, published 1999.03.10 , Int. CI. H01S3/19, describes a diode comprising multiple layers of a semiconductor of Groups II-IV that form p-n junction, the semiconductor substrate with n-type conduction comprising series of consecutive layers as follows: n-type conductive buffer layer, n-type conductive bottom contact layer, n-type conductive bottom enclosure layer, n-type conductive first optical waveguiding layer, active layer with quantum well, p-type conductive second optical waveguiding layer, p-type conductive top enclosure layer, p-type conductive top contact layer. Technical result of the invention comprises creation of laser diode emitting light in spectral region within wavelengths range of 430 - 590 nm. However, the diode does not provide high-quality radiation, and infrared carrier is not used.

[0046] The known invention 'Semiconductor light amplifier', patent RU No. 2062543, published 1996.06.20 , Int. CI. H01S3/18, describes an amplifier based on heterostructure with quantum-dimensional layers of different thickness, located between the pairs of bias voltage supplying electrodes, said heterostructure being produced in the form of alternate or randomly grouped quantum-dimensional layers of different thickness. However, infrared carrier is not used.

[0047] The known invention 'Semiconductor electroluminescent light source', patent RU No. 2233013, published 2004.07.20 , Int. CI. H01L33/00, describes a light source comprising semiconducting crystal with p-n junction formed inside, said semiconducting crystal generating light flux at direct bias application, said semiconductor light source further comprising bulk or quantum-dimensional heterostructures and/or heterostructures with quantum wells, quantum filaments, quantum dots. This emitter provides radiation in blue-violet spectral region at enhanced luminous efficacy. However, it does not provide the entire spectrum of radiation frequency, from low to high frequencies. Besides, introduction of organic luminescent region intended for partial conversion of radiation, featuring longer dominant wavelength, significantly complicates the method of crystal production.

[0048] The suggested technical decision is considered most close to invention 'Semiconductor electroluminescent light source', patent application RU No. 2002105900, published 2003.11.20 , Int. CI. H01L33/00, describes a light source comprising semiconducting crystal with p-n junction formed inside, said semiconducting crystal generating light flux at direct bias application, said semiconductor light source further comprising luminescent region partially absorbing crystal generated radiation and converting it to radiation with longer dominant wave-length. The crystal comprises bulk or quantum-dimensional heterostructures with active region embedded between wide-band emitters, and/or heterostructures with quantum wells, quantum filaments, and quantum dots. The invention uses polymer matrix providing radiation in blue-violet spectral region at enhanced luminous efficacy. However, production method of the invention is too complicate. However, it does not provide the entire spectrum of radiation frequency, from low to high frequencies. Radiation range is confined to infrared radiation with narrow spectral range of frequencies. Besides, narrow infrared range of radiation is not used as a carrier of high-frequency radiation.

[0049] It is necessary to obtain terahertz radiation in the range of 0.02 THz to 8 THz, the carrier of this radiation being infrared radiation in the range of 1 to 56 m.

[0050] The object can be achieved by means of planar silicon structures that represent a cascade of longitudinal self-ordered silicon quantum wells with p-type conductivity, formed between -barriers; said -barriers being two-dimensional ferroelectrics (see Fig. 6).

[0051] In order to achieve technical result an emitter for tissues treatment and regeneration is suggested, said emitter comprising terahertz radiation source representing semiconductor silicon light emitting diode that generates infrared radiation by means of emitting matrices of planar silicon structures, said infrared radiation being the carrier of terahertz radiation.

[0052] Further, the substrate of emitting matrix represents silicon quantum wells of p-type conductivity, self-ordered inside ultrafine diffusion boron profiles generated in the surface of single-crystalline silicon (100) wafers of n-type conductivity, which provide effect of dimensional quantization and electron-electron interaction upon transfer parameters of single current carriers. The selected wafers are, for instance, of 350- m thickness, featuring different concentration of fine phosphorus donors. Emitting element is represented by quantum-dimensional p-n junction formed by a cascade of longitudinal silicon self-ordered quantum wells with p-type conductivity, crossed by modulated quantum wire, said quantum-dimensional p-n junction is located inside self-ordered silicon microresonator. Terahertz radiation frequency is provided by means of selecting the geometry of topographic image of ultrafine diffusion boron profiles surface in silicon wafers, said frequency being achieved subject to fluctuations of surface deformation potential which cause forming self-ordered silicon microresonators with distributed feedback in the plane of self-ordered quantum wells. Geometry of p-region is selected, for instance, following Bragg equation, which define its correspondence to terahertz radiation frequency range, and modulation depth is achieved due to the rate of tension, applied both longitudinally and transversely to diffusion profile plane (see Fig. 7). For instance, provided modulated quantum wire has the length of 10 nm and is being formed at the intersection of self-ordered quantum wells.

[0053] The described light-emitting structures are based on ultrafine p<+> -diffusion profiles with the depth of, for instance, 20 nm, generated in the surface of silicon (100) with n-type conductivity by means of nonequilibrium boron diffusion under conditions of intrinsic defects overflow generation (see Fig. 8).

[0054] Emitting silicon matrices represent series of quantum-dimensional p-n junctions created on the surface of a single-crystalline silicon wafer according to planar technology. Display matrices with visible and infrared wavelengths range are the variants of emitting silicon matrices. They comprise a substrate, an emitting element and self-ordered silicon microresonators.

[0055] The substrate of emitting matrix represents silicon quantum wells with p-type conductivity, self-ordered inside ultrafine diffusion boron profiles generated in the surface of single-crystalline silicon (100) wafers with n-type conductivity, which provide effect of dimensional quantization and electron-electron interaction upon transfer parameters of single current carriers. Moreover, presence of silicon self-ordered, quantum wells inside ultrafine diffusion profiles located between highly doped -barriers, is controlled by means of registration of conductivity angular dependences and cyclotron resonance of electrons and holes, e.g. during rotation of magnetic field in the plane perpendicular to the plane of diffusion boron profile in the surface of silicon (100).

[0056] Highly doped -barriers surrounding a self-ordered quantum well are created by trigonal-doped dipoles B<+> B<-> in silicon matrix and feature both properties of ferroelectrics, i.e. metals, and superconductors. During production of display matrices with visible and infrared wavelengths range, -barriers with ferroelectric properties are used. Said -barriers are formed, for instance, by means of exchange interaction through fine phosphorus donors located in the vicinity of the plane of ultrafine diffusion boron profiles in silicon (100) with n-type conductivity.

[0057] Modulated quantum wire represents quasi-one-dimensional structure obtained in the result of intersection of two quantum wells. For instance, quantum wire with the length of 5 m can be created according to the method of splitted shutter in the plane of a silicon quantum well. (See N.T.Bagraev, A.D.Bouravleuv, W.Gehlhoff, L.E.Klyachkin and A.M.Malyarenko: White light emission from nanostructures embedded in ultra-shallow silicon p-n junction, Proc. of the 26th International Conference on the Physics of Semiconductors (ICPS - 26), Edinburgh,U.K., Physics of Semiconductors 2002, ed. by A.R.Long and J.H. Davies, Inst. of Physics, Conference series, No. 171, G3.3, 2002 ).

[0058] Quantum-dimensional p-n junction representing a cascade of longitudinal silicon self-ordered quantum wells with p-type conductivity, crossed by modulated quantum wire, is used as an emitting element. Said quantum-dimensional p-n junction is located inside self-ordered silicon microresonator.

[0059] Point systems (either charged or empty) that can be obtained at complete restriction of current carriers' movement in both quantum wires and wells, and bulk crystals, are used as a quantum dot. They can be obtained by means of electrostatics, of applied metal microcontacts, as well as due to restriction of current carriers' movement in quantum wells and in the process of nanostructures creation (the case in question). In this case, the mode of Coulomb blockade is described by generation of periodic Coulomb peaks resulting from a quantum dot one-electron charge exchange. Coulomb field at quantum dots can feature arbitrary symmetry and be continuous in the view of elementary charge. Filling of relative quantum dots shells depends primarily on the factors like electron-electron interaction and electron spin.

