Stuff & Stuff -- March 2017 -- Sci-Tech News & Olds

RIP Jerry Decker

Jerry Decker, founder of KeelyNet [ http://www.keelynet.com ], died on June 14 of a systemic blood infection.

Jerry was the internet's godfather of alt-sci, and he will be missed. His networking brought many like minds together and created a huge archive of sci-tech informations that has inspired many thousands of researchers.

https://www.cia.gov/library/readingroom/document/cia-rdp96-00792r000500380002-0

REVERSE SPEECH HIDDEN MESSAGES IN HUMAN COMMUNICATION

NEW !!! AMAZING !!!

VISIT THE REX RESEARCH

" SPECIAL SNOWFLAKE SAFE SPACE "

This warm, kind, gentle, sensitive webpage offers gratuitous Solace and Succor to Suffering Souls.

https://www.specialsnowflakesafespace.com

NEW !!! AMAZING !!!

VISIT THE REX RESEARCH

" Judi-Christo-Muslamic Cluster-Splooge Zone "

This cold, cruel, dangerously insensitive webpage proffers gratuitous Psychopathy to Suffering Souls.

https://www.specialsnowflakesafespace.com

http://alternativemediasyndicate.com/2017/06/17/senate-bill-force-citizens-register-cash-not-bank-violators-get-10-years-prison/

Congress To Force Citizens to Register Cash and Bitcoin, Violators Get 10 Years in Prison

Congress submits bill making it illegal to hold cash, Bitcoin, or other assets outside of a bank without informing them in writing

https://www.congress.gov/bill/115th-congress/senate-bill/1241/text#toc-idea0e9489fc8f46379f95bb56c8bbbda5

S.1241 - Combating Money Laundering, Terrorist Financing, and Counterfeiting Act of 2017

https://www.youtube.com/watch?time_continue=361&v=7-n4bxxn9gA
Glass Shotgun Slugs – Your Worst Nightmare

https://www.youtube.com/watch?v=W-8Dp_sXXlM

PVC Compound Slingshot Bowfishing To Shoot Huge Fish -Make n Use

https://www.youtube.com/watch?v=3n8B79bOJUc

PVC Pipe Compound BowFishing To Shoot Fish -Khmer Fishing At Siem Reap Cambodia

https://www.youtube.com/watch?v=FTCCSMOz3-o

How To Make A 45 Pound PVC Slingbow for $5 Zommbie Defence , fishing , compact

https://www.youtube.com/watch?v=vsyO8qdqLm0

Non-Newtonian Fluid Shotgun Bullets

Lots of interesting thoughts in this interview re : Hidden Civilization

https://www.youtube.com/watch?v=nP-8fgP2yLo

CATHERINE AUSTIN FITTS - BREAKAWAY TRUTH: A TALE OF TWO CIVILIZATIONS - DARK JOURNALIST

http://www.thecommonsenseshow.com/2017/06/21/the-necessary-shift-from-activism-to-survival/

The Necessary Shift From Activism to Survival

http://www.naturalnews.com/2017-06-20-health-ranger-posts-heavy-metals-test-results-for-364-more-water-samples-from-across-america-lead-copper-arsenic-and-aluminum-numbers.html

Health Ranger posts heavy metals test results for 364 more water samples from across America: Lead, Copper, Arsenic and Aluminum numbers

...You can view the 2017 water sample test results chart, sorted by zip code, at the following link at the Natural Science Journal:

http://naturalsciencejournal.org/ICP-MS-Analysis-364-Municipal-Water-Samples.html

Some of the more notable results we found are listed below. Many of these results violate EPA water quality limits and expose potentially millions of Americans to toxic heavy metals in municipal water. (Why is nobody else conducting these tests? Why does the EPA cover this up?)

413 ppb aluminum in zip code 06897
1048 ppb aluminum in zip code 18371
704 ppb copper in zip code 44035
1117 ppb copper in zip code 51025
1528 ppb copper in zip code 55418
41 ppb lead in zip code 64836
A shocking 120 ppb lead in zip code 85086
15 ppb arsenic in zip code 86351
51 ppb lead in zip code 92103...

https://arxiv.org/pdf/1609.03153.pdf
https://www.nature.com/articles/nphys4147.epdf

Room-temperature superfluidity in a polariton condensate

Giovanni Lerario, et al.

https://share.polymtl.ca/alfresco/service/api/path/content;cm:content/workspace/SpacesStore/Company%20Home/Sites/salle-de-presse---web/documentLibrary/communiques_de_presse/2017/Superfluide_lumiere/CP_Superfluide_lumiere_ANG.pdf?a=true&guest=true

Listen up !

https://www.youtube.com/watch?v=Mtgxy07t9qY

Clif High Webbot 2017 Clif High Talk about Gold, Silver, Bitcoin, Political Scum

https://www.youtube.com/watch?v=oxM6zbccT5s

Bruce Lee's FULL LENGTH fight !

https://www.youtube.com/watch?v=7CgbQaschFk

Bruce Lee Beats Karate Black Belt BLINDFOLDED !

https://www.youtube.com/watch?v=-fI8lkP00_E

Bruce Lee Punches Karate Grandmaster With The 1 Inch Punch!

https://www.youtube.com/watch?v=oMK0dEKWJdY

3D Printed AtmoMotor HV Atmospheric Motor - Wireless Energy

A high torque atmospheric motor. First tests underway. Also features the build process.

https://www.youtube.com/watch?v=xNgpMkwX5qY

Atmospheric Powered Motor 2.0

https://www.youtube.com/watch?v=2rVdEhyMR6A

How Powering with Atmospheric Electricity Works

Henri Devaux : Photograping Smells

https://books.google.com/books?id=nykDAAAAMBAJ
Popular Science - Feb 1939 - Page 116 - Vol. 134, No. 2 -

Henri Devaux of France at work his laboratory. Photographing Smells.

FOR the first time, an odor has had its picture taken. By an ingenious technique that...

http://ccp-emuseum.catnet.arizona.edu/view/objects/asitem/People@4936/3?t:state:flow=6669e171-cad9-41be-886a-4b21c9190c1c

Dr. Henri Devaux : Rose Petal Exhaling Its Fragrance

https://www.youtube.com/watch?v=GiiO8nFvtRM

21 Signs Of A False Flag And/Or HOAX!

https://www.youtube.com/watch?v=dBH0ywUUx5k

The Truth About Dalai Lama
Stefan Molyneux

Sources: http://www.fdrurl.com/dalai-lama

http://nypost.com/2017/06/13/the-human-brain-sees-the-world-as-an-11-dimensional-multiverse/

The human brain sees the world as an 11-dimensional multiverse

By Michael Blaustein

New research suggests that the human brain is almost beyond comprehension because it doesn’t process the world in two dimensions or even three. No, the human brain understands the visual world in up to 11 different dimensions.

The astonishing discovery helps explain why even cutting-edge technologies like functional MRIs have such a hard time explaining what is going on inside our noggins. In a functional MRI, brain activity is monitored and represented as a three-dimensional image that changes over time. However, if the brain is actually working in 11 dimensions, looking at a 3D functional MRI and saying that it explains brain activity would be like looking at the shadow of a head of a pin and saying that it explains the entire universe, plus a multitude of other dimensions.

The team of scientists led by a group from Scientists at the École Polytechnique Fédérale de Lausanne in Switzerland detected the previously unknown complexities of the brain while working on the Blue Brain Project. The project’s goal is to create a biologically accurate recreation of the human brain.

During their research, the scientists created simulations of the brain and applied an advanced form of mathematics, called algebraic topology, to their computer-generated models.

“Algebraic topology is like a telescope and microscope at the same time. It can zoom into networks to find hidden structures — the trees in the forest — and see the empty spaces — the clearings — all at the same time,” said study author Kathryn Hess.

What Hess and her colleagues found was that the brain processes visual information by creating multi-dimensional neurological structures, called cliques, which disintegrate the instant they are understood, according to Newsweek who first reported on the research that was published in the journal Frontiers in Computational Neuroscience.

The cliques have up to 11 different dimensions and form in holes of space, called cavities. Once the brain understands the visual information, both the clique and cavity disappear.

The appearance of high-dimensional cavities when the brain is processing information means that the neurons in the network react to stimuli in an extremely organized manner,” said researcher Ran Levi.

“It is as if the brain reacts to a stimulus by building then razing a tower of multi-dimensional blocks, starting with rods (1D), then planks (2D), then cubes (3D), and then more complex geometries with 4D, 5D, etc. The progression of activity through the brain resembles a multi-dimensional sandcastle that materializes out of the sand and then disintegrates,” he said.

Henry Markram, director of Blue Brain Project, explained just how momentous a discovery the multi-dimensional structures could be.

“The mathematics usually applied to study networks cannot detect the high-dimensional structures and spaces that we now see clearly,” he said.

“We found a world that we had never imagined. There are tens of millions of these objects even in a small speck of the brain, up through seven dimensions. In some networks, we even found structures with up to 11 dimensions.”

http://journal.frontiersin.org/article/10.3389/fncom.2017.00048/full

Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function
Michael W. Reimann, et al.

The lack of a formal link between neural network structure and its emergent function has hampered our understanding of how the brain processes information. We have now come closer to describing such a link by taking the direction of synaptic transmission into account, constructing graphs of a network that reflect the direction of information flow, and analyzing these directed graphs using algebraic topology. Applying this approach to a local network of neurons in the neocortex revealed a remarkably intricate and previously unseen topology of synaptic connectivity. The synaptic network contains an abundance of cliques of neurons bound into cavities that guide the emergence of correlated activity. In response to stimuli, correlated activity binds synaptically connected neurons into functional cliques and cavities that evolve in a stereotypical sequence toward peak complexity. We propose that the brain processes stimuli by forming increasingly complex functional cliques and cavities.

http://www.medicalnewstoday.com/articles/317896.php

Fever in pregnancy tied to higher risk of autism
By Catharine Paddock PhD

A study of a large group of children found a link between raised risk of autism spectrum disorder and their mothers reporting fever during pregnancy. The link was strongest with fevers reported during the second trimester.

The study - led by the Mailman School of Public Health at Columbia University in New York City, NY - also found that the risk of autism increased in line with the number of fevers reported after 12 weeks of gestation - rising to 300 percent higher risk with reports of three or more fevers...

https://www.nature.com/mp/journal/vaop/ncurrent/full/mp2017119a.html
Molecular Psychiatry advance online publication 13 June 2017
doi: 10.1038/mp.2017.119

Prenatal fever and autism risk
M Hornig, et al.

Some studies suggest that prenatal infection increases risk of autism spectrum disorders (ASDs). This study was undertaken in a prospective cohort in Norway to examine whether we could find evidence to support an association of the prenatal occurrence of fever, a common manifestation of infection, with ASD risk. Prospective questionnaires provided maternal exposure data; case status was established from clinical assessments and registry linkages. In a large, prospectively ascertained cohort of pregnant mothers and their offspring, we examined infants born greater than or equal to32 weeks for associations between fever exposure in each trimester and ASD risk using logistic regression. Maternal exposure to second-trimester fever was associated with increased ASD risk, adjusting for presence of fever in other trimesters and confounders (adjusted odds ratio (aOR), 1.40; 95% confidence interval, 1.09–1.79), with a similar, but nonsignificant, point estimate in the first trimester. Risk increased markedly with exposure to three or more fever episodes after 12 weeks' gestation (aOR, 3.12; 1.28–7.63). ASD risk appears to increase with maternal fever, particularly in the second trimester. Risk magnified dose dependently with exposure to multiple fevers after 12 weeks' gestation. Our findings support a role for gestational maternal infection and innate immune responses to infection in the pathogenesis of at least some cases of ASD.

Vitamin C & Doxycycline vs Cancer

http://www.salford.ac.uk/news/articles/2017/vitamin-c-and-antibiotics-a-one-two-punch-for-knocking-out-cancer-stem-cells

Vitamin C and Antibiotics: A one-two “punch” for knocking-out cancer stem cells

CANCER stem cells, which fuel the growth of fatal tumours, can be knocked out by a one-two combination of antibiotics and Vitamin C in a new experimental strategy, published by researchers at the University of Salford, UK.

The antibiotic, Doxycycline, followed by doses of ascorbic acid (Vitamin C), were surprisingly effective in killing the cancer stem cells under laboratory conditions, according to the research published in the journal Oncotarget.

In boxing terms, this would be the equivalent of two blows delivered in rapid succession; a left-hand jab, followed by a right cross.

The researchers say their method offers a new explanation for how to prevent cancer cells from becoming treatment-resistant and how combinations therapies can be developed to overcome drug resistance.

Starve cancer cells

Professor Michael Lisanti, who designed the study, explained: “We now know that a proportion of cancer cells escape chemotherapy and develop drug resistance; we established this new strategy to find out how they do it.

“We suspected the answer lay in the fact that certain cancer cells – which we call metabolically flexible - are able to switch their fuel source. Thus, when the drug treatment reduces the availability of a particular nutrient, the flexible cancer cells can feed themselves with an alternative energy source.”

This new combination approach prevents cancer cells from changing their diet (metabolically inflexible), and effectively starves them, by preventing them from using any other available types of bio-fuels.

The team at the University of Salford’s Biomedical Research Centre, added Doxycycline in ever increasing doses over a three-month period, to induce metabolic inflexibility. The result was to leave the cancer cells alive, but severely attenuated and depleted, so that they would be much more susceptible to starvation, by a second metabolic “punch”.

Combination

First, the researchers inhibited the tumour cell mitochondria, by restricting the cancer cells only to glucose as a fuel source; then, they took away their glucose, effectively starving the cancer cells to death.

“In this scenario, Vitamin C behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the “powerhouse” of the cell, explained co-author Dr Federica Sotgia.

The Salford team recently showed Vitamin C to be up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, but they say that when Vitamin C is combined with an antibiotic, it is up to ten times more effective, making it nearly 100 times more effective than 2-DG.

As Doxycycline and Vitamin C are both relatively non-toxic, this could dramatically reduce the possible side-effects of anti-cancer therapy.

Clinical trials

The Salford team also identified eight other drugs that could be used as a “second-punch” after the antibiotic regime, including berberine (a natural product) – and a number of cheap non-toxic FDA approved drugs.

Professor Lisanti added: “This is further evidence that Vitamin C and other non-toxic compounds may have a role to play in the fight against cancer.

“Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis.”

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=18428&path[]=59195
doi: 10.18632/oncotarget.18428

Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

Ernestina Marianna De Francesco Gloria Bonuccelli, Marcello Maggiolini, Federica Sotgia and Michael P. Lisanti

Abstract

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The expression of four mitochondrial DNA encoded proteins (MT-ND3, MT-CO2, MT-ATP6 and MT-ATP8) is suppressed, by up to 35-fold. This high selection pressure metabolically synchronizes the surviving cancer cell sub-population towards a predominantly glycolytic phenotype, resulting in metabolic inflexibility. We directly validated this Doxycycline-induced glycolytic phenotype, by using metabolic flux analysis and label-free unbiased proteomics.

Next, we identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for metabolically targeting the Doxycycline-resistant CSC population (Atovaquone, Irinotecan, Sorafenib, Niclosamide, Chloroquine, and Stiripentol). This new combination strategy allows for the more efficacious eradication of CSCs with Doxycycline, and provides a simple pragmatic solution to the possible development of Doxycycline-resistance in cancer cells. In summary, we propose the combined use of i) Doxycycline (Hit-1: targeting mitochondria) and ii) Vitamin C (Hit-2: targeting glycolysis), which represents a new synthetic-lethal metabolic strategy for eradicating CSCs.

This type of metabolic Achilles’ heel will allow us and others to more effectively “starve” the CSC population...

A synthetic lethal strategy for eradicating DoxyR CSCs, using natural products (Vitamin C and Berberine) and other FDA-approved drugs

Next, we tested the efficacy of glycolysis inhibitors, such as 2-deoxy-glucose (2-DG) and Vitamin C (ascorbic acid). Treatment with 2-DG inhibited the propagation of DoxyR CSCs by > 90% at 10 mM and 100% at 20 mM (Figure 10). In addition, Vitamin C was more potent than 2-DG; it inhibited DoxyR CSC propagation by > 90% at 250 µM and 100% at 500 µM (Figure 10). As such, the IC-50 for Vitamin C in this context was between 100 to 250 µM, which are within the known achievable blood levels, when Vitamin C is taken orally. Previously, we showed that the IC-50 for Vitamin C was 1 mM for MCF7 CSC propagation [13]. Therefore, DoxyR CSCs are between 4- to 10-fold more sensitive to Vitamin C than control MCF7 CSCs, under identical assay conditions.

We also examined the efficacy of 4 other clinically-approved drugs that functionally behave as either OXPHOS inhibitors (Irinotecan, Sorafenib, Niclosamide) or glycolysis inhibitors (Stiripentol) (Figure 11). In this context, Stiripentol functions as an LDH inhibitor. Their rank order potency for inhibiting DoxyR CSC propagation is: Niclosamide (IC-50 ~ 100 nM) > Irinotecan (IC-50 ~ 500 nM) > Sorafenib (IC-50 ~ 0.5 to 1 µM) > Stiripentol (IC-50 ~ 10 to 50 µM).

Finally, we tested the efficacy of Berberine, which is a naturally occurring antibiotic that also behaves as an OXPHOS inhibitor. It was used as early as 3,000 B.C. in China, for medicinal purposes. Figure 11 shows that treatment with Berberine effectively inhibited the propagation of the DoxyR CSCs by > 50% at 1 µM and > 80% at 10 µM...

Discussion

In this report, we present new functional evidence to support a novel synthetic lethal strategy to eradicate CSCs. More specifically, we demonstrate that the use of Doxycycline, a clinically approved antibiotic, induces metabolic stress in cancer cells. This allows the remaining cancer cells to be synchronized towards a purely glycolytic phenotype, driving a form of metabolic inflexibility. This Doxycycline-driven aerobic glycolysis was further confirmed and validated, by employing high-resolution proteomics analysis and metabolic phenotyping. In addition, we discovered that both natural products and FDA-approved drugs could be re-purposed to eradicate the Doxycycline-resistant CSC population. These 9 small molecules included: Vitamin C, Berberine, 2-DG, Atovaquone, Irinotecan, Sorafenib, Niclosamide, Chloroquine, and Stiripentol.

