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TetraSilver TetrOxide -- Addendae



Related :
http://www.rexresearch.com/antelman/marantech.htm
http://www.rexresearch.com/antelman/silverox.htm
http://www.rexresearch.com/tetrasilver/tetrasilver.htm
http://www.rexresearch.com/tetrasilver/tsto.html



https://pubchem.ncbi.nlm.nih.gov/compound/44150047

Tetrasilver tetraoxide
 
PubChem CID:     44150047
Chemical Names: Tetrasilver tetraoxide; Silver oxide (Ag4O4); 155645-89-9; IN001522; TETRASILVER(1+) ION TETRAOXIDANDIIDE   More...
Molecular Formula:     Ag4O4-4
Molecular Weight:     495.469 g/mol
InChI Key:     VETQHSSYYACILD-UHFFFAOYSA-N
IUPAC Name : tetrasilver;oxygen(2-)
InChI : InChI=1S/4Ag.4O/q4*+1;4*-2
InChI Key : VETQHSSYYACILD-UHFFFAOYSA-N
Canonical SMILES : [O-2].[O-2].[O-2].[O-2].[Ag+].[Ag+].[Ag+].[Ag+]
Molecular Formula
Ag4O4-4

Other Identifiers
CAS  155645-89-9

Synonyms
Tetrasilver tetraoxide
Silver oxide (Ag4O4)
155645-89-9
IN001522
TETRASILVER(1+) ION TETRAOXIDANDIIDE

Chemical and Physical Properties
Property Name    Property Value
Molecular Weight    495.469 g/mol
Hydrogen Bond Donor Count    0
Hydrogen Bond Acceptor Count    4
Rotatable Bond Count    0
Complexity    0
Topological Polar Surface Area    4 A^2
Monoisotopic Mass    491.6 g/mol
Exact Mass    495.599 g/mol
Compound Is Canonicalized    true
Formal Charge    -4
Heavy Atom Count    8
Defined Atom Stereocenter Count    0
Undefined Atom Stereocenter Count    0
Defined Bond Stereocenter Count    0
Undefined Bond Stereocenter Count    0
Isotope Atom Count    0
Covalently-Bonded Unit Count    8



testrasilver
          structure



http://www.hivaidsguide.com/2011/09/tetrasil-imusil/

Tetrasil (Imusil)

Tetrasil, also known as Imusil, is a fake-AIDS cure that is based on tetrasilver tetroxide, a chemical used to clean pool water. Apparently, people are supposed to believe that because a tiny amount of this highly dangerous chemical kills bacteria and virii in swimming water, that a larger amount will kill infections in humans. Of course, it is well known that it is poisonous to drink rubbing alcohol. Not many people are familiar with tetrasilver tetroxide. This is like saying that because you can use rubbing alcohol to clean a cut or scrape, you should drink it to kill a cold virus. This ‘cure’ is more likely to poison the user than help fight the disease.

Of course, the marketers of Tetrasil, like most proponents of fake cures, can’t have a single explanation for how their cure works. Apparently the more extreme and outrageous the claims the better. So, in addition to the ‘fact’ that tetrasilver tetroxide is used in pool ‘proves’ that it is safe to ingest and will kill infections, these tiny molecules are actually machines that generate electricity and kill the AIDS virus, HIV, by zapping it with electricity. (This claim is straight from the US patent for Tetrasil, by the way. For those who don’t know – you can file a patent for anything, including a time machine that will take you to a non-existent universe. The patent office doesn’t care if the thing works, just if you are copying someone else. So if you ever see anyone waving around a patent as proof that their crazy claim is valid – all it proves it no one else was crazy enough to want to claim the idea.)

It is, however, very very interesting that the patent claims that Tetrasil cures AIDS by electrocuting HIV, since the patent is held by a ‘Dr’. Marvin S. Antelman, the maker of Tetrasil, who claims that HIV has nothing to do with AIDS! Alright ‘Dr.’ Antelman, I’ll give you the benefit of the doubt. Assuming that HIV has nothing to do with AIDS, how do you cure a disease by killing something that is totally unrelated to it?

You can’t. And you can’t cure AIDS without attacking HIV. Which is just one more proof that the so-called doctor doesn’t know what he is talking about and is just out to make a buck. Illogical claims like this can be sold to people if the seller talks fast enough and doesn’t give them time to stop and question the absurdity of it, but a legitimate health professional wants people to ask questions, wants to have problems pointed out so they can be corrected. And a legitimate health worker does not make ridiculous claims that directly contradict his OWN PATENT!

That isn’t the only difference between ‘Dr.’ Antelman and a legitimate health worker. There are quite a few more. Among them, a real researcher wants other people to test their findings, and make sure their medicines work. This is called ‘third party testing’. A researcher wants this for two reasons. First, someone else doing the testing in a different way can make sure they didn’t miss anything in their work. Second, it’s a promise to their customers – ‘I have let my work be examined by other people, who agree that it works and is safe.’ Apparently, ‘Dr.’ Antelman feels neither of these are valid concerns, as the company he keep proclaiming has tested Tetrasil and found it safe and effective, is one that he owns. So basically he is saying ‘I have tested my own invention and proved to myself that it is safe and will work – and you can take my word for it!’

Worse, it isn’t safe, as Antelman’s own reported test results prove. All but one of the people who took part in Antelman’s ‘clinical test’ of Tetrasil developed hepatomegaly or enlarged livers. An enlarged liver only happens when a person has developed a serious medical condition such as liver disease, congestive heart failure or cancer! Of course, ‘Dr’. Antleman insists that none of the test participants were harmed, and that an enlarged liver is not dangerous. No, an enlarged liver doesn’t endanger a person – but the problems that cause it DO! Of course, Antleman couldn’t be bothered to test for further problems that might have led his patients to develop hepatomegaly.