[0060] Silicon microresonators with distributed feedback in the plane of silicon self-ordered quantum wells are used as self-ordered silicon microresonators for amplifying radiation defined by interband and intraband transitions between sublevels of dimensional quantization. For instance, microresonators can be formed by means of introducing microdefects into the plane of a self-ordered quantum well. Their geometry is defined by topographic image of ultrafine diffusion boron profiles in silicon, and changes in the result of fluctuations of surface deformation potential due to fractal mechanism of self-ordered point systems forming. Creation of self-ordered microdefects embedded in silicon quantum wells system enables creation of microresonators with distributed feedback and properties that can be identified by means of spectral dependencies of reflection and transmission factors for visible and infrared wavelengths ranges. Self-ordered microresonators significantly decrease light reflection factor in radiation short-wave region, said radiation resulting from direct interband transitions within longitudinal self-ordered quantum wells (d - 2 nm) formed in the plane of ultrafine p<+> - diffusion profile. Microresonators, self-ordering between self-ordered medium-size microdefects, are mostly responsible for decrease of R ( ) within short-wave region (200 330 nm), whereas presence of larger microdefects promotes effective reflection of light within long-wave region ( > 330 nm). Spectral dependence of radiation and its intensifying, as well as microresonator size, are interconnected within Bragg relation: X = /2n, where X is the microresonator size, is wave length, n is light refraction index for silicon.

[0061] Hence, emitting silicon matrix represents the series of emitting elements, each of said elements being located inside a silicon resonator.

[0062] High frequency modulation of infrared radiation can be provided in the form of radiation induced by intraband hole transitions inside a self-ordered quantum well with p-type conductivity, created in the silicon (100) surface with n-type conductivity under conditions of nonequilibrium boron diffusion (see Fig. 9). Spectral dependence of electroluminescence due to emitting transitions between sublevels of heavy and light holes evinces terahertz modulation. Electroluminescence spectra of self-ordered quantum wells, featuring high hole mobility, resulting from emitting transition between sublevels of heavy and light holes evince terahertz and gigahertz modulation due to radiation of boron trigonal dipolar centers B<+> B<-> , which make the base for -barriers confining a quantum well. Modulation depth is increased by introducing microresonators into the plane of a self-ordered quantum well according to Bragg relation: X = /2n, where X is the microresonator size, is wavelength; n is light refraction index for silicon. Modulations generating by boron dipolar centers within gigahertz and terahertz range of 0.02 to 8 THz allow use of p<+> region boundary as a Bragg reflector.

[0063] Hence, a single quantum well in single-crystalline silicon surface represents high-power generator of terahertz and gigahertz radiation, boundaries of said quantum well being the emitter of said radiation, whereas the carrier of said radiation being infrared radiation induced by intraband hole transitions. This provides achieving of technical result of the alleged invention.

[0064] The figures explain dependencies of radiation frequency spectra with the suggested structure of a light-emitting diode.

[0065] Fig. 6 shows planar silicon structure representing a cascade of longitudinal self-ordered quantum wells with p-type conductivity, formed between -barriers at the surface of silicon with n-type conductivity.



[0066] Fig. 7 Shows the scheme of creating self-ordered quantum wells in the surface of silicon (100) with n-type conductivity under conditions of injecting intrinsic interstitial atoms of silicon (white circles) and vacancies (black circles) during preliminary oxidation (a, b) and subsequent boron diffusion (c) :



a - overflow of intrinsic interstitial atoms of silicon and vacancies generating during preliminary oxidation of silicon (100) surface, these atoms and vacancies featuring corresponding crystallographic orientation along axes [111] and [100].

b - scheme of longitudinal self-ordered quantum wells generating between the layers of microdefects being formed at the step of preliminary oxidation of silicon (100) surface, from intrinsic interstitial atoms of silicon and vacancies.

c - scheme of longitudinal self-ordered quantum wells following subsequent passivation of microdefects under conditions of short-term boron diffusing according to vacancy mechanism (dark areas) following planar silicon technology.

[0067] Dimensions of p-type conductive region (longitudinal dimensions of diffusion profile) define terahertz radiation frequency according to Bragg equation.

[0068] Fig. 8 shows three-dimensional image of longitudinal self-ordered quantum wells formed between the layers of microdefects (a) that further transform into neutral -barriers following passivation under conditions of short-term boron diffusing according to vacancy mechanism ((b), (c)). White arrows show direction of doped boron dipoles ordering inside -barriers under conditions of source-sink strain, applied along crystallographic axes [001] (b) and [011] (c).



[0069] Fig. 9 shows spectral ranges evincing terahertz (b) and gigahertz (c) modulation of self-ordered silicon quantum wells infrared radiation. (Infrared Fourier spectrometer IFS-115 was used for registration at T=300 deg. K). Current density, A/cm<2> , made as follows: 1 - 50; 2 - 62.5; 3-75; 4-87.5; 5-100; 6-112.5.



[0070] Hence, terahertz radiation in the range of 0.02 THz to 8 THz is obtained, the carrier of said radiation being infrared radiation in the range of 1 to 56 m.



Referenced Patents

RU2233013
SEMICONDUCTOR ELECTROLUMINESCENT LIGHT SOURCE AND ITS MANUFACTURING PROCESS (ALTERNATIVES)
    
Inventor:
ERMAKOV O N [RU]
KAPLUNOV M G [RU] (+6)     

FIELD: semiconductor devices designed for light emission such as light-emitting diodes used as basic light sources. ^ SUBSTANCE: proposed p-n light-emitting diode has semiconductor electroluminescent crystal built around indium-gallium nitride heterostructure and organic photo-luminescent region. Semiconductor crystal ensures high-output light emission in blue-violet spectrum. Organic photo-luminescent region is made in the form of solid solution of one or more organic luminescent materials in translucent polymeric matrix and affords effective conversion of crystal emission into higher-wavelength light. Light source manufacturing process includes dissolution of organic luminescent material in liquid compound and production of photo-luminescent region from this solution around semiconductor crystal followed by solidification of solution under effect of physical factors such as temperature or ultraviolet radiation. ^ EFFECT: enhanced output of light of all colors, including white light, using unified manufacturing technique

 





Method for exposing cells to electromagnetic radiation
RU2197303 [ PDF ]
FIELD: medicine. SUBSTANCE: method involves superposing electromagnetic fields one of which is electromagnetic field produced by conductor and others being produced by rings having uniform magnetization areas. The rings are arranged along the conductor 1 to 5 mm far from each other. Rings material is subjected to electromagnetic field energy influence that is not less than magnetic reversal energy of one layer in uniform magnetization areas of rings material under magnetic reversal frequency being not greater than 1 GHz when varying magnetic reversal pulse amplitudes from maximum to minimum value. EFFECT: enhanced effectiveness of treatment.

Method for treatment of injured biological tissues
RU2226412
FIELD: medicine; medical engineering. SUBSTANCE: method involves applying high frequency electromagnetic field produced by amplitude modulated sinusoid signal having carrying frequency belonging to 100-1000 kHz bandwidth and modulation frequency continuously varying in 50-8000 Hz frequency bandwidth by means of radiator manufactured as resonant oscillatory circuit. The treatment is applied twice a day for 20- 30 min. The total treatment course is 6-12 procedures long. Field intensity near radiator surface is equal to 0.1-0.5 V/m. The device has action unit, power supply source and sinusoid signal source in frequency bandwidth of 100-1000 kHz designed as selfexcited oscillator oscillatory circuit of which has capacitor and inductance coil low frequency signal oscillator of continuously varying frequency within 50-8000 Hz bandwidth output of which is connected to self-excited oscillator circuit via modulator unit, timer, acoustic indication unit and control tract connected to the self-excited oscillator with its input and having in series connected amplitude detector, DC amplifier and indicator unit. Oscillatory circuit inductance coil serves as action unit radiator. The inductance coil winding is arranged as spiral mounted in dielectric carcass manufactured as radially arranged leaflets. The carcass is mounted in casing manufactured from solid dielectric shaped as bowl of round or oval shape. Each coil winding wire alternately envelops each side of every carcass leaflet. Circuit is mounted on the casing bottom having selfexcited oscillator, modulator and control tract circuit elements arranged thereon. EFFECT: enhanced effectiveness of treatment.

