Stuff & Stuff  
THE Infra-Universal Journal of Sci-Tech News-Olds & Socio-Stupidic Studies
Updated @ 23 February 2022
[ January 2022 ]
[ Archives ]
Dr. Rath Research Institute Study
A new study (Inhibitory Effects of specific combination of Natural Compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants) carried out by scientists at the Dr. Rath Research Institute compares the efficacy of combinations of plant extracts and micronutrients against the original SARS-CoV-2 virus and its, Alpha, Beta, Gamma, Delta, Kappa, and Mu variants...
Inhibitory effects of specific combination of natural compounds against SARS-CoV-2 and its Alpha, Beta, Gamma, Delta, Kappa, and Mu variants
Clif High, UFOs, Paranormal &c
Clif High: The Alien Apocalypse
Clif High's Vox Populi notices are here -- Free subscription
2005 Patent: “Quantum Vacuum Energy Extraction” (Moddel/Haisch) |
Another smoking test tube: The part about the furin cleavage site code in Moderna patents starts around 19:10..

When the pilot, et al. have adverse reaction to their stupidity/cowardice :
How YOU can land a passenger aircraft! 12 steps
Embalmers Find Veins and Arteries Filled With Rubbery Clots
Richard Hirschman, a board-certified embalmer, has been finding “strange clots” in the bodies of the deceased since the rollout of COVID-19 shots Hirschman describes, and has photographed, unnatural, fibrous clots that are filling vessels and veins, making it difficult for embalming to occur; his colleagues have had similar experiences finding the fibrous clotS.   Many of those affected were said to have died from a heart attack or strokE.   Since November, Hirschman states that more than 50% of the bodies he embalms are affected by the strange clots. 

If you’ve been injected, consider fibrinolytic enzymes on an empty stomach, which digest the fibrin that leads to blood clots, strokes and pulmonary embolisms
Doctors who disagree with the official covid narrative are now declared mentally ill and required to undergo psychiatric evaluations
New Dr. Vernon Coleman: It's Time to Be Terrified
Cataracts induced by microwave and ionizing radiation
R M Lipman, et al.
DOI: 10.1016/0039-6257(88)90088-4
Microwaves most commonly cause anterior and/or posterior subcapsular lenticular opacities in experimental animals and, as shown in epidemiologic studies and case reports, in human subjects. The formation of cataracts seems to be related directly to the power of the microwave and the duration of exposure. The mechanism of cataractogenesis includes deformation of heat-labile enzymes, such as glutathione peroxide, that ordinarily protect lens cell proteins and membrane lipids from oxidative damage. Oxidation of protein sulfhydryl groups and the formation of high-molecular-weight aggregates cause local variations in the orderly structure of the lens cells. An alternative mechanism is thermoelastic expansion through which pressure waves in the aqueous humor cause direct physical damage to the lens cells. Cataracts induced by ionizing radiation (e.g., X-rays and gamma rays) usually are observed in the posterior region of the lens, often in the form of a posterior subcapsular cataract. Increasing the dose of ionizing radiation causes increasing opacification of the lens, which appears after a decreasing latency period. Like cataract formation by microwaves, cataractogenesis induced by ionizing radiation is associated with damage to the lens cell membrane. Another possible mechanism is damage to lens cell DNA, with decreases in the production of protective enzymes and in sulfur-sulfur bond formation, and with altered protein concentrations. Until further definitive conclusions about the mechanisms of microwaves and ionizing radiation induced cataracts are reached, and alternative protective measures are found, one can only recommend mechanical shielding from these radiations to minimize the possibility of development of radiation-induced cataracts.

Best o' Stuff : Links from Back Issues of the Stuff & Stuff Blogazine :

    LYCOPENE & Cardiovascular Health
     The Guardian ( 9 June 2014  )
      Tomato extract relieves damaged arteries, finds Cambridge study

    Researchers say they have shown that lycopene improves the function of blood vessels in cardiovascular disease patients
    9 June 2014
    Tomato pill that helps your heart: Treatment can increase blood vessel flow by 50% in patients with cardiac problems
Single Ateronon pill contains as much lycopene as more than 2lb of fruit . Pigment gives tomatoes their colour and is credited with many of the Mediterranean diet health benefits. Scientists say pill improves blood vessel health in survivors of heart attacks

    Xeljanz vs Alopecia ( to die for ? See the Side Effects )
    June 20, 2014
    Drug gives bald man full head of hair
    By Elizabeth Cohen, Senior Medical Correspondent

