rexresearch
Gaurab CHAKRABARTI, et al. // Solugen
Enzyme-Catalyst Chemistry
https://solugen.com/
Engineered Enzyme-Catalysts
... Circular Feedstocks
Our process starts with simple, abundant, and inexpensive bio-based feedstocks. Dextrose, water, and compressed air is continuously pumped into our enzyme oxidation reactor where our engineered enzymes begin the conversion process.
Engineered Enzymes
The use of computational design, rational design, and AI optimizes our enzymes, resulting in superior efficiency and sustainability across a diverse range of molecules. The development process includes generating AI-filtered smart libraries, high-throughput screening of thousands of enzyme variants, and fermentation to scale up production in large bioreactors. These engineered enzymes drive highly efficient, cell-free reactions at room temperature with low energy input.
Heterogeneous Metal Catalysts
The use of proprietary metal catalysts significantly enhance the efficiency of our process. We begin by synthesizing, analyzing, and characterizing each catalyst, followed by precise adjustments in parameters for optimal performance. Once a suitable catalyst is identified, it undergoes rigorous testing in our reactors to ensure its suitability for commercial use.
[ World Economic Forum ]
https://www.weforum.org/organizations/solugen/
Solugen
Solugen is a venture-backed specialty chemicals company that applies industrial biotechnology and green chemistry principles to redesign the production of a variety of end-use and novel chemicals. The company’s first product, BioPeroxide, was created using patented enzymatic technology to convert plant sugars into hydrogen peroxide and was followed by the manufacturing of a comprehensive line of products such as their flagship ScaleSol and BioChelate solutions.
https://www.youtube.com/watch?v=PCypBUVhff8
Inside The Startup Reinventing The $6 Trillion Chemical Manufacturing Industry // Y Combinator
COMPOSITIONS, SYSTEMS AND METHODS FOR PRODUCTION OF VALUE-ADDED CHEMICALS
US2023109331
A system for the production of high value chemicals includes (a) an input selected from the group consisting of ethylene glycol, glycerol, ethanol methanol or a combination thereof. In addition, the system includes (b) an oxidation biocatalyst including an alcohol oxidase, a copper radical oxidase, a glycerol oxidase, an alditol oxidase or a combination thereof. Further, the system includes (c) an oxidized intermediate. The system also includes (d) a finishing catalyst including a supported metal catalyst, a carboligating catalyst, an amine oxidase, a glyoxalase, an acid catalyst, a base catalyst, an isomerization catalyst or a combination thereof. Still further, the system includes (e) an output.
COMPOSITIONS AND METHODS FOR 2,5-FURAN DICARBOXYLIC ACID PRODUCTION
US2023096662
A chemoenzymatic process for the preparation of 2,5-furan dicarboxylic acid includes contacting D-glucose with (i) at least two enzymes selected from the group consisting essentially of galactose oxidase, pyranose 2-oxidase, glucarate dehydratase, catalase and a combination thereof to produce an intermediate; and (ii) a heterogeneous metal catalyst to form 2,5-furan dicarboxylic acid.
HYDROCARBON UPGRADING METHOD AND APPARATUS
WO2025250647
A method of reducing impurities in a mixture of a nonaqueous fluid with an aqueous component comprising contacting the mixture with a purification additive comprising: (i) one or more sugar oxidation products, (ii) a chelating agent, (iii) a biobased additive (BBA), and (iv) an enhancing agent to form a treated mixture; allowing the treated mixture to form at least one aqueous phase and at least one nonaqueous phase; separating the at least one aqueous phase from the at least one nonaqueous phase; and recovering at least a portion of the aqueous phase, at least a portion of the nonaqueous phase, or both. A method of servicing an oil and gas field comprising a well penetrating a subterranean formation, the method comprising: recovering a hydrocarbon resource from the well, wherein the hydrocarbon resource has an aqueous component; contacting the hydrocarbon resource with a purification additive comprising (i) one or more sugar oxidation products, (ii) a chelating agent, and (iii) a biobased additive (BBA) to form a treated mixture; allowing the treated mixture to form at least one aqueous phase and at least one nonaqueous phase; separating the at least one aqueous phase from the at least one nonaqueous phase; and recovering at least a portion of the aqueous phase, at least a portion of the nonaqueous phase, or both.
Hydrogen peroxide and gluconic acid production
US11203769
A hydrogen peroxide and gluconic acid production method and system is disclosed that can include receiving an aqueous solution having glucose, water, and glucose oxidase at a reaction chamber. Here, the reaction chamber facilitates an enzymatic reaction between a gas phase and a liquid phase of the aqueous solution, thereby yielding a first solution comprising hydrogen peroxide, gluconic acid, and the glucose oxidase. The method can further include receiving the first solution at a separation chamber, wherein the separation chamber is comprised of a semi-permeable membrane having a pre-defined molecular weight barrier for separating the glucose oxidase, thereby resulting in a combined hydrogen peroxide and gluconic acid solution. The method can further include at least partially converting the gluconic acid into a gluconate salt, and separating and concentrating the hydrogen peroxide from the gluconic acid or gluconate salt via vacuum flash evaporation and vacuum distillation.