Method for wave therapy
RU2229906 [ PDF ]
FIELD: medicine, medicinal techniques. SUBSTANCE: patient's biologically active points should be affected with electromagnetic radiation ranged 30 hHz-3 tHz at the power being 10-11-10-10Wt, moreover, during this impact one should perform steady alteration of frequency within the whole range of affecting signal. EFFECT: higher efficiency of wave therapy.

Apparatus for physical therapy
RU2238773 [ PDF ]
FIELD: medical engineering. ^ SUBSTANCE: device has power supply source, M+1 electromagnetic oscillation sources and M+1 members, each manufactured as inductance element of corresponding LC-oscillation circuit, M+1 modulators, M+1 control circuits, a sound-reproducing player unit having magnetic tape carrying prerecorded low frequency signal varying in frequency in 10-10000 Hz bandwidth and in amplitude and power amplifier connected to sound-reproducing player output leads with its input and to modulator inputs with its output. The electromagnetic oscillation sources are designed as auto-oscillators, each being tuned on its carrying frequency selected in 100-1000 Hz bandwidth, and having LC-oscillation circuit having appropriate action member. Associated modulator and control circuit are connected to each auto-oscillator circuit. Every control circuit has in series connected amplitude detector, DC-amplifier and indication unit. Action member has inductance coil having separable winding. The auto-oscillator circuit having oscillation circuit having inductance coil and the modulator are united in a separate structural member. The action member is optionally manufactured as inductance coil having windings on dielectric carcass of flat or cylindrical shape. The action member is optionally manufactured as inductance coils having windings on separate dielectric carcass of flat or cylindrical shape connected in series and in conformity. ^ EFFECT: wide range of functional applications; concurrent treatment of several zones of patient body or of several patients.

Apparatus for microwave therapy
RU2134597 [ PDF ]
FIELD: medical equipment, in particular, physiotherapeutic devices using microwave electromagnetic radiation, applicable in traumatology, surgery, stomatology, sporting medicine. SUBSTANCE: the apparatus uses series-connected digital noise generator with a radiation frequency within 0.2 to 3.0 Hz, low-pass filter, current amplifier. The current amplifier output is connected to the input of generator of radiation at a frequency within 2.5 to 0.1 GHz, whose output via a coupling capacitor is connected to the second current amplifier. The radiation generator, coupling capacitor, current amplifier and indicator are positioned in a metal cup with a cover, which functions as a protective screen. EFFECT: enhanced therapeutic effect due to generation of low-intensity electromagnetic radiation with frequency indices of parameters of natural micromotions of cells and electric processes in organs and tissues.

Cyan laser diode
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WO9221170
FIE
LD: engineering physics. SUBSTANCE: laser diode has many layers of group II-IV conductors forming p-n junction; n-type semiconductor substrate may carry, for example, the following layers applied one after another: n-type buffer layer, lower n-type contact layer, lower n-type shell layer, first n-type light-conductor layer, active layer with quantum well, second p-type light-conductor layer, upper p-type shell layer, and upper p-type contact layer. Upper layer may be composite and may contain zinc and selenium or zinc, selenium, and cadmium in its composition. Laser diode emits light in spectrum region within the range of wavelengths from 430 to 590 nm.
 

Semiconductor light amplifier
RU2062543 [ PDF ]

Semiconductor electroluminescent light source
RU2002105900 



Related Patents

US6592611
W00230513
LASER TREATMENT OF AGE RELATED BIOLOGICAL DISORDERS USING QUANTUM BIOLOGY CONCEPTS

Inventor(s):     ZAWADA ROBERT H

Abstract

The present invention provides for a device, a method, and a treatment system for chronic disease conditions. The present invention was designed using the theoretical concepts of Quantum Biology. The principles of operation are based on the device's ability to stimulate a Bose-Einstein condensate and excitation of Frolich resonance in living tissue. The wavenumbers necessary for this excitation are derived from the solution to the equations for optical phonon scattering in living tissue generated by optical photon excitation. The establishment of this degeneracy condition induces a super conducting state in the tissue. This super conducting state facilitates DNA replication, transcription and translation, thereby allowing the proper formation or regeneration of healthy tissue. This superconducting state provides the conditions necessary for establishing the violation of time reversal invariance in living tissue.

FIELD OF THE INVENTION

The present invention is for a violation of time reversal invariance in living tissue, and more particularly, pertains to a violation of time reversal invariance in living tissue by means of exogenously applied electromagnetic radiation with wavenumbers between k = 33,333cm'' to k =3,333cm''.

The present invention is designed for use in non-invasive therapy.

This is a non-invasive technique for the treatment of numerous chronic diseases and conditions, primarily arthritis, chronic pain from injuries, and wound healing, such as bed sores, decubitus, and diabetic ulcers.

DESCRIPTION OF THE PRIOR ART

The present invention specifically describes the mode of biophysical mechanisms of action, which has not been accomplished in any prior art or device.

Current U. S. standard and FDA approved treatments for the above mentioned chronic diseases and conditions include medication, surgery and physical therapy. Other existing therapies and therapy devices that are known in the world market attempt to treat described conditions with non-invasive electromagnetic radiation applications, but lack an accurate explanation of a mechanism of action. Therefore, they are unable to maximize their efficiency.

SUMMARY OF THE INVENTION

The general purpose of the present invention is to provide a non-invasive treatment of disease conditions such as arthritis ; healing of wounds, and soft tissue injuries, i. e. sports injuries ; and relief from chronic conditions, such as Carpal Tunnel Syndrome and chronic ulcers.

The present invention is intended for use in general medical practice. The use of the present invention will, in many cases, eliminate the need for medication, physical therapy, surgery, and ongoing patient care.

The present invention also provides a treatment system for chronic disease conditions. The present invention is based upon application of the theoretical concepts of Quantum Biology to a variety of disease and chronic conditions. The principles of operation are based on stimulating the production of a Bose-Einstein condensate in living tissue The wavenumbers necessary for this excitation are derived from the solution to the equations for optical phonon scattering in living tissue generated by optical photon excitation. The establishment of this degeneracy condition induces a superconducting state in the tissue providing the appropriate instruction set for correct DNA replication, transcription and translation. Thus, allowing the proper formation or regeneration of healthy tissue.

Electromagnetic frequencies excite ordered water around proteins at about 10'4Hz. The present invention is based upon excitation of the Frohlich resonant frequencies in human tissue. Resonant energy transfer, generated by photon excitation at specific wavelengths of 655nom and 1060nm generate Brillouin scattered phonons at 0.424 x 10"FHz and 0.262 x 1011 Hz, respectively.

These frequencies establish a Bose-Einstein condensate within the living tissue.

The ratio of 1060nm/655nm = 1.618 which is the golden mean ratio and known to be biologically active. 655nm is the solution to the Balmer series equation for the first line of hydrogen emission. Biological tissue involves extensive hydrogen bonding. The dimensional resonance of DNA is also known to be 34A/2lA ~ 1.618 for efficient energy transfer from the golden mean ratio.

655nm is also the main absorption band of Heat Shock Protein 47 (HSP47), which is the chaperon for collagen synthesis. The use of multiple wavelengths at the golden mean ratio provide a synergistic effectiveness.

If we start with the first line of the Balmer Series for hydrogen : , (B) = 3646 (N2/N2-4) for N=3
A (B) = 656.28nm #(B) # 655nm

Therefore, this 655nm becomes the primary absorption wavelength in this invention. The Frohlich resonance of ordered water around proteins is # 10'4Hz.

The optical excitations at 655nm and 1060nm both provide excitation in this band.