Our new therapeutic strategy should provide for the more efficient eradication of CSCs using Doxycycline, as well as a practical means for solving the potential problem of Doxycycline resistance in CSCs. As such, we suggest a new synthetic lethal strategy for eradicating CSCs, by employing i) Doxycycline (to target mitochondria) and ii) Vitamin C (to target glycolysis) (Figure 12). Use of this combined metabolic strategy should help prevent CSCs from exploiting the essential nutrients that they normally derive from the tumor microenvironment.

Overcoming resistance to Doxycycline in cancer cells, using metabolic inflexibility, synthetic lethality and Vitamin C

Resistance to anti-cancer therapy remains as one of the key issues in cancer patient management. Treatment failure is regarded as an alarming outcome of numerous different therapeutic approaches. Indeed, the use of combination strategies aimed at hitting multiple aspects of tumor progression is currently considered as a promising tool to overcome resistance. Mounting evidence suggests that CSCs act as the main promoter of tumor recurrence and patient relapse [1-5]. Thus, a better understanding of the biological and biochemical behavior of CSCs during drug resistance may unveil new vulnerabilities, to be exploited in a therapeutic setting.

In this context, our data indicates that a metabolic shift from oxidative to glycolytic metabolism represents an escape mechanism for breast cancer cells chronically-treated with a mitochondrial stressor like Doxycycline, as mitochondrial dys-function leads to a stronger dependence on glucose.

Our current findings are in line with previous studies showing the highly plastic nature of CSCs allows them to adjust and adapt their metabolic environment, in order to maintain their distinctive properties, in a hostile tumor microenvironment, often characterized by an inadequate nutrient and oxygen supply (reviewed in [23]). Here, we have taken advantage of the glycolytic shift exhibited by DoxyR CSCs, as we have used several glycolysis inhibitors with the aim to turn their strict metabolic inflexibility, into a lethal phenotype. Among the agents tested in the our study, Vitamin C has been demonstrated to selectively kill cancer cells in vitro and to inhibit tumor growth in experimental mouse models [24, 25]. Remarkably, many of these actions have been attributed to the ability of Vitamin C to act as a glycolysis inhibitor, by targeting GAPDH and depleting the NAD pool [22, 26, 27].

In this context, we have previously demonstrated that Vitamin C effectively inhibits 3D breast tumor spheroid formation, with an IC-50 of 1 mM, suggesting that this micronutrient also works as an inhibitor of CSCs [13], whose activity is critically dependent on an active mitochondrial TCA cycle and OXPHOS. In contrast, here we show that DoxyR CSCs are more vulnerable to the inhibitory effects of Vitamin C, at 4- to 10-fold lower concentrations, between 100 to 250 µM. These findings are further supported by clinical studies showing that the concurrent use of Vitamin C, with standard chemotherapy, reduces tumor recurrence and patient mortality [28, 29].

It is worth noting that Vitamin C plasma levels vary considerably with the route of administration. For instance, pharmacokinetic studies performed by different research groups have assessed that, after oral administration, Vitamin C plasma levels reach concentrations of ~70-220 µM [reviewed in reference #30], which represents the maximum tolerated oral dose. By contrast, Padayatty and co-workers found that, compared to oral intake, intravenous administration results in 30- to 70- fold higher plasma concentrations of Vitamin C [31]. Furthermore, consumption of 5 to 9 servings of fruits and vegetables per day allows plasma levels of Vitamin C to reach up to 80 µM at steady-state, with peak values of 220 µM [31]. Remarkably, an intravenous infusion of Vitamin C can reach plasma levels of 15,000 µM (i.e., 15 mM). Interestingly, doses of up to 50 grams per day, infused slowly, didn’t exhibit any toxic side effects on cancer patients [30]. These observations suggest that intravenous administration of Vitamin C may have a role in cancer treatment, as this route allows higher plasma concentrations than those achievable with the maximum tolerated oral dose.

Previous studies have demonstrated that Vitamin C behaves as a potent dietary antioxidant, as well as a pro-oxidant. This pro-oxidant activity results from Vitamin C’s action on metal ions, which generates free radicals and hydrogen peroxide, and is associated with cell toxicity. Of note, it has been shown that high-dose Vitamin C is more cytotoxic to cancer cells than to normal cells [32, 33]. This selectivity appears to be due to the higher catalase content observed in normal cells (~10-100 fold greater), as compared to tumor cells. Hence, Vitamin C may be regarded as a safe agent that selectively targets cancer cells.

A recent study performed on a panel of cancer cells (A431, Panc-1, HeLa, HT29, and MCF7) showed that Vitamin C only affects cell viability at concentration of ~3 to 10 mM [34], thus providing more evidence to support a lack of toxicity for low micromolar concentrations of Vitamin C.

Similarly, phase I and II clinical trials, designed to deliver high-dose intravenous Vitamin C, have shown a lack of toxic side effects for concentrations of up to 292 µM [35]. Taken together with these findings, our data suggest that Vitamin C’s action as a glycolytic inhibitor may represent a safe and effective strategy to be used in combination therapies, with conventional anticancer drugs, as well as with Doxycycline.

Because of our success with 2-DG and Vitamin C, we explored additional FDA-approved drugs with glycolysis-inhibiting activity that could be repurposed to eradicate CSC propagation, in combination with Doxycycline. For example, we demonstrated that the LDH enzyme inhibitor Stiripentol is also effective at targeting DoxyR CSCs; this drug is currently used clinically as an anti-epileptic in children.

We also further explored other suitable metabolic approaches to overcome Doxycycline resistance. In this context, we evaluated the efficacy of a panel of compounds that share the ability to impair mitochondrial function (OXPHOS), as a common off-target side-effect. This approach was based on the assumption that DoxyR cells, which exhibit altered oxidative metabolism, are extremely sensitive to the induction of additional mitochondrial dysfunction. These effective compounds included four FDA-approved drugs, such as Atovaquone, Irinotecan, Sorafenib, and Niclosamide, as well as the natural product Berberine.

Interestingly, we observed that Chloroquine also reduces the spheroid forming efficiency of DoxyR cells, indicating that inhibition of autophagy may represent another effective combination strategy, to sensitize breast cancer cells to the actions of Doxycycline.

We believe that the emerging functional relationship between metabolism and stemness, also known as “metabo-stemness” [36], holds great promise for the future of anti-cancer therapy. Thus, our novel findings may pave the way for the discovery and validation of more effective therapeutic strategies to fully eradicate CSCs, ultimately preventing treatment failure and minimizing metastatic dissemination.

Synergistic effects of Doxycycline and Vitamin C in the treatment of infectious disease states

Is there any precedent for the use of Doxycycline in combination with Vitamin C, in clinical trials? Interestingly, another group published a report on a randomized clinical trial of the effects of Vitamin C on dyspareunia and vaginal discharge, in women receiving Doxycycline and Triple sulfa for chlamydial cervicitis infections [37]. Importantly, they concluded that the cure rate was nearly 5-fold higher in the patients that received Vitamin C, together with antibiotic therapy [37]. So, the concurrent use of Doxycycline and Vitamin C, in the context of this infectious disease, appeared to be highly synergistic in patients.

Similarly, Goc et al., 2016, showed that Doxycycline is synergistic in vitro with certain phytochemicals and micronutrients, including Vitamin C, in the in vitro killing of the vegetative spirochete form of Borrelia spp., the causative agent underlying Lyme disease [38]. Vitamin C has also been shown to be synergistic with Tetracycline and Chloramphenicol, against the pathogenic bacteria, Pseudomonas aeruginosa [39]. However, in the above examples, no follow-up mechanistic studies were conducted to determine exactly why Doxycycline, Tetracycline and Vitamin C were somehow synergistic.

Conclusions

Numerous functional studies have now directly shown that mitochondria are an important new therapeutic target in cancer cells [3, 5, 8-21, 40-53]. Since Doxycycline, an FDA-approved antibiotic, behaves as an inhibitor of mitochondrial protein translation, it may have therapeutic value in the specific targeting of mitochondria in cancer cells. However, in this paper, we have identified a novel metabolic mechanism by which CSCs successfully escape from the anti-mitochondrial effects of Doxycycline, by assuming a purely glycolytic phenotype. Therefore, DoxyR CSCs are then more susceptible to other metabolic perturbations, because of their metabolic inflexibility, allowing for their eradication with natural products and other FDA-approved drugs. Thus, understanding the metabolic basis of Doxycycline-resistance has ultimately helped us to develop a new synthetic lethal strategy, for more effectively targeting CSCs.

CN104367584
Application of doxycycline in preparation of antitumor drugs

The invention provides an application of doxycycline in the preparation of antitumor drugs. The invention discloses that doxycycline has an antitumor activity, and is capable of inhibiting the tumor growth, tumor transfer and tumor invasion. Through the inv-vitro cellular level experiments and animal level experiments, people find that doxycycline can inhibit the growth and transfer of malignant tumors such as breast cancer, liver caner, melanoma, lung cancer, pancreas cancer, colon cancer, and the like. At the same time, the antitumor effect of doxycycline on a tumor-bearing mouse model is also very good. Moreover, doxycycline has multiple unique advantages, and can be accepted by patients more easily, and the drug effect on patients can be conveniently observed. The conventional tumor chemotherapy drug market will be changed by doxycycline. Doxycycline can be used regularly, and is a clinical drug capable of effectively inhibiting tumor transfer, invasion, and relapse.

US5668122
Method to treat cancer with tetracyclines

The present invention provides a method to treat susceptible cancers in humans comprising administering a cancer-treating amount of a member of the tetracycline family or a pharmaceutically acceptable salt thereof. Doxycycline, minocycline and tetracycline are utilized in the preferred method. Preferred methods of the present invention treat osteo-, breast, lung, prostate or Kaposi's cancers. Other aspects of the invention are described in the full application.

CN103006675
Application of doxycycline in preparing medicament for treating epithelial ovarian cancer

The invention relates to the technical field of medicines, and in particular relates to a novel application of doxycycline in preparing a medicament for treating epithelial ovarian cancer. Animal experiments and in-vitro cell experiments prove that doxycycline can inhibit multiplication and invasion of ovarian cancer cells, can prevent epithelial ovarian cancer cells from transferring, can promote apoptosis of epithelial ovarian cancer cells, has a remarkable inhibition effect to ovarian cancer cells, in particular platinum-based drug-resistance ovarian cancer cells, and can inhibit growth of ovarian cancer tissues and formation of ascites, so that doxycycline can be used for preparing a medicament for treating epithelial ovarian cancer. The invention provides a novel application to doxycycline, and compared with other chemotherapeutic drugs, doxycycline has the advantages of convenient administration and small side effect in the field of treating epithelial ovarian cancer.

https://news.uoguelph.ca/2017/06/red-onions-pack-cancer-fighting-punch-study-reveals/

Red Onions Pack a Cancer-Fighting Punch, Study Reveals

The next time you walk down the produce aisle of your grocery store, you may want to reach for red onions if you are looking to fight off cancer.

In the first study to examine how effective Ontario-grown onions are at killing cancer cells, U of G researchers have found that not all onions are created equal.

Engineering professor Suresh Neethirajan and PhD student Abdulmonem Murayyan tested five onion types grown in Ontario and discovered the Ruby Ring onion variety came out on top.

Onions as a superfood are still not well known. But they contain one of the highest concentrations of quercetin, a type of flavonoid, and Ontario onions boast particularly high levels of the compound compared to onions grown elsewhere in the world.

The Guelph study revealed that the red onion also contains high amounts of anthocyanin, which enriches the scavenging properties of quercetin molecules, said Murayyan, the study’s lead author.

“Anthocyanin is instrumental in providing colour to fruits and vegetables, so it makes sense that the red onions, which are darkest in colour, would have the most cancer-fighting power.”

Published recently in Food Research International, the study involved placing colon cancer cells in direct contact with quercetin extracted from the five onion varieties.

“We found onions are excellent at killing cancer cells,” said Murayyan. “Onions activate pathways that encourage cancer cells to undergo cell death. They promote an unfavourable environment for cancer cells and they disrupt communication between cancer cells, which inhibits growth.”

The researchers have also recently determined onions are effective at killing breast cancer cells.

“The next step will be to test the vegetable’s cancer-fighting powers in human trials,” said Murayyan.

These findings follow a recent study by the researchers on a new extraction technique that eliminates the use of chemicals, making the quercetin found in onions more suitable for consumption.

Other extraction methods use solvents that can leave a toxic residue which is then ingested in food, said Neethirajan.

“This new method that we tested to be effective only uses super-heated water in a pressurized container,” he said. “Developing a chemical-free extraction method is important because it means we can use onion’s cancer-fighting properties in nutraceuticals and in pill form.”

While consumers may already add this superfood to their salads and burgers as a preventive measure, the researchers expect onion extract will eventually be added to food products such as juice or baked goods and be sold in pill form as a type of natural cancer treatment.

Don't wait for Steven Greer :

https://www.youtube.com/watch?v=W_VbRy32-E4
https://www.youtube.com/watch?v=HJCHUgL8g70
https://www.youtube.com/watch?v=lBBEc4taMIg&feature=youtu.be

The Case for a Secret Space Program"
John Lenard Walson

Lots of intriguing details re: copper / barium / nervous system @ ~ 35:00+

https://www.youtube.com/watch?v=FMwurcLr_70

BLACK GOO, CHEMTRAILS REAL PROOF
Harald Kautz Vella

http://conspiracyrevelation.com/2015/08/a-i-black-goo-archons-nasas-deep-dark-secret/

A.I., BLACK GOO, ARCHONS, & NASA’s DEEP DARK SECRET

Fast essential transcription: For me it is quite easy to think in higher dimensioanl realms… For me it is quite easy to imagine higher dimensional biology, transdimensional beings and what I observed out of this point of view when I looked at Morgellons disease…it looks like a high dimensional being abusing humans to reproduce his own species and before these pseudomorphic fruiting bodies leave the body, they extract enough bio-photons from the forehead to ascend to a parallel dimension, from then on there are invisible, but they are still within the body and this now is pure science, this is what we found in the lab, this is what can be explained with the higher dimensional theories, but it also refers to mythology. If you have an invisible creature crawling through your body, trying to access your energetic system, this is very close to what one might call a demon or an archon and if you look at the descriptions of the archons, from 2500 years ago..the description of the biology is identical of what the morgellon victim was painting… It is described that they live as light parasites and this is basically what the entire black magic tradition is about...

Black Goo For Sale :

https://www.stockgumshoe.com/reviews/global-resource-hunter/whats-the-pyramus-compound-and-the-black-goo-fake-oil-pitched-by-jr-crooks/

What’s the “Pyramus Compound” and the “black goo” fake oil pitched by JR Crooks?

What's the "256 Billion Cash Grab" teased by Global Resource Hunter?

By Travis Johnson

Happy New Year!

It’s been a long time since I looked at a teaser ad from Global Resource Hunter over at Weiss Research, and it appears they’ve changed editors over the years — now heading it up is JR Crooks, who I don’t know much about (apparently his father is Jack Crooks, who I’ve seen mentioned a few times as a currency trader).

And, more to the point, a bunch of Gumshoe readers have asked me about the latest ad from JR Crooks, which is all about turning every dollar into $60 by riding a “soon to be legendary” wave as an innovation alters “every layer of society.”

So what’s he pitching? Well, we may not get a full answer for you today — the ad, which is selling Global Resource Hunter ($49) by pitching a “special report” called “The Pyramus Compound: Profiting From This $256.5 Billion Cash Grab,” is not all that detailed in hinting at the exact investments he’s recommending… but we can at least get you started, talk briefly about the “big picture” of the spiel, and name a few stocks that are likely in his report...

Interesting statements re: Antarctica Coal Mountains, & Corey Goode / David Wilcox :

https://www.youtube.com/watch?v=_W4iQarT1_8

Clif High Web Bot Predictions: Antarctica, Bitcoin, & Woo

http://www.zmescience.com/science/n6-antibody-hiv/

NIH isolates new antibody which neutralizes 98% of HIV strains in lab trials

by Alexandru Micu

An antibody produced by an HIV-positive patient has been found to neutralize 98 percent of all HIV strains it was pitted against, including most of those resistant to other antibodies of the same class...

[A] new antibody isolated by the US National Institutes of Health (NIH) called N6 has shown it can maintain its ability to recognize HIV even as the virus changes and breaks away from it. It is also an estimated 10 times more potent than VRC01, an antibody in the same class, which has passed to phase II clinical trials on human patients after protecting monkeys against the virus for six months.

“The discovery and characterisation of this antibody with exceptional breadth and potency against HIV provides an important new lead for the development of strategies to prevent and treat HIV infection,” said Anthony S. Fauci from the US National Institute of Allergy and Infectious Diseases...

N6 was tested on 181 different strains of HIV and destroyed 98% of the samples, including 16 out of 20 strains immune to other antibodies of its class. For comparison, VRC01 is only effective against 90% of HIV strains. N6 brings not only a wider scope but also much greater potency, the researchers report...

http://www.cell.com/immunity/abstract/S1074-7613%2816%2930438-1
Immunity, Volume 45, Issue 5, p1108–1121, 15 November 2016

“Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth”
Jinghe Huang, et al.