    Y. CHO, et al.  : Pumpkin Seed vs Baldness
    Pumpkin Seed Oil Found To Help Reverse Balding
Researchers from the Republic of Korea's Pusan National University have confirmed that pumpkin seed oil increases hair growth among balding men...
    Evid Based Complement Alternat Med. 2014; 2014: 549721.
    Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial
    Young Hye Cho, et al.
  Pumpkin seed oil (PSO) has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats. This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of PSO for treatment of hair growth in male patients with mild to moderate androgenetic alopecia (AGA). 76 male patients with AGA received 400 mg of PSO per day or a placebo for 24 weeks. Change over time in scalp hair growth was evaluated by four outcomes: assessment of standardized clinical photographs by a blinded investigator; patient self-assessment scores; scalp hair thickness; and scalp hair counts. Reports of adverse events were collected throughout the study. After 24 weeks of treatment, self-rated improvement score and self-rated satisfaction scores in the PSO-treated group were higher than in the placebo group (P = 0.013, 0.003). The PSO-treated group had more hair after treatment than at baseline, compared to the placebo group (P < 0.001). Mean hair count increases of 40% were observed in PSO-treated men at 24 weeks, whereas increases of 10% were observed in placebo-treated men (P < 0.001). Adverse effects were not different in the two groups.
Personal care compositions comprising squash or pumpkin extract -- AU2012302146
Skin and hair aerosol foam preparations  -- US6045779
Composition for the prevention and treatment of the detrimental effects of dihydrotestosterone -- US2006009430
-- JP2005015415
Process for the manufacture of a hair lotion
--   CH611157
-- US7479292

Vision Regeneration by Magnets :
Regenerator for vision of human eye
Inventor(s):     REIN HANS HELMUT  
Abstract --
The regenerator is in the form of a helmet placed over the head and containing cylindrical permanent magnets positioned on the front of the head directly in front of the eyes, and on the back of the head directly in front of the cortex. The permanent magnets have two or more poles, and are magnetically screened on the side facing away from the body. The magnets are contained in adjustable holders adaptable to the size and shape of the head. The helmet consists of a ring and one or more straps.

    Nano-Silver Health Dangers
    Jun. 25, 2014
    Invisible toxins in food can damage your health
    by Jonathan Landsman

...Animals treated with silver nanoparticles exhibited reduced cognitive/motor functions and altered cellular structures in the brain. And, just to be clear, many scientific studies suggest that chronic exposure to silver nanoparticles can damage brain function. With all the pollution in our environment – should we really allow this technology to invade our food supply?
    Further data shows silver nanoparticles induce toxicity in neurons with the resulting dysfunction of physiological function. These particles, once digested, get distributed inside the brain, heart, and blood – which can result in cardiac arrhythmia, slower blood flow and impaired motor skills.
    Observations, in laboratory animals, have shown that the uptake of these particles – in the digestive track – can change the terrain. The digestive track harbors beneficial bacteria along with pathogenic bacteria. Silver nanoparticles can wipe out the ‘good bacteria’ along with toxic ones.

    January 04, 2012
    New Worms' Silk Has Spider Strength

--  US2010279415
Production of Human Glycosylated Proteins in Silk Worm
-- US2010186099
--  US2009288178
Jun 15, 2010
Almost FREE electricity with Boondee Electron generator --   Electron generator was invented by the inventor of Boondee Workshop
It needs a little power --  as little as 6 volts DC -- to start up the energy. Ater that the engine will generate electric power and not require 6 volt anymore. During the generating electricity the engine become hot -- about 120*C. -- so we are developing the next prototype to ventilate the heat. This 1st prototype can generate AC electricity 220 volt / 1000 watts. Have to stop the engine every 3 hours and wait about 5 minutes to restarting again.
    In July 16, 2011 I just built a new version of electron generator model FE-88. It use battery size AA x 8 pcs to warm up the system.