Electromagnetic radiation coherently excites the ordered water molecules, which in turn excite tunneling through the creation of evanescent photons in the nucleotide bonds. The Frohlich resonance is a non-local effect occurring in the water surrounding and in the core of the microtubules connecting all cellular structure. Excitations at a frequency of 10'4ha, excites the water surrounding the protein structure and a frequency of 10"Hz, excites water in the core of the protein structure of the microtubules. This in turn generates a collective and cooperative behavior of a great number of the constituents, known in Quantum Mechanics as the degeneracy state, or multiples of identical quantum numbers. Tins can then be associated with a non-local long range order, in which information is transmitted in the superconducting state.

This long range transfer is established through longitudinal electric modes in the microtubules and generates a single quantum state. If energy is fed into these modes and transferred to other degrees of freedom, then a stationary state will be reached where the energy content of the electric mode is larger than thermal equilibrium. A coherent electric wave is then channeled into a single mode. The local vibrations of the cell membrane then create a positive and negative part of particular sections of the membrane that vibrate against each other leading to an oscillating electric dipole frequency of the order of 10"Hz.

The hydrogen bonds have distinctive dipolar properties. The alpha helix is expected to exhibit collective dipole oscillations in the same frequency region, and also from non-localized elechons in this region of the cell.

The dielectric systems have a certain range of macroscopic wavelengths capable of longitudinal electric oscillations over the whole material.

Processes involving cell membrane or H-bonds are expected to feed energy locally to particular dipole oscillators. Long range coulomb interactions can cause energy to be shared with otlier dipoles that will oscillate coherently provided energy supply is sufficient and a single longitudinal mode can exhibit long range phase correlations. Since biological tissue exhibits very wide absorption bands, optical excitation ranging from the UVA to the near IR can stimulate biological activity.

The purpose of the present invention is to maximize this biological activity, even though a broad spectral range can still exhibit stimulatory effects.

The free energy associated with vibration can be decreased if the system is permitted to undergo deformations or interactive decoherence. Therefore, coherence must be re-established. Relevant components can be connected with certain regions in the cell membrane by H-bonds. If energy is supplied locally (in regions containing non-localized electrons), then energy is shared by all components which establish a branch of electric modes. When cells are closely packed, deformations in the cell membrane will no longer influence the di-electric response, this is known as contact inhibition.

Coherent electromagnetic excitation presents a reservoir of energy and when the absorption of light is znw kT it can lead to energy storage in a single state. This coherently excites the ordered water molecules, which in turn excite the tunneling in the nucleotide bonds. When the conformational grooves of a protein are filled with water, the entire protein is in coherent vibration. This also applies to the B form of DNA, which is the hydrated form found in living organisms. Non-local effects such as remote triggering are expected whenever a very fast coupling (i. e., optical) occurs in a system with slow local dynamics (i. e., conformational changes in biological systems). Examples include biochemical processes coupled by electric field effects, such as are present in tissue. The force constant for dangling N-H bonds, such as that seen in nucleotide base pairs, is 8.955 x 1013 ; ~ 10 1', which coincides with the Frohlich resonance in water, similar to the Meissner effect. The v3 Raman resonance in water of 2.771l generates dipoles which in turn create ordered states. 2. zu coincides with the second harmonic golden mean overtone of the applied optical radiation at a wavelength of 1060non of Appendix A, incorporated herein by reference. The ordered water in microtuules then establishes Frohlich resonances from dipole and Vander Waal forces, creating a Bose-Einstein condensate.

The Bose-Einstein condensate creates non-local communication throughout microtubules and a re-coherence of cellular state.

The calculation of the appropriate optical phonons that are generated from the excitation by optical photons is as follows: v = c/# w = 2nv (where v = frequency of light, # = wavelength of light iv = angular frequency) Q # 2Vslv (n/c) (where n = 1. 38 in tissue V, = velocity of sound in tissue
Vs = 1600m/s in tissue
Q = optical phonon frequency) = 2Vs2# n/# = 2 (1.6 x 103) (2n) (1.38/1060 x 10-9) Q (1060nm) = 0.261759 x 1011 Hz
Q (655nm) = 0.42361 x 10"Hz
These numbers fall exactly into the biologically active region for Frohlich resonance. Specifically, for H-bonds, this combination will generate maximum effectiveness because of their efficient coupling for energy to H-bonds for phonon excitation and to water for photon excitation. v = c/X v1060 = 3 x108m/s/1. 06 x 10-6m = 2.83 x 1014 Hz v655 = 3 x 108m/s/. 655 x 10-6m = 4.5 x 1014Hz
Although some biological activity will be seen in the band with from 300nm to 3p and will be effective for the process of tissue regeneration, it will be optimized for wavelengths of 655nm ~ 100nm ; 1060mu 100nm ; 2. 77 + 100nm.

New aspects of the present invention are the use of quantum biological principles to create the most effective treatment of diseased tissue. No other device or treatment method uses these principles. The wavelengths used give the best penetration depth into soft tissue and bone. 1060nm is equally effective on all skin pigmentation, as well as 2.77p. In other words, irrespective of the particular pigmentation pattern, quantity, or quality of a patient being treated, the 1060nm coherent electromagnetic radiation employed in the present invention is particularly advantageous in penetrating beneath the patient's skin and interacting with underlying tissue. Wavelengths chosen maximize energy transfer to tissue for most effective regeneration of healthy tissue. The present invention is the only one based on the exact calculations of the frequencies to excite the Frohlich resonance.

The invention is the most effective device possible for stated application, due to the exact tuning of the emission frequencies.

Any method of generating coherent electromagnetic radiation at wavelengths in the spectral region of 300nm to 3pI is suitable for generating coherent electromagnetic radiation for the present invention, provided, of course, that the radiation must be at the specific wavelengths of the invention. The use of laser diodes is the most practical and cost effective means for producing the coherent electromagnetic radiation used in this invention, at the specific wavelengths indicated. It is within the skill of art to prepare a laser diode for generation of a designated wavelength.

Having thus described embodiments of the present invention, it is the principal object of the present invention to provide a violation of time reversal invariance in living tissue.

BRIEF DESCRIPTION OF THE DRAWINGS

Other objects of the present invention and many of the attendant advantages of the present invention will be readily appreciated as the same becomes better understood by reference to the following detailed description when considered in connection with the accompanying drawings, in which like reference numerals designate like parts throughout the figures thereof and wherein:

FIG. 1 illustrates an apparatus comprising the present invention; and,



FIG. 2 illustrates handheld probes treating tissue by optical radiation.



DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

FIG. 1 illustrates a two-channel simplified schematic of the present invention consisting of a diode laser module 12 in which the effective wavelengths of light are generated and combined fiber-optically for emission functioning as a combined single output. In other words, the combined single output includes a first coherent light at a first wavelength and a second coherent light at a second wavelength, different fi-on the first wavelength. Optionally, a third, different wavelength of coherent light may also be present in the combined single output. The diode laser module 12 consists of at least two channels with identical multiple wavelengths emitted from each channel. In other words, the combined single output, having two or more different wavelengths of coherent light, is split into two or more channels, each channel identical in composition by virtue of consisting of two or more different wavelengths of coherent light.

Each channel feeds into a separate fiber optic delivery system cables 14 and 16, probes 18 and 20 containing collimating focusing lenses 22 and 24. Also included are a radiation source power supply 26, control electronics 28, and a user display 30 for monitoring of operational parameters. Preferably, the probes 18 and 20 are handheld, but alternatively may be mechanically held in a desired orientation.

FIG. 2 illustrates the preferred two or more handheld probes 18 and 20 for delivery of the optical radiation into the tissue. The purpose of the two or more probes 18 and 20 is to maintain a maximum power of 500mw/cm2 per probe, which is known to be a safe exposure to human skin. This gives the optical source a CDRH classification of Illb. The probes 18 and 20 can be separately directed to a single treatment area 32 below the skin surface to maximize light below the skin surface without causing tissue damage at the air dermal interface.

MODE OF OPERATION

The mode of operation is based on the excitation of Frohlich resonance in the microtubule cytoskeletal substructure of the cell. This excitation creates a Bose-Einstein condensate in the microtubule and a degeneracy state for information transfer. The ability to establish this singular communication system within the cellular structure is what allows for the transfer of the information necessary to correct for DNA dysfunctions or mutations causing the diseased state.