Yet this man, who wants us to take his word, has already contradicted himself about how his so-called ‘cure’ works and claims it is safe while publicly announcing that his test subjects developed medical problems. It’s hard to trust someone who won’t play straight, who contradicts himself, and is not open and aboveboard.

At this time, Tetrasil is banned in Zambia because it has no proven effects for people living with HIV. It is still legal to sell in America (people need to be able to disinfect their pools) but it is illegal to promote it as a treatment or preventative for any disease.

Key ingredients: Tetrasilver tetroxide



https://www.voanews.com/a/a-13-2007-05-27-voa5/405931.html

Zambia Bans Untested AIDS Cures
November 01, 2009

In Zambia, the government has introduced a law to protect people infected with the AIDS virus, HIV, from drugs that could harm their health. The law will require all anti-AIDS medications coming into the country to undergo clinical testing before being sold on the local market. From Lusaka, Danstan Kaunda has the story.

Many HIV patients in Zambia have abandoned life-prolonging anti-retroviral drugs for what is said to be a miracle cure, called ‘Tetrasil.’

Tetrasil appeared on the local market shortly after a Zambian weekly newspaper published a story saying it can cure HIV with 21 days.

The tabloid quoted a controversial US-based California activist, Boyd Graves, who said over 10 HIV patients have been disease-free since January.

Graves has also said the U.S government manufactured the HIV virus in a lab – a charge disputed by the mainstream scientific community. According to the Atlanta-based Centers for Disease Control, a team of international researchers reported in 1999 that they had traced the origins of HIV-1, the predominant strain of HIV in the developed world, to chimpanzees in west equatorial Africa. The CDC's web page says, "The researchers believe that HIV-1 was introduced into the human population when hunters became exposed to infected blood." (www.cdc.gov/hiv/resources/qa/qa3.htm)

In response to the controversy over the alleged cure, the government of Zambia has banned a local chemist – a sister company to the tabloid that published the claims – from selling Tetrasil. The government has also banned any press advertisements for it.

Under the new law, the Pharmaceutical Regulatory Authority of the Ministry of Health will test the safety and efficacy of all drugs and natural remedies, whether they are western medications or locally available herbs.

Dr. Canisius Banda is a spokesperson in the Ministry of Health.

"A technical working group," he said, "will be put in place to study these claims through scientific scrutiny, and if the drug (Tetrasil) passes the tests, than we will find ways on how will it be rolled out to the public, because it has to be an orderly process. We are saying that about 1.6 million people in Zambia are living with the HIV virus. Seventy-six thousand of them are on ARVs (antiretrovirals), and about 200,000 need to be on them. So if the process is not managed properly there could be a stampede or chaos."

Banda said claims of a cure for HIV / AIDS are often false – and hurt efforts to protect those infected – like government programs to provide free anti-retrovirals to pregnant mothers.

"Derailing government programs is not a wise thing to encourage," he said, "because it can threaten national security, and again that is a criminal activity. We will continue with the measures in place, but also encourage people with these claims, so that they are submitted to the ministry for scientific verification."

Meanwhile, the Network of Zambian People Living with HIV and AIDS wants the government to arrest anyone found selling Tetrasil.

Zambia has one of Africa’s highest infection rates – with about 16 percent of its population of 11 million infected.



http://pubs.acs.org/doi/abs/10.1021/ed085p863
J. Chem. Educ., 2008, 85 (6), p 863
DOI: 10.1021/ed085p863

Silver(II) Oxide or Silver(I,III) Oxide?

David Tudela

Departamento de Química Inorgánica, Universidad Autónoma de Madrid, 28049 Madrid, Spain

Abstract

The often called silver peroxide and silver(II) oxide, AgO or Ag2O2, is actually a mixed oxidation state silver(I,III) oxide. A thermochemical cycle, with lattice energies calculated within the "volume-based" thermodynamic approach, explain why the silver(I,III) oxide is more stable than the hypothetical silver(II) oxide. The coordination geometries of silver and copper in their known oxides correlate with those associated to their electron configurations in coordination compounds. The second ionization energy is higher for Ag than for Cu, which can be related to the small size of 3d orbitals and the resulting high electron repulsion for the first transition series elements.



http://pubs.acs.org/doi/abs/10.1021/ja01333a016?src=recsys
Journal of the American Chemical Society, 1933 55 (6), pp 2311–2325

The Solubility of Silver Oxide in Water, in Alkali and in Alkaline Salt Solutions
Johnston, Cuta, Garrett

http://pubs.acs.org/doi/abs/10.1021/j150267a005?src=recsys
The Journal of Physical Chemistry 1926 30 (9), pp 1179–1180
Solubility of Silver Oxide

http://pubs.acs.org/doi/abs/10.1021/ed021p523?src=recsys
Journal of Chemical Education, 1944 21 (11), p 523
The oxidation states of silver


 
http://pubs.acs.org/doi/abs/10.1021/ja01492a006?src=recsys
Journal of the American Chemical Society, 1960 82 (7), pp 1540–1543

The Thermal Decomposition of Silver Oxide

Herley, Prout



http://pubs.acs.org/doi/abs/10.1021/j100078a009?src=recsys
J. Phys. Chem., 1994, 98 (27), pp 6699–6703
DOI: 10.1021/j100078a009

Electronegativity and Bond Type. 2. Evaluation of Electronegativity Scales

Gordon Sproul
 


https://www.amazon.co.uk/AIDANCE-TERRASIL-MAXIMUM-STRENGTH-ELECTRON/dp/B0027MDN1W

AIDANCE TERRASIL MAX MAXIMUM STRENGTH MULTIPURPOSE ACTIVATED MINERAL SKIN OINTMENT
44g Jar
by Oxyvita Ltd
Currently unavailable.