CN101755568 -- Production method for electrically growth-promoted copper-rich anticancer spinach
Abstract --
The invention provides a production method for electrically growth-promoted copper-rich anticancer spinach, belonging to the application study of the white agricultural high technology in the field of the nutritious dietetic food production technology. The production method is composed of a known spinach production facility, a copper-rich microelement fertilizer employing technology and a high-voltage pulse positive-ion growth promoting machine. The spinach production facility means a spinach production greenhouse or an open-air vegetable field. The copper-rich microelement fertilizer means one of copper salts such as copper chloride, copper sulfate and the like and other copper compounds or the combination of the above. The employing quantity of the fertilizer per acre is within 1 to 15g, and the fertilizer needs to be diluted by water to the concentration of 1/1,000 to 1/100,000 (weight). The using method of the fertilizer is as follows: the fertilizer can be used for soaking seeds and can be employed on leaf surfaces in growth period for 1 to 3 times or can be employed in soil. The high-voltage pulse positive-ion growth promoting machine is composed of a high-voltage pulse power supply and a high-voltage pulse positive-ion emitting electrode, the high-voltage pulse power supply is connected with the positive end of the high-voltage pulse positive-ion emitting electrode, the voltage is within the range of 10 to 50KV, and the emitting electrode is a reticular electrode main body composed by aerial lead wires which are parallel to each other and are insulated with the ground.
Int J Radiat Biol. 1996 Apr;69(4):513-21.
Single- and double-strand DNA breaks in rat brain cells after acute exposure to radiofrequency electromagnetic radiation.
Lai H, Singh NP.
Abstract --
We investigated the effects of acute (2-h) exposure to pulsed (2-micros pulse width, 500 pulses s(-1)) and continuous wave 2450-MHz radiofrequency electromagnetic radiation on DNA strand breaks in brain cells of rat. The spatial averaged power density of the radiation was 2mW/cm2, which produced a whole-body average-specific absorption rate of 1.2W/kg. Single- and double-strand DNA breaks in individual brain cells were measured at 4h post-exposure using a microgel electrophoresis assay. An increase in both types of DNA strand breaks was observed after exposure to either the pulsed or continuous-wave radiation, No significant difference was observed between the effects of the two forms of radiation. We speculate that these effects could result from a direct effect of radiofrequency electromagnetic energy on DNA molecules and/or impairment of DNA-damage repair mechanisms in brain cells. Our data further support the results of earlier in vitro and in vivo studies showing effects of radiofrequency electromagnetic radiation on DNA.
Platonic Geometry-cum-T&A
Solar Furnace -- 2 square meters of sunlight, focused, will melt anything on Earth
Waste oil foundry furnace -- complete !
Charcoal foundry build at Chicago hackerspace
Arc furnace that melts anything
The free space simulation that lets you explore our universe in three dimensions. Celestia runs on Windows, Linux, and Mac OS X.
Building Bike Generators

US5681857 -- Alkaline salt solutions for treating cancerous tumors
Radioisotopic Energy Generation - Paul Brown - International Tesla Symposium 199n
The Gary Magnetic Efect -- Dan Davidson

The mitochondrial ATP synthase is a shared drug target for aging and dementia
J. Goldberg, et al.
Summary --
Aging is a major driving force underlying dementia, such as that caused by Alzheimer's disease (AD). While the idea of targeting aging as a therapeutic strategy is not new, it remains unclear how closely aging and age-associated diseases are coupled at the molecular level. Here, we discover a novel molecular link between aging and dementia through the identification of the molecular target for the AD drug candidate J147. J147 was developed using a series of phenotypic screening assays mimicking disease toxicities associated with the aging brain. We have previously demonstrated the therapeutic efficacy of J147 in several mouse models of AD. Here, we identify the mitochondrial a-F1-ATP synthase (ATP5A) as a target for J147. By targeting ATP synthase, J147 causes an increase in intracellular calcium leading to sustained calcium/calmodulin-dependent protein kinase kinase ß (CAMKK2)-dependent activation of the AMPK/mTOR pathway, a canonical longevity mechanism. Accordingly, modulation of mitochondrial processes by J147 prevents age-associated drift of the hippocampal transcriptome and plasma metabolome in mice and extends lifespan in drosophila. Our results link aging and age-associated dementia through ATP synthase, a molecular drug target that can potentially be exploited for the suppression of both. These findings demonstrate that novel screens for new AD drug candidates identify compounds that act on established aging pathways, suggesting an unexpectedly close molecular relationship between the two.
Sonic Geometry: The Language of Frequency and Form
Ebner Effect Update
The “Primeval Code”,Forschungsprojekte/80,Biologische_Experimente_mit_elektrostatischen_Feldern/10,Die_Experimente_von_Ciba_Geigy/Die_Experimente_von_Ciba_Geigy.html
August 17, 2007RaFöG Space Energy Development Company