VIOLATION OF TIME REVERSAL INVARIANCE IN LIVING TISSUE

PARTS LIST

10 apparatus
12 diode laser module
14 fiber optic delivery system cable
16 fiber optic delivery system cable
18 handheld probe
20 handheld probe
22 focusing lens
24 focusing lens
26 radiation source power supply
28 control electronics
30 user display
32 treatment area

Various modifications can be made to the present invention without departing from the apparent scope hereof.


 
US2007208249
METHOD FOR TISSUE REGENERATION OR DEGENERATION IN HUMAN AND AN APPARATUS THEREFORE  

Inventor(s):     KUMAR RAJAH V [IN] +
Also published as:     WO2005120171 // WO2005120171 // WO2005120171 // EP1753508

Abstract

Disclosed herein is an apparatus for tissue regeneration or degeneration in human by applying rotational field narrow focused quantum magnetic resonance on the required area. The apparatus consists of a plurality of guns for delivery the quantum magnetic resonance, a traveling platform for carrying the person under treatment, an electronic switsching system for controlling the guns, said electronic switching system being controlled by a main computer through an on board microprocessor and means for cooling and dispersing the heat generated during the operation.

TECHNICAL FIELD

[0001] This invention relates to a method for tissue regeneration or degeneration using rotational field narrow focused quantum magnetic resonance in human as well as a machine for carrying out the said method. The said machine produces high power multi frequency rotating electromagnetic beams, modulated with finely derived frequency amplitude and field strength based on the specific cell types and application that are precisely focused to the target area of repair. Throughout the specification, the term "Rotational Field Narrow Focused Quantum Magnetic Resonance" is referred to as "RFQMR".

[0002] Regeneration refers to the ability of the body to renew or reproduce cells and tissue with renewed life and vigor and degeneration refers to slowing down of cell growth in pathologically hyper reproductive tissues. While tissue regeneration helps in treating affected areas such as cartilages, bones etc., tissue degeneration helps in retarding the growth of the living cell and stop the growth of unwanted blood vessels etc. Tissue regeneration helps in treating problems associated with old age or accidental injuries whereas tissue degeneration helps in treating cancer, obesity, tumor etc.

BACKGROUND OF INVENTION

[0003] A lot of research is being done on tissue/cell degeneration and regeneration. Bone tissue regeneration to repair bone defects, whether they are the result of injury, surgery, disease or old-age, has been a common goal of medicine and dentistry. In dental field, the grafting has been more popular. Conventionally, filling the affected bone with graft material and covering the graft material with a barrier material to exclude competitive cells can achieve bone tissue regeneration.

[0004] Three different graft materials are used in bone tissue regeneration, i.e. (i) A live active bone tissue, (ii) demineralized, freeze-dried, allogenic bone and (iii) autogenous cortical bone chips. However, there exists a need to regenerate bone tissue in a reliable manner without undue risk of infection and without the need for prolonged and multiple operative procedures.

[0005] Degeneration can also be done in a number of ways. For example, for treatment of cancer cells or tumor, chemotherapy or radiation etc are used. However, some of these therapies have serious side effects and the same is not recommended to many persons suffering with cancer or tumor, and the like.

[0006] It has been known to use magnetic therapy in both cell regeneration and/or degeneration. Magnetic fields are nothing new and they are a part of all basic life processes. Scientists have discovered as to how to focus and shape magnetic fields that occur in nature in order to stimulate cell metabolism and bring about healing and recovery. Magnetic fields affect symptoms by going straight to the source-body cells. Magnetic resonance treatment is a scientific refinement available for the present generation.

[0007] A system has been known for the last few years which allows the body to be exposed to pulsating low frequency magnetic fields that stimulates cell metabolism, increases the oxygen assimilation and accelerates the removal of toxic chemicals and waste. Depending the condition and sensitivity of the person, improvement could be noticed between 2 to 8 weeks.

[0008] Electromagnetic stimulation of sensory nerves or acupuncture points has focused mainly on stimulation of nerve tracts for the purpose of promoting release of natural opiates or pain pathway blocks through gating mechanisms. Various forms of such stimulation have been tried such as application of voltages or currents to acupuncture needles, transcutaneous electrical nerve stimulation (TENS), pulsed magnetic field stimulation, local application of heat or cold, use of light radiation, and magnetic therapy. Prior art devices of this type include the use of low frequency magnetic pulses as described in U.S. Pat. No. 6,234,953 B1, issued May 22, 2001.

[0009] None of the above described adopt the principle of rotational field quantum magnetic resonance. Application of magnetic resonance to the affected area either to regenerate or degenerate the cells as the case may be, is the field of study of the present invention. In the present system, the quantum magnetic resonance applied is tissue specific and further it has no side effects.

[0010] Accordingly, the primary object of the present invention is to develop a method for tissue regeneration or degeneration using rotational field narrow focused quantum magnetic resonance. A further object of the present invention is to provide an apparatus for treatment using the said method.

SUMMARY OF THE INVENTION

[0011] This invention thus provides a method for tissue regeneration or degeneration in human using rotational field narrow focused quantum magnetic resonance depending on the cell type and their permittivity.

[0012] This invention further provides an apparatus for applying rotational field narrow focused quantum magnetic resonance on the required area of treatment comprising means of generating the quantum magnetic resonance, means for delivering the magnetic resonance which comprises of a plurality of guns, an electronic switching system for controlling the guns, said electronic switching system being controlled by a main computer through an on board microprocessor and means for cooling and dispersing the heat generated during the operation.

[0013] Rotational field narrow focused quantam magnetic resonance is an effective, non-invasive solution in the treatment of Osteoarthritis, relieving pain and disability due to trauma, temporo-mandibular joint disease, tinnitus, peridontal disease, carpal tunnel syndrome, osteoporosis, tendonitis and convalescence following surgical repair of ligaments, fresh bone fractures in elderly, aseptic necrosis, fibromyalgia, sciatica, post-polio syndrome, migraine, metatarsalgia, acute burns, immune deficiency disorders, drug resistant epilepsy, diabetic neuropathy, herniated disk, problem wound healing, Stimulation of Angiogenic Growth Factor and promoting Coronary and peripheral pro-angiogenesis and retarding the Angiogenic Growth Factor to promote Anti-Angiogenesis in Cancer.

[0014] Another possible application of RFQMR is Electroporation. Electroporation involves directly applying RFQMR pulses of millionths of a second duration and field strength of 100-1500 volts per centimeter to living cells. These pulses cause nanoscopic pores to open up through the cell's membrane. When the pulse stops, the pores close again, trapping the drug or DNA inside the cell. Applying the RFQMR pulses either directly to the target tissue to be treated in a living organism, or to cell suspensions and isolated organs can carry out Electroporation. This application of RFQMR may go a long way, as it will open up the potential for new approaches to medical problems where successful treatment depends on finding ways for the therapeutic molecules to reach the cell interior. This includes-among others-treatments such as cancer chemotherapy, the delivery of DNA for gene therapy and DNA vaccines, the delivery of drugs for treating cardiac and vascular problems as well as the treatment of the eye disease. Further research can bring about many other potential applications such as the treatment of haemophilia and other genetic defects or the treatment of cardiovascular diseases and the prevention of atherosclerosis can be explored.

[0015] RFQMR in Tissue Degeneration:

[0016] The higher end of Electromagnetic Radiation has long been used in the treatment of cancer, but there is an interesting spectrum of Electromagnetic field, at the lower end of the spectrum, when delivered in the appropriate manner, can regenerate living cells, grow new blood vessels, regenerate tissues and at the same time, when the spectral characteristics and delivery system is altered, do the reverse of all the above, degenerate the living cell, stop the growth of new blood vessels etc.

[0017] Rotational Field Narrow Focused Quantum Magnetic Resonance is a new machine, that produce high power multi frequency rotating electromagnetic beams that are precisely focused to the target area of repair. There are totally 96 beams delivering the correct dosage.

