rexresearch1
Min XING, et al
Sr-Ca-Ba-TiO3 Toothpaste
Sr-Ca-Ba-TiO3 Toothpaste
https://phys.org/news/2026-01-toothbrush-powder-whitens-teeth.html
Toothbrush-activated powder whitens, repairs and protects teeth
Min Xing, et al
Sr-, Ca-Doped BaTiO3 with Synergistic Piezoelectric Catalysis and Microbial Balance Effects Enables Tooth Whitening for Home Oral Health
...Herein, a nondestructive, convenient teeth whitening strategy based on Ba0.9Sr0.05Ca0.05TiO3 (BSCT) accompanied by piezoelectric catalysis, biomimetic remineralization, and microbial community regulation has been reported. BSCT can generate •O2– and •OH in situ under mechanical vibration, resulting in degradation of organic dyes and inhibition of cariogenic bacterial activity. Besides, the Ca2+ and Sr2+ ions released from BSCT form localized ion-enriched zones on enamel and dentin surfaces, promoting remineralization of minerals. Mechanistically, we reveal that the piezoelectric polarization field enhances antibacterial efficacy by disrupting the bacterial membrane potential and structural integrity, weakening the proton motive force (PMF), and subsequently inhibiting F0F1-ATP synthase activity to block ATP synthesis. Notably, this study presents an innovative discovery that BSCT selectively inhibits dominant pathogenic bacteria while promoting the restoration of beneficial microbial communities, thereby facilitating the reconstruction of oral ecological homeostasis....
https://pubs.acs.org/doi/10.1021/acsnano.5c16997?goto=supporting-info
Supporting Info
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CN119430910 -- Piezoelectric ceramic powder for whitening and mineralizing teeth as well as preparation method and application of piezoelectric ceramic powder
The purpose of this invention is to provide a convenient and long-lasting piezoelectric ceramic powder for promoting teeth whitening and mineralization repair, as well as its preparation method and application. This ceramic powder generates active oxygen under ultrasonic/mechanical stimulation for teeth whitening and promotes mineralization repair of the tooth surface, avoiding tooth damage caused by excessive use of bleaching agents during teeth whitening.
The method for preparing the piezoelectric ceramic powder used for teeth whitening and mineralization includes the following steps:
(1) Based on the chemical formula Ba<sub>1-2x</sub>Sr<sub>x</sub>Ca<sub>x</sub>TiO<sub>3</sub>, weigh barium acetate (99% purity), calcium acetate (99% purity), and strontium acetate (98% purity) according to the molar ratio of (1-2x):x:x, dissolve them in acetic acid, then mix them evenly at 60-90℃ for 30 min, and then cool them naturally to room temperature to obtain solution A;
(2) Dissolve tetrabutyl titanate in 1 mL of acetylacetone and 9 mL of ethylene glycol methyl ether according to the stoichiometric ratio to form homogenized solution B;
(3) Mix and stir solutions A and B for 5 hours and age for 24 to 96 hours to form homogenized solution C, and then dry it at 90 to 150°C to form dry sol;
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(4) The dry sol was heat-treated at 600-1200℃ (heating rate 5℃/min) for 2h to form BaSrCaTiO<sub>3</sub>based ceramic powder (BSCT).
In step (1), x = 0.05 and the stirring temperature is 70℃.
In step (3), the aging time is 72 hours and the drying temperature is 120℃.
The heat treatment temperature in step (4) is 900℃.
The application of the piezoelectric ceramic powder used for teeth whitening and mineralization is its application in teeth whitening and promoting the mineralization and repair of tooth surfaces.
Compared with the prior art, the beneficial effects of the present invention are as follows:
(1) The piezoelectric ceramic powder described in this invention can respond efficiently to external ultrasonic stimulation and generate active oxygen with strong oxidizing ability (such as superoxide anion, hydrogen peroxide, etc.). These active oxygens can not only effectively decompose and remove stains on the tooth surface, such as coffee stains, tea stains, tobacco stains, etc., but also have a good piezoelectric effect and can be used for teeth whitening.
(2) The piezoelectric ceramic powder of the present invention contains Ca and Sr ions, which can promote the mineralization and repair of the tooth surface, thereby enhancing the hardness and anti-caries ability of the teeth.
(3) The piezoelectric ceramic powder described in this invention has good biocompatibility, ensuring its safety in the oral environment and the feasibility of long-term use.
This invention relates to a BaSrCaTiO_NER12-based piezoelectric ceramic powder (named "BSCT"), its preparation method, and its applications.
This invention uses the sol-gel method to prepare a precursor liquid, which is then aged and dried to prepare a dry sol, and finally heat-treated to obtain piezoelectric ceramic powder.
This piezoelectric powder can generate active oxygen under mechanical stress and ultrasonic stimulation, which can be used for teeth whitening to remove stains on the tooth surface and can promote tooth surface mineralization.
The present invention will be further illustrated with examples below.
It should also be understood that the following embodiments are only used to further illustrate the present invention and should not be construed as limiting the scope of protection of the present invention.
Preparation of Ba<sub>0.9</sub>Sr<sub>0.05</sub>Ca<sub>0.05</sub>TiO<sub>3</sub> powder by sol-gel: (1) Barium acetate (purity 99%), strontium acetate (purity 99%), and calcium acetate (purity 98%) were dissolved in 30 mL of acetic acid according to the stoichiometric ratio, and magnetically stirred at 70 °C for 30 min until completely dissolved. The solution was then cooled to room temperature to form a homogenized solution A; (2) Tetrabutyl titanate was dissolved in 1 mL of acetylacetone and 9 mL of ethylene glycol methyl ether according to the stoichiometric ratio to form a homogenized solution B; (3) Solutions A and B were mixed and stirred for 5 h and aged for 72 h to form a homogenized solution C; (4) Homogenized solution C was dried at 120 °C for 24 h to form a dry sol; (5) The dry sol was heat-treated at 900 °C (heating rate 5 °C/min) for 2 h to form BaSrCaTiO<sub>3</sub>based ceramic powder, named BSCT.
the prepared powder has a particle size of approximately 80 nm and contains Ti, Ba, Ca, O, and Sr elements, which are uniformly distributed.
the amplitude and phase diagrams of the prepared powder show obvious contrast changes and distinct butterfly-shaped displacement-voltage curves and phase change curves, indicating that the polarization direction of the powder changes under voltage changes and exhibits hysteresis, suggesting that the powder has a piezoelectric effect.
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after ultrasonic treatment, obvious superoxide radical peaks and hydroxyl radical peaks can be captured in BSCT powder, indicating that BSCT powder can generate ·O<sup>2-</sup> and ·OH after ultrasonic treatment.
The ultrasonic instrument was set to 2W, and the ultrasonic treatment lasted for 40 minutes... with the extension of ultrasonic treatment time, the blue color of the indigo carmine solution in the piezoelectric powder group gradually faded, and the absorbance intensity at 600 nm decreased with the extension of time. the tooth color changed significantly after powder treatment and became similar to the color before treatment.
the SEM results show that obvious crystalline particle deposits can be observed on the enamel and dentin surfaces of teeth treated with BSCT powder. The XRD results show the appearance of weak peaks attributed to hydroxyapatite, indicating that BSCT powder helps mineralize the tooth surface.
Human gingival fibroblasts were isolated from healthy gingival tissue collected from patients and cultured in DMEM high-glucose medium (supplemented with 15% FBS and 1% penicillin and antibiotics).
Prepare DMEM high-glucose medium with 1 mg/mL BSCT powder, and collect the extract after 48 h.
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