Patents by G. Ebner:
US5888791 -- Method of producing bacteriorhodopsin and carotenoids by electrostatic treatment of Halobacterium halobium
US5048458 -- Method of breeding fish
PressReader - Trillions: 2017-12-01 - Levity's Labor Lost
Levity's Labor Lost
by Robert A. Nelson
A review of several lost levitation technologies developed in the 20th century
Science to Sage (January 2018) -- Innovation: Natures Design
How to Build a Homopolar Motor
Homopolar Electric Train
The Cubli: a cube that can jump up, balance, and 'walk'
Nature 553, 59–62 (04 January 2018)
Photonic topological boundary pumping as a probe of 4D quantum Hall physics
Oded Zilberberg, Sheng Huang, Jonathan Guglielmon, Mohan Wang, Kevin P. Chen, Yaacov E. Kraus & Mikael C. Rechtsman
When a two-dimensional (2D) electron gas is placed in a perpendicular magnetic field, its in-plane transverse conductance becomes quantized; this is known as the quantum Hall effect1. It arises from the non-trivial topology of the electronic band structure of the system, where an integer topological invariant (the first Chern number) leads to quantized Hall conductance. It has been shown theoretically that the quantum Hall effect can be generalized to four spatial dimensions2,3,4, but so far this has not been realized experimentally because experimental systems are limited to three spatial dimensions. Here we use tunable 2D arrays of photonic waveguides to realize a dynamically generated four-dimensional (4D) quantum Hall system experimentally. The inter-waveguide separation in the array is constructed in such a way that the propagation of light through the device samples over momenta in two additional synthetic dimensions, thus realizing a 2D topological pump5,6,7,8. As a result, the band structure has 4D topological invariants (known as second Chern numbers) that support a quantized bulk Hall response with 4D symmetry7. In a finite-sized system, the 4D topological bulk response is carried by localized edge modes that cross the sample when the synthetic momenta are modulated. We observe this crossing directly through photon pumping of our system from edge to edge and corner to corner. These crossings are equivalent to charge pumping across a 4D system from one three-dimensional hypersurface to the spatially opposite one and from one 2D hyperedge to another. Our results provide a platform for the study of higher-dimensional topological physics.
 A look into the fourth dimension
Magic Squares, Hypercubes, Tesseracts, & Stars, &c
Particle Physics: ‘Mind-Bending’ Negative Mass Device Reveals New Way To Create Lasers

Food composition for preventing Alzheimer's disease and protein powder containing food composition
The invention discloses a food composition for preventing Alzheimer's disease. The food composition is prepared from the following components in parts by weight: 10 to 20 parts of garlic extract, 5 to 15 parts of porphyra haitanesis extract and 2 to 8 parts of radix puerariae extract. The invention also provides protein powder containing the food composition; the protein powder is prepared from the following components in parts by weight: 10 to 15 parts of the food composition, 42 to 46 parts of hydrolyzed deep-sea cod collagen, 35 to 40 parts of soybean isolate protein powder, 12 to 18 parts of mung bean flour, 10 to 15 parts of fructus lyciipowder, 5 to 8 parts of water-soluble dietary fibers, 10 to 12 parts of functional polypeptides and 5 to 10 parts of a natural sweetener; the protein powder is prepared by mixing the components and then carrying out nanometer crushing treatment on the mixture. The food composition and the protein powder disclosed by the invention have no toxic or side effect after being taken for a long term and have the effects of preventing the Alzheimer's disease and delaying the attacking progression of the Alzheimer's disease.

Plant extract-prepared radiation-proof nutritional healthcare product and preparation method thereof
The invention discloses a plant extract-prepared radiation-proof nutritional healthcare product. The plant extract-prepared radiation-proof nutritional healthcare product is prepared from the raw materials of, by weight part, 15-25 parts of mung bean, 8-12 parts of sesame, 3-6 parts of black fungus, 12-18 parts of tomato, 10-20 parts of carrot, 6-12 parts of plant extract, 10-20 parts of algae extract and 3-8 parts of honey. The plant extract-prepared radiation-proof nutritional healthcare product is rich in vitamins, proteins and trace elements that human body needs and balanced in nutrition, and during long-term taking, can effectively enhance mental activity, eliminate vivotoxin, adjust body cell immunologic function, enhance immunity of organism and resist damage of ultraviolet, radiation and the like to body to accordingly achieve the effects of radiation resistance, fatigue resistance, eyesight and skin protection, intestine clearing, lipid lowering and the like. Meanwhile, The plant extract-prepared radiation-proof nutritional healthcare product is convenient to take, high in radiation-proof effects, safe in raw materials, high in nutritive value, free from toxic and side effects and worth popularizing.
Lucid Mind: Scientists Find Key to Make Brain Stay Young
Fountain of youth? Miracle of heavens? No, it is really just smart scientists from Stanford University trying to prevent our brain from aging.
A team of biologists conducted experiments with blood transfusions to mice and found a protein that may cause premature aging in rodents, according to a study published on
The study found out that the protein responsible for this is known as VCAM1; it interacts with immune system cells in response to inflammation.
In the course of the study, biologists observed that old blood can prematurely age the brains of young mice, and scientists discovered that VCAM1, located in the cells that form a barrier between brain and blood, may be the reason.
With time as mice and humans age, levels of this protein circulating in the blood rise, according to Alzheimer researcher Tony Wyss-Coray at Stanford University.
He and his colleagues discovered that tampering with VCAM1 may help avoid the premature aging of brains.
They genetically engineered plasma of the old mice which did not contain the protein and injected it into the young mice. The results showed that this plasma didn’t have a strong effect when injected into young mice, nor did it affect mice treated with antibodies that blocked the activity of VCAM1.
According to the publication, “those antibodies also seemed to help the brains of older mice that had aged naturally.”
The results point to anti-aging treatments targeting certain aspects of the blood-brain barrier may hold promise in slowing down the process of the brain’s aging.