Highlights

CD4bs antibody N6 potently neutralizes 98% of HIV isolates
N6 potently neutralizes isolates resistant to other CD4bs antibodies
N6 evolved from an early intermediate within a VRC01-class antibody lineage
Unique structural features circumvent mechanisms of resistance to the VRC01 class

Summary

Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best available examples of the humoral immune response to HIV are providing important information for the development of therapies and prophylaxis for HIV-1 infection. Here, we report a CD4-binding site (CD4bs) antibody, named N6, that potently neutralized 98% of HIV-1 isolates, including 16 of 20 that were resistant to other members of its class. N6 evolved a mode of recognition such that its binding was not impacted by the loss of individual contacts across the immunoglobulin heavy chain. In addition, structural analysis revealed that the orientation of N6 permitted it to avoid steric clashes with glycans, which is a common mechanism of resistance. Thus, an HIV-1-specific bNAb can achieve potent, near-pan neutralization of HIV-1, making it an attractive candidate for use in therapy and prophylaxis.

http://fieldguide.gizmodo.com/how-to-spot-and-remove-stalkerware-1796167351

How to Spot and Remove Stalkerware
David Nield

https://www.theguardian.com/science/2017/jun/01/scientists-discover-how-the-brain-recognises-faces-by-reading-monkeys-minds

Scientists discover how the brain recognises faces – by reading monkey's minds

Using brain waves researchers were able to make almost perfect replicas of human faces shown to monkeys – raising prospect of thoughts being accessible to exploration

https://www.intellihub.com/newly-discovered-jade-tablets-depict-interaction-of-advanced-alien-life-with-ancient-maya/

Newly discovered ‘Jade tablets’ depict interaction of advanced alien life with ancient Maya

Priceless discovery documents presence of advance alien life on Earth and their interactions with the Maya

By Shepard Ambellas

UPDATE 14 JUNE

Listen up !

https://www.youtube.com/watch?v=Mtgxy07t9qY

Clif High Webbot 2017 Clif High Talk about Gold, Silver, Bitcoin, Political Scum

https://www.youtube.com/watch?v=FTHJfwWOBkY

11 BRILLIANT AND EASY KNIFE HACKS

https://www.youtube.com/watch?v=oMK0dEKWJdY

3D Printed AtmoMotor HV Atmospheric Motor - Wireless Energy

A high torque atmospheric motor. First tests underway. Also features the build process.

https://www.youtube.com/watch?v=xNgpMkwX5qY

Atmospheric Powered Motor 2.0

https://www.youtube.com/watch?v=2rVdEhyMR6A

How Powering with Atmospheric Electricity Works

Henri Devaux : Photographing Smells

https://books.google.com/books?id=nykDAAAAMBAJ
Popular Science - Feb 1939 - Page 116 - Vol. 134, No. 2 -

Henri Devaux of France at work his laboratory. Photographing. Smells. FOR the first time, an odor has had its picture taken. By an ingenious technique that...

http://ccp-emuseum.catnet.arizona.edu/view/objects/asitem/People@4936/3?t:state:flow=6669e171-cad9-41be-886a-4b21c9190c1c

Dr. Henri Devaux : Rose Petal Exhaling Its Fragrance

https://www.youtube.com/watch?v=GiiO8nFvtRM

21 Signs Of A False Flag And/Or HOAX!

Bravo !!! Encore !!!!

https://www.youtube.com/watch?v=L051v3NC0F4&index=3&list=RDIPeo_X7hVe8

2CELLOS - The Show Must Go On

https://www.youtube.com/watch?v=dBH0ywUUx5k

The Truth About Dalai Lama
Stefan Molyneux

Sources: http://www.fdrurl.com/dalai-lama

http://nypost.com/2017/06/13/the-human-brain-sees-the-world-as-an-11-dimensional-multiverse/

The human brain sees the world as an 11-dimensional multiverse
By Michael Blaustein

New research suggests that the human brain is almost beyond comprehension because it doesn’t process the world in two dimensions or even three. No, the human brain understands the visual world in up to 11 different dimensions.

The astonishing discovery helps explain why even cutting-edge technologies like functional MRIs have such a hard time explaining what is going on inside our

noggins. In a functional MRI, brain activity is monitored and represented as a three-dimensional image that changes over time. However, if the brain is actually working in 11 dimensions, looking at a 3D functional MRI and saying that it explains brain activity would be like looking at the shadow of a head of a pin and saying that it explains the entire universe, plus a multitude of other dimensions.

The team of scientists led by a group from Scientists at the École Polytechnique Fédérale de Lausanne in Switzerland detected the previously unknown complexities of the brain while working on the Blue Brain Project. The project’s goal is to create a biologically accurate recreation of the human brain.

During their research, the scientists created simulations of the brain and applied an advanced form of mathematics, called algebraic topology, to their computer-generated models.

“Algebraic topology is like a telescope and microscope at the same time. It can zoom into networks to find hidden structures — the trees in the forest — and see the empty spaces — the clearings — all at the same time,” said study author Kathryn Hess.

What Hess and her colleagues found was that the brain processes visual information by creating multi-dimensional neurological structures, called cliques, which disintegrate the instant they are understood, according to Newsweek who first reported on the research that was published in the journal Frontiers in Computational Neuroscience.

The cliques have up to 11 different dimensions and form in holes of space, called cavities. Once the brain understands the visual information, both the clique and cavity disappear.

The appearance of high-dimensional cavities when the brain is processing information means that the neurons in the network react to stimuli in an extremely organized manner,” said researcher Ran Levi.

“It is as if the brain reacts to a stimulus by building then razing a tower of multi-dimensional blocks, starting with rods (1D), then planks (2D), then cubes (3D), and then more complex geometries with 4D, 5D, etc. The progression of activity through the brain resembles a multi-dimensional sandcastle that materializes out of the sand and then disintegrates,” he said.

Henry Markram, director of Blue Brain Project, explained just how momentous a discovery the multi-dimensional structures could be.

“The mathematics usually applied to study networks cannot detect the high-dimensional structures and spaces that we now see clearly,” he said.

“We found a world that we had never imagined. There are tens of millions of these objects even in a small speck of the brain, up through seven dimensions. In some networks, we even found structures with up to 11 dimensions.”

http://journal.frontiersin.org/article/10.3389/fncom.2017.00048/full

Cliques of Neurons Bound into Cavities Provide a Missing Link between Structure and Function
Michael W. Reimann, et al.

http://www.medicalnewstoday.com/articles/317896.php

Fever in pregnancy tied to higher risk of autism
By Catharine Paddock PhD

Prenatal fever and autism risk
M Hornig, et al.

Vitamin C & Doxycycline vs Cancer

http://www.salford.ac.uk/news/articles/2017/vitamin-c-and-antibiotics-a-one-two-punch-for-knocking-out-cancer-stem-cells

Vitamin C and Antibiotics: A one-two “punch” for knocking-out cancer stem cells

Abstract

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The expression of four mitochondrial DNA encoded proteins (MT-ND3, MT-CO2, MT-ATP6 and MT-ATP8) is suppressed, by up to 35-fold. This high selection pressure metabolically synchronizes the surviving cancer cell sub-population towards a predominantly glycolytic phenotype, resulting in metabolic inflexibility. We directly validated this Doxycycline-induced glycolytic phenotype, by using metabolic flux analysis and label-free unbiased proteomics.

Next, we identified two natural products (Vitamin C and Berberine) and six clinically-approved drugs, for metabolically targeting the Doxycycline-resistant CSC population (Atovaquone, Irinotecan, Sorafenib, Niclosamide, Chloroquine, and Stiripentol). This new combination strategy allows for the more efficacious eradication of CSCs with Doxycycline, and provides a simple pragmatic solution to the possible development of Doxycycline-resistance in cancer cells. In summary, we propose the combined use of i) Doxycycline (Hit-1: targeting mitochondria) and ii) Vitamin C (Hit-2: targeting glycolysis), which represents a new synthetic-lethal metabolic strategy for eradicating CSCs.

This type of metabolic Achilles’ heel will allow us and others to more effectively “starve” the CSC population...

A synthetic lethal strategy for eradicating DoxyR CSCs, using natural products (Vitamin C and Berberine) and other FDA-approved drugs

Next, we tested the efficacy of glycolysis inhibitors, such as 2-deoxy-glucose (2-DG) and Vitamin C (ascorbic acid). Treatment with 2-DG inhibited the propagation of DoxyR CSCs by > 90% at 10 mM and 100% at 20 mM (Figure 10). In addition, Vitamin C was more potent than 2-DG; it inhibited DoxyR CSC propagation by > 90% at 250 µM and 100% at 500 µM (Figure 10). As such, the IC-50 for Vitamin C in this context was between 100 to 250 µM, which are within the known achievable blood levels, when Vitamin C is taken orally. Previously, we showed that the IC-50 for Vitamin C was 1 mM for MCF7 CSC propagation [13].

Therefore, DoxyR CSCs are between 4- to 10-fold more sensitive to Vitamin C than control MCF7 CSCs, under identical assay conditions.

We also examined the efficacy of 4 other clinically-approved drugs that functionally behave as either OXPHOS inhibitors (Irinotecan, Sorafenib, Niclosamide) or glycolysis inhibitors (Stiripentol) (Figure 11). In this context, Stiripentol functions as an LDH inhibitor. Their rank order potency for inhibiting DoxyR CSC propagation is: Niclosamide (IC-50 ~ 100 nM) > Irinotecan (IC-50 ~ 500 nM) > Sorafenib (IC-50 ~ 0.5 to 1 µM) > Stiripentol (IC-50 ~ 10 to 50 µM).

Finally, we tested the efficacy of Berberine, which is a naturally occurring antibiotic that also behaves as an OXPHOS inhibitor. It was used as early as 3,000 B.C. in China, for medicinal purposes. Figure 11 shows that treatment with Berberine effectively inhibited the propagation of the DoxyR CSCs by > 50% at 1 µM and > 80% at 10 µM...

Discussion

In this report, we present new functional evidence to support a novel synthetic lethal strategy to eradicate CSCs. More specifically, we demonstrate that the use of Doxycycline, a clinically approved antibiotic, induces metabolic stress in cancer cells. This allows the remaining cancer cells to be synchronized towards a purely glycolytic phenotype, driving a form of metabolic inflexibility. This Doxycycline-driven aerobic glycolysis was further confirmed and validated, by employing high-resolution proteomics analysis and metabolic phenotyping. In addition, we discovered that both natural products and FDA-approved drugs could be re-purposed to eradicate the Doxycycline-resistant CSC population. These 9 small molecules included: Vitamin C, Berberine, 2-DG, Atovaquone, Irinotecan, Sorafenib, Niclosamide, Chloroquine, and Stiripentol.

Our new therapeutic strategy should provide for the more efficient eradication of CSCs using Doxycycline, as well as a practical means for solving the potential problem of Doxycycline resistance in CSCs. As such, we suggest a new synthetic lethal strategy for eradicating CSCs, by employing i) Doxycycline (to target mitochondria) and ii) Vitamin C (to target glycolysis) (Figure 12). Use of this combined metabolic strategy should help prevent CSCs from exploiting the essential nutrients that they normally derive from the tumor microenvironment.

Overcoming resistance to Doxycycline in cancer cells, using metabolic inflexibility, synthetic lethality and Vitamin C

Resistance to anti-cancer therapy remains as one of the key issues in cancer patient management. Treatment failure is regarded as an alarming outcome of numerous different therapeutic approaches. Indeed, the use of combination strategies aimed at hitting multiple aspects of tumor progression is currently considered as a promising tool to overcome resistance. Mounting evidence suggests that CSCs act as the main promoter of tumor recurrence and patient relapse [1-5]. Thus, a better understanding of the biological and biochemical behavior of CSCs during drug resistance may unveil new vulnerabilities, to be exploited in a therapeutic setting.

In this context, our data indicates that a metabolic shift from oxidative to glycolytic metabolism represents an escape mechanism for breast cancer cells chronically-treated with a mitochondrial stressor like Doxycycline, as mitochondrial dys-function leads to a stronger dependence on glucose.

Our current findings are in line with previous studies showing the highly plastic nature of CSCs allows them to adjust and adapt their metabolic environment, in order to maintain their distinctive properties, in a hostile tumor microenvironment, often characterized by an inadequate nutrient and oxygen supply (reviewed in [23]). Here, we have taken advantage of the glycolytic shift exhibited by DoxyR CSCs, as we have used several glycolysis inhibitors with the aim to turn their strict metabolic inflexibility, into a lethal phenotype. Among the agents tested in the our study, Vitamin C has been demonstrated to selectively kill cancer cells in vitro and to inhibit tumor growth in experimental mouse models [24, 25]. Remarkably, many of these actions have been attributed to the ability of Vitamin C to act as a glycolysis inhibitor, by targeting GAPDH and depleting the NAD pool [22, 26, 27].

In this context, we have previously demonstrated that Vitamin C effectively inhibits 3D breast tumor spheroid formation, with an IC-50 of 1 mM, suggesting that this micronutrient also works as an inhibitor of CSCs [13], whose activity is critically dependent on an active mitochondrial TCA cycle and OXPHOS. In contrast, here we show that DoxyR CSCs are more vulnerable to the inhibitory effects of Vitamin C, at 4- to 10-fold lower concentrations, between 100 to 250 μM. These findings are further supported by clinical studies showing that the concurrent use of Vitamin C, with standard chemotherapy, reduces tumor recurrence and patient mortality [28, 29].

It is worth noting that Vitamin C plasma levels vary considerably with the route of administration. For instance, pharmacokinetic studies performed by different research groups have assessed that, after oral administration, Vitamin C plasma levels reach concentrations of ~70-220 μM [reviewed in reference #30], which represents the maximum tolerated oral dose. By contrast, Padayatty and co-workers found that, compared to oral intake, intravenous administration results in 30- to 70- fold higher plasma concentrations of Vitamin C [31]. Furthermore, consumption of 5 to 9 servings of fruits and vegetables per day allows plasma levels of Vitamin C to reach up to 80 μM at steady-state, with peak values of 220 μM [31]. Remarkably, an intravenous infusion of Vitamin C can reach plasma levels of 15,000 μM (i.e., 15 mM). Interestingly, doses of up to 50 grams per day, infused slowly, didn’t exhibit any toxic side effects on cancer patients [30]. These observations suggest that intravenous administration of Vitamin C may have a role in cancer treatment, as this route allows higher plasma concentrations than those achievable with the maximum tolerated oral dose.

Previous studies have demonstrated that Vitamin C behaves as a potent dietary antioxidant, as well as a pro-oxidant. This pro-oxidant activity results from Vitamin C’s action on metal ions, which generates free radicals and hydrogen peroxide, and is associated with cell toxicity. Of note, it has been shown that high-dose Vitamin C is more cytotoxic to cancer cells than to normal cells [32, 33]. This selectivity appears to be due to the higher catalase content observed in normal cells (~10-100 fold greater), as compared to tumor cells. Hence, Vitamin C may be regarded as a safe agent that selectively targets cancer cells.

A recent study performed on a panel of cancer cells (A431, Panc-1, HeLa, HT29, and MCF7) showed that Vitamin C only affects cell viability at concentration of ~3 to 10 mM [34], thus providing more evidence to support a lack of toxicity for low micromolar concentrations of Vitamin C.

Similarly, phase I and II clinical trials, designed to deliver high-dose intravenous Vitamin C, have shown a lack of toxic side effects for concentrations of up to 292 μM [35]. Taken together with these findings, our data suggest that Vitamin C’s action as a glycolytic inhibitor may represent a safe and effective strategy to be used in combination therapies, with conventional anticancer drugs, as well as with Doxycycline.

Because of our success with 2-DG and Vitamin C, we explored additional FDA-approved drugs with glycolysis-inhibiting activity that could be repurposed to eradicate CSC propagation, in combination with Doxycycline. For example, we demonstrated that the LDH enzyme inhibitor Stiripentol is also effective at targeting DoxyR CSCs; this drug is currently used clinically as an anti-epileptic in children.

We also further explored other suitable metabolic approaches to overcome Doxycycline resistance. In this context, we evaluated the efficacy of a panel of compounds that share the ability to impair mitochondrial function (OXPHOS), as a common off-target side-effect. This approach was based on the assumption that DoxyR cells, which exhibit altered oxidative metabolism, are extremely sensitive to the induction of additional mitochondrial dysfunction. These effective compounds included four FDA-approved drugs, such as Atovaquone, Irinotecan, Sorafenib, and Niclosamide, as well as the natural product Berberine.

Interestingly, we observed that Chloroquine also reduces the spheroid forming efficiency of DoxyR cells, indicating that inhibition of autophagy may represent another effective combination strategy, to sensitize breast cancer cells to the actions of Doxycycline.

We believe that the emerging functional relationship between metabolism and stemness, also known as “metabo-stemness” [36], holds great promise for the future of anti-cancer therapy. Thus, our novel findings may pave the way for the discovery and validation of more effective therapeutic strategies to fully eradicate CSCs, ultimately preventing treatment failure and minimizing metastatic dissemination.

Synergistic effects of Doxycycline and Vitamin C in the treatment of infectious disease states

Is there any precedent for the use of Doxycycline in combination with Vitamin C, in clinical trials? Interestingly, another group published a report on a randomized clinical trial of the effects of Vitamin C on dyspareunia and vaginal discharge, in women receiving Doxycycline and Triple sulfa for chlamydial cervicitis infections [37]. Importantly, they concluded that the cure rate was nearly 5-fold higher in the patients that received Vitamin C, together with antibiotic therapy [37]. So, the concurrent use of Doxycycline and Vitamin C, in the context of this infectious disease, appeared to be highly synergistic in patients.

Similarly, Goc et al., 2016, showed that Doxycycline is synergistic in vitro with certain phytochemicals and micronutrients, including Vitamin C, in the in vitro killing of the vegetative spirochete form of Borrelia spp., the causative agent underlying Lyme disease [38]. Vitamin C has also been shown to be synergistic with Tetracycline and Chloramphenicol, against the pathogenic bacteria, Pseudomonas aeruginosa [39]. However, in the above examples, no follow-up mechanistic studies were conducted to determine exactly why Doxycycline, Tetracycline and Vitamin C were somehow synergistic.

Conclusions

Numerous functional studies have now directly shown that mitochondria are an important new therapeutic target in cancer cells [3, 5, 8-21, 40-53]. Since Doxycycline, an FDA-approved antibiotic, behaves as an inhibitor of mitochondrial protein translation, it may have therapeutic value in the specific targeting of mitochondria in cancer cells. However, in this paper, we have identified a novel metabolic mechanism by which CSCs successfully escape from the anti-mitochondrial effects of Doxycycline, by assuming a purely glycolytic phenotype. Therefore, DoxyR CSCs are then more susceptible to other metabolic perturbations, because of their metabolic inflexibility, allowing for their eradication with natural products and other FDA-approved drugs. Thus, understanding the metabolic basis of Doxycycline-resistance has ultimately helped us to develop a new synthetic lethal strategy, for more effectively targeting CSCs.