Product description -- The most exciting Multipurpose Skin Ointment for years! * Extra Strength Terrasil. Twice the volume of Restorative Minerals! Twice the strength of Terrasil Original! * For even faster relief from a variety of challenging skin problems * Powerful soothing ingredients * Unsurpassed in it's simplicity, safety and effectiveness * Contains Aidance Proprietary Restorative Mineral Blend for outstanding healing properties, elimination of toxins and the promotion of balanced healthy skin. * With soothing Aromatic Therapeutic Plant Extracts * Plus Natural Medicinal Moisturisers Beeswax and Jojoba Oil * Paraben Free * Safe and well tolerated * 44g Value Jar



https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad78d581-84b9-4f7d-ad8c-a3999a462028

TERRASIL WOUND CARE

Label: TERRASIL WOUND CARE - allantoin 0.5%, benzethonium chloride 0.5% ointment
NDC Code(s): 24909-115-44
Packager: Aidance Skincare & Topical Solutions, LLC
Category: HUMAN OTC DRUG LABEL
DEA Schedule: None
Marketing Status: OTC monograph not final



https://www.ncbi.nlm.nih.gov/pubmed/22108474
Panminerva Med. 2011 Sep;53(3 Suppl 1):29-33.

Silver oxide ointment wound dressing in venous ulcerations: home, self-management.

Belcaro G1, Cesarone MR, Errichi BM, Ricci A, Antelman P, Dugall M, Pellegrini L, Ledda A, Viscardi G.

Abstract

AIM: Venous ulcers are a common, chronic medical and social problem. These ulcers are difficult to heal in most patients with sustained venous hypertension. This pilot product evaluation registry study has evaluated the efficacy and safety of an antimicrobial silver oxide wound dressing ointment ("Silver Oxide Ointment") as part of the treatment of 'difficult' venous ulcerations.

METHODS: The study was conducted measuring the variations in the area of the ulceration and microcirculatory parameters.

RESULTS: After four weeks, treatment with the Silver Oxide Ointment proved more effective than the 'best management' used in controls. Transcutaneous PO2 was increased (improved); Laser Doppler skin flux and transcutaneous PCO2 were improved (decreased). Also in the silver oxide group a significantly higher number of venous ulcers were completely healed at four weeks. The silver oxide ointment improved both the microcirculation and the healing rate of their ulcers. No significant tolerability problems were observed.

CONCLUSION: In difficult venous ulcerations, local treatment with this Silver Oxide Ointment, as one component of the total wound dressing, improved microcirculation measurements and healing rate. Most of the treatments were done at home by the patients or by their tutors. This study indicates the important role of this type of treatment and indicates the need to plan larger and more prolonged studies.



https://www.ncbi.nlm.nih.gov/pubmed/20657533
Panminerva Med. 2010 Jun;52(2 Suppl 1):37-42.

Venous and diabetic ulcerations: management with topical multivalent silver oxide ointment.

Belcaro G1, Cesarone MR, Errichi BM, Ricci A, Dugall M, Pellegrini L, Ledda A, Grossi MG.

Abstract

AIM: In addition to contemporary compression therapy, one of the therapeutic approaches is the use of a topical wound care agent. The goal of this pilot registry study is to evaluate the efficacy and safety of a uniquely designed ointment containing multivalent silver oxide (Ag4O4) in the healing of difficult diabetic or venous ulcerations.

METHODS: Patients who had ulcers resulting from chronic venous insufficiency or diabetes participated in this open-label, randomized registry study. All patients were evaluated by measuring both the area of the ulceration and microcirculatory parameters. 148 patients were included in the study and categorized into two main groups: venous ulcers and diabetic ulcers. Each main group was then randomized into two sub-groups: topical treatment with silver oxide ointment and the control group (standard cleaning and compression management methods, without silver ointment). All patients were treated with accepted cleaning and compression management. RESULTS. In subjects with venous ulcers: After 4 weeks, the silver treatment was more effective than the control group treatment: Skin PO2 was increased 2.1 times more than the control group (17.4% to 8.2%) and skin flux (RF) was improved 1.6 times more than the control group (-38.7% to -24.2%). The total surface area of the ulcer was significantly reduced in the silver treatment group by 1.9 times the control group (-88.7% to -46.9%). In addition, in the silver treatment group we observed complete closure of the ulceration in 42% of subjects compared to 22% in the control group (P=<0.05). In subjects with diabetic ulcers: after 4 weeks, the silver treatment was more effective than the control group treatment: Skin PO2 increased 2.6 times more than the control group (23.3% to 9.1%) and skin flux (RF) was significantly improved 4.3 times more than the control group(-26.7% to -6.2%). The total surface area of the ulcer was significantly reduced in the silver treatment group by 3.7 times the control group (-89.0% to -23.9%). In addition, in the silver treatment group we observed complete closure of the ulceration in 39% of subjects compared to 16% in the control group (P</=0.05).

CONCLUSION: This pilot study provides observational data on the efficacy of local treatment of ulcers with a multivalent silver oxide containing ointment. The silver ointment improved microcirculation and the healing rate of all 78 patients that were treated with multivalent silver ointment and closed twice as many ulcers in 4 weeks compared to the control groups (40.7% silver treatment compared to 19.4% for the control). This study demonstrates the feasibility of this type of treatment and provides evidence of efficacy to plan larger randomized controlled studies. The large number of patients that were helped in this study demonstrates the efficacy of multivalent silver oxide topical ointment and its important role in ulcer therapy.



https://www.ncbi.nlm.nih.gov/pubmed/22108474
Panminerva Med. 2011 Sep;53(3 Suppl 1):29-33.

Silver oxide ointment wound dressing in venous ulcerations: home, self-management.

Belcaro G1, Cesarone MR, Errichi BM, Ricci A, Antelman P, Dugall M, Pellegrini L, Ledda A, Viscardi G.

