rexresearch
Sarcopenia Therapies
Nutritional composition for preventing and treating sarcopenia as well as preparation method and application of nutritional composition -- CN122320238
The invention relates to a nutritional composition for preventing and treating sarcopenia as well as a preparation method and application thereof, the nutritional composition for preventing and treating sarcopenia comprises high-quality protein, leucine and beta-hydroxy-beta-methylbutyric acid, and the mass ratio of the high-quality protein to the leucine to the beta-hydroxy-beta-methylbutyric acid is (80-90): (8-14): (4-8).
Application of traditional Chinese medicine composition in preparing medicine for treating sarcopenia -- CN122321055
The invention belongs to the technical field of biology, and particularly relates to application of albumin polypeptide gel beads in a product for treating or preventing sarcopenia. Egg albumin is used as a raw material to extract protein, the albumin dipeptidyl peptidase-IV inhibitory peptide is prepared through a biological enzymolysis method, the inhibitory peptide TPYMFP is screened out through bioinformatics analysis, and the IC50 value of the inhibitory peptide TPYMFP to dipeptidyl peptidase-IV reaches 3.12 +/-0.49 mmol/L. The optimal preparation conditions of sodium alginate SA and carboxymethyl chitosan CMCS-based gel beads CMCS/SA/TPYMFP are further researched, and when the concentration of SA is 1.5% (w/v), the concentration of CMCS is 0.5% (w/v) and the concentration of CaCl2 is 1% (w/v), the polypeptide encapsulation efficiency is improved to 98.26% +/-0.25%. The invention also verifies that the albumin polypeptide gel bead has a good pH response characteristic, and realizes efficient protection and intestinal targeted delivery of the sarcopenia inhibitory peptide. The traditional Chinese medicine composition is applied to preparation of products for treating or preventing sarcopenia or preparation of related products for increasing muscle mass and strength.
Senior customized nutrition shake composition to prevent sarcopenia and improve muscle loss -- KR20260101754
A senior-tailored nutritional shake composition according to one embodiment of the present invention comprises a main ingredient powder containing isolated soy protein, isolated whey protein, goat milk protein, vitamin B1, niacin, pantothenic acid, vitamin B6, biotin, vitamin D, beta-glucan, vitamin K, zinc, calcium, and magnesium, and an auxiliary ingredient powder containing roasted brown rice powder, vitamin A, vitamin B2, vitamin C, potassium, oat dietary fiber, plant mixed extract powder, MSM, N-acetylglucosamine, fructooligosaccharide, similar cell powder, and amino acid mixed powder.
The above main ingredient powder comprises 52.5 to 60.5 wt% isolated soy protein, 27.4 to 35.4 wt% isolated whey protein, 3.8 to 11.8 wt% goat milk protein, 0.002 to 0.011 wt% vitamin B1, 0.01 to 0.07 wt% niacin, 0.01 to 0.05 wt% pantothenic acid, 0.005 to 0.013 wt% vitamin B6, 0.01 to 0.03 wt% biotin, 0.02 to 0.1 wt% vitamin D, 0.02 to 0.1 wt% beta-glucan, 0.001 to 0.008 wt% vitamin K, 0.014 to 0.022 wt% zinc, 1.1 to 5.1 wt% calcium, and 0.3 to 1.1 wt% magnesium [Includes.]
The above auxiliary ingredient powder comprises 0.001 to 0.009 wt% Vitamin A, 0.007 to 0.016 wt% Vitamin B2, 0.01 to 0.09 wt% Vitamin C, 1.5 to 2.3 wt% Potassium, 9.7 to 17.7 wt% Oat dietary fiber, 42.7 to 50.7 wt% Roasted brown rice powder, 4.8 to 12.8 wt% Plant mixed extract powder, 4.2 to 12.2 wt% MSM, 1.7 to 3.7 wt% N-acetylglucosamine, 12.5 to 20.5 wt% Fructooligosaccharide, 0.1 to 0.9 wt% Lactic acid mycelium powder, and 0.1 to 0.9 wt% Amino acid mixed powder.]
The above plant mixed extract powder includes mixed extracts of mulberry leaves, Cornus fruit, balloon flower, tangerine peel, Cudrania tricuspidata, goji berries, ginger, and citron.
The above plant mixed extract powder comprises 20 to 30 weight% mulberry leaves, 10 to 20 weight% Cornus fruit, 10 to 20 weight% balloon flower root, 5 to 10 weight% dried tangerine peel, 5 to 10 weight% Cudrania tricuspidata, 5 to 10 weight% goji berries, 5 to 10 weight% ginger, and 5 to 10 weight% citron.
The above plant mixed extract is extracted by an extraction method comprising the steps of: mixing purified water with mulberry leaves, Cornus fruit, balloon flower root, dried tangerine peel, Cudrania tricuspidata, Lycium chinense, ginger, and citron, respectively, and grinding them; adding an enzyme to the ground material obtained in the grinding step and causing an enzymatic reaction; mixing purified water with the enzyme-treated ground material obtained in the enzymatic reaction step and heating it to extract an extract; concentrating the extract obtained in the extraction step to prepare a concentrate; and adding maltodextrin to the concentrate obtained in the step of preparing the concentrate, and then drying to powderize.
The enzymes mentioned above are pectinase and cellulase. The above dietary fiber is maltodextrin. After the above-mentioned powdering step, the method further includes a step of mixing extract powders of mulberry leaves, Cornus fruit, balloon flower root, dried tangerine peel, Cudrania tricuspidata, goji berries, ginger, and citron...