CN104367584
Application of doxycycline in preparation of antitumor drugs

US5668122
Method to treat cancer with tetracyclines

CN103006675
Application of doxycycline in preparing medicament for treating epithelial ovarian cancer

US2006246016
Toothpaste containing anticancer agents

Inventor: BURZYNSKI STANISLAW

A novel dentifrice composition is provided for prevention or treatment of carcinoma of the oral cavity, caries and periodontal diseases of the oral cavity. The dentifrice composition contains a silica abrasive and medicinal agents useful in the treatment of human neoplastic disease. The medicinal agent is selected from the group consisting of 3-N-phenylacetylamino-2,6-piperidinedione, phenylacetylglutamine, phenylacetylisoglutamine, phenylbutyrate, phenylacetate, combinations thereof and pharmaceutically acceptable salts thereof. The components of the dentifrice composition act advantageously to allow the composition to remove plaque, tartar, and oral disease-causing bacteria.

https://www.sciencedaily.com/releases/2017/06/170605110809.htm

Splitting carbon dioxide using low-cost catalyst materials

A promising avenue for the future of clean energy is to store it in the form of carbon-based fuels produced from renewable sources, effectively enabling the clean use of liquid fuels such as gasoline. A first step is the electrolysis of carbon dioxide into oxygen and carbon monoxide, which can be subsequently be transformed into liquid fuels. But current CO-forming catalysts are either not selective enough or too expensive to be industrially viable. EPFL scientists have now developed an Earth-abundant catalyst based on copper-oxide nanowires modified with tin oxide. A solar-driven system setup using this catalyst was able to split CO2 with an efficiency of 13.4%. The work is published in Nature Energy, and is expected to help worldwide efforts to synthetically produce carbon-based fuels from CO2 and water.

The research was carried out by the lab of Michael Grätzel at EPFL. Grätzel is known worldwide for the invention of dye-sensitized solar cells ("Grätzel cells"). The new catalyst, developed by PhD student Marcel Schreier, postdoc Jingshan Luo, and several co-workers, is made by depositing atomic layers of tin oxide on copper oxide nanowires. Tin oxide suppresses the generation of side-products, which are commonly observed from copper oxide catalysts, leading to the sole production of CO in the electroreduction of CO2.

The catalyst was integrated into a CO2 electrolysis system and linked to a triple-junction solar cell (GaInP/GaInAs/Ge) to make a CO2 photo-electrolyzer. Importantly, the system uses the same catalyst as the cathode that reduces CO2 to CO and the anode that oxidizes water to oxygen through what is known as the "oxygen evolution reaction." The gases are separated with a bipolar membrane. Using only Earth-abundant materials to catalyze both reactions, this design keeps the cost of the system low.

The system was able to selectively convert CO2 to CO with an efficiency of 13.4% using solar energy. The catalyst also reached a Faradaic efficiency of up to 90%, which describes how efficiently electrical charge is transferred to the desired product in an electrocatalysis system like the one developed here. "The work sets a new benchmark for solar-driven CO2 reduction," says Luo.

"This is the first time that such a bi-functional and low-cost catalyst is demonstrated," adds Schreier. "Very few catalysts -- except expensive ones, like gold and silver -- can selectively transform CO2 to CO in water, which is crucial for industrial applications."

This work was carried out in collaboration with Jeremy Luterbacher's Laboratory of Sustainable and Catalytic Processing at EPFL. It was funded by Siemens AG, and a Marie Sklodowska-Curie Fellowship from the European Union's Seventh Framework Programme. It included a contribution from Abengoa Research in Spain.

DE102015219131
METHOD FOR PRODUCING A PHOTOELECTROCATALYSIS SYSTEM FOR THE PHOTOELECTROCHEMICAL UTILIZATION OF CARBON DIOXIDE

Inventor:GRÄTZEL MICHAEL / SCHREIER MARCEL [CH]

The invention relates to a method for producing a photoelectrocatalysis system for the photoelectrochemical utilization of carbon dioxide. In the system, carbon dioxide (CO2) is guided through a cathode chamber (KR) and brought in contact with a cathode (20), at least a first material is provided in the cathode chamber (KR), by means of which material a reduction reaction of carbon dioxide (CO2) into at least one hydrocarbon compound or into carbon monoxide (CO) can be catalyzed. In the production process, the catalyst is bonded to a mesoporous cathode surface.

WO2016128323
REDUCTION METHOD AND ELECTROLYSIS SYSTEM FOR ELECTROCHEMICAL CARBON DIOXIDE UTILIZATION

Inventor: GRÄTZEL MICHAEL, et al.

Disclosed are a reduction method and an electrolysis system for electrochemical carbon dioxide utilization. In this method, carbon dioxide (CO2) is conducted through a cathode chamber (CR) and contacted with a cathode (C), at least one first material is provided in or introduced into the cathode chamber (CR), by means of which the reduction reaction of carbon dioxide (CO2) to give at least one hydrocarbon compound or to give carbon monoxide (CO) can be catalysed, and at least one second material is introduced into the cathode chamber (CR), by means of which the reduction reaction can be co-catalysed, by virtue of said second material promoting a charge transfer from the cathode (C) to the first material. Preferably, catalyst and co-catalyst react to give a hydrido complex.

http://www.climeworks.com/

Climeworks is an ETH Spin-off company on the way to commercialize a patent pending, highly efficient technology for CO2 capture from ambient air

Global Warming Gas Can Now Be Extracted from Air and Resold
By Tereza Pultarova

Climeworks, a Swiss company, has opened a facility that can extract carbon dioxide from the atmosphere and resell it.

The world's first commercial facility that can extract carbon dioxide from the atmosphere and resell it for commercial purposes opened today (May 31) in Switzerland. This technology could help cut 1 percent of global fossil fuel emissions by 2025, according to the company that developed the new system.

Climeworks — a spin-off company from the Swiss science, technology, engineering and mathematics university ETH Zurich — built the plant near the village of Hinwil, at a site between a waste incineration plant and a large greenhouse.

Agricultural firm Gebrüder Meier Primanatura, which runs the greenhouse, will use the atmospheric carbon dioxide (CO2) to enhance the growth of lettuce, the company said. The waste incineration plant will provide the heat and renewable electricity needed to run the facility, the company added.

"The plant will capture 900 tons of CO2 per year," said Valentin Gutknecht, a business development manager at Climeworks. "The plant consists of several CO2 collectors, which are large boxes with filters inside. We blow air through these boxes for several hours, and after the filter is saturated, we heat the box up to 100 degrees [Celsius, or 212 degrees Fahrenheit] to extract the pure CO2 and regenerate the filters."...

US2017106330
DIRECT AIR CAPTURE DEVICE

A vacuum chamber (2) for a direct air capture process and enclosing an interior space (13) for housing an adsorber structure (1) is given comprising a contiguous circumferential wall structure (115) along an axis (15), which circumferential wall structure (115) in an axial direction is closed by an inlet and an outlet axial wall (116), respectively, both axial walls (116) comprising at least one closing stainless steel lid (6) allowing for, in an open position, gas to be circulated through the vacuum chamber (2) for passing an adsorber structure (1), and, in a closed position, to close the interior space (13) and to allow evacuation of the interior space (13) down to pressure of 500 mbarabs or less.

WO2017009241
AMINE-FUNCTIONALIZED FIBRILLATED CELLULOSE FOR CO2 ADSORPTION AND METHODS FOR MAKING SAME

A method for the preparation of amine- functionalized fibrillated cellulose involves the following steps (i) providing a suspension of fibrillated cellulose and adding a reagent for providing amine functionalities to the fibrillated cellulose; (ii) mixing the resulting suspension for a time span allowing for the formation of a homogeneous suspension of fibrillated cellulose mixed and/or adsorbed and/or reacted with said reagent for providing amine functionalities; (iii) drying the resulting homogeneous suspension from step (ii) resulting in surface amine-functionalized fibrillated cellulose and converting it into granular form with a bulk density of at least 150 kg/m3. The resultant granular fibrillated cellulose can be used for reversible CO2 adsorption from a gas mixture, in particular from exhaust gases or ambient air.

US5587191
Process for making highly oxygenated drinking water and drinking water made by the process

Inventor(s): DONSBACH KURT, et al.

A process for making highly oxygenated drinking water includes initially preparing a stabilized hydrogen peroxide solution, and then adding a suitably small quantity of it to natural drinking water. The stabilized hydrogen peroxide solution is made by adding a complex polymer in the form of polyvinylpyrrolidone to a quantity of diluted hydrogen peroxide. Various different molecular weight compositions of polyvinylpyrrolidone are added at different times according to a preferred technique.

BACKGROUND ART

It is well known that oxygen is essential for humans to sustain life. Pure oxygen, therefore, has been administered in various concentrations to facilitate breathing and to provide a sense of well-being.

While the benefits of oxygen are well known, the administration of high concentrations of oxygen to human beings, has been heretofore substantially limited to gaseous administrations only. However, if a suitable highly oxygenated drinking water could be made, then one could easily and conveniently receive the benefits of oxygen by merely drinking such water. In this regard, such highly oxygenated drinking water could be readily bottled, and marketed in a similar manner to other conventional bottled drinking water. Drinking water is currently marketed in transparent or translucent glass or plastic bottles.

However, due to the nature of oxygen, it would be extremely difficult to have highly oxygenated pure drinking water stored in a conventional bottle for long periods of time, and still retain its oxygenated nature at the same effective levels of concentration. In this regard, in order to have high quality drinking water, there can not be present any undesirably high concentrations of extraneous substances used to buffer or otherwise retain the oxygen.

Such buffering or other substances could make the drinking water undesirable for human consumption. It would not be desirable to significantly alter the taste or color of the natural drinking water. Also, of course, any additives must not render the natural drinking water toxic or otherwise deteriorate the quality of the drinking water below accepted standards. Any additives should not, in any manner, adversely affect the taste or other qualities of the water.

Also, the bottled drinking water must be able to be stored for long periods of time prior to consumption. Thus, in order to permit the oxygenated drinking water to stand for long periods of time, the oxygen content must remain in tact and be stable, and not undergo unwanted decomposition. Shelf life as well as storage and transportation, are important considerations for bottled drinking water. The storage in clear bottles could also present a significant problem. In this regard, light impinging on the oxygenated water could help accelerate decomposition of the highly oxygenated drinking water.

One approach to highly oxygenated drinking water could be to add a very small concentration of hydrogen peroxide to natural drinking water. With such an additive, the hydrogen peroxide would achieve the desired result of adding the desired oxygen to the water. However, it is well known that hydrogen peroxide is very unstable, especially in the presence of water. For example, reference may be made to U.S. Pat. Nos. 3,480,557; 5,077,047; 5,130,124; 5,206,385; and 5,312,619.

The foregoing patents disclose various additives for use with hydrogen peroxide for stabilizing it, when used as an antiseptic agent or the like. Thus, it is quite clear that hydrogen peroxide is unstable, and thus its level of concentration will become diminished with time, unless stabilization steps are taken. However, in order to stabilize hydrogen peroxide in very minute concentration levels in drinking water, the stabilization problem is far more difficult, and has been heretofore unattainable.

Hydrogen peroxide will disassociate in basic or acidic water conditions, as well as in the presence of metal ions. Thus, the pH of the water, as well as the metal ion content, is critical, should hydrogen peroxide be added. Since only minute quantities of hydrogen peroxide could be added to the drinking water to avoid alteration of the taste, the presence of impurities or other ingredients in the water create a highly unstable environment for the hydrogen peroxide.

If buffering or other additives are employed in an attempt to stabilize the hydrogen peroxide, the taste of the resulting treated drinking water could be altered in an undesirable manner. Also, in view of the requirement of bottling drinking water in clear containers, achieving the stability of hydrogen peroxide in drinking water is extremely difficult.

Thus, it would be extremely desirable to have a process for making highly oxygenated drinking water, which can be stored in clear containers for long periods of time and still maintain the desired levels of concentration of additional oxygen.

DISCLOSURE OF INVENTION

Therefore, the principal object of the present invention is to provide a new and improved method of formulating highly oxygenated drinking water, which can be stored for long periods of time, even in translucent containers, while maintaining desired levels of oxygenation.

Another object of the present invention is to provide such a new and improved method of formulating highly oxygenated drinking water and the drinking water made by the method, wherein hydrogen peroxide is an additive and yet undue hydrogen peroxide breakdown does not occur during storage prior to consumption.

Briefly, the above and further objects of the present invention are realized by providing a new and improved stabilized composition of highly oxygenated drinking water made by an inventive method.

A process for making highly oxygenated drinking water includes initially preparing a stabilized hydrogen peroxide solution, and then adding a suitably small quantity of it to natural drinking water. The stabilized hydrogen peroxide solution is made by adding a complex polymer in the form of polyvinylpyrrolidone to a quantity of diluted hydrogen peroxide. Various different molecular weight compositions of polyvinylpyrrolidone are added at different times according to a preferred technique.

It has been discovered, by following the inventive process, that highly oxygenated drinking water can be produced, and it contains many times more oxygen than conventional natural drinking water. The inventive drinking water can be stored conveniently in conventional clear bottles or other containers for long periods of time, without experiencing undue decomposition of the hydrogen peroxide. Also, the quality of the water is not compromised. The color and taste of the inventive drinking water is not adversely affected.

BEST MODE FOR CARRYING OUT THE INVENTION

The following examples were given to aid in understanding the invention, but it is to be understood that the particular procedures, conditions and materials of these examples are not intended as limitations of the present invention.

In accordance with the novel process of the present invention, a stabilized complex composition of hydrogen peroxide and is added to drinking water to formulate the inventive highly oxygenated water. According to the inventive process, the stabilized hydrogen peroxide solution is made by adding slowly a suitable quantity of a 35% by weight hydrogen peroxide concentrate to purified distilled water and mixing them together in small quantities at a time. The process requires the pouring of the concentrated 35% by weight H2 O2 over the purified water in a closed glass lined reactor with continuous agitation utilizing a stainless steel stirrer driven by a pneumatic or explosion proof motor until an aqueous solution containing 17.5% by weight hydrogen peroxide is formed.

At the end of the dilution process, a sample of the diluted 17.5% by weightH2 O2 is taken to verify pH, temperature, and concentration. Upon verification of the 17.5% solution, the resulting 17.5% hydrogen peroxide solution is refrigerated in the glass lined reactor by a recirculating pump. In this regard, the temperature of the 17.5% H2 O2 solution is lowered to a temperature between about 5 DEG C. and about 8 DEG C.

A 15% by weight charge of polyvinylpyrrolidone K15 having a molecular weight of about 10,000 is then added slowly to the aqueous 17.5% hydrogen peroxide solution and continuously agitated for a sufficient amount of time of about 60 minutes until the K15 PVP charge is completely dissolved in the aqueous H2 O2 solution. When the K15 PVP is dissolved, a sample of the resulting 15% K15 PVP-H2 O2 solution is taken to verify pH, temperature, density and the concentration of the H2 O2.

Next, a 50% by weight charge of polyvinylpyrrolidone K30 having a molecular weight of about 40,000 is then added slowly to the resulting aqueous 15% K15 PVP-H2 O2 complex solution with continuous agitation for another sufficient amount of time of about until the K30 PVP charge is completely dissolved therein. When the PVP is dissolved, a sample of the resulting 50% K30 PVP-H2 O2 solution is taken to verify pH, temperature, density and H2 O2 concentration.

After proper verification, a 5% by weight charge of polyvinylpyrrolidone having a molecular weight K90 is added to the resulting complex 50% K30 PVP-H2 O2 aqueous solution and agitated continuously for still yet another sufficient period of time of about 30 minutes until the K90 PVP charge is completely dissolved.

Thereafter, the refrigeration is terminated. Agitation of the resulting 5% K90 PVP-H2 O2 complex solution, however, is continued for at least another period of time of about 8 hours.

Thereafter, the resulting 5% K90 PVP-H2 O2 solution is held at rest for a rest period time of about 24 hours. The rest period allows bonding of the PVP molecules to the hydrogen peroxide, resulting in a stabilized aqueous PVP-H2 O2 solution containing about 17% by weight of hydrogen peroxide. Thereafter, the solution is again mixed for about another 2 hour period. The resulting solution at the end of the mixing period is a 17% stabilized H2 O2 solution. The solution is then sampled and tested to verify temperature, density and the concentration of the H2 O2 solution.

The resulting stabilized solution may then be stored in a clean, perfectly degreased, high density polyethylene plastic container until the highly oxygenated water product is to be produced.

Finally the highly oxygenated water is formulated for varying strengths of available oxygen in accordance with the following examples:

EXAMPLE I

For highly oxygenated water having four times the normal quantity of oxygen add 5 milligrams of the 17% stabilized H2 O2 solution per liter of purified distilled water to form a desired oxygenated water product having about 4% stabilized oxygen.

The resulting oxygenated water product is then transferred into a suitable number of clear plastic containers or the like for shipping and marketing purposes.

This process of making Example I has been found to provide the minimum amount of oxygen to achieve the objects of the invention.

EXAMPLE II

The composition of the present invention was tested to determine the maximum additive amount of the 17% stabilized PVP-H2 O2 solution to purified water without causing an unpleasant taste or a mucous lining irritation.

For highly oxygenated water having 20 times the normal quantity of oxygen add 25 milligrams or less of the stabilized aqueous PVP-H2 O2 solution per liter of purified distilled water and mix for at least 2 hours to form the desired oxygenated water product.

The resulting oxygenated water product is then transferred into a suitable number of clear plastic containers or the like for storage and shipping purposes.

In this example, it was noted that any greater quantity than 25 milligrams per liter of the stabilized aqueous PVP-H2 O2 solution results in an unpleasant taste and slight irritation to mucous linings.

The process of making Example II is the preferred process and has been found to provide the maximum amount of stable oxygen to achieve the objects of the invention.