Kevin Galalae : Global Depopulation Series
15 Essential Global Depopulation Points
This presentation encapsulates the Global Depopulation Policy in 15 brief points and reveals the core objectives and deeply-held secrets of governments and the international community since 1945, namely the covert depopulation and coerced globalization matrix of global control.
The International System of depopulation/globalization explained
The hidden objectives and methods of the international system of covert depopulation and coerced globalization are explained.
GMOs and Depop
Are we to believe that GMOs are simply the result of market forces and the drive for profit when they in fact are responsible for far more economic loss than gain once employment, social, health, genetic and environmental factors are considered? No market force is strong enough to skew society, damage universal wellbeing and threaten life in such fundamental ways.
The reason for their success can therefore only be attributed to a cause important enough to justify the horrendous price we are all paying. And that cause is a global effort at the highest level of international governance to use food as a weapon against people and reduce the population in ways that allow governments to blame prices, drought, crop failure, and market conditions for the mass murder and genetic downgrading of their own citizens.
How to make a Microwave Gun
The Magnetic Spin Vortex
This video explains how magnetism is actually caused by the Magnetic Spin Vortex. It covers what the spin vortex is, and it is not, and the importance of understanding it in the field of Permanent Magnet
Russell Engine/Generator (Eng/Gen)

The Russell Engine/Generator (Eng/Gen), invented by Robert L Russell, is the only patented shaftless, highly scalable power unit that produces electrical energy by combining an electric generator with a unique, highly efficient internal combustion engine within a single vibration free, dust and water proof housing powered by any liquid or gaseous fuel. A new improved patent pending design will be released for review in the near future.
Magnetricity: Our New Energy Source
In his own words, professional engineer Dr. John Milewski is "part wizard, part mad scientist". An internationally-recognized leader and consultant in the field of advanced materials, Dr. Milewski is a scientist, inventor, entrepreneur, writer, publisher, editor, and lecturer. He is primarily known for his work with magnetite and his protocols for magnetizing water. Over the last few decades, SuperLight (or magneto-electric radiation) has become a core concern of his research. Dr. Milewski describes SuperLight (known to mystics and metaphysicians as the nous, chi, and orgone or zero point energy) as the opposite of electromagnetic energy, revealing the previously unacknowledged parity of light. Instead of traveling away from a source at light speed, SuperLight is emitted from black holes and travels towards the source 10 billion times faster than the speed of light. In this segment, we will explore the discovery and implications of SuperLight, electricity vs. magnetricity, increases in solar activity, and why it is smart for us to focus our efforts on getting energy independent by investing in magnetricity and magnetic infrastructure.
by J.W. Milewski
Introductory Overview of QuakeFinder

Copper vs MRSA
Plagued by fungus? Bacteria? Try copper socks
By Manuel Farias

...One Chilean entrepreneur, Joaquin Ruiz, has invented copper sponge filters to purify water on salmon farms, eliminating disease and fungi and reducing the large amounts of costly antibiotics currently employed to do the same job.
"That means huge savings. Instead of using large quantities of antibiotics and germ killing agents, with this you are just putting up a simple sanitary barrier," Ruiz, the developer of the Metal Foam sponges, told Reuters.
Codelco is experimenting with bacteria-repellent cages for the industry.
Investigators are also looking into where they can use the metal to reduce levels of infection in hospitals. They have found the metal helps to kill Methicillin-resistant Staphylococcus aureus (MRSA), a bacterium responsible for difficult-to-treat infections in humans.
"If you prevent one MRSA infection, you save $21,000, so your return on investment will be very very short, perhaps one patient," said Michael Schmidt, of the University of South Carolina medical school.
"So this is going to be a fairly efficient and inexpensive solution to combat infections."
Some hospitals in the United States are testing copper as a germ-resistant surface material in place of stainless steel. A British study several years ago showed that drug-resistant staph germs survived for three days on stainless steel surfaces but were not detectable on copper surfaces after 90 minutes.