Application of mulberry leaf ethyl acetate extract in preparation of products for treating, improving or preventing sarcopenia -- CN122251477
The invention belongs to the technical field of medicines, and particularly relates to application of a mulberry leaf ethyl acetate extract in preparation of a product for treating, improving or preventing sarcopenia. A sarcopenia model is established through dexamethasone, and tests prove that the folium mori ethyl acetate extract has the effects of reducing the content of MURF1 in serum, increasing the relative weight of gastrocnemius muscle, flatfish muscle, tibia anterior muscle and quadriceps femoris muscle of a mouse, reducing the SOD activity in liver tissue, increasing the CAT activity, inhibiting GDF-8 protein expression in the muscle, improving the SOD activity and inhibiting the GDF-8 protein expression in the muscle. The pathological state of gastrocnemius muscle is improved, and muscle fiber atrophy is relieved. The results show that the mulberry leaf ethyl acetate extract plays a role in resisting sarcopenia through a multi-target and multi-channel synergistic effect, a new technical scheme is provided for sarcopenia drug treatment and functional food development, and the application prospect is good.
Compound preparation for improving sarcopenia syndrome -- CN122097440
The invention discloses a compound preparation beneficial to muscle nutrition, which is composed of yeast extract powder, yeast beta-1, 3-glucan and ginsenoside according to a weight ratio of 8: 1: 1, and each unit of the preparation contains 200-800mg of the yeast extract powder. Wherein the essential amino acids supporting muscle nutrition comprise three branched chain amino acids, specifically isoleucine, leucine and valine, the ratio coefficient of the three branched chain amino acids is 1-1.2, and the range of the ratio coefficient is 0.94-1.14. The compound preparation disclosed by the invention can improve symptoms such as myasthenia, osteoporosis and myocardial function degeneration caused by the sarcopenia syndrome, has the advantages of easiness in absorption, high safety, synergistic interaction and the like, and is suitable for old people, weak people and people with reduced athletic ability.
SYNERGISTIC BIOACTIVE NUTRACEUTICAL COMPOSITION FOR MUSCLE HEALTH AND SARCOPENIA -- WO2026110213
The present invention relates to a synergistic bioactive composition for improving compromised muscle health and for the prevention, management or treatment of sarcopenia. The composition comprises ecdysterone, curcuminoids, and selenium, wherein the combination of these active agents exhibits a synergistic effect in enhancing muscle mass, muscle strength, and overall functional performance. The composition is intended for oral administration and may be formulated in any suitable orally administrable dosage forms including but not limited to a tablet, capsule, powder, pill, hard capsule containing liquid or solid fill, soft capsule, granule, pellet, caplet, mini-tablet, gummy, syrup, suspension, sachet or a, modified-release formulation.
SYNERGISTIC COMPOSITION FOR POOR MUSCLE HEALTH AND SARCOPENIA -- WO2026088203
The present invention relates to a synergistic composition for the improvement of compromised muscle health and management of sarcopenia. In particular, the invention provides a composition comprising ecdysterone, calcium hydroxy methylbutyrate, and selenium, wherein the constituents act synergistically to promote enhancement of skeletal muscle mass, muscular strength, and functional physical performance...
Phytobacterium plantarum with functions of improving muscle function and athletic ability as well as product and application of phytobacterium plantarum -- CN121930998
The invention belongs to the technical field of microorganisms, and particularly relates to plant lactobacillus with the function of improving the muscle function and the athletic ability and a product and application of the plant lactobacillus. According to the invention, the phytobacterium plantarum Vigo6 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35628 can promote the development of motor nerves, improve the form and density of muscle fibers, increase the muscle content and enhance the arrangement tightness of the muscle fibers; the effects of improving sarcopenia, promoting muscle growth, improving muscle strength, enhancing body coordination and balance ability, improving endurance and physical ability and improving muscle attenuation and aging equivalence are achieved. The lactobacillus plantarum Vigo6 disclosed by the invention has high intestinal tolerance, high storage stability, high safety and no pathogenicity, provides a new effective strain resource for developing related products for improving muscle health and athletic ability, and has a wide application prospect.
Collagen peptide composition with function of increasing muscle strength and application of collagen peptide composition -- CN121910164
The invention discloses a collagen peptide composition with a function of increasing muscle strength and application of the collagen peptide composition. The collagen peptide composition comprises fish collagen peptide and beef tendon collagen peptide. A mouse senescence sarcopenia model is constructed, then a collagen peptide composition is used for intragastric intervention, and the improvement effect is evaluated through behavioral testing, body component analysis and HE staining. The potential target and regulatory pathway of the collagen peptide composition are explored by combining network pharmacology and molecular docking. Results show that the four-limb grip strength, treadmill exhaustion time and movement distance of a model mouse can be remarkably improved, quadriceps femoris muscle and gastrocnemius muscle indexes are recovered, and muscle fiber atrophy and collagen deposition are relieved. And it is found that TNF, IL1B, AKT1, mTOR and MAPK1 may be core targets of the TNF, IL1B, AKT1, mTOR and MAPK1. The polypeptide plays a role by regulating and controlling biological processes such as MAPK cascade, protein processing and inflammatory reaction, cell apoptosis, a cAMP pathway and a calcium signal pathway.
Application of ganoderma lucidum spore oil in preparation of medicine or health food for improving sarcopenia -- CN121891420
The invention discloses an application of ganoderma lucidum spore oil in preparation of a medicine or health food for improving sarcopenia. Ganoderma lucidum spore oil can effectively improve weight loss and muscle hypofunction induced by glucocorticoid, and improve the holding power and exercise tolerance level of the body; meanwhile, the skeletal muscle mass and the muscle fiber cross sectional area can be increased, and the skeletal muscle tissue morphological structure is improved; in addition, the ganoderma lucidum spore oil can improve the oxidation resistance of the body and skeletal muscle and reduce the oxidative stress level, so that the skeletal muscle injury related to aging is relieved on the whole. Therefore, the ganoderma lucidum spore oil has a definite application value in the aspect of improving the skeletal muscle function.