EXAMPLE III

As a final example, a suitable vat is prepared according to well known sterile protocols. Next 50 gallons of purified distilled spring water is added to about 15 cc of a 17% stable hydrogen peroxide concentrate prepared according to the prior enumerated protocol as specified in Example 1. The resulting solution is then gently agitated for about 60 seconds with a sterile paddle. The resulting solution is a concentration of about 79 parts per millions of hydrogen peroxide which is suitable for human consumption.

In each of the above enumerated examples, the aqueous PVP-H2 O2 solutions serve as active oxygen agents, while the purified water components serve as vehicles for transporting captured oxygen molecules to the blood stream of a person drinking the oxygenated water solution. Thus, in use, the PVP-H2 O2 solution when consumed provides an immediate and beneficial oxygen lift.

In other uses, depending upon the total parts per million of H2 O2 concentrate added to purified water, the oxygenated water has a variety of applications. For example, the oxygenated water can function as a bacterial agent to preserve organic products such as meats, cheeses, vegetables, fruits and beverages from a significant number of bacteria without providing any undesired flavor and without altering the natural properties of the processed food and beverages.

While particular embodiments of the present invention have been disclosed, it is to be understood that various different modifications are possible and are contemplated within the true spirit and scope of the appended claims. There is no intention, therefore, of limitations to the exact abstract or disclosure herein presented.

https://fellowshipoftheminds.com/2017/06/04/research-finds-100-year-old-drug-suramin-reverses-symptoms-of-autism/
http://onlinelibrary.wiley.com/doi/10.1002/acn3.424/full

Low-dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial

Robert Naviaux, et al.

Abstract
Objective

No drug is yet approved to treat the core symptoms of autism spectrum disorder (ASD). Low-dose suramin was effective in the maternal immune activation and Fragile X mouse models of ASD. The Suramin Autism Treatment-1 (SAT-1) trial was a double-blind, placebo-controlled, translational pilot study to examine the safety and activity of low-dose suramin in children with ASD...

Suramin has many actions. One of its best-studied actions is as an inhibitor of purinergic signaling. It is the oldest member of a growing class of antipurinergic drugs (APDs) in development.[31] Suramin was first synthesized in 1916,[32] making it one of the oldest manmade drugs still in medical use. It is used to treat African sleeping sickness (trypanosomiasis), and remains on the World Health Organization list of essential medications. Concerns about the toxicity of high-dose suramin arose when the cumulative antitrypanosomal dose was increased 5 times or more over several months to treat AIDS or kill cancer cells during chemotherapy. When blood levels were maintained over 150 µmol/L for 3–6 months at a time to treat cancer, a number of dose-limiting side effects were described.[32] These included adrenal insufficiency, anemia, and peripheral neuropathy. In contrast, mouse studies suggested that high-dose suramin was not necessary to treat autism-like symptoms. These studies showed that low-dose suramin that produced blood levels of about 5–10 µM was effective in treating ASD-like symptoms and did not produce toxicity even when used for at least 4 months.[12, 14]...

Conclusions

The SAT-1 trial examined the effects of low-dose suramin or placebo in 10 children with autism spectrum disorder. No safety concerns were found. A two-compartment pharmacokinetic model permitted accurate forecasting of plasma drug levels from 1 h to 6 weeks after the infusion. Metabolomic studies confirmed the importance of the cell danger response (CDR)[8] and purinergic signaling.[12-14] A single intravenous dose of suramin was associated with improved scores for language, social interaction, and decreased restricted or repetitive behaviors measured by ADOS, ABC, ATEC, and CGI scores. None of these improvements occurred in the five children who received placebo. The generalizability of these findings is unknown. Future studies will be needed to confirm these findings in larger numbers of children with ASD, and to evaluate whether a few doses of suramin given over a few months are safe and might facilitate continued improvements.

https://www.veljkomilkovic.com/Docs/Jovan_Marjanovic_Basic_Principles_of_Overunity_Electro_Machines.pdf

Basic Priciples of Overunity Electro Machines

by

Jovan Maranovic

https://www.youtube.com/watch?v=T7xkGDLvXVY
https://www.youtube.com/watch?v=i2NWr6bRKWU

Bangladeshi Inventor invents AC ( Air Conditioner ) without cost and electricity

https://www.youtube.com/watch?v=hCJtjGxtrew

How to Make a Eco Air Cooler at home using Plastic Bottle ( Very Simple )

https://www.youtube.com/watch?v=6ScZiMiva9M

How To Cool Your House For 42 Cents A Day - Without A/C !!

CN105125576
Pharmaceutical composition containing titanium dioxide nanoparticles for preventing or treating cancer and application thereof

Inventor(s): XIANG GUOAN; ZHANG JINQIAN +

The invention provides a titanium dioxide nanoparticle (Tio2), and a pharmaceutical composition containing titanium dioxide nanoparticles for a non-photodynamic therapy, a non-photo thermal therapy and a non-sonodynamic therapy. The titanium dioxide nanoparticles can up-regulate channel protein alpha ENaC by regulating intracellular osmotic pressure, enable mitochondrial membrane potential to generate depolarization, induce mitochondrial pore protein VDAC1 to up-regulate, cause loss of Cyt-c and ATP, further activate caspase-3, can significantly promote apoptosis of tumor cells, inhibit the growth and proliferation of the tumor cells, so that S phase arrest occurs in a cell cycle, but a significant effect on a biological function of normal cell lines does not exist. The invention further provides a material containing the titanium dioxide nanoparticles for inhibiting tumour, and application of the titanium dioxide nanoparticles and a pharmaceutical composition thereof in treating and preventing the cancer.

UPDATED 2 JUNE

http://www.leadcold.com/technology.html

Lead Coolant for Nuclear Reactors

The use of lead as coolant for a nuclear reactor results in a so called "fast" neutron spectrum, which facilitates production of fissile fuel from U-238 with a conversion ratio larger than unity. Hence, fuel resources increase by two orders of magnitude, making nuclear power sustainable for thousands of years. Moreover, the fast neutron spectrum makes it possible to efficiently transmute the long-lived waste, such as americium and curium, into stable or short-lived fission products, with a minimum of negative side-effects on the safety of reactor and fuel-cycle facilities.

The most important advantage of lead is that it allows to combine a closure of the fuel cycle with an outstanding set of safety features, including:

No violent exothermic reaction with water
A very high boiling temperature, reducing the risk for loss of coolant
An excellent potential for decay heat removal by natural convection
Chemical retention of iodine and caesium, should a fuel failure occur
Inherent shielding of gamma radiation from fission products

Break-through innovation

A major disadvantage of using lead coolants is the risk for corrosion attack on fuel cladding and steam generator tubes. The high solubility of nickel in lead makes it necessary to form and maintain a protective oxide film on the surfaces of structural materials. However, chromium oxide scales forming on conventional stainless steels grow too thick after a year of full power operation in a lead-cooled reactor, making them mechanically unstable. Silicon or aluminium alloyed steels form thinner films of silicon and aluminium oxides, respectively, rendering the steels corrosion proof over longer exposure times. In Russia, a silicon alloyed steel has been developed for use in the SVBR-100 and BEST-300 reactors, whereas in Germany, a technique for surface alloying of steels with FeCrAlY has allowed to improve corrosion and fretting performance significantly.

In collaboration with Swedish steel industry, LeadCold materials experts have developed an aluminium alloyed steel (Fe-10Cr-4Al-Zr) which exhibits perfect corrosion resistance during exposure to lead for more than 19 000 hours at T = 550°C. The addition of zirconium reduces the risk for formation of chromium carbides that may be detrimental for corrosion resistance, and allows to keep the aluminium concentration at a level low enough to ensure weldability of the material. Based on this break-through innovation, LeadCold has designed the SEALER reactor for commercial power production in off-grid applications.

"Cold Electricity" ( cf. Moray, EV Gray, &c )

http://www.cosmic-construction.com/engelska_dokument/El-90-eng.Pdf

New electric circuit system - Cosmic Construction

Sadly, my good father Tibor Kemény passed away on May 4, 1991, ... These appendices describe the new current, “Cold Electricity”

http://gratisenergi.se/WO9118495A2.pdf

WO9118495
NEW ELECTRIC CIRCUIT SYSTEM

Inventor: KEMENY TIBOR [SE]
Applicant: ARIES MOTOR CO [SE]

A new electric circuit system for electric cars, etc. is characterized as follows: a) a closed circuit system of two battery groups consisting of six batteries (1-3, 4-6) connected with each other in series, and likewise batteries (21-23, 24-26) also connected with each other in series; b) two condensers (9, 10) in the one battery group separate batteries (1-3 and 4-6) from one another, and two other condensers (29, 30) in the other battery group which separate batteries (21, 23) and (24-26) from each other; c) that when alternating discharges between the negative poles of condensers (9, 10) and (29, 30) occur, a hitherto unknown alternating current is brought about which is without resistance, tension an loss of heat and which is not governed by Ohm's law.; This new alternating current is called "Cold Electricity". d) using this new electric circuit system the power of the electric car can be enhanced further if condensers (9, 10, 51, 52, 53, 54) are connected with each other in parallel. At the same time, however the number of thyristors is also increased.

The object of this invention is 2 new electric circuit system, which during the period of research was christened "Cold
Electricity". Technicians in te electronics industry and the field of electricity have creamed cf a system which would enable electricity to move freely in a conductor without resistance and without any loss cf the input energy at normal room temperature.

The NEW ELECTRIC CIRCUIT SYSTEM as proposed by the invention is based upon the use of two main groups consisting of six batteries in each group in which due to the unique construction there is a new type of electric current at normal room temperature.

The new electric circuit system, which has the characteristics indicated in the claims below, is not subject to Chm's law. The new electric circuit will have applications which will have a world-wide market, such as street illumination,household and industrial applications and electric motors and electric cars...

Cold Electricity

https://www.youtube.com/watch?v=fFL9xMJ9bls

Cold Electricity - Water Antenna

https://www.youtube.com/watch?v=z06ioGUXmtk

THE FREE ENERGY - SECRETS OF COLD ELECTRICITY -- Peter Lindemann

http://sciencebooksonline.info/

Science Books Online

Science Books Online lists free science e-books, textbooks, lecture notes, monographs, and other science related documents. All texts are available for free reading online, or for downloading in various formats. Select your favorite categories from the menu on the left, or browse the list of recently added books below.

http://www.e-booksdirectory.com/

E-Books Directory

E-Books Directory is a daily growing list of freely downloadable ebooks, documents and lecture notes found all over the internet. You can submit and promote your own ebooks, add comments on already posted books or just browse through the directory below and download anything you need.

http://www.abeldanger.org/the-silicon-valley-mafia/

The Silicon Valley Mafia

By Alex Lund, Audrey Finis and Connie Britley

VOLUME ONE OF A TEN VOLUME SET
Madicore Press First Edition
A Public Wiki Report To The U.S. Congress and the FBI

http://www.abeldanger.org/web/wp-content/uploads/2017/05/The-Silicon-Valley-Mafia-Update-4.2-1.pdf
https://docs.google.com/viewerng/viewer?url=http://www.abeldanger.org/web/wp-content/uploads/2017/05/The-Silicon-Valley-Mafia-Update-4.2-1.pdf&hl=en

https://www.youtube.com/watch?v=1nSFi_31WRI

Reverse Engineering Secret Method for Amplifying Aerial Electricity by Sangulani Maxwell Chikumbutso

These four simulations are my attempt to understand the secret to Saith Technologies' Aerial Extraction of Energy invented by Sangulani Maxwell Chikumbutso of Zimbabwe, Africa.

I believe that a gas discharge tube provides a pathway of ions not unlike that which precedes a thunderbolt. A simple neon bulb, plus the judicious use of transformers, may be at the heart of his amplification of aerial reception of electrical power resident all around us. My simulations in this video exemplify this possibility. I am certain of it....

Wikileaks -- Fukushima Documents

https://dunrenard.wordpress.com/2017/03/29/11000-wikileaks-documents-related-to-fukushima/

4131 files on Fukushima 2011
https://wikileaks.org/gifiles/?q=Fukushima+2011&mfrom=&mto=&title=&notitle=&date=&nofrom=&noto=&count=50&sort=0&file=&docid=&relid=0#searchresult

4062 files on reactor 2011
https://wikileaks.org/gifiles/?q=Reactor+2011&mfrom=&mto=&title=&notitle=&date=&nofrom=&noto=&count=50&sort=0&file=&docid=&relid=0#searchresult

2470 files on meltdown 2011
https://wikileaks.org/gifiles/?q=Meltdown+2011&mfrom=&mto=&title=&notitle=&date=&nofrom=&noto=&count=50&sort=0&file=&docid=&relid=0#searchresult

262 files on cesium 2011
https://wikileaks.org/gifiles/?q=Cesium+2011&mfrom=&mto=&title=&notitle=&date=&nofrom=&noto=&count=50&sort=0&file=&docid=&relid=0#searchresult

282 files on iodine 2011
https://wikileaks.org/gifiles/?q=Iodine+2011&mfrom=&mto=&title=&notitle=&date=&nofrom=&noto=&count=50&sort=0&file=&docid=&relid=0#searchresult

344 files on Uss Ronald Reagan
https://wikileaks.org/gifiles/?q=Uss+ronald+2011&mfrom=&mto=&title=&notitle=&date=&nofrom=&noto=&count=50&sort=0&file=&docid=&relid=0#searchresult

http://usawatchdog.com/suicidal-to-stay-in-this-market-charles-nenner/
USAWatchdog.com (May 31, 2017)

Suicidal to Stay in this Market-Charles Nenner

By Greg Hunter

Renowned financial and geopolitical analyst Charles Nenner is doubling down on his prediction last year that the financial markets will crash in the fall of 2017. Nenner says, “People not positioned correctly may lose everything.” Nenner points out, “We all know they say the market goes up 8% on a yearly basis. That’s based on the fact if I draw a line through the markets, it shows 8%. I don’t think anybody realizes how much we are above the line. In order to get back to 8%, we have to go much below the line . . . So, it’s total nonsense to say we go up 8% a year when we are already 40% to 50% above that trend line that averages 8%. This is almost the longest bull market in history.”

Now, Nenner has additional research that backs up his position, and it involves the number 7. Nenner explains, “You go to my research that goes back to the 1800’s, 1900’s and 2000’s. Go back a little, and you will see the market topped in 2017. The next year was 2007, which was clearly a high. If you go back to the next year that ends in 7, which was 1997, that was clearly a high. 1987 everybody knows about that, and I don’t have to go into it. Then go to ‘77 and ‘67, ‘57, ‘47 and ‘37. 1929 was a little aberration, it should have been ‘27. I still hold because it continued up and didn’t come down. That’s why they had the huge crash (in 1929) . . . . Based on the past, the future repeats. You have major correlation with major tops that are in years ending with a 7. If you are a reasonable person, you would say this is too much risk for me. If you are a super gambler, you say this time is different. . . . My cycle tops in September or October of 2017.”...

http://82.221.129.208/baaasepageu5.html
jimstone.is

Vaccinations and autism

A few weeks ago, there was a story circulating about a peer reviewed study that proved vaccinated children have a 5X higher rate of autism than non vaccinated children. I figured that was a low amount, and that unvaccinated children would have lower rates of autism than even that. No one linked to the study, anyone discussing the topic only talked about what the study said. I can see why - because the actual study will be difficult for most people to make sense of.

Well, today Natural News linked the study. I read through it, and to cut to the chase, the most meaningful information is on pages 7, 8, and 9...

http://oatext.com/pdf/JTS-3-186.pdf
Journal of Translational Science
J Transl Sci, 2017 Volume 3(3): 1-12
doi: 10.15761/JTS.1000186

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12-year-old U.S. children

Anthony R Mawson, et al.

Abstract

Vaccinations have prevented millions of infectious illnesses, hospitalizations and deaths among U.S. children, yet the long-term health outcomes of the vaccination schedule remain uncertain. Studies have been recommended by the U.S. Institute of Medicine to address this question. This study aimed 1) to compare vaccinated and unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders (NDD), if any, remained significant after adjustment for other measured factors. A cross-sectional study of mothers of children educated at home was carried out in collaboration with homeschool organizations in four U.S. states: Florida, Louisiana, Mississippi and Oregon. Mothers were asked to complete an anonymous online questionnaire on their 6- to 12-year-old biological children with respect to pregnancy-related factors, birth history, vaccinations, physician-diagnosed illnesses, medications used, and health services. NDD, a derived diagnostic measure, was defined as having one or more of the following three closely-related diagnoses: a learning disability, Attention Deficient Hyperactivity Disorder, and Autism Spectrum Disorder. A convenience sample of 666 children was obtained, of which 261 (39%) were unvaccinated. The vaccinated were less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but more likely to have been diagnosed with pneumonia, otitis media, allergies and NDD. After adjustment, vaccination, male gender, and preterm birth remained significantly associated with NDD. However, in a final adjusted model with interaction, vaccination but not preterm birth remained associated with NDD, while the interaction of preterm birth and vaccination was associated with a 6.6-fold increased odds of NDD (95% CI: 2.8, 15.5). In conclusion, vaccinated homeschool children were found to have a higher rate of allergies and NDD than unvaccinated homeschool children. While vaccination remained significantly associated with NDD after controlling for other factors, preterm birth coupled with vaccination was associated with an apparent synergistic increase in the odds of NDD. Further research involving larger, independent samples and stronger research designs is needed to verify and understand these unexpected findings in order to optimize the impact of vaccines on children’s health...

Thomas Jefferson : Letter to John Norvell, June 14, 1807

"Nothing can now be believed which is seen in a newspaper. Truth itself becomes suspicious by being put into that polluted vehicle. The real extent of this state of misinformation is known only to those who are in situations to confront facts within their knowledge with the lies of the day. I really look with commiseration over the great body of my fellow citizens, who, reading newspapers, live and die in the belief that they have known something of what has been passing in the world... I will add, that the man who never looks into a newspaper is better informed than he who reads them; inasmuch as he who knows nothing is nearer to truth than he whose mind is filled with falsehoods" --

Rex-ommended reading :

https://grahamhancock.com/hancockg17/

Why Science Should Cherish Its Rebels - The Younger Dryas Impact Hypothesis Is Anything But Dead

Graham Hancock

http://www.securityweek.com/cyber-kid-stuns-experts-showing-toys-can-be-weapons

Cyber Kid Stuns Experts Showing Toys Can be 'Weapons'

By AFP

An 11-year-old "cyber ninja" stunned an audience of security experts Tuesday by hacking into their bluetooth devices to manipulate a teddy bear and show how interconnected smart toys "can be weaponized".