Abstract

AIM: Venous ulcers are a common, chronic medical and social problem. These ulcers are difficult to heal in most patients with sustained venous hypertension. This pilot product evaluation registry study has evaluated the efficacy and safety of an antimicrobial silver oxide wound dressing ointment ("Silver Oxide Ointment") as part of the treatment of 'difficult' venous ulcerations.

METHODS: The study was conducted measuring the variations in the area of the ulceration and microcirculatory parameters.

RESULTS: After four weeks, treatment with the Silver Oxide Ointment proved more effective than the 'best management' used in controls. Transcutaneous PO2 was increased (improved); Laser Doppler skin flux and transcutaneous PCO2 were improved (decreased). Also in the silver oxide group a significantly higher number of venous ulcers were completely healed at four weeks. The silver oxide ointment improved both the microcirculation and the healing rate of their ulcers. No significant tolerability problems were observed.

CONCLUSION: In difficult venous ulcerations, local treatment with this Silver Oxide Ointment, as one component of the total wound dressing, improved microcirculation measurements and healing rate. Most of the treatments were done at home by the patients or by their tutors. This study indicates the important role of this type of treatment and indicates the need to plan larger and more prolonged studies.



https://www.ncbi.nlm.nih.gov/pubmed/21861623
Future Microbiol. 2011 Aug;6(8):933-40. doi: 10.2217/FMB.11.78.

Antimicrobial effects of TiO(2) and Ag(2)O nanoparticles against drug-resistant bacteria and leishmania parasites.

Allahverdiyev AM1, Abamor ES, Bagirova M, Rafailovich M.

Abstract

Nanotechnology is the creation of functional materials, devices and systems at atomic and molecular scales (1-100 nm), where properties differ significantly from those at a larger scale. The use of nanotechnology and nanomaterials in medical research is growing rapidly. Recently, nanotechnologic developments in microbiology have gained importance in the field of chemotherapy. Bacterial strains that are resistant to current antibiotics have become serious public health problems that raise the need to develop new bactericidal materials. Metal oxide nanoparticles, especially TiO(2) and Ag(2)O nanoparticles, have demonstrated significant antibacterial activity. Therefore, it is thought that this property of metal oxide nanoparticles could effectively be used as a novel solution strategy. In this review, we focus on the unique properties of nanoparticles, their mechanism of action as antibacterial agents and recent studies in which the effects of visible and UV-light induced TiO(2) and Ag(2)O nanoparticles on drug-resistant bacteria have been documented. In addition, from to previous results of our studies, antileishmanial effects of metal oxide nanoparticles are also demonstrated, indicating that metal oxide nanoparticles can also be effective against eukaryotic infectious agents. Conversely, despite their significant potential in antimicrobial applications, the toxicity of metal oxide nanoparticles restricts their use in humans. However, recent studies infer that metal oxide nanoparticles have considerable potential to be the first-choice for antibacterial and antiparasitic applications in the future, provided that researchers can bring new ideas in order to cope with their main problem of toxicity.



http://www.healthyworldstore.com/product-p/ts.htm

Tetrasil

Tetrasil (Terrasil) attacks bacterial, viral, and fungal infections like no other skin cream or ointment. It is highly recommended to relieve itching, rashes, redness, burning and other unwanted symptoms of skin infections. Customers say the result is not just rapid relief of symptoms, but the entire elimination of the root causes of these ailments.

Laboratory analysis, clinical studies, and patient feedback has convinced Dr. Horowitz that Tetrasil's active ingredient, Tetrasilver Tetroxide, interacts with the surfaces of bacterial, fungal and viral membranes to help people heal better and faster than any other product in its class.    
    
Features & Ingredients

Upon contact, TETRASIL's unique chemical structure releases both a micro-electrical charge and therapeutic oxygen, which immediately begins to kill pathogens.
Dr. Horowitz expects this product, and advertisment, will be attacked vigorously by the FDA simply because it works so well, at such low cost, without any risks of toxicity when used correctly, and without dangerous side effects presented by all pharmaceutical antibiotics. (See instructions.)



https://www.youtube.com/watch?v=i-nI19OLyMM

Tetrasil, tetrasilver-tetroxide, silver oxide

Tetrasilver tetroxide - prepared at home. I prepared it from AgNO3, NaOH and NaS2O8. I dissolved it in neutral organic solvent and applied against my athletes feet twice and it worked-signs disappeared.



https://cynthiabarringtontetrasilver.wordpress.com/2012/02/29/autism-brains-have-dna-with-8-rna-viruses-which-may-be-inhibited-by-tetrasilver-tetroxide-us-pat-6485755/

Autism brains have DNA with 8 RNA viruses which may be inhibited by Tetrasilver Tetroxide US PAT 6485755

Hello parents and family members of autistic children:

I have found some interesting information about the RNA viruses associated with autism.  RNA viruses for HIV and cancer are inhibited by Tetrasilver Tetroxide US Pat 5676977 and US Pat 6485755 respectively.