Application of epimedin A as unique active ingredient in preparation of medicine for preventing and/or improving sarcopenia -- CN121891388
The invention relates to application of traditional Chinese medicine herba epimedii, especially an aqueous extract of herba epimedii and epimedin A in prevention and/or improvement of sarcopenia. Compared with a blank control group and a negative control group, the body lengths of the herba epimedii aqueous extract with the concentration of 1 mg/mL, the total flavonoids with the concentration of 0.026 mg/mL, the epimedium A with the concentration of 50 [mu] M, the epimedium B with the concentration of 200 [mu] M, the epimedium C with the concentration of 100 [mu] M, the icariin with the concentration of 200 [mu] M and the icaritin with the concentration of 100 [mu] M are increased by 21.40%, 23.09%, 26.69%, 24.91%, 29.22%, 33.15% and 28.35% respectively. The icariin administration concentration is improved, and the growth promoting effect concentration dependence is obviously enhanced. The body length of the caenorhabditis elegans is increased by 24.19% and even exceeds that of a positive control group. Epimedin A of 50 mu M can effectively increase the body length of caenorhabditis elegans, and other Epimedin A needs higher concentration; 50 [mu] M has the best effect of protecting and relieving the muscular structure. The invention provides a thought for developing medicines for improving dyskinesia and muscle volume reduction, prolonging life, improving muscle fiber atrophy, treating muscle strength decline, tonifying liver and kidney and strengthening muscles and bones, and the medicine is high in safety.
COMPOSITION AND FOOD SUPPLEMENTARY FOR SARCOPENIA AND PERIODONTAL DISEASES CONTAINING ALDER AND ELM COMPLEX EXTRACTS AS ACTIVE INGREDIENTS -- US20260102450
The present disclosure provides a pharmaceutical composition for preventing and treating sarcopenia and periodontal disease, comprising extracts of Alnus japonica and Elm japonica as active ingredients, wherein the Elm japonica extract comprises catechin 7-O-β-D-apiofuranoside (catechin 7-O-β-D-apiofuranoside), wherein a weight ratio of the extract of Alnus japonica and the extract of Elm japonica is 3:7 to 7:3.
Lactobacillus paracasei and application thereof in sarcopenia -- CN121852258
The invention relates to the field of microorganisms, and discloses a lactobacillus paracasei (Lactobacillus paracasei) and an application of the lactobacillus paracasei in prevention, alleviation or treatment of sarcopenia. The probiotics can promote muscle protein synthesis, inhibit protein degradation, improve mitochondrial functions and reduce visceral fat accumulation by regulating and controlling AKT/mTOR, NF-kB, FOXO3a and other signal channels, so that muscle mass decline, function decline and inflammatory state induced by sarcopenia are remarkably relieved. In addition, the lactobacillus paracasei improves metabolic health and inflammatory status by reducing the level of proinflammatory factors (such as TNF-alpha and IL-6) and up-regulating the expression of anti-inflammatory factors (such as IL-10). The traditional Chinese medicine composition is suitable for muscle loss caused by senile sarcopenia, obesity sarcopenia and heat limitation, has the advantages of clear mechanism, high safety, stable curative effect and the like, and provides a novel adjuvant therapy scheme for clinic.
Traditional Chinese medicine composition for enhancing functions of mature skeletal muscle cells and application -- CN121818834
The invention discloses a traditional Chinese medicine composition for enhancing functions of mature skeletal muscle cells and application of the traditional Chinese medicine composition. The composition is prepared from ginseng, astragalus membranaceus, pericarpium citri reticulatae, dogwood and rhizoma polygonati according to a specific ratio. The invention also provides an establishment method based on the quality standard of various active components (ginsenoside Rg1, hesperidin and the like) in the composition. The traditional Chinese medicine composition disclosed by the invention does not have a remarkable activity promoting effect on undifferentiated C2C12 myoblasts in a proliferation period, but can specifically enhance the cell activity of differentiated mature C2C12 myotubular cells. The action characteristics of the cell state dependence show that the composition does not simply stimulate cell proliferation, but is targeted to improve the functional state of mature muscle cells, so that a high-precision solution is provided for treating diseases (such as sarcopenia) characterized by mature muscle fiber function decline.
COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING SARCOPENIA, COMPRISING PLANTAGO ASIATICA EXTRACT AS ACTIVE INGREDIENT -- WO2026059072
The present invention relates to a composition for preventing, alleviating or treating sarcopenia, comprising a Plantago asiatica extract as an active ingredient. The Plantago asiatica extract of the present invention has no C2C12 cytotoxicity, has an effect in alleviating muscle loss in a cell experimental model through inhibition of muscle cell differentiation, and has an effect on muscle loss by alleviating skeletal muscle loss in a cachexia-induced muscle loss animal model.
Product for preventing and treating sarcopenia or skeletal muscle atrophy and application thereof [ Mulberry ] -- CN121622630
The invention belongs to the technical field of medical products and health care products, and particularly relates to a product for preventing and treating sarcopenia or skeletal muscle atrophy and application of the product. According to the application, it is found for the first time that morusin can effectively increase the cross sectional area of muscle fibers and improve muscle quality and muscle strength, shows a clear and prominent treatment effect in the aspect of reversing the muscle atrophy process, and has important application value in preparation and development of products for resisting sarcopenia and skeletal muscle atrophy.
Combined probiotics for improving sarcopenia and preparation method and application thereof -- CN121610378
The invention discloses combined probiotics for improving sarcopenia as well as a preparation method and application of the combined probiotics, and belongs to the field of probiotics. The invention relates to a combined probiotic for improving sarcopenia. The combined probiotic comprises a lactobacillus reuteri body, a lactobacillus johnsonii body, a lactobacillus fermentum body and a bifidobacterium adolescentis body. The combined probiotics disclosed by the invention can be used for remarkably improving the overall symptoms of sarcopenia model mice, including inhibiting weight loss, constipation symptoms and colonic mucosa destruction, prolonging load swimming time, improving muscle endurance, improving skeletal muscle atrophy, improving the expression of I-type slow muscle fiber protein MyHC I and promoting slow muscle fiber repair, and has the effects of preventing and treating sarcopenia. The invention discloses a probiotic intervention method for treating sarcopenia, which comprises the following steps of: preparing probiotics for treating sarcopenia, reducing the content of inflammatory cytokines in muscular tissues, increasing the content of hepatic glycogen, improving systematic metabolism of mice with sarcopenia and damaged serum markers, including lactic acid, lactic dehydrogenase, creatine kinase, creatinine, alanine transaminase ALT and aspartate transaminase AST, providing a new scheme for probiotic intervention for sarcopenia, and being used for preparing related functional products or intervention means.