CZ303861 -- Antibacterial layer acting against pathogenic bacteria, especially against MRSA bacterial strain and method of making such layer  
CZ303250 -- Antibacterial layer acting against pathogenic bacteria, especially against bacterial strain MRSA and method of making such layer
GB2491596 -- Composition containing epoxy resin and copper
US2009148540 -- Antibacterial composition and method of production --
GB2455413 -- Anti-microbial cleaning aid
Scientists Discover A Way To Rejuvenate Old Human Cells

A team led by Professor Lorna Harries, Professor of Molecular Genetics at the University of Exeter, has discovered a new way to rejuvenate inactive senescent cells. Within hours of treatment the older cells started to divide, and had longer telomeres – the ‘caps’ on the chromosomes which shorten as we age.
he research, Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence, is published in the journal BMC Cell Biology.
This discovery builds on earlier findings from the Exeter group that showed that a class of genes called splicing factors are progressively switched off as we age. The University of Exeter research team, working with Professor Richard Faragher and Dr Elizabeth Ostler from the University of Brighton, found that splicing factors can be switched back on with chemicals, making senescent cells not only look physically younger, but start to behave more like young cells and start dividing.
The researchers applied compounds called resveratrol analogues, chemicals based on a substance naturally found in red wine, dark chocolate, red grapes and blueberries, to cells in culture. The chemicals caused splicing factors, which are progressively switched off as we age to be switched back on. Within hours, the cells looked younger and started to rejuvenate, behaving like young cells and dividing.
Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence
Eva Latorre, et al.
Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology. However, the relationship between these two processes is opaque. Accordingly we developed a novel panel of small molecules based on resveratrol, previously suggested to alter mRNA splicing, to determine whether altered splicing factor expression had potential to influence features of replicative senescence.
Treatment with resveralogues was associated with altered splicing factor expression and rescue of multiple features of senescence. This rescue was independent of cell cycle traverse and also independent of SIRT1, SASP modulation or senolysis. Under growth permissive conditions, cells demonstrating restored splicing factor expression also demonstrated increased telomere length, re-entered cell cycle and resumed proliferation. These phenomena were also influenced by ERK antagonists and agonists.
his is the first demonstration that moderation of splicing factor levels is associated with reversal of cellular senescence in human primary fibroblasts. Small molecule modulators of such targets may therefore represent promising novel anti-degenerative therapies.
Speed breeding LED technique grows food six times faster than conventional farming
by Tibi Puiu
Australian researchers have demonstrated a ‘speed breeding’ technique for common crops. Their method yields far more food per unit area than conventional farming, relying on specially calibrated LEDs that emit light at specific frequencies onto crops to accelerate plant growth.
Using this setup, researchers showed that they could grow six generations of wheat, chickpea, and barley, as well as four generations of canola plants, in a single year. Typically, farmers in the field only grow one generation of each crop. The yields are strikingly high even when compared to crops grown in a lamp glasshouse environment, which produced two to three generations.
This means that for the same unit area, it’s possible to grow six times more food than in the open field and up to three times more food than typical glasshouses, the authors reported in the journal Nature Plants — and this could prove extremely important.
By 2050, the number of people on Earth is expected to soar to ten billion. At the same time, there’s an increasing demand for protein-rich foods, i.e. meat, spurred by an improved standard of living in developing countries. The problem is that the amount of arable land at our disposal will only marginally increase, which can only mean yield needs to improve if we want to satisfy the food requirements of the world.
Genetically modified crops that are more resistant to pests and yield more nutrients per unit area are one part of the solution. Artificially developed food like lab-grown burgers may also play a role. But the truth is we need all the help we can get, and speed breeding looks very enticing at the moment.
Speed breeding was initially explored by NASA over a decade ago as a means to enhance food production during space missions where efficiency is critical and every square inch counts. Scientists at the University of Sydney, the University of Queensland, and the John Innes Centre, continued the project, picking up from where NASA left off.
Their setup involves specially-tuned LEDs that emit light in the far-red spectrum and at a high intensity to accelerate photosynthesis in intensive regimes of up to 22 hours per day.
    “In the glasshouse, we currently use high-pressure sodium vapor lamps and these are quite expensive in terms of the electricity demand,” said Lee Hickey, a researcher at the University of Queensland and study co-author. “In our paper, we demonstrate that wheat and barley populations can be grown at a density of about 900 plants per square meter, thus in combination with LED light systems, this presents an exciting opportunity to scale up the operation for industry use.”
The yields are certainly impressive but what was really surprising, even for the researchers themselves, was the quality of the crops. Raising plants this fast typically comes with significant downsides, leading to frail looking plants. However, the Australian researchers grew crops that not only yield more but also look better and healthier than those grown in standard conditions.
    “People said you may be able to cycle plants fast, but they will look tiny and insignificant, and only set a few seed. In fact, the new technology creates plants that look better and are healthier than those using standard conditions. One colleague could not believe it when he first saw the results,” explained in a statement Dr Brande Wulff of the John Innes Centre, Norwich, a lead author on the paper.
Right now, there is no genetically modified (GM) wheat grown commercially so speed breeding could provide a promising alternative. What’s more, the authors acknowledge that speed breeding can be combined with GM crops to obtain even more outstanding results. Already, wheat breeders have lined up to gain access to this technology — companies such as Dow AgroSciences which is using speed breeding to grow wheat with tolerance to pre-harvest sprouting (PHS), a major problem in Australia.
The growing human population and a changing environment have raised significant concern for global food security, with the current improvement rate of several important crops inadequate to meet future demand1. This slow improvement rate is attributed partly to the long generation times of crop plants. Here, we present a method called ‘speed breeding’, which greatly shortens generation time and accelerates breeding and research programmes. Speed breeding can be used to achieve up to 6 generations per year for spring wheat (Triticum aestivum), durum wheat (T. durum), barley (Hordeum vulgare), chickpea (Cicer arietinum) and pea (Pisum sativum), and 4 generations for canola (Brassica napus), instead of 2–3 under normal glasshouse conditions. We demonstrate that speed breeding in fully enclosed, controlled-environment growth chambers can accelerate plant development for research purposes, including phenotyping of adult plant traits, mutant studies and transformation. The use of supplemental lighting in a glasshouse environment allows rapid generation cycling through single seed descent (SSD) and potential for adaptation to larger-scale crop improvement programs. Cost saving through light-emitting diode (LED) supplemental lighting is also outlined. We envisage great potential for integrating speed breeding with other modern crop breeding technologies, including high-throughput genotyping, genome editing and genomic selection, accelerating the rate of crop improvement.