Hydrogen peroxide production method, system, and apparatus
US10947566
A hydrogen peroxide production method, system, and apparatus is provided for producing large volumes of hydrogen peroxide having concentrations up to and excess of 80% in one continuous cycle. In one aspect, the hydrogen peroxide production system can include an aqueous solution comprised of an NQO1 enzyme, an NQO1 activated compound or molecule, and an NADH or NADPH cofactor for producing hydrogen peroxide, a production chamber having a semi-permeable membrane for receiving the aqueous solution. Here, the membrane can further include one or more molecular weight barriers configured to diffuse the produced hydrogen peroxide there through. The system can also include a collection chamber for receiving the produced hydrogen peroxide, and one or more pumps for circulating the aqueous solution having the hydrogen peroxide to the collection chamber and back to the production chamber.
COMPOSITIONS AND METHODS FOR GLYCOLIC ACID PRODUCTION
WO2025259650
A method for the production of glycolic acid comprising contacting ethylene glycol with an oxidase catalyst system under conditions suitable for the formation of glycolaldehyde; contacting glycolaldehyde with one or more metal oxidation catalysts under conditions suitable for the formation of glycolic acid; and recovering at least a portion of the glycolic acid. A method for the production of glycolic acid comprising contacting ethylene glycol with an oxidase catalyst system comprising galactose oxidase under conditions suitable for the formation of glycolaldehyde; contacting glycolaldehyde with an oxidation catalyst comprising gold on a carbon support under conditions suitable for the formation of glycolic acid; and recovering at least a portion of the glycolic acid.
METHODS AND COMPOSITIONS FOR THE PRODUCTION OF GLYOXAL
WO2024249896
A chemoenzymatic process comprising contacting ethylene glycol with a biocatalyst in the presence of oxygen under conditions suitable for the formation of glycolaldehyde, glyoxal or combinations thereof. A method of producing glyoxal comprising contacting ethylene glycol with an oxidase selected from the group consisting of a copper radical oxidase, an alcohol oxidase, a glycerol oxidase, and combinations thereof in the presence of oxygen and a catalase under conditions suitable for the formation of a product mixture comprising glycolaldehyde, glyoxal or combinations thereof.
COMPOSITIONS AND METHODS FOR IRON CHELATION
US12338392
A composition for efficient metal chelation includes a primary chelant. The primary chelant comprises gluconic acid, a gluconate, glucaric acid, a glucarate, one or more derivatives thereof, or a combination thereof. The primary chelant is present in an amount ranging from about 10 wt. % to about 25 wt. % based on total weight of the composition. In addition, the composition includes a secondary chelant. The secondary chelant comprises lactic acid, citric acid, or both lactic acid and citric acid. Further, the composition includes a solvent.
COMPOSITIONS AND METHODS FOR THE PRODUCTION OF GLUCARIC ACID
US2025178995
A method of preparing glucaric acid comprising contacting D-glucose and oxygen with a first catalyst composition comprising a first copper radical oxidase, a single electron oxidizer, and a small molecule activator under conditions suitable for formation of glucodialdose; and contacting glucodialdose and oxygen with a second catalyst composition comprising a second copper radical oxidase, a single electron oxidizer and a small molecule activator under conditions suitable for the formation of a product mixture comprising glucaric acid or salts thereof. A method comprising contacting a sugar with a catalyst composition comprising an oxidoreductase, a single electron oxidizer and a small molecule activator under conditions suitable for the formation of one or more oxidized sugar oxidation products comprising glucaric acid wherein the oxidoreductase comprises at least two copper radical oxidases, at least two mutated copper radical oxidases or combinations thereof.
BIOBASED COMPOUNDS FOR POLYMER PRODUCTION
WO2025097180
A polymeric material comprising a base monomer and a multifunctional biobased molecule wherein the multifunctional biobased molecule is a glucose derivative. A polymeric material comprising a base polymer and a polymeric additive comprising glucaric acid, glucodialdose, gluconic acid, erythorbic acid, 2-ketoglucose, lactic acid, adipic acid, sorbitol, glycerol, mannitol, lactones thereof, salts thereof, or combinations thereof wherein the additive when introduced to a base polymer forms a modified polymer wherein the modified polymer has a tensile strength that is increased by from about 10% to about 100% wherein compared to the base polymer.