Traditional Chinese medicine composition for treating chronic cardiac failure sarcopenia -- CN121550285
The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating chronic cardiac failure sarcopenia and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10-20 parts of red ginseng, 10-20 parts of salvia miltiorrhiza, 15-25 parts of beautiful millettia root and 15-25 parts of philippine flemingia root. Based on the theory of tonifying qi, activating blood, invigorating spleen and promoting tissue regeneration in traditional Chinese medicine, the traditional Chinese medicine composition aims at the core pathogenesis of the chronic cardiac failure sarcopenia of qi deficiency, blood stasis and muscle and meat malnutrition. Animal experiments show that the traditional Chinese medicine composition can significantly improve the heart function, increase the skeletal muscle mass and muscle fiber cross-sectional area and enhance muscle strength and exercise tolerance, and the mechanism of the traditional Chinese medicine composition may be related to the reduction of skeletal muscle tissue inflammatory response. Clinical cases prove that the traditional Chinese medicine can effectively improve symptoms such as weakness, shortness of breath and weakness of limbs of patients and improve the life quality. The invention provides a brand-new, effective and safe traditional Chinese medicine treatment scheme for preventing and treating the chronic cardiac failure sarcopenia.
Application of orange peel-derived extracellular vesicles in preparation of medicines for treating sarcopenia and osteoporosis -- CN121466181
The invention discloses application of orange peel-derived extracellular vesicles in preparation of a medicine for treating sarcopenia and osteoporosis, and belongs to the technical field of medical application of natural extracellular vesicles. In an animal model, the orange peel-derived extracellular vesicles can promote expression of muscle-related transcription factors and repair muscle fibers, activate osteoblast activity and inhibit osteoclast activity at the same time, so that the symptoms of muscle mass decrease and muscle strength decline of a patient suffering from sarcopenia are improved, and bone mass loss and bone microstructure damage of a patient suffering from osteoporosis are delayed. In view of the problems of limited effect, obvious side effect and the like of the current clinical treatment means for sarcopenia and osteoporosis, the medicinal value of the orange peel which is a natural-source waste is excavated, a novel candidate medicine is provided for combined prevention and treatment of the two diseases, and the application has good clinical application prospect and conversion value.
Application of forsythin in preparation of medicine for preventing or treating muscular atrophy -- CN121401285
The invention belongs to the field of biological medicines, and particularly relates to a novel application of forsythin in preparation of a medicine for preventing and treating amyotrophy. In-vivo and in-vitro experiments prove that the phillyrin can remarkably improve the level of endogenous prostaglandin E2 by inhibiting the activity or expression of 15-hydroxyprostaglandin dehydrogenase in muscular tissues, so that the expression of muscular atrophy key factors FOXO3a and Atrogin-1 is inhibited, and finally the effects of protecting muscle quality and improving muscle functions are achieved. The invention reveals that forsythin has the functions of inhibiting 15-PGDH and relieving muscle atrophy for the first time, and brand new medical application is provided for forsythin. The invention provides a brand-new therapeutic scheme and pharmaceutical composition for treating sarcopenia by using forsythin as an active component and regulating the 15-PGDH/PGE2 pathway. The invention provides an important candidate compound for developing efficient and safe sarcopenia resisting medicines, and has important practical significance.
Pharmaceutical composition and health food for preventing and treating sarcopenia and periodontal diseases, containing both red poplar and elm extracts as active ingredients -- CN121311233
The present invention provides a pharmaceutical composition for preventing and treating muscle loss and periodontal diseases, which contains both a red poplar extract and an elm extract as active ingredients, and the extract of the present invention contains both a red poplar extract and an elm extract as active ingredients, and has a prevention and treatment effect of reducing muscle and periodontal diseases.
Traditional Chinese medicine composition for treating post-stroke sarcopenia -- CN121287845
The invention discloses a traditional Chinese medicine composition for treating post-stroke sarcopenia as well as a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from radix rehmanniae preparata, fructus corni, radix morindae officinalis, herba cistanche, herba dendrobii, radix ophiopogonis, fructus schizandrae, poria cocos, radix aconiti lateralis preparata, cortex cinnamomi, radix astragali seu hedysari, radix codonopsis, fructus jujubae and caulis spatholobi. The 14 medicinal materials are prepared according to a specific weight ratio. Based on a traditional Chinese medicine treatment method of tonifying liver and kidney, strengthening spleen and stomach and dredging meridians and collaterals, the composition is precise and appropriate, and the pertinence is strong. Clinical research proves that the composition can remarkably improve the muscle strength, muscle quality and movement function of a patient suffering from post-stroke sarcopenia, and the curative effect is remarkably superior to that of conventional rehabilitation treatment. The research on the mechanism of action shows that muscle synthesis can be promoted by up-regulating an IGF-1/Akt/mTOR (Insulin-like Growth Factor 1/Akt/mTOR) signal channel, and muscle decomposition can be inhibited by down-regulating the expression of MuRF-1/Atrogin-1 at the same time. A detailed dose ratio optimization research proves that a specific ratio (an optimal embodiment) has a synergistic effect. The invention provides an innovative traditional Chinese medicine treatment scheme with definite curative effect and high safety for the post-stroke sarcopenia, and has important clinical value and development prospect.