Association of Autism with Polyoma Virus Infection in Postmortem Brains.
Journal Neurovirology, 2010 March – Lintas C, Altieri L, Lombardi F, Sacco R, Persico AM.Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy.[1]

These viruses were found in the brain DNA of 15 autistic children in Italy who died by 2010 but had diagnoses of autism.   How did the JC virus from the US and the BK virus from the US survive from 1971 until 2010 for 39 years?  Tissue decomposes when someone dies usually within 3 months in a moist climate {see http://fac.utk.edu/}

Interestingly to note there were a total of FIVE herpes viruses and two people viruses from patients who died in 1971 in the US!  Lastly Lintas found the AIDS or HIV virus from green monkeys’ kidneys.  This virus has been called the SV-40 virus and first was named the SE Polyoma virus for Dr. Bernice Eddy, PhD, and Dr Sarah Stewart, MD, PhD who found it in polio vaccine complement used in the 1950s through 1963.  They found that the SE Polyoma virus could cause cancer in many animal species and feared that it would cause cancer in humans.[2]

Carla Lintas found these RNA viruses: cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus type 1 (HSV1), herpes simplex virus type 2 (HSV2), human herpes virus 6 (HHV6), BK virus (BKV), JC virus (JCV), and simian virus 40 (SV40) in genomic DNA

The most prevalently occurring viruses were RNA Herpes Viruses to include Herpes 1, 2, 4 EBV, 5 CMV, and 5 measles roseola., Herpes I is herpes simplex virus type 1
HSV2 herpes simplex virus type 2 (HSV2), Epstein-Barr virus (EBV) herpes virus 4 (HV4), cytomegalovirus (CMV) human virus 5 (HV5),
human herpes virus 6 (HHV6) also known as roseola or Measles,BK virus (BKV),JC virus (JCV), Green Monkey Kidney virus simian virus 40 (SV40) found by Maurice Hilleman, PhD of Merck fame in the late 1950s following research by Drs. Eddy and Stewart; bkvirus – Nephropathy from BK virus (BKV) infection is an evolving challenge in kidney transplant recipients.

(cjasn.asnjournals.org/content/2/Supplement_1/S36.full)

Who is BK of the bkvirus and what family is it in?

The BK virus was first isolated in 1971 from the urine of a renal transplant patient, initials B.K.[3]The BK virus is similar to another virus called the JCV since their genome sequences share 75% homology. [Essentially these viruses are very identical they share 75% of the same genome sequences but BK and JC were not related humans.]  Polyomaviridae is  the bkvirus family. ] Polyoma is the genus of the bkvirus and jcvirus.  Both of these viruses can be identified and differentiated from each other by carrying out serological tests using specific antibodies or by using a PCR based genotyping approach.

Who is JC of the jcvirus?

The jcvirus was from a patient with progressive multifocal leukoencephalopathy (PML).[4]

Why are the animal and herpes RNA viruses mentioned in the work of Carla Lintas so significant?
Where else are so many and varied animal viruses present to make cells infected with Multiple Sclerosis? In the cell of a woman patient with multiple sclerosis cultured in US PAT 6582703 See Figure 45. A total of 18 different animal viruses were found in the Multiple Sclerosis cell of an infected woman that were tissue cultured for sale by Perron and Jean Marie Seigneurin co-holders of US Patent 6582703 In FIGURE 45 RNA Viruses from Asian Indian Gibbon Ape, West African Green Monkey, South African Baboon, Chimp, Central/South American Squirrel Monkey, Icelandic Sheep Nazi Maedi VISNA virus, Cow Lymphoma, Horse Leukemia, + Simian Foamy Virus etc. are mentioned.

18 Animal Viruses in Multiple Sclerosis tissue culture infection

http://www.patentstorm.us/patents/6582703/fulltext.html

What does a tetrasilver tetroxide recipient look like after being cured of HIV and having no RNA viruses detectable in the blood?

http://www.facebook.com/media/set/?set=a.247457775273179.65761.100000268761354&type=3

Autism is a highly heritable behavioral disorder. Yet, two decades of genetic investigation have unveiled extremely few cases that can be solely explained on the basis of de novo mutations or cytogenetic abnormalities. Vertical viral transmission represents a nongenetic mechanism of disease compatible with high parent-to-offspring transmission and with low rates of disease-specific genetic abnormalities. Vertically transmitted viruses should be found more frequently in the affected tissues of autistic individuals compared to controls. Our initial step was thus to assess by nested polymerase chain reaction (PCR) and DNA sequence analysis the presence of cytomegalovirus (CMV)[Herpes Virus V], Epstein-Barr virus (EBV)[Herpes Virus iV], herpes simplex virus type 1 (HSV1), herpes simplex virus type 2 (HSV2), human herpes virus 6 (HHV6)[Herpes Virus known as roseola or measles such as measles vaccine], BK virus (BKV)[from BK’s kidney], JC virus (JCV)[from JC’s brain leukoencechalopathy], and simian virus 40 (SV40)[from a West African green monkey kidney] in genomic DNA extracted from postmortem temporocortical tissue (Brodmann areas 41/42) belonging to 15 autistic patients and 13 controls. BKV, JCV, and SV40 combined are significantly more frequent among autistic patients compared to controls (67% versus 23%, respectively; P < .05). The majority of positives yielded archetypal sequences, whereas six patients and two controls unveiled single-base pair changes in two or more sequenced clones. No association is present with the remaining viruses, which are found in relatively few individuals (N </= 3). Also polyviral infections tend to occur more frequently in the brains of autistic patients compared to controls (40% versus 7.7%, respectively; P = .08). Follow-up studies exploring vertical viral transmission as a possible pathogenetic mechanism in autistic disorder should focus on, but not be limited to, the role of polyoma viruses. PMID: 20345322″

1 Association of Autism with Polyoma Virus Infection in Postmortem Brains. Journal Neurovirology, 2010 March – Lintas C, Altieri L, Lombardi F, Sacco R, Persico AM.Laboratory of Molecular Psychiatry and Neurogenetics, University Campus Bio-Medico, Rome, Italy.
http://umanitoba.ca/faculties/medicine/medical_microbiology/SeminarPDF/polyomavirus_infection_Stachowiak_Nov2010.pdf
http://www.ncbi.nlm.nih.gov/pubmed/20345322

2 EDDY BE, STEWART SE. Characteristics of the SE polyoma virus. Am J Public Health Nations Health. 1959 Nov;49:1486–1492. 
http://www.ncbi.nlm.nih.gov/pubmed/13819251

3 Gardner SD, Field AM, Coleman DV, Hulme B (June 1971). “New human papovavirus (B.K.) isolated from urine after renal transplantation”. Lancet 1 (7712): 1253–7. PMID 4104714.