American wunderkind Reuben Paul, may be still only in 5th grade at his school in Austin, Texas, but he and his teddy bear Bob wowed hundreds at a timely cyber security conference in The Netherlands.

"From airplanes to automobiles, from smart phones to smart homes, anything or any toy can be part of the" Internet of Things (IOT)," he said, a small figure pacing the huge stage at the World Forum in The Hague.

"From terminators to teddy bears, anything or any toy can be weaponised."

To demonstrate, he deployed his cuddly bear, which connects to the icloud via wifi and bluetooth smart technology to receive and transmit messages.

Plugging into his laptop a rogue device known as a "raspberry pi" -- a small credit card size computer -- Reuben scanned the hall for available bluetooth devices, and to everyone's amazement including his own suddenly downloaded dozens of numbers including some of top officials.

Then using a computer language programme, called Python, he hacked into his bear via one of the numbers to turn on one of its lights and record a message from the audience.

"Most internet-connected things have a blue-tooth functionality ... I basically showed how I could connect to it, and send commands to it, by recording audio and playing the light," he told AFP later.

"IOT home appliances, things that can be used in our everyday lives, our cars, lights refrigerators, everything like this that is connected can be used and weaponised to spy on us or harm us."

They can be used to steal private information such as passwords, as remote surveillance to spy on kids, or employ a GPS to find out where a person is.

More chillingly, a toy could say "meet me at this location and I will pick you up," Reuben said.

His father, information technology expert Mano Paul, told how aged about six Reuben had revealed his early IT skills correcting him during a business call.

Using a simple explanation from dad on how one smart phone game worked, Reuben then figured out it was the same kind of algorithm behind the popular video game Angry Birds.

"He has always surprised us. Every moment when we teach him something he's usually the one who ends up teaching us," Mano Paul told AFP.

But Paul said he been "shocked" by the vulnerabilities discovered in kids toys, after Reuben first hacked a toy car, before moving onto more complicated things.

"It means that my kids are playing with timebombs, that over time somebody who is bad or malicious can exploit."

Now the family has helped Reuben, who is also the youngest American to have become a Shaolin Kung Fu black belt, to set up his CyberShaolin non-profit organisation.

Its aim is "to inform kids and adults about the dangers of cyber insecurity," Reuben said, adding he also wants to press home the message that manufacturers, security researchers and the government have to work together.

Reuben also has ambitious plans for the future, aiming to study cyber security at either CalTech or MIT universities and then use his skills for good.

Failing that maybe he could become an Olympian in gymnastics -- another sport he excels in.

RUN AWAY !!!

http://yournewswire.com/i-was-in-the-illuminati-im-going-to-tell-you-everything-shocking-expose/

I Was In The Illuminati I’m Going To Tell You Everything, Shocking Expose

Sean Adl-Tabatabai

An ex illuminati member has penned a letter outlining the plans the secret society has in store for humanity in the next few years.

After spending 47 years as a high-ranking illuminati member, the anonymous insider says that he wants to “reveal everything” after the burden of keeping it a secret became “too much to bear”...

...Scientists working for the Illuminati have found a way that they can “shut” off the sun. A weapon has been created that shoot a beam of high density radiation right into the heart of a planet or star. This beam of radiation penetrates through the planet creating a very large cylinder in the exact middle of it. The radiation that is left behind begins to eat at the star or planet and the effects spread like wildfire. This technology has been tested on various stars in our immediate solar system and is very effective. The first thing that occurs to the star is that the radiation eats a perfect cylinder through the middle of the star, the radiation left behind begins working its way outward degenerating anything in its path. The radiation continues to build and spread. Some stars hung on until they were totally deteriorated from the radiation; however, some stars became so unstable that they combusted at a certain point.

Scientists are certain that this technology can be used on the sun, but also on other planets. One estimate that I overheard was that from the initial shot of radiation, it would take approximately nine years for the entire sun to be entirely consumed. We would begin seeing the effects of the radiation in approximately 3 and a half years however. The first signs would be shorter days and a decreased amount of sunlight during those days. The sun would start becoming unstable at about the seven year point, and we will begin seeing massive solar flares. Once the nine years is up, all life on earth will be dead...

http://www.informationclearinghouse.info/47165.htm

The Truth About US Involvement in Syria

By Robert Fisk

http://www.filmsforaction.org/articles/20-supporters-of-universal-basic-income-throughout-history/
http://www.makewealthhistory.org

20 Supporters of Universal Basic Income Throughout History

By Jeremy Williams

The basic guaranteed income is one of those ideas, like land value taxation or the Tobin tax, that circles endlessly around. There are times when it’s obscure, and times when it’s being talked about again. It’s currently in the ascendant, and I suspect that it won’t be long before a country bites the bullet and puts a basic national income (BNI) or citizen’s income in place.

To illustrate the broad and diverse support for a basic income, here are twenty people who have supported it over the ages. Not all of them stand for the BNI as currently understood, but their ideas have all fed into the debate in one form or another and give weight to the arguments for a guaranteed minimum income.

Pericles – let’s start with the old school, and Pericles and Ephialtes. They came to power in Athens in 461 BC with plans for payments to citizens in return for public duties such as jury duty or public service.

Sir Thomas More – coined the word Utopia in 1516 with his fictional account of an ideal island. The Utopia he describes included a basic income, and nobody ever needed to steal.

Thomas Paine – this revolutionary and founding father of the United States argued for grants to young people and the elderly.

Dennis and Mabel Milner – a number of Quaker activists called for the BNI. The best known are this husband and wife team who were influential in calling for a new settlement after the First World War.

Lady Juliet Rhys-Williams – a Liberal Party campaigner and a member of the Beveridge Committee, the group that shaped Britain’s welfare state in 1942. Had she had won the argument, we might have had a basic income instead.

Bertrand Russell – the philosopher and Nobel laureate argued that a basic income combined the best of socialism and anarchism.

Martin Luther King – argued in his last book that “the solution to poverty is to abolish it directly by a now widely discussed measure: the guaranteed income”.

J K Galbraith – “We need to consider the one prompt and effective solution for poverty,” argued the economist, “which is to provide everyone with a minimum income.”

Milton Friedman – not the same thing as a BNI but similar, the American economist and godfather of neoliberalism was an advocate of the negative income tax.

Desmond Tutu – South Africa has trialed guaranteed incomes, and the social activist and bishop Desmond Tutu has campaigned for it.

Margaret Mead – the influential anthropologist and cultural commentator believed that a guaranteed income “would provide dignity for every citizen and choice for every citizen”.

Richard Nixon – not the only president to consider it, but Nixon got closer than most with his Family Assistance Plan, before it was killed by Democrats in the Senate.

Marshall McLuhan – in his writing about technology, Marshall McLuhan debated the need for a guaranteed income to protect people from job losses from automation.

Elon Musk – along similar lines, the pioneering technologist and businessman has come to the conclusion that the BNI is the best way to deal with robots taking human jobs.

Gary Johnson – while he didn’t campaign on it, the libertarian candidate in the 2016 US election has spoken positively about the idea as a small government alternative to welfare.

Tim Berners-Lee – “I think a basic income is one of the ways of addressing massive global inequality,” says the inventor of the internet.

James Hansen – NASA’s leading climate expert suggests putting a tax on fossil fuels and distributing it equally as a dividend or basic income.

Caroline Lucas – co-leader of the Green Party and Britain’s most useful MP, Caroline Lucas has long been a champion of the idea, and suggests the basic income “could be the big answer that everyone’s looking for”.

Stephen Hawking – the legendary physicist believes that technological change and inequality may be best addressed through a basic income.

Nicola Sturgeon – under her leadership the Scottish National Party has endorsed the BNI. If Scotland were to go independent, it may well choose this as part of its own welfare system.

http://www.filmsforaction.org/articles/how-to-fund-a-universal-basic-income-fairly/

How to Fund a Universal Basic Income Fairly

By Chris Agnos / chrisagnos.com

A universal basic income (UBI) – an idea in which the government replaces all other forms of monetary assistance (welfare, social security, etc.) with yearly stipend – has enormous potential to radically transform our current unsustainable consumer economy based on individual ownership into a much more sustainable economy based on access if it is designed and funded carefully. Implementing a UBI would require a cultural shift in our attitudes towards work and money but in a world where money is access, the idea of granting everyone enough money to meet their basic needs has sound philosophical logic behind it. However, all of this potential is highly dependent on the way a UBI is funded. A poorly conceived plan may wind up doing far more harm to a society already ravaged by class divisions and extreme inequality.

Properly conceived, a universal basic income could radically transform society.

Popular Criticisms Of A Universal Basic Income

The idea around a universal basic income is not a new idea. It has backers all across the political and economic spectrum. On the right, many people have rightly seen the potential in eliminating expensive bureaucratic government agencies and processes that exist primarily to determine eligibility for assistance programs. If everyone is eligible, the process is simplified greatly. On the left, people are recognizing the emerging “crisis of capitalism” in which the majority of people lose access to their purchasing power as most jobs are replaced by automation and robots. However, very few ideas actually consider how the UBI should be funded.

The reason why many people are opposed to the idea of a UBI is because most plans use income tax as the source of the revenue that would fund it. More often than not, earning an income requires incredibly hard work and sacrifice and the idea that some people might be given the same monetary reward without having to work at all seems unfair. We begin to think “why should we have to give our lives to a job to earn money while others can live without giving anything?” The truth is the income tax really amounts to extortion – why should anyone else be entitled to the fruits of another’s labor? For this reason, funding a UBI through income tax is a terrible idea and will never get anywhere.

Taxing one's labor is theft but taxing the use of resources that people did not create themselves is not.

We All Deserve Access To The Planet That Gave Birth To Us

Instead, to fund the UBI in a way that is fair, we need to create a new narrative based on a different understanding of the principles of private ownership that our economy is founded upon. When the Europeans first came to North America, they wanted to try to buy the land from the Native Americans. But the native tribes couldn’t understand the logic behind owning land. “How could anyone own the land?” they thought, “for they did not create it.”

The Native Americans saw land as the equivalent of both water and air. These are things that can’t belong to people. They believed all beings had a right to access these basic resources by virtue of the simple fact that they were born on this planet. The idea that because you owned land you had the right to exclude other people from occupying it was a radical idea to them. We need to realize that there are certain things that shouldn’t ever be able to be owned – things like air, water, and land – if that means giving some people the ability to exclude others from meeting their needs.

A properly constructed UBI would be based on the idea that the resources that weren’t created by human labor – the land, the airwaves, our public spaces, the skies, and even money itself – belong to everyone. And therefore, if you want exclusive access to any of these resources either to live or to start a business, you should have to compensate the rest of humanity for their reduced access. These economic “rents” already exist in the form of property taxes, licenses, and interest payments. But instead of sharing this wealth (that no human being created) with everyone, the wealthy elites appropriate it all to themselves. This is what must change.

What right does anyone have to own that which they did not create?

Giving Everyone A Base Level Of Access

The UBI ought to be funded from these “rent” payments. Just how much would that be? In the United States, the value of all the land (just the land itself, not the buildings or roads which were made from human labor) is estimated to be valued at $23 trillion. A five percent “exclusivity fee” would generate $1.15 trillion annually. Interest paid on money loaned ought to be another public asset. After all, no individual gives money its value. The value of money comes from our collective willingness to believe that it has value. Nearly $4 trillion was paid in collective interest from US households, businesses, governments, and non-profits in 2015. Instead of this money flowing to the shareholders of private banks, it, too, should form the collective pool that the UBI is drawn from. Combining these revenue sources into a $5 trillion yearly fund would yield a net of $18,000 a year for every adult and $9,000 a year for every child in the United States.

To save money, some have proposed means testing the UBI by only giving it to those who make below a certain income. This, too, is a terrible idea. To avoid the disastrous social implications that have been applied to people on government assistance in the past, it is critical that the UBI be given to all, even those with well-off means. If the wealthy choose to donate their UBI allotment to a cause of their choice, that should be their decision to make. The UBI is not earned the way additional money would be earned by trading one’s labor for it. Instead, the UBI should be considered to be every human being’s inheritance from the gifts and toils of all previous generations.

Everyone deserves the ability to meet their needs without having to be controlled.

It Is Far Cheaper To Feed The World Than It Is To Bomb It

But the true economic efficiency resulting from this form of a UBI comes much later. Today, enormous amounts of money are spent at both the collective and individual levels on various form of security. A typical response to the theft of a $30,000 car might be to put the thief in jail for 5 years at a total cost of $250,000. Wouldn’t it have been cheaper just to ensure that everyone had access to a car? The implementation of a UBI would likely spawn the creation of an entirely new $5 trillion a year “life services” market that would create unprecedented levels of access for the average person. In a society in which everyone has the ability to meet their basic needs, crime would be dramatically reduced. The main cause of crime and international conflict is scarcity. When people (and any animal really) can meet their needs, they are less likely to harm each other. Today, the US spends $39 billion a year on prisons, $350 billion a year on security, and $1100 billion a year on military. It isn’t hard to imagine that these expenditures could be drastically reduced in a world where people no longer had conflict over meeting their basic needs.

Intuitively, I think we all know that it is far cheaper to feed the world than it is to bomb it. But our stories around private property, money, wealth, ownership, and access must evolve before we will have access to the tools that can solve the economic crises we face today. In our society, money is the fuel of creation. The rich know this very well. Given enough money, you can pay just about anyone to do just about anything. A universal basic income gives everyone the chance to find their place in this world. It will be important to educate people that the UBI is a gift that is given to them by the previous generations of human beings who toiled and sacrificed their blood, sweat, tears, and lives while they endured the growing pains of industrial civilization. Only by sharing in the fruits of our collective success will be able to continue evolving human society sustainably far into the future.

http://www.filmsforaction.org/watch/what-is-universal-basic-income/

What Is Universal Basic Income?

http://www.filmsforaction.org/articles/do-they-owe-us-a-living-7-reasons-the-universal-basic-income-is-worth-fighting-for/

7 Reasons The Universal Basic Income Is Worth Fighting For

By Andrew Dolan / wire.novaramedia.com

http://12160.info/profiles/blogs/transcript-amp-audio-if-you

Aldous Huxley Berkeley Speech 1962

Aldous Huxley, author of ‘Brave New World’, gives his speech “The Ultimate Revolution” at Cal Berkeley, 1962.

Moveable Mini-Frets :

https://www.youtube.com/watch?v=XT4oOYj4SwQ

The Major 3rd Problem of All Guitars in the World

https://www.youtube.com/watch?v=iRsSjh5TTqI

Microtonal Guitar

Nothing to read here... stick your head back in your colon and keep eating :

http://www.wnd.com/2017/06/man-who-infiltrated-muslim-mafia-speaks-out/

Man who infiltrated 'Muslim Mafia' speaks out

'They are incredibly organized, and they're at this day in and day out'

http://www.the-scientist.com/?articles.view/articleNo/49469/title/How-to-Tell-a-Person-s--Brain-Age-/

How to Tell a Person’s “Brain Age”

Using brain scans and methylation markers, scientists develop ways to assess neurologic aging in humans.

By Diana Kwon

https://www.newscientist.com/article/2116040-future-air-conditioning-could-work-by-beaming-heat-into-space/

Future air conditioning could work by beaming heat into space

By Matt Reynolds

With temperatures as cold as -270 °C, space is one hell of a heat sink.

Physicists have achieved record levels of temperature reduction using the process of radiative cooling, by which heat is beamed from Earth’s surface into outer space. Zhen Chen and his colleagues at Stanford University lowered the temperature of a thermal emitter – a device designed to give out more heat than it takes in – to 42.2 °C below that of the surrounding air

“To achieve high-performance cooling, the key is to couple whatever object you want to cool with outer space and to decouple it from the ambient environment,” says Chen. The researchers placed the emitter in a vacuum chamber, isolating it from the atmosphere and cutting off almost any heat transfer through conduction or convection, which could cause the emitter to warm up. Heat from the emitter was radiated out of a specially designed window on top of the vacuum chamber, which was directed at a clear patch of sky.

Earth’s atmosphere allows thermal radiation of wavelengths between 8 and 13 micrometres to pass through it into outer space – but most objects release heat at different wavelengths. The Stanford emitter, however, was specifically designed so that most of the heat it emits falls within that range, meaning that on a clear day it will pass straight out into space without being bounced back by the atmosphere

Within half an hour of pumping air out of the vacuum chamber, the temperature of the emitter plummeted to 40 °C below that of the surrounding air. Over the next 24 hours, it averaged 37 °C below the air temperature, and reached its biggest reduction of 42.2 °C when exposed to the peak of the sun’s heat.
Bigger reduction

Previous attempts at radiative cooling have achieved maximum temperature reductions of up to 20 °C, unless they are at high altitude and with very low humidity.

Jeremy Munday at the University of Maryland in College Park, says the team’s record-breaking results are down to their use of vacuum chambers and sun shades, which prevent sunlight from directly hitting the emitter. “They’re getting significantly below water-freezing temperature during daylight by improving their set-up,” he says.

Similar technology could be used to refrigerate food and medicine in areas where the ambient temperature is high, or in air-conditioning units on top of buildings, says Chen. To scale the technology up for these applications, however, they will need to find a cheaper alternative to the zinc selenide used in the window of the vacuum chamber, a material that is very effective at allowing radiation through at the right wavelengths to be transferred into space.

For situations in which it is not necessary to achieve such dramatic levels of cooling, however, zinc selenide could be substituted for less effective materials. “In the real application, you don’t need such transparent material – you can use cheaper material such as silicon or aluminium,” says Chen.