Euphytica (May 2013, Volume 191, Issue 2, pp 311–316)
A procedure allowing up to eight generations of wheat and nine generations of barley per annum
Z. ZhengH. B. WangG. D. ChenG. J. YanC. J. LiuEm
Generating segregating populations and ‘pure lines’ is an essential component in many projects of plant breeding and biological studies. Time taken to obtain these materials is often a critical factor restricting the progress of such projects. We report a procedure here which, by combining embryo culture with managements of watering regimes, lighting intensity and duration, temperature and quantity of potting mixture, allows the production of up to eight generations of wheat and nine generations of barley per annum. By dramatically shortening the time frame required to obtain segregating populations and ‘pure lines’, the procedure could find wide applications in breeding and biological studies.
Patrick Kelly's Channel
Patrick Kelly : Handbook of Free Energy Devices
Aerial technology for high power systems of 100 kilowatts and higher
Using Copper to Improve the Well-Being of the Skin
Gadi Borkow
Copper has two key properties that are being exploited in consumer and medical device products in the last decade. On the one hand, copper has potent biocidal properties. On the other hand, copper is involved in numerous physiological and metabolic processes critical for the appropriate functioning of almost all tissues in the human body. In the skin, copper is involved in the synthesis and stabilization of extracellular matrix skin proteins and angiogenesis. This manuscript reviews clinical studies that show that the use of textile consumer and medical device products, embedded with microscopic copper oxide particles, improve the well-being of the skin. These include studies showing a) cure of athlete’s foot infections and improvement in skin elasticity, especially important for individuals suffering from diabetes; b) reduction of facial fine line and wrinkles; and c) enhancement of wound healing; by copper oxide embedded socks, pillowcases and wound dressings, respectively. The manuscript also reviews and discusses the mechanisms by which the presence of copper in these products improves skin well-being.
(Nov, 1957)
Pills to keep you Warm
A pill that may increase resistance to cold is being tested at the Arctic Aeromedical Laboratory near Fairbanks, Alaska. The pill contains glycine, an amino-acid that causes the body to generate more heat than it can otherwise produce. It is hoped the pill might enable men to stay alive longer in icy water, and hasten the warming of a man who has been chilled to a critical point of exposure. At the laboratory, operated by the Air Force at Ladd Air Force Base, volunteers are taking the pills with no evidence of ill effect. If the tests are successful the pills could be included in survival kits. Glycine also may make possible a technique of heart surgery in which the heart can be chilled to the point where it stops for an hour or more without suffering damage. According to scientists working at the Air Force laboratory, the heart suffers “ventricular fibrillation” when its temperature is lowered to about 78 degrees Fahrenheit. This is a loss of rhythmic beat, which causes death. Hence, in heart surgery, the organ can be chilled only enough to stop its beating for six or eight minutes. Glycine in the bloodstream may enable the heart to be chilled past this critical temperature. Extensive research has been carried out at the laboratory with Negroes, Eskimos, and whites to find out why some ethnic groups seem more resistant to cold than others. Among Negroes who agreed to act as subjects in the experiments, basal metabolism—that is, their rate of energy production—fell more rapidly than it did in white men. Similar studies of Eskimos produced no evidence that their bodies were better equipped for the cold than those of white men. The Eskimos’ ability to endure extremely low temperatures seems based on acquired skills and excellently adapted clothing and diet.
28 March 2008
J. American Chemical Society and American Institute of Chemical Engineers (10.1021/bp0703329)
Electroshocking plants brings chemical rewards
by Phil McKenna
It sounds like something an insane doctor might administer to a depressed plant. Electroshock treatment has been used on plants, but as a way of deriving useful biochemicals, not for therapy.
The roots of garden pea plants were exposed to low-level electric current and subsequently produced 13 times more pisatin, an antifungal chemical, than plants that were not exposed to electricity.
Joel Cuello, of the University of Arizona in Tucson, US, says the technique could be used to generate large amounts of chemicals that plants typically only produce in trace amounts as a defense against microbial attack.
It could be adapted, he says, to make an inexpensive and efficient method of producing pharmaceuticals and pesticides.
'No damage'
Cuello came up with the idea of shocking plants after testing a number of other methods to mimic a biological attack in plants that would induce chemical production.
"If [plant] cells are infected with fungi, they produce these chemicals as a response to physiological stress," says Cuello of the garden pea (Pisum sativum). "Anything that stresses the cells should result in overproduction of whatever they produce in response to that stress," he adds.
Similar shock treatments applied to cell cultures of barrel medic (Medicago truncatula) – a plant similar to alfalfa – yielded a 168-fold increase in production of one chemical and at least a two-fold increase in 54 other compounds.
"It's a completely novel approach to stimulate production of bio-chemicals in plants," says Fabricio Medina-Bolivar of Arkansas State University, who was not involved in the study but has examined other methods of eliciting chemical production in plants.
"It really opens the door to producing high-value compounds without damaging plant tissue that could lead to significant reductions in cost in producing these compounds," he says.