4 BL, Walker DL et al (1971). “Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy”.Lancet 1 (7712): 1257–60. doi:10.1016/S0140-6736(71)91777-6. PMID 4104715.



http://europepmc.org/patents/PAT/CN101336640

Tetrasilver tetroxide bactericide, preparation method and use thereof (PAT - CN101336640)

KAIMING JIANG , SHUNNAN HU
Abstract

The present invention discloses a tetrasilver tetroxide fungicide, a preparing method and an application thereof. The tetrasilver tetroxide fungicide comprises the following components by weight part: weak alkaline solution 800-1200 parts, tetrasilver tetroxide 0.1-0.5 parts, and polyvinyl alcohol 8-20 parts. The preparing method of the tetrasilver tetroxide fungicide comprises the following steps: using the weak alkaline solution with pH value of 7.0-7.5 as dissolvent, fetching 800-1200 parts of weak alkaline solution, and adding 0.1-0.5 parts of tetrasilver tetroxide, sufficiently diluting and uniformly mixing 8-20 parts of polyvinyl alcohol with the obtained solution in which the polyvinyl alcohol is used as carrier, and then the tetrasilver tetroxide fungicide is prepared. The invention also discloses the application of the tetrasilver tetroxide fungicide as a disinfection additive. The preparing method of the tetrasilver tetroxide fungicide according to the invention is simple and is suitable for large-scale production.

Technical field

The present invention relates to a four silver oxide bactericide, its preparation and application.

Background technique

At present, the research and application of bactericides mainly focus on the medicaments for preventing and curing the diseases caused by fungi, and the research and development of medicaments for preventing and curing diseases caused by bacteria and viruses is not enough. Silver bactericidal effect has long been found in recent years, people in the process of sterilizing silver sterilization, but also gradually want to apply the principle of sterilizing silver products to go, but the market has not yet as a bactericide to prevent bacteria and viruses , And the example applied to the product appears. In the July 2005 issue of "Chinese Journal of New Drugs and Clinical Medicine", "Progress in the research of medicinal silver tetraoxide" was reported, indicating that it is expected to become a novel antimicrobial agent and be used in the treatment of AIDS, cancer and other diseases .

Content of the invention

Object of the Invention: The purpose of the present invention is to provide a four-silver tetrabasic bactericide prepared from tetra-silver tetraoxide, a preparation method thereof and its use as a bactericidal additive.

Technical solution: a silver tetrabasic fungicide, which comprises the following components in weight: 800 to 1200 parts of weak alkaline solution, 0.1 to 0.5 parts of silver tetraoxide, and 8 to 20 parts of polyvinyl alcohol.

Four silver tetrafluoroborate bactericide includes the following components by weight: 1000 parts of weak alkaline solution, 0.2 parts of silver tetraoxide, and 10-15 parts of polyvinyl alcohol.

Preparation of tetrabasic silver fungicides, which comprises the following steps:

(1)Take weak alkaline solution with PH value of 7.0-7.5 as solvent, take weakly alkaline solution of 800-1200 parts and add 0.1-0.5 parts of silver tetraoxide to dilute thoroughly;

(2)8 to 20 parts of polyvinyl alcohol as a carrier, polyvinyl alcohol and the solution obtained in step (1) were uniformly mixed to obtain a tetrad silver oxide bactericide.

The weakly alkaline solution in step (1) is ammonia, sodium hydroxide or potassium hydroxide.

Four silver oxide fungicides as bactericidal additives.

Application of Four Silver Oxide Bactericide as Antibacterial Additive in Antibacterial Plastic Products.
Application of Four Silver Tetraoxide Bactericide as Antibacterial Additive in Antibacterial Fiber Products.
Application of Four Silver Oxide Bactericide as Antibacterial Additive in Antibacterial Fabric.
Application of Tetraoxysilver Antibiotics as Bactericidal Additives to Plant Diseases Caused by Microbes of Various Pathogens.
Application of Four Silver Oxide Bactericide as Antibacterial Additive in Antibacterial Coatings.

According to two kinds of fungicide mechanism of action: ① by interfering with the respiratory process of germs, inhibit the production of energy to kill bacteria. ② interfere with microbial life substances such as proteins, nucleic acids, alcohols and other biosynthesis to kill bacteria. Tetraoxide silver tetraoxide prepared four silver fungicides as fungicides belong to the second type of mechanism of action. The mechanism of Ag4O4 was analyzed. The antibacterial order of Ag4O4 was: Ag <3 +> Ag <2 +> Ag <1+>, and Ag4O4 was a kind of Ag4O4 with A unique conformation of "multivalent silver" oxide that redox reactions with exposed 2N and 2S groups on the protein surface produces electrical kill and chelation that result in altered protein conformation. Its mechanism of action is different from the general antimicrobial agents, the mode of action is not easy to cause the pathogen resistance or mutation, no toxicity to normal tissues, with anti-microbial and anti-inflammatory cells.

Beneficial effects: Four silver tetraoxide interferes with the function of preventing biosynthesis of bacterial cells, especially bacteria and viruses, and antimicrobial plastic products, antimicrobial fiber products, antibacterial fabrics , Against various pathogenic microorganisms caused by plant diseases, medical equipment and reagent additives, antibacterial coatings and antibacterial ware widely used in these fields, with good inhibition of bacteria, viruses, the preparation method of the present invention is simple, suitable for large Scale industrial production, application method is simple and practical.

Detailed description

The present invention will be further described below in combination with specific embodiments.

Example 1: Preparation of tetrad silver oxide bactericide.