[0018] There is a wide agreement in the scientific community on the damage and cancer causing effect of radiation in the ionising region of the Electromagnetic spectrum (>10<15 > Hz or above) in the Ultraviolet region. The Heating effect of microwaves on tissue is known. It is now understood that Controlled Quantum Magnetic Resonance can Accelerate or Decelerate growth.

[0019] The Hypothesis is one of biosynthesis involving the formation of new chemicals affected by RFQMR signals altering the atomic properties with in the living cells.

[0020] If one considers a living cell as having a diameter of about 10 micrometers and subjected to a RFQMR field, the effect is one of an increase in the rate of protein production, including enzymes. One way this appears to happen involves a two-stage process involving transcription and translation.

[0021] In the transcription stage the DNA unravels partially forming messenger RNA, (mRNA) that goes out of the DNA nucleus and latches into the ribosome in the cell fluid surrounding the DNA nucleus. In the second stage the protein is produced. There is also a feedback mechanism that control how much of protein enzymes are produced, depending on the body's needs. Protein production or enzyme activity seems to increase in the presence of a RFQMR field.

[0022] There is a known mechanism, formerly known as heat shock, whereby a cell produces extra protein/enzymes in response to shock such as thermal shock. These proteins are called heat shock proteins (HSPs). This is now referred to as a stress response rather than heat shock because the process apparently applies to any stress, not only thermal. RFQMR radiation appears to be merely another form of stress on the cell.

[0023] One interesting result is that the response from increasing the RFQMR field in a cell from 8 milligauss to 80 milligauss is similar to the effect of increasing the temperature from 37 deg C. to 42 deg C.

[0024] Another interesting effect is the stress tolerance. When a cell has its temperature raised from 37 deg C. to 45 deg C. the cell will die within a few minutes. But if the cell's temperature is raised first to about 42 deg C., allowed to fall back to 37 deg C. then raised to 45 deg C. the cell doesn't die, as if, the memory of the previous stress has conditioned the cell to cope with more stress than before.

[0025] There also appears to be a negative feedback mechanism operating whereby the HSPs reduce the rate of production of further HSPs. What are the implications for these effects with RFQMR radiation? Does this mean that people subjected to continuous or occasional RFQMR radiation are more able to tolerate further Electromagnetic radiation?.

[0026] What is happening at the molecular level? It appears that the process is one affecting the Sodium Potassium Adenosine Triphosphatase (Na-K-ATP-ase) pump that drives the cell.

[0027] Consider a continuous cell membrane (phospho-lipase). There are molecules that cross the membrane with one particular pear-shaped one having its narrow end extending beyond the outer edge of the membrane and its broader end extending beyond the inner edge. This is the larger of a two-part molecule; the pear-shaped one is accompanied by a smaller elliptical part. Most of the interesting characteristics of the molecule occur in the part.

[0028] For this 100,000 molecular weight cell the ATP converts to ADP with the production of 3 Na+ ions and 2 K+ ions.

[0029] It is the business of these enzymes to use the energy from the ATP to get the Na to move out of the cell and the K to move inside. It appears to do this by modifying the permeability of the cell walls to allow these interchanges.

[0030] This enzyme activity appears to be related to the movement of electric charge e-. Thus the movement of these negative charges probably mediates the movement of these positive ions through the cell membrane and the amount of activity enhancement depends on the availability of these charges.

[0031] The enzyme activity is enhanced for magnetic fields at all enzyme activities but for electric fields is limited to low enzyme activity. Any electric field present does not permeate the membrane. Instead it builds up a +ve charge on the outer layer of the membrane. Its ability to produce a corresponding -ve charge on the inner surface of the membrane relies on the scavenging of free charges within the membrane. So this enhancing effect is limited to low enzyme activities presumably because of the limitation of the availability of sufficient free charges within the membrane.

[0032] Hypothesised Mechanism:

[0033] It is thought that the chromosomes, following the messages received as a result of the variations of potential (-70 to -90 mV normal, -40 to -60 when infected, -20 to -30 in cancer and 0 when dead) in the cytoplasmic membrane, activate through electromechanical effects (stress responsive), the emission of messages by the genes that regulate cell dynamics for normal cell functions or for the mitochondrial activities for ATP production. An electrical equivalent circuit composed of a zener diode attached to the base of a bipolar transistor is offered as a model for the operation of the mitochondrion. The zener diode represents the on/off pulse operation of some cell functions, the combined circuit impedance represents the impedance of the glycoproteinic sensors present on the mitochondrial membrane, and the transistor represents the ATP activation process.

[0034] It is supposed that the excessive production of ATP is related to an alteration of the glycoproteinic sensors present on the mitochondrion membrane with consequent lowering of the impedance that in turn does not discriminate between the signals in frequency and activates the production of ATP in an almost continual way. The cancer cell would therefore go into mitosis due to the excess of ATP.

[0035] RFQMR fields are used to act on the mitochondrial membrane, increasing the impedance of the glycoproteinic sensors through the lengthening of the polyglycidic chain. The spin of the RFQMR field is used to interfere with the communications between the genes and the protoplasmic glycoproteinic complexes involved in the promotion of cell mitosis.

[0036] It is thought that the impedance of the mitochondrial membrane to the messages coming from the genes increase with the RFQMR treatment and with increase in the malignancy (the highest impedance for undifferentiated tumours). This is related to a greater alteration of the sensors of the undifferentiated tumours and therefore to their greater predisposition to the bond with polyglycidic chains. The undifferentiated cancer cells, because of the high impedance induced on the mitochondrial membrane by the RFQMR exposure, it stops producing ATP and therefore 'possibly' enter into necrosis. Following the treatment the differentiated cancer cells have an impedance which is still sensitive to some messages coming from the chromosomes promoting the normal production of ATP, so these cells change their state of mitosis; however, they continue to live in a quiescent state (vegetative form of life). The normal cells are not influenced by the RFQMR radiation treatment as the impedance of their mitochondrial sensors is not modified and remain sensitive to messages that arrive from the chromosomes for the activation of the ATP synthesis.

[0037] Influence of RFQMR Radiation on Cell Functions in Degeneration:

[0038] Tissue Degeneration is mainly useful in the treatment of Pathologically Hyper Reproducing Tissues, like a tumor in a cancer patient. RFQMR basically alters the Membrane potential of the tumor cells thus halting Mitosis (cell division).

[0039] The preliminary observations conducted in vitro show an alteration of cell morphology, a halt to proliferation, fusion, and necrosis in lymphoblastoid cell lines, and in some neoplastic lines, after treatment with specifically modulated QMR radiation (HeLa, mammary carcinoma, CCL-178, colon adenocarcinoma, H 23, H 32, h 12.1, 1411 H, testicle carcinoma, M 5, M51, stomach carcinoma, MCF-7 human Caucasian breast adenocarcinoma ECACC 86012803, normal cell line, and MDBK bovine kidney cells).

[0040] It is known that cells communicate with each other by means of direct metabolic exchanges or through the transfer of ions or molecules that act as messengers. Multi-cell signals, which originate in the interaction of ligands with membrane receptors, can activate a closely connected series of biochemical reactions. The biological membranes represent multi-molecular operative structures, and even a slight alteration in the composition of the membrane can lead to significant changes in its functions. RFQMR radiations can influence this communication between cells and within the cells themselves due to their ability to activate or change the motion of the electrical charges. In fact, an increasing amount of literature illustrates the possibility of inducing biological effects in cells when appropriate electrical and electromagnetic fields are applied to have a direct effect on the membranes.

[0041] Among the various effects obtained are those on Na+ and K+ dynamics and their role in ATPasi, as well as the effects on the intermembrane exchanges of the Ca++ ion, which, because of its presence in most biomolecular processes, has earned the name of second messenger. Moreover, exposure conditions that have led to effects on the membrane permeability of the Ca++ ion have shown a negative influence on the mitotic fuso, and this influence is selectively tied to the characteristic of the quantum electromagnetic field used. Up to now, the results obtained imply that the membrane receptors (e.g., the gluco-protein complexes), are able to decipher quantum signals at a well defined frequency and amplitude by reacting in a specific way. The energy transformed form the fields are absorbed and directly coupled to guide biochemical reactions. These results have served as the bases for some applications in the therapeutic field, particularly in the reproduction of cartilage tissue. This is due to the fact that the activation of some cell functions is bound to quantum signals of the on/off type, that is, not with linear but with modulated non-sinusoidal wave shapes. The quantity of charge/current density involved is quite large being equivalent to currents in a conductor of about 10,000 amperes; perhaps approaching superconductivity.

