rexresearch
Oleg GANG, et al.
DNA-Silica
https://www.zmescience.com/science/news-science/mix-dna-with-glass-stronger-material-rep/
Iron Man-inspired material made from DNA and glass is 5x stronger than steel — and 4x lighter
Regular glass is brittle and fragile. But pure glass coated on DNA is a different beast entirely.
...Scientists have successfully combined the intricate structure of DNA with the purity of glass to create a material that boasts both lightness and unprecedented strength. The resulting supermaterial is five times lighter yet four times stronger than steel. This makes it “the strongest known” for its given density, according to the scientists who forged the material from the University of Connecticut, Columbia University, and Brookhaven National Lab.
https://www.cell.com/cell-reports-physical-science/fulltext/S2666-3864(23)00254-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2666386423002540%3Fshowall%3Dtrue
High-strength, lightweight nano-architected silica
Aaron Michelson, et al
[ PDF ]
Summary -- Continuous nanolattices are an emerging class of mechanical metamaterials that are highly attractive due to their superior strength-to-weight ratios, which originate from their spatial architectures and nanoscale-sized elements possessing near-theoretical strength. Rational design of frameworks remains challenging below 50 nm because of limited methods to arrange small elements into complex architectures. Here, we fabricate silica frameworks with ∼4- to 20-nm-thick elements using self-assembly and silica templating of DNA origami nanolattices and perform in situ micro-compression testing to examine the mechanical properties. We observe strong effects of lattice dimensions on yield strength (𝜎𝑦) and failure mode. Silica nanolattices are found to exhibit yield strengths higher than those of any known engineering materials with similar mass density. The robust coordination of the nanothin and strong silica elements leads to the combination of lightweight and high-strength framework materials offering an effective strategy for the fabrication of nanoarchitected materials with superior mechanical properties.
Patents
US20260158477 -- 3D Metal, Metal Oxides, And Semiconductor Nanoscale Frameworks Through Templating Of DNA-Programmable Lattice Scaffolds
A composite, comprising: a three-dimensional (3D) silicate lattice, the silicate lattice comprising a first porous motif, the first porous motif optionally being characterized as polyhedral, the first porous motif optionally defining a pore size of from about 5 to about 100 nm; and a first inorganic layer superposed over the silicate lattice, the first inorganic layer optionally coupled to the silicate lattice. A device, the device comprising a composite according to the present disclosure. A method, comprising: forming a silicate layer superposed on a 3D nucleic acid lattice, the nucleic acid lattice comprising a first porous motif, the first porous motif optionally being characterized as polyhedral, the first porous motif optionally defining a pore size of from about 5 to about 100 nm; and forming a first inorganic layer superposed over the silicate layer, the first inorganic layer optionally coupled to the silicate layer.
US12548243 -- 3D-organized nanomaterials through DNA-prescribed and valence-controlled material
The present subject matter relates to a voxel and methods of organizing an object into a three-dimensional (3D) array using the voxel. The voxel can include a plurality of frames including at least one single stranded (ss) DNA motif with at least one free base, wherein the at least one ssDNA motif hybridizes with a complementary strand fragment of other frames.
US11739162 -- Side chain modified peptoids useful as structure-stabilizing coatings for biomaterials
The current invention pertains compositions and methods to generate compositions providing stability to biomolecules, including providing physiologically stable and functional DNA origami-based drug/gene delivery carriers by surface coating with the oligo-ethylene glycol conjugated peptoids of Formulas (I), (II), and (III).
US11866775 -- METHODS FOR ISOTHERMAL MOLECULAR AMPLIFICATION WITH NANOPARTICLE-BASED REACTIONS
The present method of detection involves increasing an amount of analyte molecules by an isothermal molecular amplification approach. In the present approach a starting molecule of interest may be amplified through a reaction it induces with specifically engineered and functionalized particles, namely protected particles A and storage particles B. This reaction may result in a set of output DNA molecules that is larger in number than the input DNA molecules. Thus the reaction between nanoparticles for amplification of a certain DNA sequence (input DNA molecules) may occur when there is a match with a targeted molecule (stored molecules on storage particles B) and if the DNA sequence of the input DNA molecules does not match (partially or completely) the targeted molecule the reaction may not occur. Without a certain molecular input of the input DNA molecule the reaction may not occur.
US9751758 -- RATIONAL ASSEMBLY OF NANOPARTICLE SUPERLATTICES WITH DESIGNED LATTICE SYMMETRIES
A method for lattice design via multivalent linkers (LDML) is disclosed that introduces a rationally designed symmetry of connections between particles in order to achieve control over the morphology of their assembly. The method affords the inclusion of different programmable interactions within one linker that allow an assembly of different types of particles. The designed symmetry of connections is preferably provided utilizing DNA encoding. The linkers may include fabricated “patchy” particles, DNA scaffold constructs and Y-shaped DNA linkers, anisotropic particles, which are preferably functionalized with DNA, multimeric protein-DNA complexes, and particles with finite numbers of DNA linkers.
US2016176988 -- METHODS FOR THE BIO-PROGRAMMABLE CRYSTALLIZATION OF MULTI-COMPONENT FUNCTIONAL NANOPARTICLE SYSTEMS
The bio-programmable crystallization of multi-component functional nanoparticle systems is described, as well as methods for such bio-programmable crystallization, and the products resultant from such methods. Specifically, the systems disclosed and taught herein are directed to improved strategies for the DNA-mediated self-assembly of multi-component functionalized nanoparticles into three-dimensional order superlattices, wherein the functionalization of the nanoparticles with DNA is independent of either the composition of the material, or the shape of the nanoparticles.
US2013137602 -- ARBITRARY ASSEMBLY OF NANO-OBJECTS INTO DESIGNED 1D AND 2D ARRAYS
The present invention is directed to nanoscale fabrication of nano-materials with application in electronics, energy conversion, bio-sensing and others. Specifically, the invention is directed to arbitrary, that is periodic and non-periodic, assembly of nano-objects on I D and 2D arrays. The present invention utilizes self-organization properties of nanoscale bio-encoded building blocks, programmability of biomolecular interactions, and simple processing techniques for providing arbitrary by-design fabrication capability. Specifically, the present invention utilizes double stranded DNA attached to a surface and intercalating PNA-DNA hybrids attached to nano-objects to bind the nano-objects to the dsDNA in a site specific manner. The present invention allows for an integration of a large number of nano-components in unified well-defined systems. Accordingly, the present invention is applicable for fabrication of I D and 2D structures of various by-design placements of nano-objects of multiple types, including metal, semiconducting and organic nano-objects.
US8729012 -- Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents
The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.