(1)To PH value of 7.0 ammonia (NH3) solution 1 kg solvent, adding 200 mg of silver tetraoxide fully diluted;

(2)0.01 kg of polyvinyl alcohol as a carrier, and the solution obtained in step (1) were uniformly mixed to obtain 1 kg of silver tetrafluoroborate fungicide.

Example 2: Four silver tetrabasic bactericides as bactericidal additives in antimicrobial plastic products.

The reagent containing the silver tetrafluoroborate obtained in Example 1 was sprayed on the air filter element to naturally cure and dry the air filter element with antibacterial effect. Tetraoxide silver fungicide can also be added in the form of plastic coupling agent, about to dissolve the solution of tetrad silver anti-bacterial agent sprayed on the plastic particles, and then dried to use.

After testing, spray sterilized four four silver oxide air-conditioning filter in Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Campylobacter brevis, the survival rate of mixed strains were 0 , Which shows that four silver antimicrobial agent has the role of killing bacteria and mold.

Example 3: Four silver tetrabasic bactericides as bactericidal additives in antimicrobial plastic products.

The tetracycline antimicrobial agent obtained in Example 1 was directly combined with the air conditioning case in the form of a mist or coating on the formed air conditioning case. Because the exterior of the air conditioning is very smooth, you can use corona treatment, that is, under the action of high voltage electric field, the electron current exerts a powerful impact on the surface of the air conditioning enclosure, which can make the surface of the enclosure furred, roughened and increase the surface area. When in contact with its surface, it will create a good wetting that will penetrate into the furrows that have been pulled, and will be firmly anchored to the plastic shell by anchoring. Use this principle, the corona treatment will be four silver tetrachloride bactericide spray applied or coated by the temperature of 60 ~ 80 ° C for 8 to 12 minutes to dry, so that the four silver tetrachloride bactericide by complexation Fixed on the plastic shell surface.

After testing, spraying four tetra-antimicrobial tetracycline in the air-conditioned housing Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Bacillus crillium, species mixed survival rate was 0 , Which shows that four silver antimicrobial agent has the role of killing bacteria and mold.

Example 4: Preparation of tetrad silver oxide bactericide.


(1)To PH value of 7.2 sodium hydroxide solution 0.5 kg as solvent, add 100 mg of silver tetraoxide fully diluted;

(2)With 0.006 kg of polyvinyl alcohol as a carrier, the solution obtained in step (1) was uniformly mixed to obtain 0.5 kg of silver tetrafluoroborate bactericide.

Example 5: Tetraoxide silver fungicide as bactericidal additives in the application of antibacterial fiber products.

The PP brushed fiber products and 60 ~ 85 ° C dissolved in Example 4 was prepared four tetrabutyl silver fungicide solution warm water cross-linked, and then dried to obtain a bactericidal antibacterial fiber products.

After testing, coated silver tetrabuicides disinfectant PP drawing grade fiber products Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Campylobacter sp., A mixture of strains Survival rate is 0, we can see that four silver tetrabasic fungicides have the role of killing bacteria and mold.

Example 6: Use of Tetraoxysilver Antibiotics as Antibacterial Additives in Antibacterial Fiber Products.

The tetrad silver oxide bactericide obtained in Example 4 is added to the hot melt adhesive, and the child with a bactericidal effect can be made to be wet by the coating method.

After testing, children coated with silver tetrasulfate antimicrobial agents used in diabetics, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Campylobacter crispus, bacteria mixed kind of survival The rate is 0, we can see that four silver tetrabasic fungicides have the role of killing bacteria and mold.

Example 7: Use of Tetraoxysilver Antibiotics as Antibacterial Additives in Antibacterial Fiber Products.

The tetrafluoroborate antimicrobial agent obtained in Example 4 was added to the hot melt adhesive, and the sanitary napkin and the panty liner with bactericidal effect were prepared by the coating method.

After testing, coated with four silver tetrasulfide disinfectant sanitary napkins, sanitary pads in Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Bacillus crillium, mixed species Survival rate is 0, we can see that four silver tetrabasic fungicides have the role of killing bacteria and mold.

Example 8: Use of a silver tetraborate antimicrobial agent as an antimicrobial additive in an antimicrobial fabric.

The medical staff and patient clothing were immersed in the solution of the silver tetrabasic fungicide prepared in Example 4, and the antibacterial effect of medical staff and patient clothing were obtained by centrifuging and recovering the solution, drying and drying.

After testing, infiltration of tetrabenzene antimicrobial tetracycline antibacterial agents and patient clothing Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Campylobacter brevis, the survival rate of mixed species Are 0, we can see that four silver tetrabasic fungicides have the role of killing bacteria and mold.

Example 9: Use of Tetraoxysilver Antibiotics as Antibacterial Additives in Antibacterial Fabrics.

The wound paste was immersed in a solution of the silver tetraborate antimicrobial agent obtained in Example 4, and the wound paste with antibacterial effect was obtained by centrifugal dehydration recovery solution, drying and drying.

After testing, infiltrated four antimicrobial silver tetrazolium agents in the wound paste E. coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Campylobacter brevis, the survival rate of mixed strains were 0 , Which shows that four silver antimicrobial agent has the role of killing bacteria and mold.

Example 10: Preparation of tetrad silver oxide bactericide.

(1)To PH value of 7.5 potassium hydroxide solution 2 kg solvent, add 400 mg of silver tetraoxide fully diluted;

(2)With 0.03 kg of polyvinyl alcohol as a carrier, the solution obtained in step (1) was uniformly mixed to obtain 2 kg of silver tetrafluoroborate bactericide.

Example 11: Application of Tetraoxotetra Fungal Bacteria in Plant Resistance to Diseases Caused by Various Pathogenic Microorganisms.

When watering wheat, the silver tetrabasic bactericide prepared in Example 10 can be diluted at a concentration of 10 to 30 ppb, and diseases caused by various pathogenic microorganisms can be effectively prevented by spraying or pouring.