Safe method
To shock the plants, Cuello applied a 30 to 100 milliamp current to the growth-medium of plants grown hydroponically, or, in the case of barrel medic, to the solution surrounding the cell cultures.
Other compounds that have been tested to stress plant cells include heavy metals, chemicals such as methyl jasmonate and sodium acetate, and the cell walls of microorganisms.
But these methods have drawbacks: introduced metals and chemical compounds can taint desired plant chemicals and microbe preparation and introduction can be costly and time consuming.
"I thought about electricity because you can optimise the magnitude and exposure time of the current," says Cuello, adding that the current he and colleagues used wouldn't be enough to electrocute a human and doesn't burn the plant's cells.
"You just introduce two electrodes and you can turn it on and off, it's that convenient," he says.
Cows find milky way to happiness
Happy cows produce more milk, according to researchers at Newcastle University. Cattle that are named and treated with a "more personal touch" can increase milk yields by up to 500 pints a year.
6th March 2008
How the herb Charles II used to keep royal mistresses in shape could help fight today's obesity epidemic
Heath pea: Could curb hunger pangs
29 Nov 2010
Oxytocin 'polarises men's opinions of their mothers'
Oxytocin – the love hormone – could cure shyness
Love hormone Oxytocin helps soldiers like each other and hate the enemy
DOI: |
Current Biology, Volume 27, Issue 18, pR994–R996, 25 September 2017
Restoring consciousness with vagus nerve stimulation
Martina Corazzol, et al.
Patients lying in a vegetative state present severe impairments of consciousness [1] caused by lesions in the cortex, the brainstem, the thalamus and the white matter [2] . There is agreement that this condition may involve disconnections in long-range cortico–cortical and thalamo-cortical pathways [3] . Hence, in the vegetative state cortical activity is ‘deafferented’ from subcortical modulation and/or principally disrupted between fronto-parietal regions. Some patients in a vegetative state recover while others persistently remain in such a state. The neural signature of spontaneous recovery is linked to increased thalamo-cortical activity and improved fronto-parietal functional connectivity [3] . The likelihood of consciousness recovery depends on the extent of brain damage and patients’ etiology, but after one year of unresponsive behavior, chances become low [1] . There is thus a need to explore novel ways of repairing lost consciousness. Here we report beneficial effects of vagus nerve stimulation on consciousness level of a single patient in a vegetative state, including improved behavioral responsiveness and enhanced brain connectivity patterns.

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