CHEMOENZYMATIC CARBOXYLATION COMPOSITIONS AND METHODS
US2025145981
A method of increasing the carbon content of an organic compound comprising carboxylating an organic compound characterized by the general formula R1—H and carbon dioxide in the presence of a biocatalyst under conditions suitable for the formation of a carboxylic acid characterized by the general formula R1—OOH, wherein R1 is a C1 to C30 organyl group; a C1 to C30 hydrocarbyl group, a C3 to C30 aromatic group; a C1 to C30 alkyl group, a C4 to C30 cycloalkyl group, a C4 to C30 substituted cycloalkyl group, a C3 to C30 aliphatic heterocyclic group, a C3 to C30 substituted aliphatic heterocyclic group, a C6 to C30 aryl group, a C6 to C30 substituted aryl group, a C3 to C30 heteroaryl group, or a C3 to C30 substituted heteroaryl group or combinations thereof.
SUGAR OXIDATION CATALYST WITH IMPROVED SELECTIVITY
WO2025090691
A method comprising contacting a support material with a platinum salt and alkali aurate to form a metallated support; heat treating the metallated support to form a heat-treated metallated support; and reducing the heat treated metallated support to form a selective oxidation catalyst. A method comprising contacting a polyol with a catalyst comprising an alkali metal aurate and platinum salt on a support under conditions suitable for the formation of an oxidized product.
SMALL MOLECULE ACTIVATORS
WO2025076549
A catalyst composition comprising an oxidoreductase, a single electron oxidizer and a small molecule activator. A method comprising contacting a sugar with a catalyst composition comprising an oxidoreductase, a single electron oxidizer and a small molecule activator under conditions suitable for the formation of one or more oxidized sugar oxidation products.
METHODS AND COMPOSITIONS FOR THE PRODUCTION OF DIACIDS AND GLYCOLIC ACID
WO2025035157
A method for preparing one or more acids comprising contacting a glycol with one or more oxidation catalysts under conditions suitable for formation of an aldehyde intermediate; contacting the aldehyde intermediate with one or more oxidation catalysts under conditions suitable for the formation of an acid and recovering the acid.
COMPOSITIONS AND METHODS FOR PRODUCTION OF ANTIMICROBIAL AGENTS FROM BIO-RENEWABLE FEEDSTOCKS
US2025011265
A chemoenzymatic method of producing a polyhydroxybenzene includes contacting glucose with one or more biocatalysts under conditions suitable for the formation of D-glucodialdose; and thermally treating D-glucodialdose in the presence of a dehydration catalyst under conditions suitable for the formation of the polyhydroxybenzene. A chemoenzymatic method of producing 1,2,3,4-tetrahydroxybenzene includes contacting glucose with a mutated copper radical oxidase and catalase under conditions suitable for the formation of D-glucodialdose; and subjecting D-glucodialdose and a dehydration catalyst to temperatures ranging from about 40° C. to about 100° C. suitable for the formation of 1,2,3,4-tetrahydroxybenzene.
COMPOSITIONS AND METHODS FOR PRODUCTION OF VALUE-ADDED CHEMICALS
US2024368642
A molecular manufacturing process includes contacting a platform molecule with (i) a biocatalyst and (ii) a chemical catalyst under conditions suitable to produce a value-added chemical.
BIOBASED POLYESTERS AND METHODS OF MAKING AND USING SAME
WO2024227189
A method for formation of a biobased monomer comprising contacting a sugar with one or more oxidation catalysts at least once under conditions suitable for the formation of a primary oxidation product; and subjecting the primary oxidation product to at least one process selected from the group consisting of oxidation, dehydration, acetylation, hydrogenation, ion exchange, and combinations thereof under conditions suitable for formation of a product mixture. A method for formation of a biobased monomer comprising contacting glucose with one or more oxidation catalysts at least once under conditions suitable for the formation of a primary oxidation product; and subjecting the primary oxidation product to at least one process selected from the group consisting of oxidation, dehydration, acetylation, hydrogenation, ion exchange, and combinations thereof under conditions suitable for formation of a product mixture.
IMPROVED BIOCIDE COMPOSITIONS.
MX2023012573
MULTIFUNCTIONAL BIO-BASED ADDITIVES
WO2024138026
BIOBASED SYNTHESIS OF GLUCODIAMINE
EP4634396
COMPOSITIONS TO CONTROL LEVEL OF UNDESIRABLE MATERIALS
WO2024081958
MAMMALIAN CELLS AND METHODS FOR ENGINEERING THE SAME
US2024076655
COMPOSITIONS AND METHODS FOR PRODUCTION OF GLUCOSE OXIDATION PRODUCTS.
MX2022011053
COMPOSITIONS AND METHODS FOR PRODUCTION OF HIGH VALUE CHEMICALS FROM ETHANOL
WO2023212665
METHODS AND COMPOSITIONS FOR THE TREATMENT OF PRODUCED WATER.
MX2022001391
SULFIDE SCAVENGING USING BIODEGRADABLE COMPLEXES
US2023227733