The researchers have launched a start-up company to explore commercial use of the technology, but Chen warns that it won’t be able to completely replace existing air-conditioning units because overcast skies almost eliminate the effect of radiative cooling.

https://www.nature.com/articles/ncomms13729
Nature Communications 7, Article number: 13729 (2016)
doi:10.1038/ncomms13729

Radiative cooling to deep sub-freezing temperatures through a 24-h day–night cycle

Zhen Chen, Linxiao Zhu, Aaswath Raman & Shanhui Fan

Abstract

Radiative cooling technology utilizes the atmospheric transparency window (8–13?µm) to passively dissipate heat from Earth into outer space (3?K). This technology has attracted broad interests from both fundamental sciences and real world applications, ranging from passive building cooling, renewable energy harvesting and passive refrigeration in arid regions. However, the temperature reduction experimentally demonstrated, thus far, has been relatively modest. Here we theoretically show that ultra-large temperature reduction for as much as 60?°C from ambient is achievable by using a selective thermal emitter and by eliminating parasitic thermal load, and experimentally demonstrate a temperature reduction that far exceeds previous works. In a populous area at sea level, we have achieved an average temperature reduction of 37?°C from the ambient air temperature through a 24-h day–night cycle, with a maximal reduction of 42?°C that occurs when the experimental set-up enclosing the emitter is exposed to peak solar irradiance.

http://www.wakingtimes.com/2017/05/23/ekg-evidence-smart-meters-negatively-affect-human-heart/

EKG Evidence that Smart Meters Negatively Affect the Human Heart

by
Nathaniel Mauka

There have been numerous whistleblowers to warn of the negative effects of smart meters on human health but perhaps none has been so successful in scientifically proving this claim as Warren Woodward of Sedona, Arizona. He recently put AMI ‘smart’ meters to the test, and using EKG technology, has proven that smart meters throw the human heart off its balanced beat....

https://www.nasa.gov/press-release/a-whole-new-jupiter-first-science-results-from-nasa-s-juno-mission

A Whole New Jupiter: First Science Results from NASA’s Juno Mission

https://sputniknews.com/science/201705281054047131-memristor-computer-processing-device/

Revolutionary New 'Memristor' Device Boosts Brainpower of Neural Networks

A new component called a "memristor" has the potential to revolutionize data processing, one of its creators told Sputnik...

https://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2017.83.html

Sparse coding with memristor networks
Patrick M. Sheridan, et al.

Sparse representation of information provides a powerful means to perform feature extraction on high-dimensional data and is of broad interest for applications in signal processing, computer vision, object recognition and neurobiology. Sparse coding is also believed to be a key mechanism by which biological neural systems can efﬁciently process a large amount of complex sensory data while consuming very little power. Here, we report the experimental implementation of sparse coding algorithms in a bio-inspired approach using a 32 × 32 crossbar array of analog memristors. This network enables efﬁcient implementation of pattern matching and lateral neuron inhibition and allows input data to be sparsely encoded using neuron activities and stored dictionary elements. Different dictionary sets can be trained and stored in the same system, depending on the nature of the input signals. Using the sparse coding algorithm, we also perform natural image processing based on a learned dictionary.

[ The Memristor is not a "new" component" : ]

https://worldwide.espacenet.com

Approximately 386 results found in the Worldwide database for: memristor in the title, e.g. :

SWITCHED MEMRISTOR ANALOG-TO-DIGITAL CONVERSION / US2017134038
REGULATING MEMRISTOR SWITCHING PULSES / US2017062048
MULTIMODAL MEMRISTOR MEMORY / US2017040055
MEMRISTOR AND METHOD OF PRODUCTION THEREOF / US2017047512
Bi-polar memristor / TW201637008
MEMRISTOR ARRAY WITH ACTIVE MEMRISTORS / WO2017014719
ON-CHIP TRAINING OF MEMRISTOR CROSSBAR NEUROMORPHIC PROCESSING SYSTEMS / US2017011290
MEMRISTOR DEVICE ARRAY BASED SNEAK CURRENT CONTROL / KR20160136222
FLOATING MEMRISTOR EMULATOR / US2016378896
MEMRISTOR DEVICES WITH A THERMALLY-INSULATING CLADDING / KR20160130468
Memristor and electronic synaptic function enhancing method therefor / CN106098936
Memristor using parallel asymmetrical transistors having shared floating gate and diode / US9514818
Non-volatile memory device with memristor / US9514817
MEMRISTOR MEMORY / US2016351259
ASYMMETRICAL MEMRISTOR / HK1216801
MEMRISTOR MEMORY WITH VOLATILE AND NON-VOLATILE STATES / US2016343435
CHARGE TRAPPING MEMRISTOR / US2016343430
Linear slowly-changed memristor and preparation method therefor / CN106098932
Low-power consumption oxide linear memristor and method for realizing electronic junction function of low-power consumption oxide linear memristor / CN106098935
MEMRISTOR APPARATUS WITH VARIABLE TRANSMISSION DELAY / WO2016175770
MEMORY INCLUDING BI-POLAR MEMRISTOR / WO2016175822
MEMRISTIVE CROSSBAR ARRAY HAVING MULTI-SELECTOR MEMRISTOR CELLS / WO2016175744
Preparation method of large-grain perovskite film memristor memory cell / CN106058049
SPECTRALLY PROGRAMMABLE MEMRISTOR-BASED OPTICAL COMPUTING / WO2016171700
SPECTRALLY PROGRAMMABLE MEMRISTOR / WO2016171701
Chaotic circuit based on Wien bridge oscillator and piecewise linear memristor / CN106027223
APPARATUS FOR MEMORY BASED MEMRISTOR / KR20160111692
Diode Wien-bridge operating circuit based on first-order general memristor / CN106020767
Filter circuit based on memristor / CN106026969
Simplest memristor circuit / CN105895151 .... &c...

http://www.szynalski.com/tone-generator/

Online Tone Generator

To play a constant pure tone (sine wave), click Play or press Space.

To change the frequency, drag the slider or press ? ? (arrow keys). To adjust the frequency by 1 Hz, use the ?? and ?? buttons or press Shift?+?? and Shift?+??. To adjust the frequency by 0.01 Hz, press Ctrl?+?? and Ctrl?+??; to adjust it by 0.001 Hz, press Ctrl?+ Shift +?? and Ctrl?+?Shift+ ? To halve/double the frequency (go down/up one octave), click ×½ and ×2.

You can mix tones by opening the Online Tone Generator in several browser tabs.

Robert Murray-Smith DIY Graphene Battery R&D --

https://www.youtube.com/watch?v=P266pdT71tI

Big Battery Bike Build - Testing The EESD

https://www.youtube.com/watch?v=2alSybwwSEk

The EESD - A Supercapacitor Print Process

https://www.youtube.com/watch?v=pBnKHieCg0s

Non Graphene Battery Works Better Than Graphene Battery?

https://www.youtube.com/watch?v=hFUOsZ0LSkQ&t=6s

Graphene - A Simple Method For Mass Production

https://www.youtube.com/watch?v=yXAnvuqeWVc

How To Make Graphene Sheets As Big As You Like

https://www.youtube.com/watch?v=oisuvRXFU_8

Easy Graphene Sheets-Laminator & Graphite

https://www.youtube.com/watch?v=Ar3C5JgzhgE

Easy DIY Graphene SuperCapacitors

This video covers the complete capacitor build process. Link to materials used: http://laserhacker.com/?p=543

https://www.youtube.com/watch?v=UY6oImYvFNo

New Supermaterial Carbyne is the World's Strongest Material, Beats Out Graphene and Diamond

https://www.youtube.com/watch?v=A5pZZJ23rDM&t=344s

Levitate a Magnet with Bismuth Crystals - No Energy Cost, Indefinite Levitation

https://www.youtube.com/watch?v=grpSfjUImUs

How to Extract Bismuth Metal from Pepto-Bismol Tablets

http://www.nrg4u.org/downloads/FreeShield.pdf

FreeShield

What is FreeShield and How Does it Work?

FreeShield is the smallest product in a line of several amazing technologies. FreeShield uses advanced geometry and frequency equations to generate a full-spectrum vibration.

This full-spectrum vibration helps harmonize and cancel out the harmful effects of disrup-
tive vibrations, such as those emitted by cell phones.

Thorough mathematical research has proven that not only do different colors have different frequencies, but the same is true of angles. So by using a diverse combination of colors and angles, a very broad frequency range is achieved.

Is it Advanced... or Sacred Geometry?

FreeShield was developed through research into the unknown field of sacred geometry.
If the word “sacred” distresses you in any way, feel free to refer to it as advanced geometry—as FreeShield certainly is an advanced technology.

You may have first heard of sacred geometry when it was featured on the hit MTV program, “Rob & Big.” Pro skateboarder and host Rob Dyrdek liked sacred geometry so much that an entire episode was dedicated to what he popularized as “Sacred G.” Click here to watch
this episode.

Although sacred geometry may strike you as unusual, you actually see it every day. Sacred geometry is found in many religious icons, the symbols of Freemasonryand ancient civilizations, and the works of the legendary Leonardo Da Vinci...

How Does FreeShield Work If I Can’t See It?

One thing you might find curious is how FreeShield technology works even when hidden behind your cell phone battery cover, case or skin. To answer that question, we must realize that what the human can eye see is a very small fraction of the total light spectrum.

A good analogy to consider is that of a high-pitched canine whistle that dogs can hear clearly, but we cannot. Similarly, although you may have placed FreeShield out of sight, it’s really only dark in terms of our perception. The vast majority of the total light spectrum is still interacting with FreeShield and its EMF-neutralizing effects.

What Else Do I Need to Know?

Some people are more sensitive to radiation than others. If you are currently free from obvious symptoms of cell phone radiation (headaches, excessive heat ear/face, red eyes, etc.) then a single application of Free-Shield may be all you need.

People who are more sensitive to radiation may require several strips of FreeShield or may wish to use a complementary EMF-shielding technology as well. In this regard, you have many options available.

SARshield is an excellent cell phone product that I use personally.

Using more Sacred G technology may also prove helpful to you.

Put Sacred G under your pillow tonight and in the morning you’ll better understand what this technology is really about. You’ll soon be experiencing enhanced dream activity, improved mental clarity, less stress, and more energy as this amazing technology improves
your sleep and boosts you with good vibrations.

Enjoy Your FreeShield !

Be well,

Craig Brockie

http://marywmaxwell.com/

Autism book -- A Balm in Gilead

Autism. A very terrible problem. But this is a rather happy book. It was written in response to the debut of Ido Kedar’s book -- which I consider a historic event in the annals of science. He named his book "Ido in Autismland." Written at age 16, if you please.

My book, “A Balm in Gilead,” outlines the many cures and treatments for autism, yes, ones that have actually worked. But it also canvasses the possibility of using cures related to other illnesses such as Parkinson’s and multiple sclerosis. Quite a few surprises here.

There is also a new theory, proposed by none other than Yours Truly, that autism is caused by a lentivrus. If you wish to see me put my case, go to Youtube here.

Or why not just download the book for free right now?

http://keelynet.com/news/051517u.html
http://realfarmacy.com/scientists-reveal-ramen-noodles-cause-heart-disease-stroke-metabolic-syndrome/

Scientists Reveal Ramen Noodles Cause Heart Disease, Stroke & Metabolic Syndrome

The dangers of ramen noodles are self-evident to most, however there will always be those who will deny the dangers of consuming them. After all, it’s a staple food for college kids so how bad could it be? It can’t kill you right? New research from Baylor University and Harvard says it can. The noodles increase people’s risk of metabolic changes linked to heart disease and stroke, researchers found. Ramen noodles contain Tertiary-butyl hydroquinone (TBHQ), which is a byproduct of the petroleum industry and food additive frequently to preserve cheap processed foods. A gastrointestinal specialist conducted an experiment with a time lapse video inside the stomach to what would happen after two hours of digesting ramen noodles and the results were staggering.

In the most recent study in the Journal of Nutrition, women in South Korea who consumed more of the precooked blocks of dried noodles were more likely to have “metabolic syndrome” regardless of what else they ate, or how much they exercised, the researchers found. People with metabolic syndrome may have high blood pressure or high blood sugar levels, and face an increased risk of heart disease, stroke and diabetes. The dried noodle block was originally created by flash frying cooked noodles, and this is still the main method used in Asian countries, though air-dried noodle blocks are favoured in Western countries. The main ingredients of the dried noodle are wheat flour, palm oil, and salt. Common ingredients of the flavouring powder are salt, monosodium glutamate, seasoning, and sugar. A typical cup-type instant noodles contain 2700 mg of sodium.

“Although instant noodle is a convenient and delicious food, there could be an increased risk for metabolic syndrome given [the food’s] high sodium, unhealthy saturated fat and glycemic loads,” said study co-author Hyun Shin, a doctoral candidate at the Harvard School of Public Health in Boston. Shin and his colleagues at Baylor University and Harvard analyzed the health and diet of nearly 11,000 adults in South Korea between ages 19 to 64. The participants reported what they ate, and the researchers categorized each participant’s diet as centered on either traditional healthy food or fast food, as well as how many times weekly they ate instant noodles.

The study focused on individuals in South Korea, Shin said, as the country has the highest per-capita number of instant noodle consumers in the world, and because, in recent years, health problems there, including heart disease and obesity, have been on the rise. But the findings appear to be quite relevant to consumers stateside too, as the United States ranked sixth globally in instant noodle sales, according to the World Instant Noodles Association, which found that the United States accounted for 4,300 billion units sold in 2013 (coming in just behind China, Indonesia, Japan, Vietnam, and India — and one spot above South Korea, in fact).

Women who ate instant noodles twice a week or more had a higher risk of metabolic syndrome than those who ate ramen less, or not at all, regardless of whether their diet style fell into the traditional or fast-food category. The researchers found the association even among young women who were leaner and reported doing more physical activity.

As for men, Shin and his colleagues guessed that biological differences between the genders, like the effect of sex hormones and metabolism, might account for the lack of an apparent association among males between eating instant noodles and developing metabolic syndrome. The study was conducted in South Korea, an area known to have the largest ramen consumption group in the world, where people consumed 3.4 billion packages of instant noodles in 2010.

https://www.youtube.com/watch?v=tPuKu5J-_64

How To Make Mini Spot Welder Using old Microwave Transformer

https://www.youtube.com/watch?v=neR_RFTblqg

Project no.23 Diy Homemade Spot Welder Microwave Oven Transformer(MOT)(MICROWAVE HACKS)

By modifying the secondary coil on a MOT, the transformer is converted from a high voltage/low current device into a low voltage/high current metal melter. High current can be directed to one focused location to fuse sheets of metal together on contact.

Using some scavenged parts from the microwave, as well as wood panels and a few other accessories, we can make a fully functional Spot Welder that works well.

This Project is Made out of a Microwave Oven Transformer. I uses two Microwave Transformer (MOT) I Connect them in series So it is Powerful Enough to Weld some light thick Sheet Metals.

WARNING: Burning galvanized metal may release toxic Zinc Oxide fumes. This project is extremely dangerous and should not be attempted without adult supervision and adequate training. Misuse, or careless use, of tools or projects may result in severe electric shock, cardiac arrest, serious injury, permanent damage to equipment and property, and/or death. Use of this video content is at your own risk.

https://www.youtube.com/watch?v=A7CHQbWcFZ0

Spot Welder from microwave - how to increase the power

http://www.theeventchronicle.com/good-news/14-year-old-wins-science-fair-new-gmo-detection-device/

14 Year Old Wins Science Fair with New GMO Detection Device

By Pao Chang

Genetically modified organisms (GMOs) are becoming a big problem, because every year more GMOs are being created and sold on the public market without proper testing of how they affect the environment and the human body. As the published date (April 6, 2017) of this article, there are no effective laws that require GMOs to be labelled in the USA. Fortunately, many other countries throughout the world have GMO labeling laws.

The problem with GMOs is that they do not harmonize well with the energy and genes of our bodies. Scientific studies have linked GMOs to serious health problems, such as infertility, birth defects, immune disorders, growth and digestive problems, and premature aging. The health hazards of GMOs are becoming mainstream, causing one of the outlets of the mainstream media to admit that GMOs are health hazards.

Because GMOs are health hazards and most of them are not labelled properly, we need to find alternative ways to detect GMOs. One alternative way is to use a GMO detection device.

Here is an excerpt from LancasterOnline.com about a GMO detection device created by Gaurav Mittal, a 14 year old freshman at Manheim Township High School:

    "While his classmates were playing video games or scrolling through Facebook, as many teenagers tend to do, Gaurav Mittal was creating a homemade polymerase chain reaction thermal cycler.

    "That is, a device used to detect whether a food is genetically modified.

    "The 14-year-old’s invention earned him the honor of grand champion at the annual North Museum Science & Engineering Fair, held Wednesday at Spooky Nook Sports."

“I’m pretty proud,” Gaurav, a freshman at Manheim Township High School, said. “The fact that I can come this far and actually achieve a really big thing with this, it makes me happy.”

Gaurav said he worked up to 20 hours a week since December trying to perfect the thermal cycler.

In the end, the device, which uses varying temperatures to replicate and amplify a plant’s DNA in order to tell whether it is genetically modified, didn’t work as well as Gaurav hoped.

https://www.youtube.com/watch?v=Z7a6...6W7TtVFlh4dFQT
https://www.youtube.com/user/MrMBB333

UV Light Index

http://www.zmescience.com/science/n6-antibody-hiv/

NIH isolates new antibody which neutralizes 98% of HIV strains in lab trials

https://www.youtube.com/watch?v=tqGPIvIZo3I

Furniture transformer. Inventions

Alien-SubGenius Sexxx :

https://www.youtube.com/watch?v=2ZbetseYGxQ

Reproduction Cycle In Lower Life Forms Under the Rocks of Mars

Ivan Stang

A classroom biological science documentary from the future which shows what the Spirit and Opportunity landers are filming on the planet Mars RIGHT NOW with
their electron microscope-cameras, but not sharing with us.

Some monster nudity, simulated stop-motion sex. Animated in claymation (in 1976) by Douglass Smith, aka Rev. Ivan Stang, devotee of Slack master and Sex God J. R. "Bob" Dobbs, who discovered the Conspiracy and an invasion by UFOs, and founded The Church of the SubGenius, an adults-only religion for mutants, misfits, weirdos.