Application of beer yeast peptide in improvement of sarcopenia -- CN121265747
he invention relates to application of beer yeast peptide in improving sarcopenia caused by aging, and belongs to the field of food science and nutriology. The beer yeast peptide takes beer yeast as a raw material, is obtained through complex enzyme enzymolysis and purification processes, and has low molecular weight and good bioavailability. The beer yeast peptide improves the activity of antioxidant enzymes (SOD and GSH-Px) in muscular tissues and serum, reduces the level of lipid peroxidation products (MDA), and enhances the oxidation resistance; meanwhile, the expression of inflammatory factors IL-6 and TNF-alpha is inhibited, and the anti-inflammatory effect is achieved, so that the sarcopenia caused by aging is improved, and the muscle function and quality are improved. Animal experiments prove that the traditional Chinese medicine composition has remarkable effects in the aspects of improving exercise tolerance, enhancing muscle grip strength, increasing the content of type I collagen and the like. Theoretical basis and technical support are provided for development and application of the beer yeast peptide in the field of functional food.
Dietary composition for preventing and treating senile sarcopenia and application thereof -- CN121242229
The invention discloses a dietary composition for preventing and treating senile sarcopenia and application thereof, and relates to the technical field of dietary nutrition and health. The dietary composition disclosed by the invention comprises lactobacillus paracasei LC86, lactobacillus rhamnosus LRa05, lactobacillus plantarum Lp05 and plant protein, and the components are combined according to the proportion of (8.3-50) * 10 < 9 > CFU of lactobacillus paracasei LC86, (8.3-50) * 10 < 9 > CFU of lactobacillus rhamnosus LRa05 and (8.3-50) * 10 < 9 > CFU of lactobacillus plantarum Lp05 in every 5g of plant protein. The dietary composition improves the biological value of vegetable protein, does not introduce the fat intake risk of animal protein, improves the symptoms of the senile sarcopenia, and has a remarkable effect.
Muscle-building dietary flavone compound protein composition as well as preparation method and application thereof -- CN121196172
The invention discloses a muscle-building dietary flavone compound protein composition as well as a preparation method and application thereof, and belongs to the field of dietary supplements. The composition is prepared from the following components in parts by weight: 50 to 80 parts of concentrated whey protein powder, 5 to 20 parts of separated whey protein powder, 0.01 to 3 parts of hydrolyzed whey protein powder, 0.1 to 1 part of bovine colostrum powder, 0.01 to 0.05 part of kaempferol and 0.01 to 0.1 part of glucomannan. The composition can improve the muscle synthesis and growth rate, inhibit muscle reduction caused by sarcopenia, improve the muscle oxidation resistance, accelerate the muscle repair speed and activate the protein synthesis rate-limiting enzyme AKT and the growth kinase ERK. The composition can be used for preparing food, special diet and health food.
Nutrient composition for improving muscle function and application -- CN121058892
The invention relates to the technical field of nutritional foods, and particularly discloses a nutritional composition for improving muscle functions and application. The nutritional composition for improving the muscle function, provided by the invention, is prepared from the following components in parts by mass: 40 to 60 parts of 1, 3-dioleic acid-2-palmitic acid triglyceride and 20 to 70 parts of 1-oleic acid-2-palmitic acid-3-linoleic acid triglyceride. A specific amount of OPO and OPL are compounded, and the two components have a synergistic effect, so that the exercise amount and the ATP content of an organism are remarkably increased, sarcopenia is relieved by improving energy metabolism, the muscle function is improved, and the food has a wide application prospect in the field of food and is worthy of popularization and application. The food can be used in health-care food, formula food for special medical purposes, infant formula food or special diet food.
COMPOSITIONS FOR TREATING AND/OR RELIEVING SARCOPENIA AND USES THEREOF -- US2025352586
A composition for treating and/or relieving sarcopenia includes Clostridium butyricum M1. A microbial number of Clostridium butyricum M1 ranges from 10<6 >CFU/g to 10<12 >CFU/g. The composition further includes Bacillus coagulans CC212. Bacillus coagulans CC212 is deposited in Bioresource Collection and Research Center. A deposit number of Bacillus coagulans CC212 is BCRC911233. A microbial number of Bacillus coagulans CC212 is ranges from 10<6 >CFU/g to 10<12 >CFU/g. A use of the composition is to orally administer the composition to a subject. Clostridium butyricum M1 release a Clostridium butyricum exosome. The Clostridium butyricum exosome could promote muscle growth of the subject. Bacillus coagulans CC212 release a Bacillus coagulans exosome. The Bacillus coagulans exosome and the Clostridium butyricum exosome could effectively reduce a fat mass of the subject. Therefore, the subject could experience an increase in muscle mass and a reduction in fat after taking the composition.
COMPOSITION FOR PREVENTING OR TREATING AGING AND AGING-RELATED DISEASES COMPRISING SAMBUCUS SPP. EXTRACT OR COMPOUND ISOLATED THEREFROM AS ACTIVE INGREDIENT -- WO2025234809
The present invention relates to a composition for preventing or treating aging and aging-related diseases, comprising a Sambucus spp. extract or a compound isolated therefrom as an active ingredient. It has been confirmed that the Sambucus spp. extract or the compound isolated therefrom exhibits effects of suppressing the expression of p16, which is a cellular aging biomarker, and promoting autophagy. Accordingly, the Sambucus spp. extract or the compound isolated therefrom of the present invention is expected to be applicable to the development of therapeutic agents, functional health foods for amelioration, veterinary medicines, and animal feed compositions for aging or aging-related diseases such as idiopathic pulmonary fibrosis, cardiovascular diseases, diabetes, neurodegenerative diseases, sarcopenia, and osteoarthritis-related diseases.
Traditional Chinese medicine composition for treating chronic heart failure complicated with sarcopenia -- CN120860171
The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating chronic heart failure complicated with sarcopenia and application thereof. The traditional Chinese medicine composition consists of the following traditional Chinese medicines: 25-35g of astragalus membranaceus, 6-12g of ginseng, 4-8g of cinnamon, 25-35g of maltose, 6-12g of cassia twig, 15-20g of white paeony root, 4-8g of honey-fried licorice root, 6-12g of ginger and 4-8 Chinese dates. The traditional Chinese medicine composition can obviously improve the left ventricular ejection fraction of a patient with chronic heart failure complicated with sarcopenia, improve the body weight of the patient, improve the muscle quantity index of skeletal muscles of limbs of the patient and improve the grip strength of the patient, and has a remarkable treatment effect on chronic heart failure complicated with sarcopenia. The traditional Chinese medicine composition has the advantages of low side effect, high compliance and the like, is suitable for treating chronic heart failure and sarcopenia, and has a better market application prospect.