After testing, pouring over the water containing four tetrabasic silver disinfectant of wheat, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Campylobacter crispus, the survival rate of mixed strains Are 0, we can see four silver oxide bactericide has the effect of killing bacteria and fungi, thereby effectively inhibiting the pathogenic microorganisms caused by the disease.

Example 12: Application of Tetraoxide Tetraoxide Bactericide in Plant Resistance to Diseases Caused by Various Pathogenic Microorganisms.

The silver tetraborate antimicrobial agent prepared in Example 10 was diluted to a concentration of 10 to 30 ppb and sprinkled onto apple trees by spraying or pouring to effectively prevent apple tree diseases caused by various pathogenic microorganisms.

After testing, poured over the water containing four tetrasulfan antimicrobial apple trees, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Campylobacter crispus bacteria, mixed species of survival The rate is 0, we can see that four silver tetrabasic fungicides have the role of killing bacteria and fungi, which effectively inhibit the disease caused by pathogenic microorganisms.

Example 13: Use of Tetraoxide Tetraoxide Bactericide in Plant Diseases Against Various Pathogenic Microorganisms.

The silver tetraborate antimicrobial agent obtained in Example 10 was diluted to a concentration of 10 to 30 ppb and sprinkled onto the lawn by spraying or pouring to effectively prevent the lawn disease caused by various pathogenic microorganisms.

After testing, after pouring water containing tetra-oxystericum water after the lawn, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, Campylobacter sp., The survival rate of mixed species Are 0, we can see four silver oxide bactericide has the effect of killing bacteria and fungi, thereby effectively inhibiting the pathogenic microorganisms caused by the disease.

Example 14: Use of Tetraoxysilver Antibiotics as Antibacterial Additives in Antibacterial Coatings.

The silver tetraborate antimicrobial agent obtained in Example 10 was added to the paint and paint at a concentration of 10 to 50 ppm, and the paint or paint was sprayed on handrails, computers, telephones, toys, wood floors and the like frequently. More bacteria were used Of the items, so that spray paint, paint items with antibacterial effect.

After testing, spray paint containing antifouling agent of tetraoxide, paint handrails, computers, telephones, toys and wooden floors, etc., Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Aerobacter aerogenes, orange Gram-positive bacteria, bacteria mixed kind of survival rates are 0, we can see that four silver tetrabuicides kill bacteria and fungi have the role.



http://silverquine.com/what-is-silverquine/

What is SilverQuine?

SILVERQUINE Animal Wound Dressing is a water-base hydro gel wound dressing for use in moist wound care management. The gel contains silver that may help inhibit the growth of microorganisms within the dressing. SILVERQUINE Animal Wound Dressing Gel has been evaluated in standard tests that show it can reduce the level of common microorganisms.
 
Indications for Use: Topical management of Minor Cuts, Lacerations, Abrasions, 1st and 2nd Degree Burns, Skin Irritations

It has been known for over a century that certain preparations of silver have germicidal properties. As a result, prior to the invention of modern day antibiotics, silver was used to help treat wounds and other types of infections in animals. With the development of natural antibiotics, silver preparations were phased out in favor of synthetic antibiotics. Unfortunately, over the course of the past 25 years, multiple bacteria have developed resistance to common antibiotics on the market today. In some circumstances, prolonged courses of expensive antibiotics have to be used to get a minimal response and expose your pet to potent side effects. Worse yet, some antibiotics are totally ineffective in some cases. As a result, the pet industry is in urgent need of new technology that has broad spectrum antimicrobial activity to reduce wound healing times and reduce the risk of side effects from current treatments.

Silverquine Animal Wound Dressing is a new, unique, nano-particulate based silver that is very different from the synthetic antibiotics used for the past 80 years in the animal arena. Our technology is ALL NATURAL and contains no alcohol or synthetic chemicals that inhibit stem cell activity or epithelization. In addition, the silver in our animal wound dressing gel is not just another silver. Silverquine Animal Wound Dressing consists of silver nanomolecules (less than .015 micrometers in size) with an interior metallic silver and an exterior of ionic silver suspended within a water molecule.

How Does it Work?

Silverquine Animal Wound Dressing Gel is manufactured using a patented technology to produce metallic silver nanoparticles (Ag0) coated with tetrasilver tetroxide (Ag4O4). The silver hydro-gel has both ionic and covalent properties. The metallic core (Ag0) facilitates continuous electron transfer, versus an action of single-electron transfer per silver ion.

The ingredients in Silverquine Animal Wound Dressing Gel are all natural. In addition to the patented, unique, nano-particles of silver, the product also contains purified water, TEA, and carbomer. TEA (triethanolamine) and carbomer are organic products that are mixed together in very low concentrations to form a gel. Our Silverquine Gel product contains these two ingredients in minute concentrations for a gelling effect. Both of these ingredients are commonly used in cosmetic products for animals and are considered very safe.
 
Safety

The key antimicrobial agent in Silverquine Animal Wound Dressing Gel is the patented silver nanoparticles. For the past 15 years, there has been a significant push to use the lowest possible dose effective to treat an infection. Lower doses typically result in fewer side effects. For example, one of the most common topical therapies currently used in the pet industry is silver sulfadiazine cream. That product contains 10,000ppm of silver. Such high concentrations often time leads to wound maceration and the need for debridement of some skin around the infected wound area. Such high concentrations can have a negative impact on stem cell activity and epithelization (new skin growth and wound closing) resulting in slower wound healing. Ironically, our products containing Silverquine Animal Wound Dressing Gel contains less than 100ppm of silver, does not negatively impact stem cell activity and epithelization, and promotes effective wound healing.

Silverquine Animal Wound Dressing Gel has been studied in a series of safety studies including animals. These safety and toxicology studies have demonstrated safe, beneficial, and non-toxic data.