[0042] The Following are the Typical Steps Involved in the Treatment of a Cancer Patient Using RFQMR:

[0043] The patient is first diagnosed for cancer using the conventional methods. A biopsy is done to establish the type of cancer cells and their morphology. A MRI of the affected region or a whole body MRI is done depending on the type of cancer (some cancer cells spread faster than the other or like some tumor cells spread through the circulatory system and some will spread through the lymphatic system).

[0044] The radiologist and the oncologist will decide on the primary site of the cancer, and decide on the "Tumor of first Attack". The radiologist will then prepare the "Target Planning Films", this is derived from the MRI slices, that shows the core of the tumor and then he will position all the 96 QMR guns in firing position. These films are given to the Engineers who apply RFQMR.

[0045] The Engineers then plan the RFQMR Dose Parameters from the TPF. The patient is then sent for physical marking to the radiologist, who will physically mark the exact location of the tumor under the control of a computerised tomography.

[0046] The patient is then put on the RFQMR machine and a template is made out of a special transparent plastic sheet. The first exposure starts on the same day or on the next day.

[0047] On the day of the exposure, the patient is made to lie down on the RFQMR machine and is rolled in, the guns are now focused at the target using a laser guided system.

[0048] FIG. 5 illustrates the visible changes in the patient's knee before and after the RFQMR treatment for tissue regeneration; and



[0049] FIGS. 6 to 8 illustrate the various changes in the patient's tumor before, during and after the RFQMR treatment for tissue degeneration.



[0050] One can observe that the RFQMR machine of the present invention looks like a MRI or CT machine (see FIG. 1). The affected joint (knee) is placed inside RFQMR machine and the desired exposure characteristics (like the cartilage to bone gap, skin to cartilage distance, Name, age, gender, height and weight etc., in regenerative RFQMR or the distance to the tumor core, and details of other cell type around the tumor etc., is obtained using a Magnetic Resonance Imaging (MRI) in case of a Degenerative RFQMR) are fed into the computer, the computer then computes various wave front and spin frequencies, pulse amplitudes, field strength etc., there after the operator will precisely focus the beams, with the aid of the subject's x-rays in case of a regenerative RFQMR or the patient is precisely marked using a CT-scan in case of a degenerative RFQMR. The treatment is for 60 minutes daily for a period of 21 days in case of regenerative RFQMR or 28 days in case of degenerative RFQMR, depending on the RFQMR purpose, outcomes are evaluated by x-ray and other methods, at the end of the treatment. The treatment is to be uninterrupted.

[0051] The Subjects do not feel any pain or discomfort during the treatment, the field strength on the body surface is periodically measured by the computer, and if there is any deviation, it will alarm, change in field strength may be because of absence of a beam, In all 96 QMR-beams are used at an angle of 11.25 degrees.

[0052] FIG. 1 shows the details of the RFQMR machine, the circular part of the machine is called the QMR head 1, which consists of 96 QMR generators 2 i.e. guns made of a special metal alloy. These QMR guns produces the QMR beams 3 and are mounted on a Heat sinking material to disperse the heat generated as fast as possible. The heat sink is further cooled using an appropriate cooling system 4, such as air circulators. The patient putting weight on the joint, the cartilage is compressed, the fluid gets displaced, and it carries with it mobile ions, the sodium ions, leaving behind the negatively charged proteoglycan carboxyl and sulfate ions. That generates a electric potiential because you have unneutralised negative charges. This is called a streaming potiential. RFQMR can recreate this streaming potential and its restorative rewards in joints impaired due to disease or trauma even though they are at rest. Preliminary clinical trials have shown that, patients with severe Osteoarthritis have achieved cartilage regeneration ranging from one to three millimeters in 21 days of exposure to RFQMR.



[0053] The exact expected mechanism in tissue regeneration in cartilage cells i.e. the Method of RFQMR exposure is shown in FIGS. 2a to 2c.

[0054] FIG. 2a shows the change in equilibrium between hydrogen protons and negative charge carriers in the extracellular cartilage matrix-NO Streaming Potential-at rest.



[0055] FIG. 2b shows the creation of a streaming Potential in the ECM during loading caused by the compression of fixed negative charged fluid forced out of cartilage tissue with forced influx of Hydrogen Protons under load.

[0056] FIG. 2c shows the generation of streaming voltage potentials flow in the joint caused by forced movement of hydrogen Protons in the ECM caused by the alteration in RFQMR spin in the Hydrogen Atoms, as a stimulation of Chondrocytes in the ECM at rest during quantum magnetic resonance radiation.

[0057] Rotational Field Narrow Focused Quantum Magnetic Resonance is administered using the RFQMR machine illustrated in the drawings.

[0058] In the drawings:

[0059] FIG. 1 illustrates the general layout of the RFQMR machine of the present invention;

[0060] FIG. 2a to 2c illustrate the Mechanism of the effect of RFQMR spin on the chondrocytes;

[0061] FIG. 3 illustrates the RFQMR head along with other controls used in the machine;



[0062] FIG. 4 illustrates the block diagram of the RFQMR machine of the present invention;



[0063] The exposure is for 1 hour each day for 28 days. Every 7 days the echogenicity of the tumor is assessed using an ultra sound and the blood tests are repeated. MRI is done on the 15th and 30th day to assess the Tumor Necrosis. The tumor is expected to get necrosed from the core of the tumor, a kind of implosion. After the 28 days treatment, the patients gets back to his or her normal life, the patient is further assessed after 6 weeks after the last exposure.

 

[0064] RFQMR in Tissue Regeneration:

[0065] Tissue Regeneration is more or less the opposite of the tissue degeneration. This has a wider application then Degeneration, application can be in Osteoarrites, Grow new blood vessels where required, wound healing, treating non healing fractures etc.,

[0066] In Tissue Regeneration, RFQMR is simply used in the somewhat reverse gear. Depending on the type of the cell type, and their permittivity, RFQMR exposure is planned. Most of the expected reactions are reverse of what is mentioned above. Though the hypothesis of regeneration may be different for different tissue types, we can comment on the tissue regeneration in human cartilage cells.

[0067] Hypotheses of RFQMR Theory in Cartilage Regeneration:

[0068] Like other tissues, bone and cartilage are constantly being built up and broken down by a variety of metabolic and physical influences. The major stimulus for bone and cartilage formation is a piezoelectric signal generated when these structures are subjected to tension or compression. This explains why bone atrophies in the absence of any significant pressure, such as weightlessness during space travel or immobilization in a cast. The transmission of this signal is also impaired following joint injury due to, trauma or diseases such as osteoarthritis. RFQMR is designed to characterize and reproduce the piezoelectric signal that initiates these regenerative activities by the induction of a spin in the hydrogen atoms thus creating a streaming potential in the extracellular matrix (ECM) when bone or cartilage are placed under a load. In other words, when you take a step, high current low voltage power sources for the operation of various sub-assemblies as well as the RFQMR guns. This sub-assembly is the energy source for the entire system.

[0069] Power Controller sub-assembly receives the power from the HCHV power supply and controls the distribution of the same to the various other sub-assembly under the command and control of the SCS. It also takes care of the safety aspects, like over loads, temperature or thermal shutdown etc. for the safe running of the system.

[0070] High Speed Switching Sub-Assembly receives multiple inputs from signal modulators and field rotators and operates under the command and control of the SCS. The HSS sub-assembly is capable of handling high voltages and currents and switch them on and off at very high frequencies, thus is capable of producing fine modulated pulses of millionth of a second. This sub-assembly directly fires the QMR guns, under the instruction and regulation of the SCS.