Traditional Chinese medicine composition for strengthening spleen and building muscle -- CN120789189
The invention provides a traditional Chinese medicine composition for strengthening spleen and building muscle, a medicinal preparation and a preparation method thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition comprises the following components: Chinese yam, bighead atractylodes rhizome, sun-dried ginseng, hyacinth bean and malt. The traditional Chinese medicine composition and the pharmaceutical preparation provided by the invention have the effects of tonifying spleen and qi, promoting digestion and resolving dampness, and regulating middle warmer and increasing muscle, and can be used for treating senile sarcopenia and improving symptoms such as weakness of spleen and stomach, reduction of muscle strength, deficiency of qi and blood and the like.
Traditional Chinese medicine composition for treating sarcopenia by regulating CXCR4/GPX4 axis to inhibit ferroptosis -- CN120661559
The invention discloses a traditional Chinese medicine composition for treating sarcopenia by regulating a CXCR4/GPX4 axis to inhibit ferroptosis and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-15 parts of eucommia ulmoides, 5-15 parts of herba epimedii, 5-15 parts of fructus psoraleae and 5-15 parts of semen cuscutae. The traditional Chinese medicine composition disclosed by the invention has the traditional effects of tonifying kidney, strengthening yang and strengthening tendons and bones, and is proved to be capable of promoting GPX4 expression and inhibiting ferroptosis of muscle cells by up-regulating CXCR4 expression, so that muscle strength is effectively enhanced, proliferation and differentiation of muscle satellite cells are promoted, oxidative stress is reduced, and the traditional Chinese medicine composition is used for preventing or treating sarcopenia.
Application of traditional Chinese medicine composition in preparation of medicine for preventing and treating sarcopenia related to metabolism-related fatty liver diseases -- CN120617392
The invention discloses application of a traditional Chinese medicine composition in preparation of a medicine for preventing and treating sarcopenia related to metabolism-related fatty liver diseases. The traditional Chinese medicine composition comprises ginseng, bighead atractylodes rhizome, poria cocos, liquorice, pinellia ternate and pericarpium citri reticulatae. The traditional Chinese medicine composition recuperates the spleen and strengthens the transportation mechanism, the spleen qi is excess so that phlegm becomes turbid, the muscle is fine and nutrient, the abnormal lipid in the liver is also reduced, and the condition of muscle reduction is improved.
Nutritional formula food suitable for patients with cognitive impairment with sarcopenia -- CN120514108
The present invention provides a nutritional formula food suitable for patients with cognitive impairment with sarcopenia and a preparation method thereof, and relates to the technical field of formula foods, the nutritional formula food comprises the following components: maltodextrin, vegetable oil, whey protein, soybean protein, dietary fibers, fish oil, minerals, carboxymethyl pachymaran, calcium beta-hydroxy-beta-methylbutyrate and ginsenoside, and vitamins. The technical problem that in the prior art, a nutritional formula food for patients with cognitive impairment with sarcopenia is lacked is solved, through the synergistic interaction among ginsenoside, calcium beta-hydroxy-beta-methylbutyrate and carboxymethyl pachymaran, the anti-inflammatory effect is greatly improved, and the effects of providing treatment for the patients with cognitive impairment and providing health care for the patients with cognitive impairment with sarcopenia are achieved. Nutrition can also be provided to support the growth of neuronal cells, neuroinflammation is reduced, the recovery of cognitive functions is promoted, and the attenuation of muscles is slowed down.
Composition containing rhizoma polygonati as well as preparation method and application thereof in prevention and treatment of sarcopenia -- CN120478527
The invention discloses a composition containing rhizoma polygonati for preventing and/or treating sarcopenia. The composition is prepared from rhizoma polygonati, radix angelicae sinensis, radix codonopsis, radix rehmanniae preparata, herba cistanche, fructus lycii, poria cocos and fructus crataegi. Wherein the mass ratio of the rhizoma polygonati to the radix angelicae sinensis to the radix codonopsis to the radix rehmanniae preparata to the herba cistanche to the fructus lycii to the poria cocos to the fructus crataegi is (6-20) to (3-15) to (6-20) to (7-15) to (3-11) to (10-15) to (6-14) to (3-11). The composition can effectively improve the muscle strength, muscle quality, exercise tolerance, holding power and coordination function of model animals, improves the muscle structure and fibrosis state, and has a good sarcopenia resistance effect and a good clinical application prospect.
Food for improving muscle quality and function as well as preparation method and application thereof -- CN120477375
The invention provides a food capable of improving muscle quality and functions as well as a preparation method and application of the food. The food contains lactoferrin and creatine, and the mass ratio of the lactoferrin to the creatine is (3-9): 1. In terms of the total dry matter content of the food, the content of the lactoferrin in the food is 0.1-90 g/100 g, and the content of the creatine in the food is 0.01-30 g/100 g. The food disclosed by the invention can play an important role in preventing, treating and improving the sarcopenia syndrome by improving muscle quality, muscle strength and functions, promoting myogenic differentiation and the like in multiple aspects and multiple dimensions.
Food for improving muscle attenuation and promoting myogenic differentiation... -- CN120477376
The invention provides a food for improving muscle attenuation and promoting myogenic differentiation as well as a preparation method and application of the food. The food comprises lactoferrin and coenzyme Q10, wherein the mass ratio of the lactoferrin to the coenzyme Q10 is (40-60): 1; based on the total dry matter content of the food, the content of the lactoferrin in the food is 0.1 to 98g/100g, and the content of the coenzyme Q10 in the food is 1.7 to 2450mg/100g. The food disclosed by the invention can play an important role in preventing, treating and improving the sarcopenia syndrome by improving muscle quality, muscle strength and functions, promoting myogenic differentiation and the like in multiple aspects and multiple dimensions.