Part of a SubGenius feature-length anthology of comedy shorts, although this particular short predates the SubGenius projects (http://www.subgenius.com for more info.)

http://www.geoengineeringwatch.org/a-new-warning-of-deadly-ozone-layer-collapse-from-a-former-nasa-engineer/

Geoengineering: A New Warning Of Deadly Ozone Layer Collapse From A Former NASA Engineer

... front-line data does not support the "ozone recovery" official narrative. Since the start of this century UV levels comparable to the surface of Mars have been recorded. The same sources of false "ozone layer recovery" data do not even mention the massive and growing northern hemisphere ozone hole....

http://www.businessinsider.com/wifi-camera-sees-through-walls-2017-5

Scientists have found a way to photograph people in 3D through walls using Wi-Fi

by Dave Mosher

... Holl's method differs from the others in few significant ways.

First, it uses two antennas: one fixed in place and another that moves. The fixed antenna records a Wi-Fi field's background, or reference, for the spot it's placed in. The other antenna is moved by hand to record the same Wi-Fi field from many different points.

"These antennas don't need to be big. They can be very small, like the ones in a smartphone," Holl says.

Second, both antennas record not only the intensity (or brightness) of a Wi-Fi signal, but also its phase: a property of light that comes from the fact it's a wave. Laser light is all one phase, for example (which makes it an excellent method to create holograms), while an incandescent bulb puts out a mix of different phases of light. Similar to lasers, Wi-Fi routers emit microwave radiation in discrete frequencies and phases.

Finally, the signals from both antennas are simultaneously fed into a computer, and software teases out the differences of intensity and phase "more or less in real-time," Holl says.

This is where the magic happens: The software builds many 2D images as one antenna is waved around and then stacks them together in a 3D hologram. And because Wi-Fi travels through most walls, those holograms are of objects inside a room...

Hey, Stupid ! Praise Gaia and Pass the Chlorella...

http://www.thecommonsenseshow.com/2017/05/23/the-algae-conspiracy/

[ Excerpt ]

Algae Is Dumbing Down America

by David Hodges

...Several years ago, as I was investigating the algae phenomenon, I found that Mike Adams had already blazed the trail of the dumbing down effect of the substance :

From NATURAL NEWS --

“Scientists at Johns Hopkins Medical School have identified a mysterious virus that literally makes people stupid, and it has so far been found in about 45% of the people tested.

The discovery of the “stupid” virus, normally found in algae, was revealed at the Proceedings of the National Academy of Sciences. The study, entitled “Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice” is found at this link on the PNAS.org website.

http://www.pnas.org/content/early/2014/10/23/1418895111.abstract

The rather shocking take away from the study is that the virus alters the gene expression of brain cells, literally making people perform more poorly on cognitive tests, visual processing and spatial awareness.

So far, 90 people have been tested for the presence of the virus, and 40 tested positive, according to The Independent. [2] “Those who tested positive performed worse on tests designed to measure the speed and accuracy of visual processing. They also achieved lower scores in tasks designed to measure attention,” reports the paper.

According to the study abstract, the virus alters gene expression relating to “…synaptic plasticity, learning, memory formation, and the immune response to viral exposure.”

This virus, in other words, can truly suppress your brain function, memories and immune response. And it is apparently quite common in humans…”

http://www.independent.co.uk/news/science/virus-that-makes-humans-more-stupid-discovered-9849920.html

Virus that 'makes humans more stupid' discovered

A virus has been discovered that affects cognitive abilities in healthy people

Ben Tufft

A virus that infects human brains and makes us more stupid has been discovered, according to scientists in the US.

The algae virus, never before observed in healthy people, was found to affect cognitive functions including visual processing and spatial awareness.

Scientists at Johns Hopkins Medical School and the University of Nebraska stumbled upon the discovery when they were undertaking an unrelated study into throat microbes.

Surprisingly, the researchers found DNA in the throats of healthy individuals that matched the DNA of a virus known to infect green algae.

Dr Robert Yolken, a virologist who led the original study, said: “This is a striking example showing that the ‘innocuous’ microorganisms we carry can affect behaviour and cognition.

“Many physiological differences between person A and person B are encoded in the set of genes each inherits from parents, yet some of these differences are fuelled by the various microorganisms we harbour and the way they interact with our genes.”

http://www.pnas.org/content/early/2014/10/23…

Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice

Robert H. Yolkena, et al.

Significance

Human mucosal surfaces contain a wide range of microorganisms. The biological effects of these organisms are largely unknown. Large-scale metagenomic sequencing is emerging as a method to identify novel microbes. Unexpectedly, we identified DNA sequences homologous to virus ATCV-1, an algal virus not previously known to infect humans, in oropharyngeal samples obtained from healthy adults. The presence of ATCV-1 was associated with a modest but measurable decrease in cognitive functioning. A relationship between ATCV-1 and cognitive functioning was confirmed in a mouse model, which also indicated that exposure to ATCV-1 resulted in changes in gene expression within the brain. Our study indicates that viruses in the environment not thought to infect humans can have biological effects.
Abstract

Chloroviruses (family Phycodnaviridae) are large DNA viruses known to infect certain eukaryotic green algae and have not been previously shown to infect humans or to be part of the human virome. We unexpectedly found sequences homologous to the chlorovirus Acanthocystis turfacea chlorella virus 1 (ATCV-1) in a metagenomic analysis of DNA extracted from human oropharyngeal samples. These samples were obtained by throat swabs of adults without a psychiatric disorder or serious physical illness who were participating in a study that included measures of cognitive functioning. The presence of ATCV-1 DNA was confirmed by quantitative PCR with ATCV-1 DNA being documented in oropharyngeal samples obtained from 40 (43.5%) of 92 individuals. The presence of ATCV-1 DNA was not associated with demographic variables but was associated with a modest but statistically significant decrease in the performance on cognitive assessments of visual processing and visual motor speed. We further explored the effects of ATCV-1 in a mouse model. The inoculation of ATCV-1 into the intestinal tract of 9–11-wk-old mice resulted in a subsequent decrease in performance in several cognitive domains, including ones involving recognition memory and sensory-motor gating. ATCV-1 exposure in mice also resulted in the altered expression of genes within the hippocampus. These genes comprised pathways related to synaptic plasticity, learning, memory formation, and the immune response to viral exposure.

US7176482
DNA-based electronics

Inventor(s): BEN-JACOB ESHEL [IL]; HERMON ZIV [IL]; CASPI SHAY [IL] +

Digital computational circuit comprising a network made of a plurality of identical repetitive DNA-based conductive elements. The DNA-based elements used for the purposes of the invention employ a P-bridge as a tunnel junction for a net charge. The DNA-based element of which the circuit is made may be a DNA SET transistor. The circuit may comprise a DNA resistor built from a plurality of SET transistor elements a series, with a constant over-threshold gate voltage. The circuit may further comprise NOT and NOR gates. The NOT gate can be made of a DNA-based transistor and a resistor, and the resistor can be made by using a DNA SET transistor with a constant over-threshold gate voltage, and by placing a plurality of such DNA SET transistors in series until the resistivity reaches the desired value. The NOR gate, on the other hand, can be built from two NOT elements wherein the output of the first NOT element is connected to the resistor of the second NOT element as it voltage supply.

https://www.youtube.com/watch?v=YVc0wBLri1A

Die Gedanken sind frei (Thoughts are free)

Rundfunk-Jugendchor Wernigerode, conducted by Friedrich Krell. Featured photograph: Hans Scholl, Sophie ...

https://www.youtube.com/watch?v=dbwQXVcbkU0

Pete Seeger- Die Gedanken Sind Frei

I think as I please,
and this gives me pleasure
my conscience decrees,
this right I must treasure.
My thoughts will not cater
to duke or dictator.
No man can deny:
Die Gedanken sind frei!

And should tyrants take me,
and throw me in prison.
My thoughts will burst free,
like blossoms in season.
Foundations will crumble,
and structures will tumble.
And free men will cry:
‘Die Gedanken sind frei!’

http://flashbak.com/sophie-scholl-and-the-white-rose-rebellion-55957/

Sophie Scholl And The White Rose Rebellion

By Paul Sorene

On February 22 1943, Sophie Scholl died. She was beheaded by the Nazis for being part of the anti-Nazi passive resistance group The White Rose (Die Weisse Rose). Also killed by guillotine that day were Sophie’s brother, Hans Scholl, 24, and their best friend, Christoph Probst, 22...

https://aeon.co/essays/revisiting-the-american-dream-in-the-cold-light-of-today

American dreaming 3.0

by
Jennifer Ratner-Rosenhagen

It’s almost impossible to think about the promises and shortcomings of the United States and not think in terms of the ‘American Dream’. US advertisers promote its seductions of individual freedom and material comfort, while school teachers use it to impart civic values. Even in the rough and tumble world of US Realpolitik there is a special place for the ‘American dream’. It’s what helped to inspire Martin Luther King Jr’s ‘I Have a Dream’ speech in 1963, animated Barack Obama’s memoir Dreams from My Father (1995), and gave the title to the 2001 ‘Dream Act’ on immigration reform...
...
No doubt, the prospect of an individual’s imagination as a preserve of freedom emboldened Scholl and Seeger. They believed that in safeguarding the boundaries of their innermost thoughts they were defying political domination. It is a very appealing notion. But is it accurate?

In a totalitarian society, even sleep wasn’t a safe space for the private self.

Charlotte Beradt’s The Third Reich of Dreams (1966) suggests that the verdict is ‘nein’. One of the most important modern collections of dreams from an oppressive political society, Beradt’s study reluctantly disproves the claim of a Nazi authority who maintained that ‘the only person in Germany who still leads a private life is the person who sleeps’. Beradt came to the idea of recording others’ dreams as a result of her own nightmares. Immediately after Hitler seized power in 1933, Beradt, a Jewish journalist living in Berlin, spent night after night being ‘hunted from pillar to post – shot at, tortured, scalped’ in her dreams. It occurred to her that she couldn’t possibly be the only one suffering through her sleep. So she set out to document as many dreams as she could of those who similarly faced oppression and possible persecution – namely Jews and critics of the regime – with the belief that ‘they might one day serve as evidence’ about ‘people’s deepest feelings and reactions as they became part of the mechanism of totalitarianism’...

https://www.chienergyheals.com/energy-healing-and-the-science-of-biophotons/
The Online School of Chi Energy Training, The Rhine Center Bio-Energy Lab and the School of Chi Energy Biophoton Experiment

How Can Bioenergy Be Measured
by

Don E. Brown II

How Bioenergy is measured in the body is done by means of a photomultiplier tube instrument that monitors a person’s bioenergy at the biophoton level. Sifu Cicero, an Instructor for the School of Chi Energy, who practices a nerve fiber building energy exercise that builds up her body’s nerve fiber system to release high levels of biophotons, did undergo this type of measurement. She was invited by the Rhine Center to have her level of biophoton emissions measured. Sifu Cicero was able to have her bio electromagnetic energy [chi] measured via a well-documented and innovative technique.

Below you’ll watch a video of this experiment that shows Sifu Cicero undergoing this biophoton test as researchers at the Rhine Research Center, associated with Duke University, measured her electromagnetic output with a biophoton measuring machine. The Rhine Center uses “a multiphasic ultra-violet light detector which is designed to measure individual photons produced per half second, Rhine researchers were able to measure dramatic increases in the number of photons in the light-proof room when certain people were meditating, performing healings, or claiming to manipulate Chi.”

The equipment used to measure bio-emissions are several special devices. The thermoelectric cooler is used to cool the photomultiplier tube to a negative 26 degrees centigrade. This is done to reduce interference from the electrical devices.. The baseline is taken for each individual before they begin their healing, meditation, or energy work. The photomultiplier tube actually measures the increase in photon emissions from the baseline for the individual being tested. Then it is the photomultiplier tube that measures biophotons. When one photon of light strikes this sensitive surface it dislodges several other electrons. The dislodged electrons accelerate striking many more electrons that cause a change reaction event...

Bio-Emissions Lab Experiment & The Chi Energy Cultivation Method

Sifu Cicero had the unique opportunity to have her bio electromagnetic energy (bioenergy) measured by the scientists at the Rhine Research Center. Sifu Cicero provided us with a video of the experiment as well as a first person account of her experience. Learn more about biophotons and energy healing: The School of Chi Energy Head Instructor Sifu Jones and Sifu Brown put together an mp3 that explains what biophotons or bioenergy is all about. You can listen online or download the mp3 for your convenience...

Using very sensitive equipment in a controlled environment, including a photo multiplier tube and an EMI Shielded Room, the scientists at the Rhine Research Center counted the numbers of biophotons emitted by Sifu Cicero as well as their wavelength/frequency.

As per the “Bio-emissions Lab Experiment” video and Sifu Cicero’s first person account, the scientists performing the experiment were markedly impressed with Sifu Cicero’s ability to raise, lower, and raise again her energy projections. In fact, Sifu Cicero is now the fifth person in 30 years with over thousands of men and women performing this experiment, to reach the energy levels of the Ultraviolet frequencies.

Looking back to Figure 2, it is clear why the scientists were so very impressed. The Ultraviolet frequency/wavelength is not only very high in energy, but also incredibly hot. Sifu Cicero’s ability to raise her energy, at will, on demand and on command, to such a high level is impressive in and of itself. What raises the bar, is that at the same time, Sifu Cicero was able keep herself physically cool while projecting her energy within the Ultraviolet range; mindboggling indeed. Of course, students of the School Chi Energy engage in a methodology and curriculum architected in such a way that Sifu Cicero’s results are the norm, not the exception...

https://www.youtube.com/watch?v=-ZgJz7rB6rs

Chi Energy Training in the First Year
Sifu Cicero

https://www.chienergyheals.com/chi-energy-acupressure-points-manual/#!prettyPhoto

Free Chi Energy Acupressure Manual & Organ Balancing Exercise

https://www.newscientist.com/article/2116040-future-air-conditioning-could-work-by-beaming-heat-into-space/

Future air conditioning could work by beaming heat into space

By Matt Reynolds

With temperatures as cold as -270 °C, space is one hell of a heat sink.

Physicists have achieved record levels of temperature reduction using the process of radiative cooling, by which heat is beamed from Earth’s surface into outer space. Zhen Chen and his colleagues at Stanford University lowered the temperature of a thermal emitter – a device designed to give out more heat than it takes in – to 42.2 °C below that of the surrounding air

“To achieve high-performance cooling, the key is to couple whatever object you want to cool with outer space and to decouple it from the ambient environment,” says Chen. The researchers placed the emitter in a vacuum chamber, isolating it from the atmosphere and cutting off almost any heat transfer through conduction or convection, which could cause the emitter to warm up. Heat from the emitter was radiated out of a specially designed window on top of the vacuum chamber, which was directed at a clear patch of sky.

Earth’s atmosphere allows thermal radiation of wavelengths between 8 and 13 micrometres to pass through it into outer space – but most objects release heat at different wavelengths. The Stanford emitter, however, was specifically designed so that most of the heat it emits falls within that range, meaning that on a clear day it will pass straight out into space without being bounced back by the atmosphere

Within half an hour of pumping air out of the vacuum chamber, the temperature of the emitter plummeted to 40 °C below that of the surrounding air. Over the next 24 hours, it averaged 37 °C below the air temperature, and reached its biggest reduction of 42.2 °C when exposed to the peak of the sun’s heat.

Bigger reduction

Previous attempts at radiative cooling have achieved maximum temperature reductions of up to 20 °C, unless they are at high altitude and with very low humidity.

Jeremy Munday at the University of Maryland in College Park, says the team’s record-breaking results are down to their use of vacuum chambers and sun shades, which prevent sunlight from directly hitting the emitter. “They’re getting significantly below water-freezing temperature during daylight by improving their set-up,” he says.

Similar technology could be used to refrigerate food and medicine in areas where the ambient temperature is high, or in air-conditioning units on top of buildings, says Chen. To scale the technology up for these applications, however, they will need to find a cheaper alternative to the zinc selenide used in the window of the vacuum chamber, a material that is very effective at allowing radiation through at the right wavelengths to be transferred into space.

For situations in which it is not necessary to achieve such dramatic levels of cooling, however, zinc selenide could be substituted for less effective materials. “In the real application, you don’t need such transparent material – you can use cheaper material such as silicon or aluminium,” says Chen.

The researchers have launched a start-up company to explore commercial use of the technology, but Chen warns that it won’t be able to completely replace existing air-conditioning units because overcast skies almost eliminate the effect of radiative cooling.

https://www.nature.com/articles/ncomms13729
Nature Communications 7, Article number: 13729 (2016)
doi:10.1038/ncomms13729

Radiative cooling to deep sub-freezing temperatures through a 24-h day–night cycle

Zhen Chen, Linxiao Zhu, Aaswath Raman & Shanhui Fan

Abstract

Radiative cooling technology utilizes the atmospheric transparency window (8–13 μm) to passively dissipate heat from Earth into outer space (3 K). This technology has attracted broad interests from both fundamental sciences and real world applications, ranging from passive building cooling, renewable energy harvesting and passive refrigeration in arid regions. However, the temperature reduction experimentally demonstrated, thus far, has been relatively modest. Here we theoretically show that ultra-large temperature reduction for as much as 60 °C from ambient is achievable by using a selective thermal emitter and by eliminating parasitic thermal load, and experimentally demonstrate a temperature reduction that far exceeds previous works. In a populous area at sea level, we have achieved an average temperature reduction of 37 °C from the ambient air temperature through a 24-h day–night cycle, with a maximal reduction of 42 °C that occurs when the experimental set-up enclosing the emitter is exposed to peak solar irradiance.

http://www.wakingtimes.com/2017/05/23/ekg-evidence-smart-meters-negatively-affect-human-heart/

EKG Evidence that Smart Meters Negatively Affect the Human Heart
by
Nathaniel Mauka

Copyright Disclaimer : Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use."

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Project : Replication of the Sprink / Ravatin "Activator"

[ Thanks to the support given by 2 Donors to date, it has been possible to buy the 2V --> 800 KV transformer from eBay ( ~$6 ).
Using scant scarce precious moneys otherwise allocated for sex/drugs/gambling, other components have been purchased to construct the frame; Construction has begun !

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