[0071] Signal Modulator Sub-Assembly is an important unit of the system. It receives multiple commands from the SCS and modulates them producing a unique Quantum Pulse that is supplied to the HSS sub-assembly for firing.

[0072] The field Rotator Sub-assembly receives rotational information from the SCS and sends it to the HSS sub-assembly for the control of field rotation. Both field rotators and signal modulators play an important role in the finally achieving the desired magnetic resonance.

[0073] QMR Guns are special cores, made of high permeability material that is precisely coiled with pure copper. There are in total 96 guns that are placed at 11.25 degrees and 3 in a sequence along the MR aperture. These guns are accurately focused at the target tissue at the time of treatment. 96 independent switching devices drive these guns from the HSS sub-assembly. Since these Guns get heated when they are firing, so a cooling system, based on heat dissipation and forced air cooling is required.

[0074] bed 5 is a traveling platform surfaced with sponge and leather to provide comfort to the patient. The target area is marked by reference numeral 6.

[0075] The 96 guns are controlled by appropriate electronic control system and switching system, generally marked by reference numeral 7, which is capable of handling high voltage and currents. The switching system is controlled by an on board microprocessor, which receives instruction from the main control computer.

[0076] The Main Control Computer has software designed for the purpose of planning the RFQMR exposure dose and precise focusing and targeting. The RFQMR can be applied in almost all degenerative disease.

[0077] Explanation of the Block Diagram of the Rotational Field Quantum Magnetic Resonance Tissue Engineering System Shown in FIG. 4:

[0078] The RFQMR system consists of the following sub-systems:

[0079] 1. On Board Microcontroller based Supervisory Control System (SCS)

[0080] 2. High Current/High Voltage Power supply sub-assembly

[0081] 3. Power Controller sub-assembly

[0082] 4. High speed switching sub-assembly

[0083] 5. Signal Modulator

[0084] 6. Field Rotator

[0085] 7. QMR guns with cooling sub-assembly

[0086] 8. Main Control Computer

[0087] On Board Microcontroller based supervisory control system is the main processing part of the RFQMR system. This sub-assembly receives the commands pertaining to the dose such as wave front frequency, spin frequency applied field strength etc. from the main control computer. This information is computed and made suitable to be transmitted to the Signal Modulation, field rotator and High speed switching sub-assemblies.

[0088] High Current/High Voltage Power supply is a sub-assembly that takes in the AC 230 volts power from the mains and converts into various high voltage low current as well as

[0089] Main Control Computer is the Master control of the entire system. It is here that all treatment related computation is done. This system takes the inputs like the Cell and Tissue type, the target distance and other required parameters and computes all necessary dosage information to be passed on to the on-board SCS for starting the treatment exposures.

[0090] The following are the typical steps involved in the treatment of osteoarthritis using RFQMR:

[0091] The steps here are simple, but depends on the type of tissue that has to be regenerated. In case of Osteoarthritis; The patients are first diagnosed for Osteoarthrites by conventional x-rays. A special Computer software is used for measuring the Cartilage thickness. A High Frequency ultra sound scan of the knee is done to measure the cartilage thickness and the target distance from the surface of the skin. The RFQMR engineers will now plan the Dose parameters, from the data obtained from the scan.

[0092] Patient is loaded on the RFQMR machine and the guns are targeted precisely using a laser guided system. There are 21 exposures of one hour each every day. After the 21 days, the patients are re-evaluated.

[0093] There is a patient follow-up after 30 days after the last exposure.

CLINICAL TRIAL EXAMPLES OF TISSUE REGENERATION AND DEGENERATION

[0094] Tissue Regeneration:

[0095] The Clinical trials were involving 40 volunteers, with moderate to severe Osteoarthritis, with radiological evidence of severe disease were recruited after obtaining their informed consent. Other investigation had done included Blood tests, dynamometry etc.

[0096] The synopsis below is of one of the 40 patients have shown significant growth of cartilage tissue using RFQMR exposure. The Patient underwent 21 days of exposure for a period of one hour every day. X-rays were taken before and after exposure.

[0097] The Patient Mrs. SN, female, aged 63 years, was one of the volunteers for the RFQMR tissue regeneration study. She took the prescribed 21 RFQMR exposures. From the 7th exposure, she was totally out of pain and was not taking any painkillers, by the 14th exposures she could walk comfortably about 2 KM every day. The exposure continued until the 21<st > day and the X-ray, Blood tests and Dynamometry was repeated.

[0098] The results were evaluated using the Knee Society rating, which is internationally accepted method to assess knee function. The result were as follows, and was better than total knee replacement.

  Assessment  Before Treatment  After Treatment

  Pain  80%  10%
  Range of Motion  44%  60%
  Total Knee Score  21/100  73/100
  Total Functional Score  30/100  78/100

[0099] The above knee society assessment score shows tissue regeneration using RFQMR can give great symptomatic relief to the patient suffering with pain due to osteoarthritis.

[0100] The patient's radiological evidence, that is more objective also showed substantial amount of tissue growth.

[0101] One can even see significant visible changes in the X-ray of the patients knee before and after the exposure. Refer FIG. 5

[0102] It is now established beyond doubt that RFQMR tissue engineering can regenerate a degenerative tissue like the cartilage, over the period of time we will be able to regenerate most human tissues using the technology.

[0103] Tissue Degeneration:

[0104] As an Index to technology proving, we had recruited 3 patients with end stage cancer, with no other medical options or surgery. These patients had estimated life expectancy ranging from 1 to 3 weeks. Here below is the case of one of them.

[0105] Patient Mr. R, with carcinoma of the lungs, operated successfully and metastatic end stage Sarcomatidcarcinoma in the abdomen, not responding to any existing therapy, the patient was in great pain and was on morphine every four hours. FIG. 6 illustrates the tumor measuring 74 mm*73 mm before RFQMR exposure. Food intake was very poor, sleep and bowl moments were erratic and irregular with severe nausea and vomiting when food intake was attempted. The patient was scheduled for 28 RFQMR exposures with assessment every 7 days considering the Disease State.

[0106] The assessment during the exposure was very encouraging and was as follows.

[0107] The severe pain totally relived by the first two exposures and gradual reduction of morphine was initiated, by the end of 4th exposure the patient was totally out of morphine. After the third exposure, the bowls were normalised, and by the 5th exposure the urine output increased, food intake increased nausea and vomiting stopped.

[0108] The patient developed excessive hunger, and was consuming excessive food, this soon turned to painful hunger and the patient was continuously eating. A blood test was done to assess, Blood Glucose, Liver function and blood count. This reveled that glucose was normal, Liver function was normal. The patient was put on Omeprazole, to regulate acid secretion and soon hunger was under control. An MRI (FIG. 7) scan was done after 15 exposures which indicated that the tumor has shown some non-specific changes in contrast at its core.
 
[0109] The exposures were continued until 28th day. On the 30th day a blood test was done to assess the blood count and other parameters. It was found that the patients Haemoglobin had increased from 10.1 before the start of the treatment, to 12.5 after the treatment. The patient had put on 6 kgs of weight in 28 days.

[0110] An MRI (FIG. 8) after the completion of the exposures, i.e. on the 30th Day, showed that there is clear evidence of Tissue Necrosis from the core of the Tumor covering approximately about 45% of the tumor volume. It is expected that the tissue necrosis would continue until the entire tumor is destroyed.

[0111] The patient is now symptom free, and has resumed his duties as a manager in a government Insurance Company, after 4 months.

[0112] He is being followed up every three days from the last 45 days. He is now not on any medications. The patient will report back for another MRI scan, to assess the tumor in the due course.

CONCLUSION

[0113] Considering the above two cases as example, picked out of a larger study, shows that Rotational Field Quantum Magnetic Resonance, will be a new tissue engineering method for regeneration and degeneration of human tissues that would aid in fighting many diseased states.

[0114] This new invention will go a long way in the years to come, as this is the first step to communicate with the living cell and alter their functional process. As seen above, the invention is simple to use, non-pharmaceutical and natural. This is the first time that there is a clear establishment of communication at the cellular level.





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