Composition and application thereof as well as food or medicine containing composition for delaying skeletal muscle senescence -- CN120458277
The invention provides a composition and application thereof, and a food or a medicine containing the composition and used for delaying skeletal muscle senescence. The composition comprises lactoferrin and pyrroloquinoline quinone disodium salt in a weight ratio of (20: 1)-(30: 1). The composition can be used for preparing foods or medicines for delaying skeletal muscle senescence, has the application of preventing and delaying sarcopenia, and has a good application prospect for preventing sarcopenia.
Medicine for treating sarcopenia and preparation method thereof -- CN120437249
The invention discloses a medicine for treating sarcopenia and a preparation method of the medicine. The medicine is prepared from codonopsis pilosula, prepared rehmannia roots, poria cocos, fried rhizoma atractylodis macrocephalae, fried white hyacinth beans, lotus seeds, fried Chinese yam, fructus amomi, fried coix seeds, platycodon grandiflorum, angelica sinensis, radix paeoniae alba, ligusticum wallichii and honey-fried licorice roots. The traditional Chinese medicine composition has the effects of replenishing qi and enriching blood, tonifying spleen and excreting dampness, and tonifying kidney and replenishing essence, can be used for treating spleen and stomach disharmony and deficiency of qi and blood of patients with colorectal cancer sarcopenia and improving the sarcopenia symptom of the patients with colorectal cancer, and also can be used for resisting damage of toxicity of chemotherapeutic drugs to organisms; meanwhile, the traditional Chinese medicine composition can also treat senile sarcopenia caused by reduction of whole body muscle mass and reduction of muscle strength and activity of old people along with age increase, and is suitable for chemotherapy patients with colorectal cancer sarcopenia and senile sarcopenia patients.
New application of indole-3-carbinol or dimer 3, 3 '-diindolylmethane for treating muscle degenerative diseases -- CN120284953
The invention belongs to the technical field of biological medicines, and particularly relates to a novel application of indole-3-methanol or dimer 3, 3 '-diindolylmethane thereof in preparation of medicines for treating muscle degenerative diseases. According to the indole-3-carbinol and the dimer 3, 3 '-diindolylmethane thereof, muscle function decline is obviously delayed, a myofibril structure and a mitochondrial form are protected, and amyloid protein deposition and accumulation are reduced, so that the indole-3-carbinol and the dimer 3, 3'-diindolylmethane thereof play a good role in treating muscle decline related diseases such as sarcopenia and inclusion body myositis. The compound is natural in source and high in safety, can be applied to prevention and treatment of the muscle diseases in forms of oral administration, dietary supplements or pharmaceutical preparations and the like, and has a good industrial application prospect.
Medicinal and edible functional ointment for preventing and treating senile sarcopenia and preparation method thereof -- CN120267798
The invention belongs to the field of functional ointment preparation, and particularly relates to medicinal and edible functional ointment for preventing and treating senile sarcopenia and a preparation method of the medicinal and edible functional ointment. Chinese herbal medicine powder obtained through powdering is mixed with whey protein powder, beef extract, pea protein powder and a mold fungicide for fermentation, and muscle synthesis and repair components obtained through adsorption of muscle cell absorption promoting colloids can efficiently promote muscle synthesis and repair; the lactide, the glycolide, the stannous octoate and the dichloromethane are mixed to react to form a polymer, the composition for improving the nerve cell function and the hormone secretion regulating component are mixed, and the nerve cell regulator obtained by spray drying can be endocytosed by small intestine cells; the anti-inflammatory mixture capable of effectively inhibiting inflammatory reaction is mixed with the composition for preventing and treating senile sarcopenia, and the obtained medicinal and edible functional ointment for preventing and treating senile sarcopenia is obvious in senile sarcopenia prevention and treatment effect, high in bioavailability, capable of playing a role for a long time and stable in efficacy in the storage process.
Preparation method and application of composition with sarcopenia resisting effect -- CN120227408
The invention relates to the technical field of pharmaceutical compositions, and particularly discloses a preparation method and application of a composition with an anti-sarcopenia effect, and the composition is prepared from radix astragali extract, rhizoma atractylodis macrocephalae extract, vitamin D and lecithin. According to the invention, the astragalus extract is used for enhancing the mitochondrial function, the bighead atractylodes rhizome extract is used for improving muscle nutrition, the vitamin D is used for promoting protein synthesis, and the lecithin is used for repairing cell membranes, so that the astragalus extract, the bighead atractylodes rhizome extract, the vitamin D and the lecithin cooperate to resist sarcopenia from energy metabolism and structure repair to function enhancement in multiple dimensions.
ORAL COMPOSITION -- JP7701090
To provide a new oral composition for improvement of osteoporosis and sarcopenia, capable of ameliorating osteoporosis or sarcopenia with reduced side effects.SOLUTION: An oral composition for improving osteoporosis and sarcopenia contains strain NS8 belonging to the species Lactobacillus helveticus. The oral composition may be a food composition or may be a pharmaceutical composition.
Bean dreg solid-state fermentation preparation and application thereof in treating or preventing sarcopenia -- CN120189448
The invention discloses a bean dreg solid state fermentation preparation and application thereof in treating or preventing sarcopenia, and relates to the field of bean dreg processing, the bean dreg solid state fermentation preparation is obtained by taking lactobacillus paracasei LMX1 and pediococcus acidilactici IFJ1 as fermentation strains, taking bean dregs as a fermentation substrate, firstly performing solid state fermentation and then performing extraction. A myotubular atrophy model is established by inducing mouse myoblast C2C12 injury with TNF-alpha in vitro, the effect of the bean dreg solid-state fermentation preparation on C2C12 cells is explored, the influence of the bean dreg solid-state fermentation preparation on LPS-induced muscular atrophy mice is researched in vivo, and the result shows that the bean dreg solid-state fermentation preparation has potential effects of delaying senescence, promoting growth of muscular atrophy, preventing and treating muscular atrophy. The composition has the effects of preventing muscle atrophy and weakness related to aging and treating sarcopenia, and reference is provided for exploring potential application of plant active ingredients in the aspect of preventing or treating muscle functions.
Probiotic composition for relieving sarcopenia obesity and application thereof -- CN120173823
The invention relates to the technical field of biology, and provides a probiotic composition for relieving sarcopenia obesity and application of the probiotic composition. The composition comprises at least two of lactobacillus plantarum, lactobacillus rhamnosus and bifidobacterium animalis subsp. Lactis. Wherein the preservation number of the lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) No.25839; the preservation number of the lactobacillus rhamnosus is CGMCC (China General Microbiological Culture Collection Center) No.26968; the preservation number of the animal bifidobacterium subsp. Lactis is CGMCC (China General Microbiological Culture Collection Center) No. 27998. The composition disclosed by the invention can be used for increasing the muscle content of an organism, improving the muscle tissue form, increasing adenosine triphosphate and inhibiting abnormal increase of body weight, so that the composition can be used for effectively preventing and treating sarcopenia obesity.
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR ALLEVIATING SARCOPENIA COMPRISING SOYBEAN LEAF EXTRACT -- WO2025121471
The present invention relates to a pharmaceutical composition and a health functional food for preventing, treating, or alleviating sarcopenia, which, by comprising a soybean leaf extract, prevent the loss of muscle fibers and help the recovery and regeneration of muscles, thus exhibiting excellent medicinal effects.
Composition for preventing and treating sarcopenia as well as preparation method and application thereof -- CN122056991
The invention discloses a composition for preventing and/or treating sarcopenia, which is prepared from the following raw material medicines in parts by weight: 9 to 11 parts of rhizoma polygonati, 7.2 to 8.8 parts of rhizoma dioscoreae, 7.2 to 8.8 parts of folium cortex eucommiae, 9 to 11 parts of fructus mori, 7.2 to 8.8 parts of fructus lycii, 7.2 to 8.8 parts of poria cocos, 9.9 to 12.1 parts of fructus ziziphi jujubae and 7.2 to 8.8 parts of rhizoma curcumae longae. The composition can improve muscle strength, improve skeletal muscle pathological injury, increase muscle fiber cross-sectional area and reduce expression of atrophy related markers, which indicates that the traditional Chinese medicine composition can be used as a medicine for treating sarcopenia.
NUTRITIONAL COMPOSITION COMPRISING RESVERATROL -- EP4559325
The present invention disclose enteral composition comprising resveratrol, grape seed extract and dietary fibers selected from resistant dextrin, oligofructose, inulin, acacia fiber and citrus fiber. The composition is useful in providing nutrition to a persons suffering from disorder selected from diabetes, GI disorders, malnutrition in general or disease-related malnutrition or are in risk of malnutrition, or to a persons suffering from sarcopenia and age related nutrition consequences.
NUTRITIONAL COMPOSITION COMPRISING CURCUMIN -- EP4559326
The present invention discloses an enteral composition comprising curcumin and dietary fibers selected from resistant dextrin, oligofructose, inulin, Acacia fiber and Citrus fiber. The composition is useful for the nutrition of people suffering from diabetes, GI disorders, general or disease-related malnutrition or are at risk of malnutrition, for people suffering from sarcopenia and age related nutritional consequences.
Traditional Chinese medicine composition for treating sarcopenia -- CN120037316
The invention discloses a traditional Chinese medicine composition for treating sarcopenia, the traditional Chinese medicine composition is prepared from six medicines of sugared ginseng, cistanche, rhizoma polygonati, poria cocos, gastrodia elata and bighead atractylodes rhizome through compatibility, the traditional Chinese medicine composition takes spleen strengthening, qi supplementing, kidney tonifying and essence replenishing as the treatment rule, syndrome differentiation treatment is carried out aiming at the spleen and kidney deficiency pathogenesis of sarcopenia, multi-target intervention on sarcopenia is achieved, and the traditional Chinese medicine composition has the advantages that the curative effect is good; the traditional Chinese medicine composition not only can quickly improve muscle strength and endurance functions, but also can continuously promote muscle mass reconstruction, and has dual effects of atrophy resistance and fibrosis resistance, and animal experiment results show that the traditional Chinese medicine composition has a remarkable curative effect on liver and kidney deficiency type sarcopenia.
Traditional Chinese medicine composition for preventing and treating sarcopenia -- CN120037275
The traditional Chinese medicine composition is mainly prepared from the following raw material medicines in parts by weight: 1-30 parts of astragalus membranaceus, 1-30 parts of codonopsis pilosula, 1-12 parts of bighead atractylodes rhizome, 1-15 parts of poria cocos, 1-9 parts of herba epimedii and 1-3 parts of liquorice. In addition, the invention further discloses a preparation method and application of the traditional Chinese medicine composition. Pharmacological studies prove that the traditional Chinese medicine composition has the effects of tonifying qi, strengthening the spleen and tonifying the kidney, and can be used for preventing and treating sarcopenia.
Combined preparation for its use in the improvement of the muscle health -- US2025161362
A combined preparation of two compositions acting synergistically are useful in muscular regeneration, in the treatment and/or prevention of muscular atrophy and sarcopenia in a subject, as well as for the healing of muscular wounds, improved muscular performance, of muscle senescence and in the reversal of muscular degeneration preferably associated with ageing. The compositions include hyaluronic acid, mucopolysaccharides, collagen and whey protein isolate concentrate.
Korean Patents -- No Abstract/Description:
A compositions for preventing or treating of sarcopenia comprising extracts Veronicastrum sibiricum as an active ingredient -- KR20260058917
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A compositions for preventing or treating of sarcopenia comprising extracts Veronicastrum sibiricum as an active ingredient -- KR20260058917